Clinical trials: Amnestic Mild Cognitive Impairment, active
Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic
Acoustic Stimulation During Sleep: Effects on Memory and p-tau217 in MCI
The goal of this clinical trial is to determine whether acoustic stimulation during sleep can enhance slow-wave sleep (SWS), improve cognitive function, and reduce AD-related pathology in individuals with mild cognitive…
- Conditions
- Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic, Cognitively Unimpaired
- Trial name
- PAS-MCI (NCT07529015)
- Testing
- Plase-Locked Acoustic Stimulation during slow-wave sleep
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder
Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease
The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in…
- Conditions
- Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease
- Trial name
- LIFUP-MCIAD (NCT05417555)
- Testing
- Low-Intensity Focused Ultrasound Pulsation (LIFUP)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Mild Cognitive Impairment (MCI), Dementia
Telemedicine Self-examination of Speech and Memory for Rapid Detection of Cognitive Impairments Using Machine Learning Methods
Early cognitive disorders diagnosis is becoming increasingly important due to population aging. The most common causes include Alzheimer's disease and frontotemporal dementia.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia, Mild Cognitive Impairment (MCI) Amnestic, Frontotemporal Degeneration (FTD)
- Trial name
- NCT07558785
- Testing
- The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Mississippi Aphasia Screening Test, Amnesia Light and Brief Assessment (ALBA)
- Where
- 3 sites in Czechia
- Volunteers
- 500 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Alzheimer Disease
Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease
The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease.
- Trial name
- ADVISe (NCT04576793)
- Testing
- 11C-ER176, 18F-MK6240, 18F-Florbetaben
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Columbia University
AMCI - Amnestic Mild Cognitive Impairment
Effects of Photobiomodularion on Brain Connectivity and Cognitive Function in Cognitive Impairment
The goal of this clinical trial is to learn if transcranial photobiomodulation (t-PBM), a light-based brain therapy, can help improve memory and cognitive skills in older adults with amnestic mild cognitive impairment (aMCI).
- Trial name
- PBM-CogConnect (NCT07287527)
- Testing
- Active transcranial Photobiomodulation, Cognitive Rehabilitation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Uskudar University
Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Amnestic
Deep Brain Stimulation Guided by Brain Mapping to Treat Cognitive Impairment
This trial is a 12-month safety and feasibility study, enrolling up to six participants. These participants will serve as their own controls, structured in multiple parts that follow an initial short-term stereo…
- Conditions
- Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Amnestic, Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Memory Deficit
- Trial name
- NCT07887737
- Testing
- Abbott St Jude Medical Infinity™
- Volunteers
- 6 people
- Sponsor
- University of Texas Southwestern Medical Center
Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment
Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases
The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative…
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment, Parkinson's Disease With Mild Cognitive Impairment
- Trial name
- NCT07449117
- Testing
- Active Temporal Interference Stimulation (TIS)
- Where
- Czechia
- Volunteers
- 70 people
- Sponsor
- Masaryk University
Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD)
Early Stage of Alzheimer's and Parkinson's Diseases, HearIng Relevance (SAPHIR)
The study aims to phenotype hearing in patients with early stage of neurodegenerative disorders to explore the prevalence of various hearing disorders in comparison to a control population.
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD), Healthy Participants
- Trial name
- SAPHIR (NCT07083089)
- Testing
- Thorough Hearing assessment
- Where
- 4 sites in France
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Cilcare SAS
Normal Physiology, Amnestic Mild Cognitive Impairment
MRI Guided Closed-loop TMS-EEG
The goal of this interventional study is to develop an individualized approach using transcranial magnetic stimulation (TMS) in a high-precision manner.
- Trial name
- NCT06050603
- Testing
- TMS
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Sleep Disturbance, Amnestic Mild Cognitive Impairment
Sleep Interventions and Neurocognitive Outcomes
This protocol focuses on the effect of sleep interventions on improving sleep and building cognitive/brain resilience in older adults with amnestic mild cognitive impairment and sleep disturbance.
- Trial name
- SINA (NCT05987007)
- Testing
- Acoustic slow-wave activity enhancement, Cognitive behavioral therapy for insomnia
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- New York State Psychiatric Institute
Atypical Alzheimer's Disease, Logopenic Progressive Aphasia (LPA)
Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study
This is a neuroimaging study designed to learn more about amyloid and tau burden in the brain of patients with typical and atypical Alzheimer's Disease and how burden may change over a one year period.
- Conditions
- Atypical Alzheimer's Disease, Logopenic Progressive Aphasia (LPA), Posterior Cortical Atrophy (PCA), Alzheimer Disease
- Trial name
- NCT02740634
- Testing
- F-18 AV 1451, C-11 PiB
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Long-Term Memory Decline, Mild Cognitive Impairment
Wayfinding Intervention and Long-Term Memory
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment.
- Trial name
- Quest-Tablet (NCT05625425)
- Testing
- LabyrinthVR software, Labyrinth Tablet software, Labyrinth VR wireless
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alzheimer Disease, Early Onset, Mild Cognitive Impairment
Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study
The objective of the study is to determine the safety, feasibility, and efficacy of senolytics in older adults with amnestic mild cognitive impairment (MCI) or early-stage AD (Clinical Dementia Rating (CDR)=0.5 or 1) who are tau…
- Trial name
- SToMP-AD (NCT04685590)
- Testing
- Dasatinib + Quercetin
- Where
- 5 sites in United States, Spain
- Volunteers
- 48 people
- Sponsor
- Washington University School of Medicine
AMCI - Amnestic Mild Cognitive Impairment, Sleep Disturbance
Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone
To investigate the effect of trazodone on sleep, hippocampal-dependent memory and hippocampal excitability. The investigators hypothesize that trazodone will improve total sleep time and proportion of time in Slow Wave Sleep…
- Trial name
- REST (NCT05282550)
- Testing
- Trazodone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment
Comparison of Two Non-invasive Neuromodulation Techniques as Synergistic Therapy to Cognitive Stimulation in Amnestic Mild Cognitive Impairment (aMCI)
This is a comparative, double-blind, randomized controlled clinical trial for people with Amnestic Mild Cognitive Impairment. The investigators will compare the effects of two non-invasive neuromodulation techniques (Repetitive…
- Trial name
- NCT06467253
- Testing
- 1. rTMS + CS, 3. tDCS + CS
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Amnestic Mild Cognitive Impairment - aMCI, AD-MCI
Temporal Interference Stimulation Treatment in Patients With Cognitive Impairment
This study aims to evaluate the efficacy and safety of temporal interference stimulation (TIS), a non-invasive neuromodulation technique, in improving cognitive function in patients with cognitive impairment.
- Conditions
- Amnestic Mild Cognitive Impairment - aMCI, AD-MCI, AD - Alzheimer's Disease, FTD
- Trial name
- TIS (NCT07643363)
- Testing
- Temporal Interference Stimulation, Targeted Cognitive Training, General Cognitive Training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tianjin Huanhu Hospital
Mild Cognitive Impairment (MCI), AMCI - Amnestic Mild Cognitive Impairment
Effects of Combined Aerobic and Cognitive Training in a Simultaneous or Sequential Paradigm on Cognition and Brain Functional Activity in Patients with AMCI
Mild Cognitive Impairment (MCI) is a condition in which patients show an objective evidence of impairment in one or more cognitive domains but a spared independence in daily functional abilities.
- Conditions
- Mild Cognitive Impairment (MCI), AMCI - Amnestic Mild Cognitive Impairment, Neurodegenerative Dementia, Neurodegenerative Disease
- Trial name
- NCT06755164
- Testing
- Simultaneous aerobic and cognitive training (SIM), Sequential aerobic and cognitive training (SEQ)
- Where
- Italy
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Mild Cognitive Impairment, Alzheimer Disease
Senicapoc in Alzheimer's Disease
Development of novel disease-modifying therapies for Alzheimer's disease (AD) remains of paramount importance. This study will be a Phase II randomized clinical trial testing Senicapoc in patients with mild or prodromal AD.
- Trial name
- Senicapoc (NCT04804241)
- Testing
- Senicapoc
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder
Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History
This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS)…
- Conditions
- Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Amnestic Mild Cognitive Impairment, Mild Traumatic Brain Injury
- Trial name
- PATH (NCT05446584)
- Testing
- High Definition Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
MCI, MCI Conversion to Dementia
Neurocognitive Assessment Platform 4 Alzheimer
The aging population in Europe is leading to an increase in neurodegenerative diseases, such as Alzheimer's disease (AD), which is expected to affect 152 million people worldwide by 2050.
- Conditions
- MCI, MCI Conversion to Dementia, AMCI - Amnestic Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NAP4A2020 (NCT07272811)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele