Clinical trials: Amputation of Knee
Amputation of Knee, Back Pain
Biofeedback Retention in Individuals With AKA
More than two million Americans are currently living with a full or partial limb loss, and an additional 185,000 amputations occur each year. The majority of amputations occur in the lower limbs.
- Conditions
- Amputation of Knee, Back Pain, Osteo Arthritis Knee
- Trial name
- NCT05126485
- Testing
- Haptic Biofeedback from SageMotion Biofeedback System
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- San Jose State University
Amputation, Surgical, Amputation, Traumatic
Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation
When a limb is severed, pain perceived in the part of the body that no longer exists often develops and is called "phantom limb" pain.
- Conditions
- Amputation, Surgical, Amputation, Traumatic, Phantom Limb Pain, Phantom Pain Following Amputation of Lower Limb
- Trial name
- NCT06071715
- Testing
- ACTIVE cryoneurolysis
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Diego
Wound Healing, Lower Extremity Amputation
Pilot Study to Assess the Use of Spy Elite for Assessment of Amputation Healing
The purpose of the study is to evaluate the use of the SPY Elite System to assess real-time tissue perfusion of lower extremity amputation sites and to develop parameters to predict healing of amputations at the time of surgery.
- Conditions
- Wound Healing, Lower Extremity Amputation, Above Knee Amputation, Below Knee Amputation
- Trial name
- NCT02440295
- Testing
- Lower Extremity Amputation, SPY Elite Imaging System, Indocyaine Green
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Corewell Health West
Lower Extremity Amputation
Adherence and Perspiration While Wearing Lower Limb Prostheses
Individuals with lower limb amputation often complain about uncomfortable residual limb skin temperatures and the accumulation of sweat inside their prostheses.
- Trial name
- NCT03900845
- Testing
- Dynamic Air Exchange - Rising Edge Design (DAE-RED), Perforated elastomeric liner, As-prescribed prosthesis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Amputation, Prosthesis User
Sagittal Knee Kinematics of Transtibial Amputee with Running Blade
Introduction: People with transtibial amputation often suffer musculoskeletal deformities in the form of knee osteoarthritis or osteophytosis due to asymmetric movement patterns and often complain of associated symptoms.
- Trial name
- NCT06586762
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Baskent University
Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee
Pain in Trans Femoral and Trans Tibial Amputees
Phantom limb is difficult to manage and has a significant impact on the patient's quality of life. At present, the scientific evidence shows that the infusion of local anesthetics with epidural and perineural catheters in the…
- Trial name
- AMPUPHANTOM (NCT03789435)
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Istituto Ortopedico Rizzoli
Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury)
Enhancing Abilities in Amputees and Patients With Peripheral Neuropathy Through Restoration of Sensory Feedback
Many amputees suffer from Phantom Limb Pain (PLP), a condition where painful perceptions arise from the missing limb. Leg amputees wear prostheses that do not provide any sensory feedback, apart from the stump-socket interaction.
- Conditions
- Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Diabetic Peripheral Neuropathy
- Trial name
- NCT04217005
- Testing
- Sensory Feedback
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- ETH Zurich
Parkinson's Disease and Parkinsonism, Dementia
Context- and Terrain-aware Gait Analysis
The average lifespan of individuals in many developed countries is increasing. This factor paired with the increase in global population has the potential to put a strain on healthcare systems with regards to age-related…
- Conditions
- Parkinson's Disease and Parkinsonism, Dementia, Acquired Brain Injury, Multiple Sclerosis
- Trial name
- CTAGA (NCT07491588)
- Testing
- All-terrain Gait Analysis System
- Sponsor
- University of Leeds
Lower Limb Amputation Below Knee (Injury)
Comprehensive Evaluation of the Passive Talaris Demonstrator
The passive Talaris Demonstrator (TD) is developed in continuation of previous prototypes. The main goal of the experiment is to evaluate the effectiveness of TD during daily activities.
- Trial name
- NCT05127993
- Testing
- Passive Talaris Demonstrator
- Where
- Belgium
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Amputation
Effect of Socket Wall Height With Vacuum Suspension for Above Knee Amputees
Individuals with transfemoral (TF) amputation (above the knee amputation) may benefit from a socket that uses vacuum assisted suspension (VAS) to hold the socket onto the amputated limb.
- Trial name
- NCT01559909
- Testing
- Vacuum assisted socket technology (Harmony System, Otto Bock Healthcare)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Stony Brook University
Unilateral Traumatic Amputation, Amputation, Traumatic
Determining the Potential Benefit of Powered Prostheses
The goal of this research is to determine the effectiveness of a powered prosthesis compared to an unpowered prosthesis during short bouts of walking, extended periods of walking (to fatigue), and performance in the community.
- Trial name
- NCT02828982
- Testing
- Powered ankle prosthesis, Dynamic Response Foot
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Deanna H Gates
Amputation, Lower Limb
Virtual Reality in the Rehabilitation in Patients With Lower Limb Amputation.
The goal of this clinical trial is to test the impact of virtual reality on rehabilitation for the patients after a major amputation.
- Conditions
- Amputation, Lower Limb, Rehabilitation, Activities of Daily Living
- Trial name
- NCT05773560
- Testing
- virtual reality rehabilitation
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Erlangen
Lower Limb Amputation Above Knee (Injury)
New Microprocessor-Controlled Prosthetic Knee Evaluation
The target of this clinical investigation is to compare the achievement of personal functional goals using a new MPK and current MPK.
- Trial name
- NCT06017024
- Testing
- microprocessor-controlled knee (MPK) assessment
- Where
- 5 sites in France
- Volunteers
- 18 people
- Sponsor
- Proteor Group
Intrathecal, Dexmedetomidine
Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity
The current work evaluated whether the combination of intrathecal dexmedetomidine and fentanyl provides superior postoperative analgesia to fentanyl alone when administered with hyperbaric bupivacaine.
- Conditions
- Intrathecal, Dexmedetomidine, Fentanyl, Bupivacaine
- Trial name
- NCT07276867
- Testing
- Fentanyl + Dexmedetomidine, Fentanyl
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- National Cancer Institute, Egypt
Amputees, Amputation
Extremity Thermographic Values in Individuals With Transtibial Amputation
The goal of this observational study is to compare thermographic values in the knee region of the healthy extremity and the amputated extremity and learn about the relationship between thermographic value and pain in the knee…
- Conditions
- Amputees, Amputation, Amputation Stump, Amputation of Knee
- Trial name
- NCT06258343
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Baskent University
Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee
Study on a Prosthetic Foot With Adjustable Heel Height
Most prosthetic feet have a fixed heel height, which requires users to always wear shoes with the same heel height. A fixed heel height is a significant constraint, whereas the ability to choose one's clothing freely is an…
- Trial name
- ADJUST (NCT07214493)
- Testing
- Taleo Adjust, The usual participant's foot
- Where
- 5 sites in France
- Volunteers
- 30 people
- Sponsor
- Otto Bock France SNC
Prosthesis User, Amputation
Clinical Investigation (Beta) of Power Knee Mainstream - Dynamic
Prospective two group cross over investigation, comparing the investigational device (Power Knee, a powered microprocessor controlled prosthetic knee) and subjects prescribed microprocessor prosthetic knee (MPK).
- Trial name
- NCT04787627
- Testing
- Power Knee
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Össur Iceland ehf
Amputation of Lower Limb Below Knee, Amputation, Traumatic
REsistance and LOADing Exercise for Bone Health
Lower limb amputation, often resulting from military conflict and road traffic accidents, is associated with reduced hip bone mineral density (BMD) and increased risk of hip fractures.
- Conditions
- Amputation of Lower Limb Below Knee, Amputation, Traumatic, Amputation, Limb Loss
- Trial name
- RELOAD (NCT07817381)
- Testing
- Resistance and high-impact exercise training
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Defence Medical Rehabilitation Centre, UK
Diabetes Mellitus, Type 2
Sodium-glucose Co-transporter 2 (SGLT2) Inhibitor Risk of Below-Knee Lower Extremity Amputation: A Retrospective Cohort Study Using a Large Claims Database in the United States
The purpose of the study is to estimate the incidence of below-knee lower extremity amputation in type 2 diabetes mellitus (T2DM) participants newly exposed to sodium-glucose co-transporter 2 inhibitors (SGLT2i)/ non-SGLT2i…
- Trial name
- NCT02857764
- Volunteers
- 127,690 people
- Sponsor
- Janssen Research & Development, LLC
Peripheral Arterial Disease, Peripheral Vascular Disease
The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD
Lower limb amputation is common in the United States, with approximately 150,000 amputations annually. Most individuals walking with a prosthesis demonstrate asymmetrical loading-i.e., they favor the amputated side by placing…
- Conditions
- Peripheral Arterial Disease, Peripheral Vascular Disease, Amputation, Lower Limb Amputation Knee
- Trial name
- NCT04937179
- Testing
- Ischemic Conditioning High - Active Comparator
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Illinois Chicago