Clinical trials: Amitriptyline
Pruritus
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine
The purpose of this study is to examine the antipruritic efficacy of topical ketamine, amitriptyline, lidocaine, and a tri-combination of ketamine, amitriptyline and lidocaine (hereafter referred to as "KeAmLi") using…
- Trial name
- NCT03096444
- Testing
- Ketamine Hydrochloride, Amitriptyline Hydrochloride, Lidocaine Hydrochloride
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Gil Yosipovitch
Migraine, Preventive Treatment
Prediction of Migraine Prevention Efficacy Based on Individual's Pain Modulation
A major reason for the substantial underuse of pharmacological prevention of migraine is its inadequate efficacy, since only ~50% of patients respond to a specific agent.
- Trial name
- NCT02101892
- Testing
- Amitriptyline
- Where
- Israel
- Volunteers
- 54 people
- Sponsor
- Rambam Health Care Campus
Headache, Migraine, Migraine
Mind and Body Approaches to Pain Reduction in Youth With Migraine
The overarching objective of this protocol is to identify and understand the neural and pain processing mechanisms by which youth with migraine improve in response to preventive treatment.
- Conditions
- Headache, Migraine, Migraine, Migraine Disorders, Headache
- Trial name
- NCT03472092
- Testing
- Cognitive Behavioral Therapy (CBT), Amitriptyline, Biofeedback-Assisted Relaxation Training (BART)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Thermal Burn, Amitriptyline
Pilot Studies Blocking Injury-Induced MVP Release in Skin Using Topical Amitriptyline
The purpose of this study is to determine the amount of substances contained in skin known as microvesicle particles (MVP). Studies suggest these MVP are involved in many conditions such as after the thermal burn injury.
- Trial name
- NCT07716722
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wright State University
Diabetic Peripheral Neuropathy, Neuralgia
A Study of the Efficacy and Safety of Amitriptyline/Ketamine Topical Cream in Patients With Diabetic Peripheral Neuropathy
This is a multicenter, randomized, placebo-controlled, parallel group study of EpiCept™ NP-1 Topical Cream (amitriptyline 4%/ketamine 2%) in approximately 200 patients with pain in the lower extremities due to diabetic nerve pain.
- Trial name
- NCT00476151
- Testing
- EpiCept NP-1 (4% Amitriptyline/ 2% Ketamine) Topical Cream
- Where
- India
- Volunteers
- 226 people
- Sponsor
- EpiCept Corporation
Cystic Fibrosis, Pneumonia
Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo
Cystic fibrosis patients suffer from a chronic destruction of the lung, frequent and finally chronic pneumonia and a reduced life expectancy.
- Trial name
- APA-IIb (NCT01309178)
- Testing
- Amitriptyline, Mannite
- Where
- 3 sites in Germany
- Volunteers
- 30 people
- Sponsor
- University Children's Hospital Tuebingen
Chronic Oral Food Refusal
Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age
Gastrojejunal (G-J) feeding tubes are placed in infants and children who refuse to eat or are unable to eat enough to have normal growth.
- Trial name
- NCT01206478
- Testing
- Amitriptyline, Megestrol
- Where
- 3 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Ann Davis, PhD, MPH, ABPP
Fibromyalgia
Combining N-of-1 Trials to Assess Fibromyalgia Treatments
This study will compare the effectiveness of combination therapy with the drugs amitriptyline and fluoxetine (AM+FL) and amitriptyline (AM) alone in the treatment of people with fibromyalgia.
- Trial name
- NCT00000428
- Testing
- Amitriptyline, Amitriptyline plus Fluoxitine
- Where
- 7 sites in United States
- Volunteers
- 58 people
- Sponsor
- Tufts Medical Center
Low Back Pain
A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol
Non inferiority, multicentric, double blind study whose the primary objective is to compare the effectiveness of two products in pain reduction.
- Trial name
- NCT01421433
- Testing
- Tandrilax, Dolamin Flex
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Farmoquimica S.A.
Laryngeal Diseases
Treatment of Chronic Laryngitis With Amitriptyline
This randomized, double-blind, placebo-controlled trial will compare the effectiveness of amitriptyline versus placebo (inactive medication) in treating chronic laryngitis.
- Trial name
- NCT02552225
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Boston Medical Center
Vulvodynia
Physical Therapy as Adjuvant Treatment of Vulvodynia: a Randomized Controled Trial
INTRODUCTION: Vulvodynia (chronic vulvar pain in the absence of clinical findings) has a negative impact over quality of life in women with this diagnose. The existing treatments, however, are manifold but insufficient.
- Trial name
- NCT02871661
- Testing
- Amitriptyline, Kinesiotherapy, IC (Quark)
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- University of Campinas, Brazil
Diabetes Mellitus, Peripheral Neuropathies
Effects of Pregabalin, Duloxetine & Amitriptyline on Pain & Sleep
The purpose of this study is to assess the effectiveness of pregabalin, duloxetine and amitriptyline compared with placebo in reducing pain in diabetic patients as assessed by Brief Pain Inventory (BPI).
- Trial name
- NCT00370656
- Testing
- Pregabalin, Duloxetine, Amitriptyline
- Where
- 3 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Surrey
Functional Dyspepsia
Effect of Amitriptyline and Trifluoperazine on Patients With Functional Dyspepsia
The goal of this clinical trial is to assess and compare the effect of amitriptyline and trifluoperazine in improving dyspeptic symptoms in patients with functional dyspepsia.
- Trial name
- NCT07008235
- Testing
- Tablet Amitriptyline 10 milligrams, Tablet Trifluoperazine 1 milligrams twice daily, Standard First-Line Therapy
- Where
- Bangladesh
- Volunteers
- 120 people
- Sponsor
- Md. Moktadirul Hoque Shuvo
Diabetic Neuropathy, Painful
Tolerability of Switching to Duloxetine for the Management of Diabetic Nerve Pain
This study is to compare the tolerability of different methods for switching from another medication to duloxetine for the management of diabetic nerve pain.
- Trial name
- NCT00266643
- Testing
- duloxetine hydrochloride
- Where
- 20 sites in United States, Puerto Rico
- Volunteers
- 205 people
- Sponsor
- Eli Lilly and Company
Transformed Migraine, Chronic Daily Headache
Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines
This study will compare a local anesthetic technique that has been used to treat subjects suffering from transformed migraines (chronic migraines) versus medical management with traditional antidepressant Amitriptyline / Elavil.
- Trial name
- NCT02090998
- Testing
- SPG Block with 5% Lidocaine gel, Amitriptyline
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rutgers, The State University of New Jersey
Migraine
Comparison of Efficacy Between Combination of Amitriptyline-propranolol and Pizotifen for Migraine Prophylaxis.
The goal of this clinical trial is to compare efficacy and observe common adverse effects of a combination of amitriptyline-propranolol and pizotifen as prophylactic treatments for migraine.
- Trial name
- NCT06158230
- Testing
- Pizotifen, Amitriptyline-propranolol
- Where
- Bangladesh
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Fibromyalgia, Sleep Initiation and Maintenance Disorders
Nabilone Versus Amitriptyline in Improving Quality of Sleep in Patients With Fibromyalgia
Most chronic pain patients with insomnia are currently not well-managed using existing medications. If found to safely improve sleep with chronic pain patients, nabilone could be added to the treatment options available in the…
- Trial name
- NCT00381199
- Testing
- Amitriptyline Hydrochloride, Nabilone
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pain, Neuropathic, Leprosy
Treatment of Neuropathic Pain in Leprosy
Despite large efforts to eradicate leprosy, this curable mycobacterial infection still affects 250,000 new individuals annually. Half of the globe's leprosy patients live in Brazil and India.
- Conditions
- Pain, Neuropathic, Leprosy, Leprosy Neuropathy, Amitriptyline
- Trial name
- AmyNeLe (NCT03324035)
- Testing
- Amitriptyline, Tramadol
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- University of Sao Paulo
Functional Gastrointestinal Disorders
Study of Medication for Functional Abdominal Pain in Children
The purpose of this study is to determine where amitriptyline is effective in the treatment of functional abdominal pain in children.
- Trial name
- NCT00564525
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Muscle Type Temporomandibular Disorders, Myofascial Pain of the Masticatory Muscles
Myofascial Pain Patients' Response to the Administration of Low Doses of Amitriptyline and Citalopram Compared With the Use of Bite Splint
The aim of this study is evaluate the effectiveness of the use of antidepressants in the treatment of muscle type temporomandibular disorders, with a sample of 60 to 80 participants.
- Trial name
- NCT04777838
- Testing
- Citalopram 10 MG, Amitriptyline, Bite Splint
- Where
- Portugal
- Volunteers
- 80 people
- Sponsor
- University of Coimbra