Clinical trials: Amputation, Wound
Wound (Morphologic Abnormality)
Hyperbaric Oxygen Treatment as Adjuvant Treatment for Frost Injury
The aim of this study is to see weather hyperbaric oxygen treatment is beneficial as adjuvant treatment for frost damage. The investigators hope to include at least 20 patients in a randomized manner.
- Trial name
- FROST (NCT01270477)
- Testing
- Hyperbaric oxygen treatment
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Diabetic Foot
Trial of Vacuum Assisted Closure® Therapy in Amputation Wounds of the Diabetic Foot
The purpose of this study is to compare the effectiveness of Vacuum Assisted Closure® (V.A.C.®) Therapy to moist wound therapy of amputation wounds of the diabetic foot.
- Trial name
- NCT00224796
- Testing
- V.A.C. ® System
- Volunteers
- 146 people
- Sponsor
- KCI USA, Inc
Limb Salvage
Limb Salvage Post Venous Injury:Case Series
The venous injury diagnosis depends on history of trauma with symptoms and signs suggestive of venous injuries and color flow duplex study is of increasing value as a screen for detection of an occult venous injuries.
- Trial name
- NCT05223283
- Volunteers
- 75 people
- Sponsor
- Jabir Ibn Hayyan Medical University
Surgical Wound, Surgical Site Infection
Clinical Assessment of Next Science Wound Gels in Healing Below the Knee Amputation Surgical Wound Compared to SOC
This is a 64-patient, 90-day, open -label study on adult patients undergoing below knee amputation for various etiologies. The objective of this study is to assess surgical wound healing and wound bioburden using combination…
- Conditions
- Surgical Wound, Surgical Site Infection, Surgical Wound Infection, Amputation Stump; Infection
- Trial name
- NCT04053946
- Testing
- Next Science Wounds Gels
- Sponsor
- Next Science TM
Amputation, Traumatic
Changes in Trans Tibial Amputee Running Asymmetry During Prolonged Effort
The purpose of this study is to determine the effect of prolonged effort in long distance running on the biomechanical bilateral asymmetry in the lower limbs of trans tibial amputee running with running specific prosthesis.
- Trial name
- NCT02601456
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Multiple Sclerosis, Spinal Cord Injury
Power Over Pain (POP) Study
Many individuals with multiple sclerosis (MS), spinal cord injury (SCI), acquired amputation (AMP), muscular dystrophy (MD), and low back pain (LBP) experience pain. There has been little research on how to treat this pain.
- Conditions
- Multiple Sclerosis, Spinal Cord Injury, Chronic Pain, Other and Unspecified Amputation Stump Complications
- Trial name
- POP (NCT01800604)
- Testing
- Pain Self-Management Intervention #1, Pain Self-Management Intervention #2, Pain Self-Management Intervention #3
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- University of Washington
Residual Limb Pain, Post-Traumatic Limb Pain
Kinematics-Based Prediction of Chronic Pain After Combat-Related Extremity Trauma
Combat-related extremity trauma frequently results in persistent pain, including neuropathic, residual limb, and phantom limb pain.
- Conditions
- Residual Limb Pain, Post-Traumatic Limb Pain, Extremity Trauma, Combat-Related Limb Injury
- Trial name
- KIN-LIMB (NCT07432685)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Amputation
Hand Transplantation
The purpose of this study is to see if an investigational surgery that transfers tissue from a non-living donor to living individual will help restore greater function, appearance, and sensation to the hand and forearm areas of…
- Trial name
- NCT02476838
- Testing
- Hand Transplantation
- Where
- United States
- Sponsor
- NYU Langone Health
Prosthesis User, Amputation
Evaluating the Experience of Upper Limb Prosthesis Use
The goal is to understand the critical factors associated with outcome acceptance following upper limb loss. The investigators aim to develop a unified theoretical model that describes the psychosocial experience of upper limb…
- Conditions
- Prosthesis User, Amputation, Upper Limb Amputation at the Wrist, Upper Limb Amputation Above Elbow (Injury)
- Trial name
- NCT04855214
- Testing
- Qualitative Analysis
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Louis Stokes VA Medical Center
Extremity Lower Wounds
Wound Necrosis in Lower Extremity Surgery
Researchers are performing this study to evaluate if intraoperative angiography can be shown numerically to determine which wounds are at high risk of wound necrosis/breakdown.
- Trial name
- NCT03351387
- Testing
- SPY Intra-operative Angiography
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Infections, Infected Wound
PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation
This is a Phase III clinical randomized control trial to investigate differences between patient with an infected nonunion treated by PO vs. IV antibiotics.
- Conditions
- Infections, Infected Wound, Nonunion of Fracture, Injury Leg
- Trial name
- POvIV2 (NCT05699174)
- Testing
- Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics
- Where
- 13 sites in United States
- Volunteers
- 250 people
- Sponsor
- Major Extremity Trauma Research Consortium
Thumb Injury
Repair of Thumb Defect by Using the Toe Nail Flap
The thumb accounts for 50% of the total hand function. This study reports the functional outcomes and complications of people with traumatic thumb amputations who underwent toe-to-thumb reconstruction.From 2013-01 to 2018-01, 29…
- Trial name
- RTDUTNF (NCT03879941)
- Volunteers
- 29 people
- Sponsor
- Hebei Medical University
Postamputation Pain, Lower Limb Amputation
Acute Post-Amputation Pain Management After Combat-Related Lower Limb Injury
Acute post-amputation pain remains a significant clinical challenge in patients with combat-related lower limb injuries and may negatively affect early rehabilitation, mobility, and opioid consumption.
- Conditions
- Postamputation Pain, Lower Limb Amputation, Combat Trauma
- Trial name
- APAPMACRLLI (NCT07863921)
- Testing
- Continuous Peripheral Nerve Blocks, Peripheral Nerve Cryoablation, Standard multimodal analgesia
- Where
- Ukraine
- Volunteers
- 36 people
- Sponsor
- Kharkiv National Medical University
Amputation, Traumatic, Limb Defect
Assessing Force Feedback With the SoftHand Pro
The trial is designed to test the effectiveness of a force-feedback cuff in combination with a myoelectric prosthesis in conveying information on grasp strength to the user, as well as the user's preference regarding the feature.
- Trial name
- CUFF (NCT03412656)
- Testing
- SoftHand Pro with CUFF force feedback device
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Kristin Zhao, PhD
Wound Infection, Amputation Wound
The Amputation Surgical Site Infection Trial (ASSIT)
Lower limb amputations are performed usually as a last resort in patients with acute and chronic limb ischaemia (CLI) caused by vascular disease, poorly controlled diabetes or, infection.
- Trial name
- ASSIT (NCT02018094)
- Testing
- Co-amoxiclav, Iodine, Metronidazole
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Leg Lower Amputation, Traumatic Amputation
The Injury and Its Consequences in the Sports Lower Limb Amputee
This study was motivated by the lack of data in the literature on the injury of the major lower limb amputee playing sports and its socio-professional impact. It aims to study sports-related injuries in lower limb amputees.
- Trial name
- PREV'AMP SPORT (NCT05059886)
- Testing
- completion of a questionnaire on the practice of sports and possible injuries
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pain Management, Pain
Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection
Neuroma-related pain is a frequent and disabling condition after limb trauma and amputation. Available treatments often provide short-lasting or insufficient analgesia.
- Conditions
- Pain Management, Pain, Phantom Limb Pain, Phantom Limb Pain After Amputation
- Trial name
- SILENCE-NEUROM (NCT07431944)
- Testing
- Botulinium toxin type A injection, Local Anesthesia
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Lower Limb Amputation Below Knee (Injury)
Restoration of Normative Postural Control
The objective of this proposal is to investigate the effects of training to use direct electromyographic (dEMG) control of a powered prosthetic ankle on transtibial amputees'. The aimed questions to answer: 1.
- Trial name
- NCT06452186
- Testing
- direct EMG controlled prosthetic ankle, PT guided prosthetic training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- North Carolina State University
Blindness, Cerebrovascular Accident
Mechanisms of Human Plasticity in the Human System
The purpose of this study is to investigate the physiology associated with plasticity of the motor system. Plasticity refers to the process by which neighboring brain cells assume the responsibilities of damaged or diseased brain…
- Conditions
- Blindness, Cerebrovascular Accident, Spinal Cord Injury
- Trial name
- NCT00001661
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Amputation, Prosthesis User
Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators
The goal of this study is to find out if using microprocessor-controlled prosthetic knees (MPKs), prosthetic knees with a built-in computer, improves health outcomes related to falls in adults who use above-knee prostheses.
- Conditions
- Amputation, Prosthesis User, Amputation; Traumatic, Leg: Thigh, Between Hip and Knee, Limb; Absence, Congenital, Lower
- Trial name
- NCT06937242
- Testing
- Ottobock C-Leg 4 Microprocessor Knee, Ottobock Kenevo
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hanger Institute for Clinical Research and Education, LLC