Clinical trials: Amputation Neuroma, open to volunteers
Neuroma, Neuropathic Pain
Pain Outcomes After Digital Amputation Using Tulavi Allay™ Nerve Cap
In 2016, one in five individuals in the United States (US) experienced chronic pain, and approximately 40% of them suffered from neuropathic pain.
- Trial name
- NCT06915662
- Testing
- Tulavi allay Nerve Cap
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Pain Management, Pain
Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection
Neuroma-related pain is a frequent and disabling condition after limb trauma and amputation. Available treatments often provide short-lasting or insufficient analgesia.
- Conditions
- Pain Management, Pain, Phantom Limb Pain, Phantom Limb Pain After Amputation
- Trial name
- SILENCE-NEUROM (NCT07431944)
- Testing
- Botulinium toxin type A injection, Local Anesthesia
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Amputation Stump, Amputation Neuroma
Comparison Between Digital Nerve Microanastomosis and Traction Neurectomy in Post-Digital Amputation Pain
The goal of this prospective observational study is to assess the post-operative pain in adults with digital amputation following two different surgical interventions: microanastomosis of digital nerves or traction neurectomy.
- Conditions
- Amputation Stump, Amputation Neuroma, Amputation, Traumatic/Surgery, Amputation, Surgical
- Trial name
- NCT07102654
- Volunteers
- 50 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Amputation, Surgical, Phantom Limb Pain
Prevention of PostAmputation Pain With Targeted Muscle Reinnervation
The goal of this study is to compare postamputation pain (phantom limb pain and residual limb pain) one year postoperatively in patients who received a lower extremity amputation (LEA) with standard nerve handling (neurectomy)…
- Conditions
- Amputation, Surgical, Phantom Limb Pain, Neuroma Amputation, Surgery
- Trial name
- PreventPAP (NCT06719245)
- Testing
- Targeted Muscle Reinnervation (TMR), Standard neurectomy
- Where
- 7 sites in Netherlands
- Volunteers
- 203 people
- Sponsor
- Leiden University Medical Center
Amputation Neuroma, Amputation
Short-term Implanted Electrodes Following Regenerative Peripheral Nerve Surgery for Improving Prosthetic Limb Control Signals
The device, a bipolar percutaneous intramuscular electromyography electrode, is intended for use in upper-limb amputation patients who have received the regenerative peripheral nerve interface surgical procedure, in order to…
- Trial name
- NCT03260400
- Testing
- a bipolar percutaneous intramuscular electromyography electrode
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
Residual Limb Pain, Amputation Neuroma
Surgical Treatments for Postamputation Pain
This is a double-blind randomised controlled trial (RCT) which compares the effectiveness of three surgical techniques for alleviating residual limb pain (RLP), neuroma pain and phantom limb pain (PLP).
- Conditions
- Residual Limb Pain, Amputation Neuroma, Phantom Limb Pain, Pain, Neuropathic
- Trial name
- NCT05009394
- Testing
- Targeted Muscle Reinnervation (TMR), Regenerative Peripheral Nerve Interface (RPNI), Standard neuroma treatment, neuroma excision, and muscle burying
- Where
- 9 sites in United States, Australia and 5 more
- Volunteers
- 110 people
- Sponsor
- Prometei Pain Rehabilitation Center
Amputation Neuroma
Results of Nerve Surgery to Treat PostAmputation Pain
Rationale: Postamputation pain (PAP) is frequently seen after amputations and is a severe lifelong disabling condition affecting quality of life (QoL).
- Trial name
- TreatPAP (NCT07605754)
- Testing
- Fascicular split, Targeted Muscle Reinnervation
- Where
- Netherlands
- Volunteers
- 98 people
- Sponsor
- Leiden University Medical Center
Neuroma
Regenerative Peripheral Nerve Interfaces to Treat Painful Digit and Hand Neuromas After Amputation
This study is being done to demonstrate the effectiveness of Regenerative Peripheral Nerve Interfaces (RPNI) surgery in treating symptomatic neuromas of the hand and digits following amputation compared to standard of care using…
- Trial name
- NCT05008185
- Testing
- Regenerative Peripheral Nerve Interface (RPNI) surgery, Traction Neurectomy
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Symptomatic Neuroma, Phantom Limb Pain After Amputation
Evaluation of RPNI for Symptomatic Neuromas in Lower Limb Amputees
This prospective, observational cohort study evaluates the long-term outcomes of Regenerative Peripheral Nerve Interface (RPNI) surgery in patients with major lower extremity amputations suffering from symptomatic neuromas.
- Conditions
- Symptomatic Neuroma, Phantom Limb Pain After Amputation, Residual Limb Pain, Neuropathic Pain
- Trial name
- RPNI-AMPUTEE (NCT07420192)
- Testing
- Regenerative Peripheral Nerve Interface (RPNI) Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Saglik Bilimleri Universitesi