Clinical trials: Amputation Neuroma
Neuroma, Neuropathic Pain
Pain Outcomes After Digital Amputation Using Tulavi Allay™ Nerve Cap
In 2016, one in five individuals in the United States (US) experienced chronic pain, and approximately 40% of them suffered from neuropathic pain.
- Trial name
- NCT06915662
- Testing
- Tulavi allay Nerve Cap
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Amputation Neuroma, Amputation
Short-term Implanted Electrodes Following Regenerative Peripheral Nerve Surgery for Improving Prosthetic Limb Control Signals
The device, a bipolar percutaneous intramuscular electromyography electrode, is intended for use in upper-limb amputation patients who have received the regenerative peripheral nerve interface surgical procedure, in order to…
- Trial name
- NCT03260400
- Testing
- a bipolar percutaneous intramuscular electromyography electrode
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
Neuroma Amputation
Efficacy of Acupuncture in Patients With Lower Extremity Amputation With Neuroma
Neuroma often occurs after major nerve damage or transection and can be diagnosed with pain at the tip of the stump, positive tinel, imaging (USG/MR).
- Trial name
- NCT05244369
- Testing
- Only TENS, Acupuncture+TENS
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Phantom Limb Pain, Residual Limbs
Focused Ultrasound Treatment of Stump Neuromas for the Relief of Chronic Post-Amputation Neuropathic Pain
AIM: To provide initial information on the efficacy (pain reduction) and safety of focused ultrasound surgery for the ablation of stump neuromas in amputees with chronic neuropathic pain.
- Conditions
- Phantom Limb Pain, Residual Limbs, Amputation
- Trial name
- NCT03255395
- Testing
- Magnetic resonance-guided focused ultrasound
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rambam Health Care Campus
Chronic Pain Due to Injury, Neuroma of Lower Limb
Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation
Patients with combat-related amputations frequently experience persistent neuroma pain that may interfere with rehabilitation, prosthesis use, sleep, mobility, and quality of life.
- Conditions
- Chronic Pain Due to Injury, Neuroma of Lower Limb, Neural Injury, Neuroma of Upper Limb
- Trial name
- NEUROQUIET (NCT07626983)
- Testing
- Botulinum Toxin Type A (BoNT-A), Local Anesthetic Solution
- Where
- 2 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Amputation Neuroma
Results of Nerve Surgery to Treat PostAmputation Pain
Rationale: Postamputation pain (PAP) is frequently seen after amputations and is a severe lifelong disabling condition affecting quality of life (QoL).
- Trial name
- TreatPAP (NCT07605754)
- Testing
- Fascicular split, Targeted Muscle Reinnervation
- Where
- Netherlands
- Volunteers
- 98 people
- Sponsor
- Leiden University Medical Center
Amputation Stump, Amputation Neuroma
Comparison Between Digital Nerve Microanastomosis and Traction Neurectomy in Post-Digital Amputation Pain
The goal of this prospective observational study is to assess the post-operative pain in adults with digital amputation following two different surgical interventions: microanastomosis of digital nerves or traction neurectomy.
- Conditions
- Amputation Stump, Amputation Neuroma, Amputation, Traumatic/Surgery, Amputation, Surgical
- Trial name
- NCT07102654
- Volunteers
- 50 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Phantom Limb Pain, Postoperative Pain
Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain
Limb loss is frequently associated with postamputation pain that can be challenging to treat and often involves opioids. Advances in the field of neuromodulation has led to development of an intentionally reversible percutaneous…
- Conditions
- Phantom Limb Pain, Postoperative Pain, Neuroma, Acute Pain
- Trial name
- NCT03484429
- Testing
- Peripheral nerve stimulation, Standard Medical Therapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Symptomatic Neuroma, Phantom Limb Pain After Amputation
Evaluation of RPNI for Symptomatic Neuromas in Lower Limb Amputees
This prospective, observational cohort study evaluates the long-term outcomes of Regenerative Peripheral Nerve Interface (RPNI) surgery in patients with major lower extremity amputations suffering from symptomatic neuromas.
- Conditions
- Symptomatic Neuroma, Phantom Limb Pain After Amputation, Residual Limb Pain, Neuropathic Pain
- Trial name
- RPNI-AMPUTEE (NCT07420192)
- Testing
- Regenerative Peripheral Nerve Interface (RPNI) Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Saglik Bilimleri Universitesi
Neuropathic Pain, Neuroma
Identification of Neuromas by High Resolution Ultrasound in Patients With Peripheral Nerve Injury and Amputations
Neuromas are frequent after trauma and surgery, including amputation and can be identified by high-resolution ultrasound. The role of neuromas as the cause of neuropathic pain is uncertain.
- Trial name
- NCT03051113
- Where
- Denmark
- Volunteers
- 67 people
- Sponsor
- Danish Pain Research Center
Pain, Neuropathic, Amputation Neuroma
Surgical Treatments for Neuroma Pain in Amputees
Amputees often suffer from relentless pain and disability resulting from symptomatic neuromas within the amputation stumps. When conservative measures fail to address these symptoms, two contemporary surgical approaches to treat…
- Conditions
- Pain, Neuropathic, Amputation Neuroma, Phantom Limb Pain
- Trial name
- STOCAP (NCT04204668)
- Testing
- TMR, RPNI, VDMT
- Where
- 2 sites in United States
- Sponsor
- Johns Hopkins University
Neuroma Amputation
Evaluation of Ultrasonic Neuroma Size With Residual Limb Pain in Above-Knee Amputees
Background: The formation of neuromas, a fusiform swelling of a nerve or nerve ending, is a well documented response to limb amputation.
- Trial name
- NCT00686764
- Testing
- Observational
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Targeted Muscle Reinervation, Digital Amputation
Targeted Muscle Reinnervation in the Hand for the Managment of Symptomatic Neuroma Following Digit and Hand Amputations
Neuromas are a common complication after digital and hand amputations, resulting in significant pain, discomfort, and functional impairment.
- Conditions
- Targeted Muscle Reinervation, Digital Amputation, Neuroma
- Trial name
- NCT06923566
- Testing
- Targeted muscle reinnervation
- Where
- Egypt
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Symptomatic Neuroma, Amputation
Tolerability and Feasibility Pilot Clinical Study of a Large-Diameter Nerve Cap for Protecting and Preserving Terminated Nerve Ends
This pilot study evaluates the tolerability and feasibility of the Axoguard Large-Diameter Nerve Cap (sizes 5-7 mm) for protecting and preserving terminated nerve endings after limb trauma or amputation when immediate attention…
- Conditions
- Symptomatic Neuroma, Amputation, Chronic Nerve Pain
- Trial name
- REPOSE-XL℠ (NCT04865679)
- Testing
- Axoguard Nerve Cap®
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Axogen Corporation