Clinical trials: Amoxicillin-clavulanate
Community-Acquired Pneumonia
Comparison Between Amoxycillin/Clavulanic Acid and Oxacillin/Ceftriaxone for Community Acquired-pneumonia
Objective: To compare the clinical effectiveness and hospital costs, the initial empirical treatment, Oxacillin / Ceftriaxone and Amoxicillin / Clavulanate in children with Community Acquired Pneumonia (CAP) severe.
- Trial name
- NCT01166932
- Testing
- Amoxycillin/clavulanic acid, ceftriaxone/oxacillin
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Infections, Bacterial
A Pharmacokinetics and Safety Study of Augmentin ES-600 in Children With CAP and ABRS
The purpose of this study is to evaluate the pharmacokinetics, safety or tolerability through treatment emergent adverse event (TEAE) and to explore primary and secondary clinical response of treatment with Augmentin ES in…
- Trial name
- NCT05340257
- Testing
- Augmentin ES
- Where
- 2 sites in Brazil
- Sponsor
- GlaxoSmithKline
Protracted Bacterial Bronchitis
Higher Versus Standard Dose of Amoxicillin-clavulanate in Pediatric PBB
Chronic wet cough is one of the most common symptoms of respiratory diseases in children. Protracted bacterial bronchitis (protracted bacterial bronchitis, PBB) is the most common cause of chronic wet cough in children.
- Trial name
- NCT04378231
- Testing
- Amoxicillin-Clavulanate 200 Mg-28.5 Mg Oral dry suspension
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Tuberculosis
Evaluating the EBA of Meropenem With Amoxicillin/Clavulanate and Pyrazinamide or Bedaquiline in Adults With PTB
A single-center, open-label clinical trial to determine the early bactericidal activity (EBA) and safety of the combination of meropenem and amoxicillin/clavulanate plus pyrazinamide vs.
- Trial name
- TB_COMBO_01 (NCT04629378)
- Testing
- Meropenem Injection, Amoxicillin Clavulanate, Pyrazinamide
- Where
- South Africa
- Volunteers
- 22 people
- Sponsor
- TASK Applied Science
Infection
Preoperative Dose of Co-amoxiclav for Prevention of Postoperative Complications in Dentoalveolar Surgery
There was no evidence to judge the effects of preventative antibiotics for extractions of severely decayed teeth, teeth in diseased gums, or extractions in patients who are sick or have low immunity to infection.
- Trial name
- NCT03844776
- Testing
- Co-Amoxiclav, Paracetamol, Chlorhexidine mouthwash
- Where
- Saudi Arabia
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Taibah University
Post Operative Wound Infection, Graft Uptake
Does Antibiotics Use During Surgery Help to Decrease Wound Infection and Increase Success After Ear Surgery in Children
This study assess whether there is any role of antibiotics to decrease wound infection and increase the success of surgery
- Conditions
- Post Operative Wound Infection, Graft Uptake, Myringoplasty
- Trial name
- NCT03700814
- Testing
- Co-amoxiclav
- Volunteers
- 60 people
- Sponsor
- Tribhuvan University, Nepal
Acute Otitis Media
A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media
The primary objective is to compare the safety and efficacy of cefdinir oral suspension, 7 mg/kg/day ql2hrs for 5 days, to amoxicillin/clavulanate oral suspension 45 mg/kg/day (based on amoxicillin component), in divided doses…
- Trial name
- NCT00644943
- Testing
- cefdinir (Omnicef), amoxicillin
- Where
- 32 sites in United States
- Volunteers
- 425 people
- Sponsor
- Abbott
Pediatric, Bacterial Infections
A Pharmacokinetic Study of LP-001 in Children With a Bacterial Infection
The purpose of this study is to determine the pharmacokinetic profiles of LP-001, an amoxicillin and clavulanate formulation compared to the pharmacokinetic profiles of Augmentin ES-600 for use in pediatric patients with a…
- Trial name
- NCT05584683
- Testing
- Amoxicillin potassium clavulanate, Amoxicillin potassium clavulanate (Augmentin ES-600)
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Kaizen Bioscience Co.
Healthy
Amoxicillin-Clavulanic Acid 400 Mg-57 mg Chewable Tablets Under Fasting Conditions
The objective of this study is to compare the rate and extent of absorption of amoxicillin-clavulanic acid 400 mg-57 mg chewable tablets (test) versus Augmentin® (reference) administered as 1 x 400 mg-57 mg chewable tablet under…
- Trial name
- NCT00835705
- Testing
- amoxicillin-clavulanic acid, Augmentin®
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Healthy
600 mg Amoxicillin/42.9 mg Clavulanate Postassium /5 mL Suspension Under Fasting Conditions
The objective of this study is to assess the bioequivalence between Amoxicillin and Clavulanate Potassium for Oral Suspension, 600/42.9 mg/5 mL and Augmentin ES-600™ for Oral Suspension, 600/42.9 mg/5 mL in healthy, male and…
- Trial name
- NCT00840099
- Testing
- 600 mg Amoxicillin/42.9 mg Clavulanate Postassium /5 mL, Augmentin ES-600™ 600 mg/42.9 mg/5 mL Suspension
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Acute Otitis Media
Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children
This is a randomized, controlled trial studying the effects of various antimicrobial treatments on the intestinal microbiome of small children.
- Trial name
- AOMMi (NCT02935374)
- Testing
- Amoxicillin, Amoxicillin-Potassium Clavulanate, Macrolide
- Where
- Finland
- Volunteers
- 73 people
- Sponsor
- University of Oulu
Infection
Pharmacokinetics of Small Spectrum Beta-lactam Antibiotics (Amoxicillin/Clavulanic Acid and Cefuroxime) in Patients on Intensive Care Units
Adequate antibiotic therapy is very important in the treatment of infections. Spectrum and dosing of the antibiotics are two factors of the therapy: the spectrum of an antibiotic can't be changed, but the dosing scheme can be…
- Trial name
- AMOCEF (NCT01581047)
- Where
- Belgium
- Volunteers
- 37 people
- Sponsor
- University Hospital, Ghent
Otitis Maedia
Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media)
This post-marketing surveillance study of CLAVAMOX® was designed to collect and assess the information on proper use, such as safety and efficacy, under actual use conditions, targeting pediatric Japanese patients with diseases…
- Trial name
- NCT01406275
- Testing
- Amoxicillin and clavulanate
- Volunteers
- 363 people
- Sponsor
- GlaxoSmithKline
Pneumonia
Hospitalised Pneumonia With Extended Treatment (HOPE) Study
An intervention study to determine if a longer duration of antibiotics (compared to shorter duration) improves the short and long term clinical outcomes of children hospitalised for pneumonia
- Trial name
- HOPE (NCT02783859)
- Testing
- Amoxicillin-clavulanic Acid
- Where
- 5 sites in Australia, Malaysia and 1 more
- Volunteers
- 314 people
- Sponsor
- Menzies School of Health Research
Urinary Tract Infections, Bacteremia
Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in ESBL UTIs
To evaluate if the combination of pivmecillinam and clavulanic acid (PAC) is non-inferior to ciprofloxacin, trimethoprim-sulfamethoxazole or ertapenem as step down oral therapy in patients with febrile UTI caused by extended…
- Conditions
- Urinary Tract Infections, Bacteremia, Antibiotic Resistant Infection
- Trial name
- PACUTI (NCT05224401)
- Testing
- Pivmecillinam and amoxicillin/clavulanic acid, Standard treatment, ciprofloxacin, trimethoprim/sulfamethoxazole or ertapenem depending on susceptibility
- Where
- 5 sites in Sweden
- Volunteers
- 330 people
- Sponsor
- Lund University
Pulmonary Tuberculosis
Study to Evaluate EBA, Safety and Tolerability of Carbapenems in Adults With Pulmonary Tuberculosis
The goal of this single-center, open-labelled, clinical trial in two groups aims to proof that a specific group of antibiotics (carbapenems) can be used to treat pulmonary tuberculosis if it is combined with another antibiotic…
- Trial name
- NCT05896930
- Testing
- Meropenem 6g IV over 6 hours, Ertapenem 1g IM, Meropenem 3g IV
- Where
- South Africa
- Volunteers
- 134 people
- Sponsor
- TASK Applied Science
Fever, Pneumonia
The Impact of Antibiotic Prophylaxis on Incidence of Post-bronchoscopy Fever and Change of Serum Cytokines
Fever can develop after fiberoptic bronchoscopy (FB) in about 2.5 - 16 % of adult patients. We evaluated the impact of oral amoxicillin/clavulanate (AC) on incidence of postbronchoscopic fever and pneumonia.
- Trial name
- NCT01089218
- Testing
- oral amoxicillin/clavulanate 1g (875/125mg), control
- Volunteers
- 241 people
- Sponsor
- Seoul National University Hospital
Sinusitis
Zmax Compared to Augmentin in Sinusitis
This study will enroll patients with Bacterial Sinusitis who will be treated with either Zmax (Azithromycin Extended Release) or Augmentin (Amoxicillin/Clavulanate).
- Trial name
- NCT00367120
- Testing
- Azithromycin Extended Release, Amoxicillin/Clavulanate
- Volunteers
- 762 people
- Sponsor
- Pfizer
Pharmacokinetics, Amoxicillin-clavulanate
Antibiotic Dosing in Pediatric Intensive Care
Pharmacokinetics of antibiotics in critically ill neonates, infants and children
- Conditions
- Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam, Vancomycin
- Trial name
- ADIC (NCT02456974)
- Testing
- blood sampling in patients receiving amoxicillin-clavulanate as part of routine clinical care, blood sampling in patients receiving piperacilline-tazobactam as part of routine clinical care., blood sampling in patients receiving vancomycin as part of routine clinical care.
- Where
- Belgium
- Volunteers
- 640 people
- Sponsor
- University Hospital, Ghent
Bronchitis, Chronic
A Multicentre, Randomised, Open-Label Study To Compare The Efficacy And Safety Of Azithromycin For 5 Days With Those Of Amoxicillin-Clavulanic Acid In Patients With Chronic Bronchitis
This study compared the clinical efficacy and safety of azithromycin with that of amoxicillin-clavulanic acid, in patients between the ages of 35 and 75 years, presenting with an exacerbation of chronic bronchitis.
- Trial name
- NCT00649831
- Testing
- Amoxicillin/clavulinic acid, Azithromycin
- Where
- 31 sites in France
- Volunteers
- 250 people
- Sponsor
- Pfizer