Clinical trials: Amphetamine-related Disorders
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders
Study to Evaluate the Likeability, Safety, and Abuse Potential of NRP 104 in Adults With Histories of Stimulant Abuse
This research is being done to evaluate if NRP104 is a safe drug. The other purpose is to learn if NRP104 produces a high and any other effects like amphetamine and other stimulant drugs that are abused.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00248092
- Testing
- NRP104
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- New River Pharmaceuticals
Amphetamine-Related Disorders
Tyrosine for Methamphetamine Dependence - 1
The purpose of this study is to evaluate efficacy of tyrosine as a treatment for methamphetamine dependence in an outpatient treatment setting providing group psychosocial interventions.
- Trial name
- NCT00000322
- Testing
- Tyrosine
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Amphetamine Addiction
Robot-Assisted Intelligent Rehabilitation Treatment for Methamphetamine Use Disorders.
The purpose of this research is to evaluate the efficacy and safety of Robot-assisted rehabilitation intelligent system as a virtual stand-alone treatment, delivered with minimal clinical monitoring compared with treatment as…
- Trial name
- NCT04531384
- Testing
- robot-assisted rehabilitation intelligent treatment, standard psychotherapy treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Mental Health Center
Cocaine-Related Disorders, Opioid-Related Disorders
Dextroamphetamine as Adjunct in Cocaine/Opiate Dependent Patients - 3
The purpose of this study is to evaluate dextroamphetamine sulfate (sustained release) as an adjunct in concurrent cocaine and opiate dependent patients.
- Trial name
- NCT00000306
- Testing
- Dextroamphetamine
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Amphetamine Addiction, Pharmacotherapy
Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction
The investigators will conducted a randomized double-blind placebo-controlled study to investigate the treatment outcomes of add-on low dose dextromethorphan (DM), memantine (MM), or dextromethorphan and memantine combination…
- Trial name
- NCT04687566
- Testing
- Dextromethorphan, Memantine, Dextromethorphan and memantine
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Cheng-Kung University Hospital
Heroin Dependence, Amphetamine Dependence
Mirtazapine as a Treatment for Co-Occurring Opioid and ATS Dependence in Malaysia
The purpose of this study is to evaluate tolerability, acceptability and potential efficacy of 4 months of maintenance treatment with Mirtazapine as compared to placebo for patients with co-occurring amphetamine-type stimulant…
- Trial name
- NCT02541526
- Testing
- Mirtazapine
- Where
- Malaysia
- Volunteers
- 80 people
- Sponsor
- Universiti Sains Malaysia
Amphetamine-Related Disorders
Assessment of Potential Interactions Between Methamphetamine and Bupropion - 1
The purpose of this study is to assess potential interactions between intravenous (IV) methamphetamine and oral bupropion.
- Trial name
- NCT00040040
- Testing
- Bupropion
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Methamphetamine Addiction, Crystal Meth Addiction
An Assessment of the Safety of Varenicline in Methamphetamine-dependent Volunteers
More people worldwide use amphetamine-type stimulants than any illicit drug besides cannabis, and methamphetamine (MA) abuse and dependence is the fastest growing drug problem in the United States.
- Conditions
- Methamphetamine Addiction, Crystal Meth Addiction, Amphetamine Addiction
- Trial name
- NCT00713479
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, Los Angeles
Amphetamine-Related Disorders
Mirtazapine for the Treatment of Methamphetamine Dependence Among MSM (M2.0)
The investigators recently conducted a double-blind, randomized controlled trial (n=60) of limited duration (12 weeks), and found that compared with placebo, oral mirtazapine, an FDA-approved antidepressant, significantly reduced…
- Trial name
- NCT01888835
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Phillip Coffin, MD, MIA
Amphetamine-Related Disorders
Cognitive Correlates of Substance Abuse, Part 2 - 16
Part II: Examine cognitive performance of stimulant abusers (methamphetamine and cocaine) during recovery by assessing their cognitive function at monthly intervals.
- Trial name
- NCT00000351
- Volunteers
- 43 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-use Disorder, Amphetamine Use Disorders
Neurocognitive Empowerment for Addiction Treatment (NEAT) in Opioid Use Disorder and Amphetamine Use Disorder
Chronic drug addiction is not only associated with increased mental health symptoms, such as anxiety and depression, but also with brain (neural and cognitive) deficits.
- Trial name
- NEAT (NCT03922646)
- Testing
- Neurocognitive Empowerment for Addiction Treatment (NEAT), Active Control
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Methamphetamine Abuse, Methamphetamine-dependence
Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder
Methamphetamine use disorder (MUD) is becoming an increasing public health concern in Canada. While the evidence on the efficacy and safety of prescription psychostimulants for the treatment of MUD is promising, the knowledge on…
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance Abuse
- Trial name
- NCT06788587
- Testing
- LDX-01 plus TAU
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Drug Dependence
Brain Function in Response to Motivational Stimuli
This study seeks more information about the biology of substance dependency by exploring the brain areas involved in feeling positive and negative emotions.
- Trial name
- NCT00047866
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder (AUD), Alcoholism
Role of Pavlovian Mechanisms for Control Over Substance Use
During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Cannabis Use Disorder
- Trial name
- ReCoDe (NCT06701487)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Pavlovian-to-instrumental transfer (PIT) paradigm
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technische Universität Dresden
Healthy Volunteers, Drug Users
A Study to Evaluate the Abuse Potential of EB-1020 Immediate-Release in Healthy Recreational Stimulant Users
This single-center study will be a single-dose, randomized, double-blind, placebo- and active-controlled crossover study with a single inpatient treatment visit.
- Trial name
- NCT02144415
- Testing
- EB-1020 400 mg, EB-1020 800 mg, lisdexamfetamine 150 mg
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Amphetamine Dependence
Extended Release Naltrexone for Treating Amphetamine Dependence in Iceland
Until positive results were found with oral naltrexone, no medication has been effective against amphetamine dependence. The primary aim of this pilot study is to replicate the findings of the Swedish team that showed oral…
- Trial name
- NCT01100853
- Where
- Iceland
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Methamphetamine Dependence
A Cognitive Behavioral Therapy-Based Text Messaging Intervention for Methamphetamine Dependence
This Phase I, randomized, 22-day crossover study seeks to improve treatment outcomes for methamphetamine-dependent subjects by developing a cognitive behavioral therapy (CBT)- based short message service (SMS) text messaging…
- Trial name
- NCT01577797
- Testing
- Text messages
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New Leaf Treatment Center
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders
Safety, Tolerability and Abuse Liability Study of Intravenous NRP104 in Adults With Stimulant Abuse Histories
This research is being done to evaluate if NRP 104 is a safe drug. The other purpose is to learn if NRP104, when injected into a vein, produces a high and any other effects like amphetamine and other stimulant drugs that are…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00247572
- Testing
- NRP104
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- New River Pharmaceuticals
Cocaine-Related Disorders
Treatment of Cocaine Dependence: Comparison of Three Doses of Dextro-Amphetamine Sulfate and Placebo
Dextro-amphetamine sulfate is a central nervous system stimulant that increases the release of the neurotransmitter dopamine in the brain.
- Trial name
- NCT00218348
- Testing
- Dextro-Amphetamine Sulfate
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- The University of Texas Health Science Center, Houston
Methamphetamine Use Disorder, Human Immunodeficiency Virus (HIV)
Psilocybin Therapy for Methamphetamine Use Disorder and HIV
The goal of this clinical trial is to learn whether it is possible to use psilocybin in combination with motivational support therapy to treat moderate-to-severe methamphetamine use disorder (MeUD) in people with HIV who are…
- Trial name
- PRISM (NCT07756736)
- Testing
- Psilocybin 5 mg, Psilocybin 25 mg, Motivational Support
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nicky Mehtani, MD, MPH