Clinical trials: Amphetamine-related Disorders
Substance Dependence, Amphetamine Dependence
A Dose Ranging Study of Modafinil for Methamphetamine Dependence
Patients treated for methamphetamine dependence have high rates of relapse, and no pharmacotherapy has yet been demonstrated to be efficacious.
- Trial name
- NCT00630097
- Testing
- modafinil
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- California Pacific Medical Center Research Institute
Heroin Dependence, Opioid-Related Disorders
Sustained Release d-Amphetamine & Buprenorphine on Drug Seeking Behavior in Opioid & Cocaine Dependent Individuals
The purpose of this study is to determine whether maintenance on different oral doses of sustained release d-amphetamine (SR-AMP) combined with constant-dose sublingual buprenorphine (BUP) is safe and well tolerated and decreases…
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Cocaine Abuse or Dependence
- Trial name
- NCT00429767
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wayne State University
Drug Abuse
Stimulant Abuser Groups to Engage in 12-Step
The purpose of this study is to determine whether a combined group and individual 12-Step facilitative (TSF) intervention, Stimulant Abuser Groups to Engage in 12 -Step (STAGE-12), improves substance -related outcomes.
- Trial name
- STAGE-12 (NCT00573183)
- Testing
- STAGE-12, Treatment as Usual
- Where
- 10 sites in United States
- Volunteers
- 471 people
- Sponsor
- University of Washington
Heroin Dependence, Amphetamine Dependence
An Open Label Study of Oral Minocycline for the Treatment of Patients With Co-occurring Opioid and ATS Dependence
The proposed study will evaluate the tolerability, acceptability and potential efficacy of minocycline for the treatment of co-occurring opioid and amphetamine-type stimulant (ATS) dependence.
- Trial name
- NCT02541500
- Testing
- Minocycline
- Where
- Malaysia
- Volunteers
- 40 people
- Sponsor
- Universiti Sains Malaysia
Amphetamine-Related Disorders
Extended-Release Naltrexone to Treat Methamphetamine Dependence in Men Who Have Sex With Men (MSM)
Extended-release naltrexone (XR-NTX, VIVITROL) is an FDA-approved medication with efficacy in treating alcohol dependence and prevention of relapse to opioid dependence.
- Trial name
- TREX (NCT01449565)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- San Francisco Department of Public Health
Heroin Dependence, Opioid-Related Disorders
Treatment Study: Reducing Cocaine/Heroin Abuse With SR-Amphetamine and Buprenorphine (ARC)
This research study takes place at Wayne State University and will take about 11 weeks to complete. This is a treatment research study for individuals who currently have cocaine abuse or dependence, and who may also have heroin…
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Cocaine Abuse or Dependence
- Trial name
- ARC (NCT00698737)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wayne State University
Nicotine Dependence
Imaging Extrastriatal Dopamine Release in Tobacco Smokers and Nonsmokers
The goal is to examine sex differences in amphetamine-induced dopamine release in tobacco smokers and nonsmokers.
- Trial name
- NCT02348385
- Testing
- Amphetamine
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Yale University
Bipolar II Disorder
Differential Responses to Drugs and Sweet Tastes
Young adults who exhibit "bipolar phenotype" (BPP), defined as occasional episodes of mood elevation and heightened activity, are at risk for several psychiatric disorders, including problem use of drugs and alcohol.
- Trial name
- HAP (NCT03810703)
- Testing
- d-amphetamine 10 mg oral capsule, d-amphetamine 20 mg oral capsule
- Where
- 2 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Methamphetamine-dependence, Substance Abuse
Safety Interaction Trial Ibudilast and Methamphetamine
This study is designed to collect data to determine whether a medication, ibudilast, is safe for use as a potential treatment for methamphetamine-dependent people.
- Trial name
- NCT01217970
- Testing
- Ibudilast 20mg, Ibudilast 50mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Los Angeles
Amphetamine Dependence
Trial of Modafinil for Methamphetamine Dependence
The study aims to evaluate the safety and efficacy of modafinil (200 mg/day) over 10 weeks plus a tailored cognitive behavioural therapy program in the treatment of methamphetamine dependence.
- Trial name
- NCT00123370
- Testing
- Modafinil
- Where
- 2 sites in Australia
- Volunteers
- 87 people
- Sponsor
- The University of New South Wales
Amphetamine-Related Disorders
Treatment Effect of Cross-frequency Transcranial Alternating Current Stimulation on the MUD
The purpose of this research is to evaluate the efficacy of multiple sessions of theta-gamma cross-frequency transcranial alternating current stimulation in patients with methamphetamine (MA) use disorders.
- Trial name
- NCT06145698
- Testing
- Cross-frequency transcranial alternating current stimulation via the Neuroelectrics Starstim 32 transcranial electric stimulation device
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Shanghai Mental Health Center
Amphetamine-Related Disorders, Amphetamine Abuse
Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging
Illicit use of the psychostimulant "Ecstasy" (3,4-methylenedioxymethamphetamine, MDMA) is considered a major public health issue.
- Trial name
- DEXFEN_PET (NCT01296802)
- Testing
- dexfenfluramine
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Craving, Depression, Anxiety
Non-invasive Brain Stimulation in Patients With Methamphetamine Use Disorder
The study aims to apply the intermittent theta burst transcranial magnetic stimulation (iTBS) treatment and evaluate the effect in improving craving, affective symptoms, and cognitive function for those participants in the…
- Conditions
- Craving, Depression, Anxiety, Amphetamine Addiction
- Trial name
- NCT05535101
- Testing
- Intermittent theta burst transcranial magnetic stimulation (iTBS)
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Stroke
Evaluation of the Effect of Dextro-Amphetamin Added to Physiotherapy in Patients After Stroke
The aim of the study is to evaluate the effect of Dextro-amphetamin added to physiotherapy on motor recovery in patients after stroke. The study is a double-blinded placebo-controlled randomised controlled trial.
- Trial name
- NCT00572767
- Testing
- Dextro-Amphetamin, Glucose
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- Reha Rheinfelden
Substance Withdrawal Syndrome
EA for PAAS: A pRCT
In 2019, around 27 million people worldwide, corresponding to 0.5% of the adult population, have used amphetamine-type stimulants (ATS). More than one-third of these 27 million users of ATS were in East and South-East Asia.
- Trial name
- NCT04917185
- Testing
- Electro-Acupuncture
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Substance Abuse, Intravenous, HIV
Change the Cycle: An RCT to Prevent Injection Initiation
The study will test the efficacy of a hour long, one-on-one, active listening counseling session (called Change the Cycle or CTC) aimed at reducing behaviors among active people who inject drugs (PWID) that research has found to…
- Conditions
- Substance Abuse, Intravenous, HIV, Heroin Dependence, Opioid Dependence
- Trial name
- CTC (NCT02774954)
- Testing
- Change the Cycle
- Where
- 2 sites in United States
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Amphetamine Abuse, Amphetamine Dependence
Combination of Psychosocial Intervention and Slow Prosecutions for the Treatment of Methamphetamine Abuse/Dependence
The hospital where this study will be conducted is responsible for the one-year contingency management treatment for methamphetamine drug offenders referred from the Yunlin District Prosecutors Office.
- Conditions
- Amphetamine Abuse, Amphetamine Dependence, Methamphetamine Abuse, Methamphetamine Dependence
- Trial name
- NCT01273701
- Testing
- Psychosocial intervention, Telephone reminding
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Amphetamine-Related Disorders
Hospital-Based Contingency Management
This study aims to adapt an outpatient mobile app-based contingency management intervention to the hospital setting to understand how we can use contingency management to improve health outcomes in hospitalized patients with…
- Trial name
- NCT05515757
- Testing
- Mobile-app based contingency management
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Mood Disorder, Substance-Related Disorders
Pharmacological Interaction Between Clonidine and Methylenedioxymethamphetamine (MDMA)
The purpose of this study is to determinate the effect of a pre-treatment with centrally acting alpha2-receptor agonist clonidine on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA…
- Conditions
- Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
- Trial name
- NCT01136278
- Testing
- 3,4-Methylenedioxymethamphetamine, Clonidine
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Opioid Use Disorder, Severe, Amphetamine Use Disorder
Applying Low-Intensity Focused Ultrasound in Treating Severe Substance Use Disorder: Tolerability and Effectiveness
The goal of this clinical trial is to investigate the safety and efficacy of applying low-intensity focused ultrasound targeting the nucleus accumbens in individuals with opioid or amphetamine use disorders.
- Trial name
- NCT07734623
- Testing
- Low-intensity focused ultrasound, false stimulus
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital