Clinical trials: Amputation, open to volunteers
Limb Pain, Phantom, Residual Limbs Pain
Pain and Disability Outcomes in Post Amputation Patients
The objective of this study is to evaluate efficacy of varied medical and procedural therapies used to treat pain after surgical amputation of a limb.
- Conditions
- Limb Pain, Phantom, Residual Limbs Pain, Disability Physical
- Trial name
- NCT05716321
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Milton S. Hershey Medical Center
Prosthesis User, Amputation
Prosthetic Limb Movement Feedback for Upper and Lower Extremity Amputees
To assess the functional characteristics and utility of upper and lower limb prosthetic devices (advanced bionic and current clinical standard-of-care) that incorporate physiologically relevant touch and/or movement feedback.
- Trial name
- NCT03135847
- Testing
- Tactor
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Amputation, Diabetes Complications
Measuring Plantar Pressures in Diabetic Patients With Lateral Forefoot Amputation
This study aims to understand how pressure is placed on the bottom of the foot when people walk after a lateral forefoot amputation (for example, removal of the 5th toe).
- Conditions
- Amputation, Diabetes Complications, Foot Complications, Biomechanics
- Trial name
- NCT07865208
- Where
- 2 sites in Singapore
- Volunteers
- 70 people
- Sponsor
- Nanyang Technological University
Amputation
Multicenter Trial Evaluating the Safety and Efficacy of Autologous Volar Fibroblast Injection Into the Terminal Limb of Amputees.
The study will enroll 20 adults ages 18-75 with a transtibial amputation with mature residual limbs who are ambulatory prosthesis users.
- Trial name
- NCT04839497
- Testing
- Autologous Volar Fibroblast Injection into the Terminal Limb of Amputees
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Major Extremity Trauma Research Consortium
Transtibial Amputation, Peripheral Artery Disease
Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation
The population of older Veterans with non-traumatic lower limb amputation is growing. Following lower limb amputation, asymmetrical movements persist during walking and likely contribute to disabling sequelae including secondary…
- Conditions
- Transtibial Amputation, Peripheral Artery Disease, Diabetes Mellitus
- Trial name
- GEM (NCT03995238)
- Testing
- Error-augmentation gait training, Error-correction gait training, Supervised walking
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- VA Office of Research and Development
Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Caesar Foot Take-Home Validation Testing
The rationale for this study is to conduct a take-home clinical trial to evaluate the impact of the bimodal Caesar foot in a real-world environment.
- Trial name
- NCT07075198
- Testing
- Caesar Foot
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Liberating Technologies, Inc.
Amputation of Lower Limb, Prosthesis
LIMBER UniLeg: Rapid, On-demand, and Scaled-up Manufacturing of Customized Transtibial Prosthetic Legs for Amputees
The LIMBER UniLeg, a 3D printed single-piece transtibial prosthetic limb, is sufficiently equivalent to traditional passive prosthetic limbs (no motors or sensors), while reducing the cost and time of manufacturing and enabling…
- Conditions
- Amputation of Lower Limb, Prosthesis, Non-inferiority Trial of Prothesis
- Trial name
- NCT06648798
- Testing
- Limber Limb
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- LIMBER Prosthetics & Orthotics Inc
Phantom Pain Following Amputation of Lower Limb, Amputation
Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment
After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb.
- Trial name
- PLP Home-Based (NCT07044323)
- Testing
- Active Virtual Reality Treatment
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Albert Einstein Healthcare Network
Residual Limb Pain, Stump Pain
Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort Study
Persistent residual limb pain is common after traumatic amputation and significantly impairs rehabilitation and prosthetic use. Postoperative stump infection may contribute to peripheral nerve sensitization, scar fibrosis, and…
- Conditions
- Residual Limb Pain, Stump Pain, Post-Amputation Pain, Surgical Site Infection
- Trial name
- INF-STUMP-PAIN (NCT07438795)
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Phantom Limb Pain After Amputation, Lower Limb Amputation Above Knee
Clinical Application Observation on the Evaluation of Phantom Limb Pain With the Suralis System
This study tests whether a vibration-based feedback device (Suralis) can reduce phantom limb pain in people with lower-leg amputations over 3 weeks.
- Conditions
- Phantom Limb Pain After Amputation, Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee, Lower Limb Amputation Knee
- Trial name
- NCT07324109
- Testing
- Vibrotactile sensory feedback
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Median
Transfemoral Amputation
Evaluation of a Neural-Controlled Powered Prosthesis Across Diverse Real-World Tasks
The purpose of this study is to evaluate the performance and adaptability of a neural-controlled powered knee or ankle prosthesis across diverse real-world mobility tasks.
- Trial name
- NCT07204912
- Testing
- MIT Powered Leg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts Institute of Technology
Intrathecal, Dexmedetomidine
Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity
The current work evaluated whether the combination of intrathecal dexmedetomidine and fentanyl provides superior postoperative analgesia to fentanyl alone when administered with hyperbaric bupivacaine.
- Conditions
- Intrathecal, Dexmedetomidine, Fentanyl, Bupivacaine
- Trial name
- NCT07276867
- Testing
- Fentanyl + Dexmedetomidine, Fentanyl
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- National Cancer Institute, Egypt
Phantom Limb Pain
Evaluation of Neuroprosthesis with Sensory Feedback for Modulation of Phantom Limb Pain and Enhancing Quality of Life
This clinical trial is designed to assess the effectiveness of advanced neuromodulation techniques in reducing phantom limb pain by improving sensory feedback in bionic prostheses.
- Trial name
- NCT06702904
- Testing
- Peripheral Nerve Stimulation, Spinal cord stimulation, Dorsal Root Ganglion Stimulation
- Where
- 2 sites in Russia
- Volunteers
- 50 people
- Sponsor
- Skolkovo Institute of Science and Technology
Amputation
Pro APP Prosthetic Outcome Registry
A national, multi-center registry of patients using lower-limb prosthesis, their profiles and devices, and their long-term follow-up and clinical outcomes.
- Trial name
- NCT06210620
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Össur Iceland ehf
Diabetic Foot Disease
Development and Application of a Decision-Making Aid Tool for Amputation Surgery in Diabetic Foot Patients Based on the Ottawa Decision Support Framework
To verify whether amputation decision-making aids can alleviate the decisional dilemma in diabetic foot patients.
- Trial name
- NCT07252089
- Testing
- Applications of Decision-Support Tools in Amputation Decision-Making for Diabetic Foot Patients, Routine Clinical Consultation and Nursing Care
- Volunteers
- 80 people
- Sponsor
- Shiwen Hong
Amputation of Upper Limb
A Multicenter, Multinational, Cohort Long-term Post-market Clinical Follow-up (PMCF) of the Safety and Efficacy of the Osseoanchored Prostheses for the Rehabilitation of Amputees (OPRA) Implant System When Used for Transhumeral Implantation in Amputee Patients
This non-interventional clinical investigation is initiated for the purpose of long-term Post-Market Clinical Follow-up (PMCF) and the follow-up time of patients is expected to span from 6 months to >20 years in function.
- Trial name
- ReTHro (NCT06753110)
- Testing
- OPRA transhumeral
- Where
- 6 sites in Australia, Austria and 3 more
- Volunteers
- 70 people
- Sponsor
- Integrum
Amputation
Training Independent Muscle Activation From a Common Source
In this study, the investigators are evaluating a new surgical technique that may allow participants to control their muscles in a new way after their amputation or revision surgery.
- Trial name
- NCT07831278
- Testing
- amputation or revision procedure with additional RPNI construction
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Amputation, Transtibial Amputation - Unilateral
Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes
A clinical trial utilizing cross-over study design in which individuals with transtibial amputation using either a bone-anchored limb or standard socket prosthesis will perform activities of daily living with varying prosthetic…
- Conditions
- Amputation, Transtibial Amputation - Unilateral, Bone Anchored Devices, Osseointegration
- Trial name
- TBAL (NCT07263945)
- Testing
- As-prescribed prosthetic foot stiffness, A prosthetic foot that is two prosthetic foot stiffness categories stiffer than the stiffness of the as-prescribed prosthetic foot, A prosthetic foot that is two prosthetic foot stiffness categories softer than the stiffness of the as-prescribed prosthetic foot
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Diabetic Foot Ulcer
Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic Gait Correction in Reducing Diabetic Foot Ulceration Or Subsequent Amputation in Patients With a History of a Diabetic Foot Ulceration
Determining whether the utilization of Noraxon myoRESEARCH Software gait analysis Evaluation and orthotic gait Correction can reduce diabetic foot ulceration Or subsequent amputation in patients with a history of a diabetic foot…
- Trial name
- NECRO (NCT04164641)
- Testing
- Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Johns Hopkins University
Amputation, Amputation, Traumatic
Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control
The goal of this clinical trial is to systematically evaluate whether or not two commonly held fundamental assumptions for pattern recognition control translates to functional performance when tested on individuals aged 18 years…
- Conditions
- Amputation, Amputation, Traumatic, Amputation, Congenital, Prosthesis User
- Trial name
- NCT07011420
- Testing
- Experimental socket with 4 untargeted channels active, Experimental socket with 8 untargeted channels active, Experimental socket with up to 16 untargeted channels active
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Liberating Technologies, Inc.