Clinical trials: Amitriptyline
Migraine, Prophylaxis
Efficacy of Flunarizine Vs Amitriptyline in Prophylaxis of Migraine Prophylaxis
To compare the frequency of acute attack and mean pain score ( assessed by visual analog scale) among subjects using either flunarizine or amitriptyline among patients with migraine coming to tertiary care Hospital in Lahore…
- Trial name
- NCT06162819
- Testing
- Amitriptyline, Flunarizine 5mg
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Shalamar Institute of Health Sciences
Fibromyalgia, Sleep Initiation and Maintenance Disorders
Nabilone Versus Amitriptyline in Improving Quality of Sleep in Patients With Fibromyalgia
Most chronic pain patients with insomnia are currently not well-managed using existing medications. If found to safely improve sleep with chronic pain patients, nabilone could be added to the treatment options available in the…
- Trial name
- NCT00381199
- Testing
- Amitriptyline Hydrochloride, Nabilone
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Herniated Disc, Intervertebral Disc Displacement
Efficacy of Gabapentin or Amitriptyline to Reduce Postoperative Pain After Lumbar Laminectomy and Diskectomy
The hypothesis of this study is that Gabapentin or Amitriptyline has no role in preemptive analgesia to reduce postoperative pain after lumbar diskectomies.
- Trial name
- NCT01014520
- Testing
- Gabapentin , Amitriptyline
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Tabriz University
Microvesicle Particles, Thermal Burn
Pilot Studies Testing the Use of Oral Amitriptyline in Reducing Localized Burn Injury-induced Microvesicle Particle Release
The purpose of this study is to determine the amount of substances contained in skin known as microvesicle particles (MVP). The hypothesis to be tested in this study is that treatment with a single dose of 75mg of amitriptyline…
- Trial name
- NCT07640061
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wright State University
Fibromyalgia
Immune-Pineal Axis Function in Fibromyalgia
Fibromyalgia is a common condition in clinical medical practice, characterized by diffuse musculoskeletal pain. Sleep disorders, chronic fatigue, depression, intestinal disorders and headache are also commonly associated with the…
- Trial name
- NCT02041455
- Testing
- Melatonin and Amitriptylin
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Major Depressive Disorder
Safety and Efficacy Study Comparing ETS6103 With Amitriptyline in the Treatment of Major Depressive Disorder (MDD)
To demonstrate that the antidepressant activity of ETS6103 is not inferior to amitriptyline in subjects who have an unsatisfactory response to / are resistant to treatment with SSRIs.
- Trial name
- ETS6103-003 (NCT02014363)
- Testing
- ETS6103 (low dose), ETS6103 (high dose), Amitriptyline
- Where
- United Kingdom
- Volunteers
- 164 people
- Sponsor
- e-Therapeutics PLC
Depression
A Genotype Stratification Study for Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Male Subjects
A total of 24 healthy Korean male subjects will receive a single oral dose of amitriptyline, 25 mg. Subjects will be enrolled in this study based on their cytochrome P450 2D6 and cytochrome P450 2C19 genotypes, and serial blood…
- Trial name
- NCT02519400
- Testing
- Amitriptyline
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Neuropathy in Cacer Patien
Comparison of the Efficacy and Safety of Duloxetine Augmented With Gabapentin and Duloxetine Augmented With Amitriptyline vs Duloxetine Alone in Chemotherapy -Induced Neuropathy
This study aimed to elucidate the relationship between the Efficacy and Safety of Comparison of the Efficacy and Safety Duloxetine augmented with gabapentin and amitriptyline augmented with Duloxetine vs duloxetine alone in…
- Trial name
- NCT06091553
- Testing
- Duloxetine alone, Duloxetine augmented with gabapentin, Duloxetine augmented with amitriptyline (as combined therapy)
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Beni-Suef University
Migraine, Headache
Amitriptyline vs GON and SON Blocks in Migraine
Comparison of efficacy and safety of amitriptyline and nerve blocks
- Trial name
- NCT04750967
- Testing
- Lidocaine 1% Injectable Solution, Amitriptyline
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Chemotherapy-induced Peripheral Neuropathy
Efficacy and Safety of ATX01 in Adult Patients With CIPN (Chemotherapy-induced Peripheral Neuropathy)
The purpose of this clinical trial is to compare the efficacy of twice daily applications of ATX01 (10% \& 15%) versus placebo during a 12-week treatment period in treating chemotherapy-induced peripheral neuropathy (CIPN) in…
- Trial name
- ACT (NCT05593614)
- Testing
- ATX01 10%, ATX01 15%
- Where
- 43 sites in United States, Belgium and 5 more
- Volunteers
- 276 people
- Sponsor
- AlgoTherapeutix
Interstitial Lung Disease
Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related Cough
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with interstitial lung disease (ILD)-related cough.
- Trial name
- MACS-2 (NCT05120934)
- Testing
- Amitriptyline 25 MG, Amitriptyline 50 MG, Duloxetine 30 MG
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Depressive Disorder
Bioavailability Study of Amitriptyline Hydrochloride Tablets
Main Objectives: In Chinese healthy subjects under both fasting and postprandial conditions, amitriptyline hydrochloride tablets (size: 25 mg) produced by Sandoz Inc., US Orange Book, were used as reference preparations.
- Trial name
- AMTL-BE (NCT03646526)
- Testing
- Amitriptyline Hydrochloride 25Mg Tablet（Hunan Dongting）, Amitriptyline Hydrochloride 25Mg Tablet（Sandoz）
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Rosacea
Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea
Rosacea is a common skin condition associated with easy blushing and red face; many patients with rosacea react to sunlight with increased redness.
- Trial name
- NCT06312813
- Testing
- Imipramine, Amitriptyline, Vehicle
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Wright State University
Chronic Neuropathic Pain
Effects of Amitriptyline for the Treatment of Pain on Driving Performance and Cognition.
The acute and subchronic effects of amitriptyline were compared to placebo in a double-blind crossover randomized study on driving ability and driving-related skills in chronic neuropathic pain patients.It was hypothesized that…
- Trial name
- NCT00189059
- Testing
- amitriptyline
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- UMC Utrecht
Cystic Fibrosis, Infection
Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo
Our data indicate that the CFTR-molecule functions as a transporter for sphingosine-1-phosphate and sphingosine or regulates the uptake of these sphingolipids by epithelial cells.
- Conditions
- Cystic Fibrosis, Infection, Pseudomonas Aeruginosa
- Trial name
- NCT00515229
- Testing
- amitriptyline
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- University Hospital Tuebingen
Muscle Type Temporomandibular Disorders, Myofascial Pain of the Masticatory Muscles
Myofascial Pain Patients' Response to the Administration of Low Doses of Amitriptyline and Citalopram Compared With the Use of Bite Splint
The aim of this study is evaluate the effectiveness of the use of antidepressants in the treatment of muscle type temporomandibular disorders, with a sample of 60 to 80 participants.
- Trial name
- NCT04777838
- Testing
- Citalopram 10 MG, Amitriptyline, Bite Splint
- Where
- Portugal
- Volunteers
- 80 people
- Sponsor
- University of Coimbra
Cystic Fibrosis, Pneumonia
Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo
Cystic fibrosis patients suffer from a chronic destruction of the lung, frequent and finally chronic pneumonia and a reduced life expectancy.
- Trial name
- APA-IIb (NCT01309178)
- Testing
- Amitriptyline, Mannite
- Where
- 3 sites in Germany
- Volunteers
- 30 people
- Sponsor
- University Children's Hospital Tuebingen
Adhesive Capsulitis
Amitriptyline Regarding Nimesulide in Acute Idiopathic Adhesive Capsulitis
The adhesive capsulitis is a disease of the shoulder characterized by pain and limitation of movement amplitude. It is defined as for etiology, having discordant theories that related it to an inflammatory condition or to an…
- Trial name
- NCT01306708
- Testing
- amitriptyline
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Universidade do Sul de Santa Catarina
Bladder Diseases, Interstitial Cystitis
Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS)
This is a randomized clinical trial study to test the efficacy and safety of amitriptyline in the treatment of patients newly diagnosed with painful bladder syndrome (PBS).
- Trial name
- IC01 (NCT00124306)
- Testing
- Amitriptyline
- Where
- 10 sites in United States, Canada
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
HIV Infections, Peripheral Nervous System Disease
The Efficacy of a Standardized Acupuncture Regimen and Amitriptyline Compared With Placebo as a Treatment for Pain Caused by Peripheral Neuropathy in HIV-Infected Patients
To evaluate the separate and combined efficacy of a standardized acupuncture regimen and amitriptyline on the relief of pain due to peripheral neuropathy and on the quality of life of HIV-infected patients.
- Trial name
- NCT00000817
- Testing
- Amitriptyline hydrochloride, Point acupuncture
- Where
- 11 sites in United States
- Volunteers
- 260 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)