Clinical trials: Amputation Pain
Pain Management, Pain
Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection
Neuroma-related pain is a frequent and disabling condition after limb trauma and amputation. Available treatments often provide short-lasting or insufficient analgesia.
- Conditions
- Pain Management, Pain, Phantom Limb Pain, Phantom Limb Pain After Amputation
- Trial name
- SILENCE-NEUROM (NCT07431944)
- Testing
- Botulinium toxin type A injection, Local Anesthesia
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Stump Neuroma, Residual Limb Pain
Ultrasound-Guided Radiofrequency Ablation Versus Steroid Injection for Stump Neuroma
This prospective clinical study aims to compare the effectiveness of ultrasound-guided radiofrequency ablation and ultrasound-guided corticosteroid injection in individuals with symptomatic stump neuroma following lower extremity…
- Conditions
- Stump Neuroma, Residual Limb Pain, Lower Extremity Amputation
- Trial name
- NCT07431424
- Testing
- Radiofrequency ablation alone, Corticosteroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Pediatric, Neuropathic Pain
Amputations in Childhood and Neuropathic Pain
This observational study aims to assess the presence of neuropathic pain in children and adolescents who underwent limb amputation during childhood.
- Conditions
- Pediatric, Neuropathic Pain, Phantom Limb Pain, Amputation
- Trial name
- NAPE (NCT07401966)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hopitaux de Saint-Maurice
Symptomatic Neuroma, Phantom Limb Pain After Amputation
Evaluation of RPNI for Symptomatic Neuromas in Lower Limb Amputees
This prospective, observational cohort study evaluates the long-term outcomes of Regenerative Peripheral Nerve Interface (RPNI) surgery in patients with major lower extremity amputations suffering from symptomatic neuromas.
- Conditions
- Symptomatic Neuroma, Phantom Limb Pain After Amputation, Residual Limb Pain, Neuropathic Pain
- Trial name
- RPNI-AMPUTEE (NCT07420192)
- Testing
- Regenerative Peripheral Nerve Interface (RPNI) Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Saglik Bilimleri Universitesi
Amputation, Surgical, Pain Management
Early Postoperative Pain Following a Limb Amputation
The primary aim of this study is to characterize the trajectory of pain and functional recovery in the first post-operative period following a limb amputation.
- Conditions
- Amputation, Surgical, Pain Management, Rehabilitation
- Trial name
- Pain-Amp (NCT07393139)
- Testing
- Pain assessment
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Ortopedico Rizzoli
Pain, Postoperative, Amputation
Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations
Through this pilot prospective trial, we aim to obtain preliminary data investigating the effectiveness of perineural catheters and liposomal bupivacaine, both currently accepted as standard care at Maine Medical Center, for the…
- Trial name
- NCT05140499
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride 0.5 % Injectable Solution
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Aurora Quaye
Phantom Limb Pain After Amputation, Lower Limb Amputation
Operant Conditioning of Sensory Brain Responses to Reduce Phantom Limb Pain in People With Limb Amputation
The study will investigate the application of a non-pharmacological operant conditioning approach to reduce phantom limb pain (PLP). PLP afflicts 60-90% people who have lost a limb.
- Conditions
- Phantom Limb Pain After Amputation, Lower Limb Amputation, Upper Limb Amputation, Phantom Pain
- Trial name
- OCS-PLP (NCT05880251)
- Testing
- Operant Conditioning with Peripheral Stimulation, Control Group with Peripheral Stimulation Only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees, 90-Day
The goals of this study are to provide sensory information to amputees and reduce phantom limb pain via electrical stimulation of the lumbar spinal cord and spinal nerves.
- Trial name
- SCS-90 (NCT04547582)
- Testing
- Spinal cord stimulator
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Lee Fisher, PhD
Phantom Limb Pain After Amputation, Lower Limb Amputation Above Knee
Clinical Application Observation on the Evaluation of Phantom Limb Pain With the Suralis System
This study tests whether a vibration-based feedback device (Suralis) can reduce phantom limb pain in people with lower-leg amputations over 3 weeks.
- Conditions
- Phantom Limb Pain After Amputation, Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee, Lower Limb Amputation Knee
- Trial name
- NCT07324109
- Testing
- Vibrotactile sensory feedback
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Median
Limb Ischemia, Low Back Pain
Comorbidity Screening and Referral by Prosthetists
Lower-limb amputation is associated with life-altering and life-limiting comorbidities. Currently, onus is on primary care providers to diagnose, educate, and refer patients for appropriate management.
- Conditions
- Limb Ischemia, Low Back Pain, Depression, Neuropathy;Peripheral
- Trial name
- NCT05410548
- Testing
- Standard-of-Care, Clinical Screening
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Delaware
Amputation, Sensation, Phantom
Sensory Responses to Dorsal Root Stimulation
The goal of this project is to characterize the types of sensations that can be evoked via electrical stimulation of the spinal cord and spinal nerves.
- Trial name
- NCT04725006
- Testing
- Spinal cord stimulation system
- Where
- United States
- Sponsor
- Lee Fisher, PhD
Phantom Limb Pain, Amputation, Traumatic
Optimizing Rehabilitation for Phantom Limb Pain Using Mirror Therapy and Transcranial Direct Current Stimulation (tDCS)
This is a two-site study that explores the effects of mirror therapy and transcranial Direct Current Stimulation (tDCS, Soterix ©) in a randomized factorial controlled trial in which patients will be assigned to one of four…
- Trial name
- NCT02487966
- Testing
- transcranial Direct Current Stimulation (tDCS): active (Soterix ©), Mirror Therapy: active
- Where
- 2 sites in United States, Brazil
- Volunteers
- 132 people
- Sponsor
- Spaulding Rehabilitation Hospital
Amputation, Surgical, Phantom Limb Pain
Prevention of PostAmputation Pain With Targeted Muscle Reinnervation
The goal of this study is to compare postamputation pain (phantom limb pain and residual limb pain) one year postoperatively in patients who received a lower extremity amputation (LEA) with standard nerve handling (neurectomy)…
- Conditions
- Amputation, Surgical, Phantom Limb Pain, Neuroma Amputation, Surgery
- Trial name
- PreventPAP (NCT06719245)
- Testing
- Targeted Muscle Reinnervation (TMR), Standard neurectomy
- Where
- 7 sites in Netherlands
- Volunteers
- 203 people
- Sponsor
- Leiden University Medical Center
Phantom Limb Pain After Amputation
Preventing Chronification of Phantom Limb Pain Through Mirror Therapy in Conjunction With tDCS
Background: Most amputees experience phantom limb pain (PLP), for years after amputation. Virtually all PLP research to date has focused on the mechanisms of chronic PLP, ignoring the mechanisms of chronification.
- Trial name
- NCT07139483
- Testing
- Trans Direct-Cranial Stimulation (tDCS), Mirror therapy
- Where
- 3 sites in Israel
- Volunteers
- 108 people
- Sponsor
- University of Haifa
Phantom Pain Following Amputation of Lower Limb, Amputation
Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment
After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb.
- Trial name
- PLP Home-Based (NCT07044323)
- Testing
- Active Virtual Reality Treatment
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Albert Einstein Healthcare Network
Post-Amputation Pain, Phantom Limb Pain
Electrical Nerve Block for Amputation Pain
The purpose of the clinical trial is to learn whether electrical nerve block via the Altius System is a safe and effective treatment for patients with post-amputation pain.
- Conditions
- Post-Amputation Pain, Phantom Limb Pain, Residual Limb Pain, Stump Pain
- Trial name
- NCT02221934
- Testing
- Altius
- Where
- 22 sites in United States
- Volunteers
- 607 people
- Sponsor
- Neuros Medical, Inc.
Pain, Neuropathic, Amputation Neuroma
Surgical Treatments for Neuroma Pain in Amputees
Amputees often suffer from relentless pain and disability resulting from symptomatic neuromas within the amputation stumps. When conservative measures fail to address these symptoms, two contemporary surgical approaches to treat…
- Conditions
- Pain, Neuropathic, Amputation Neuroma, Phantom Limb Pain
- Trial name
- STOCAP (NCT04204668)
- Testing
- TMR, RPNI, VDMT
- Where
- 2 sites in United States
- Sponsor
- Johns Hopkins University
Chronic Pain, Amputation
Chronic Pain and Amputation: A Quality of Life Comparison
The aim of this observational, cross-sectional study is to investigate and compare the impact of chronic pain and amputation on patients' quality of life.
- Trial name
- NCT06704386
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Kastamonu University
Phantom Limb Pain, Phantom Pain
VR to Evaluate Phantom Limb Pain
The objective of this study is to develop a virtual rehabilitation system that can be used to effectively treat Phantom Limb Pain (PLP) within the research setting and for at-home use by individuals with upper and lower extremity…
- Conditions
- Phantom Limb Pain, Phantom Pain, Phantom Sensation, Phantom Limb Syndrome With Pain
- Trial name
- NCT05915065
- Testing
- Coapt Phantom Limb Pain Management System
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Shirley Ryan AbilityLab
Pain, Amputation
Sciatic Block in Contralateral Limb Phantom and Residual Limb Pain
Participants with chronic, refractory phantom limb pain (PLP) or residual limb pain (RLP) for more than 6 months will be enrolled in this clinical trial.
- Trial name
- NCT05046639
- Testing
- 10 mL 2% lidocaine, 10 mL preservative free saline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Northwestern University