Clinical trials: Amputations
Urologic Injuries, Genital Diseases, Male
Human Penile Tissue Allotransplantation for Devastating Penile and Concomitant Genital Trauma
This is a 4-year, non-randomized, single center, patient self-controlled, clinical trial (though enrolled subjects will be followed for life as are all transplant patients) for patients seeking allotransplantation of the male…
- Conditions
- Urologic Injuries, Genital Diseases, Male, Amputation
- Trial name
- NCT03240822
- Testing
- Penile Transplant, Monoclonal Antibody (Humanized Anti-CD52), Tacrolimus
- Sponsor
- Wake Forest University Health Sciences
Lower Limb Loss
Musculoskeletal Measurements in Transfemoral Amputees
The aim of this study was to identify posture asymmetries in transfemoral amputees utilizing clinical evaluation measures. The purposes of this investigation were: 1) to measure the limb length indirectly to determine the…
- Trial name
- NCT00909922
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Miami VA Healthcare System
Amputation
Immediate Fit Using Innovative Technology Transtibial & Transfemoral Prosthesis
iFIT Prosthetics, LLC® created and commercialized a modular, immediate fit, fully adjustable, prosthetic system suitable for mass production using high strength injection molded polymer materials.
- Trial name
- NCT02886936
- Testing
- iFIT Transtibial Prosthesis, iFIT Transfemoral Prosthesis
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Pennsylvania
Amputation of Knee
Effect of Early Prosthetic Fitting in Patients With Below Knee Amputation
A randomized control trial of 50 patients to identify the effect of early prosthetic fitting and physical rehabilitation. Previous studies show a significant impact of early induction of prosthetic rehabilitation of amputation.
- Trial name
- NCT06631014
- Testing
- Early Rehab, Delayed Rehab
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Superior University
Wound, Diabetes
Pathology of Skin, Nerve and Vasculature in the Amputated Limb of Diabetes
1. To explore the pathology of nerve, vascular, and skin in the amputated leg 2. To diagnose small-fiber sensory neuropathy of the contralateral leg by investigating the skin intervention 3.
- Conditions
- Wound, Diabetes, Amputation
- Trial name
- NCT00840164
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Amputation
The Effect of Different Microprocessor Knee Prostheses on Mobility and Gait Parameters in Transfemoral Amputees
Microprocessor knee joints are prosthetic knee joints with an integrated processor or a computer that can analyze data. During walking, parameters such as step speed, joint angles, and weight transferred through sensors are…
- Trial name
- NCT04966936
- Testing
- questionnaires for clinical assessments, 2 minute walking test, The gait analysis at the motion analysis laboratory.
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Neuroma, Neuroma Amputation
Evaluation of Neuroma Perfusion with Indocyanine Green Fluorescence Angiography
The purpose of this study is to characterize the perfusion of neuromas using indocyanine green fluorescence angiography
- Conditions
- Neuroma, Neuroma Amputation, Neuroma of Upper Limb, Neuroma of Lower Limb
- Trial name
- NCT06164392
- Testing
- Indocyanine green
- Where
- United States
- Sponsor
- Northwestern University
Amputation, Muscle Activation
The Relationship Between Trunk Position Sense and Muscle Activation, Balance and Quality of Life in Amputees
This study was planned to examine the relationship between trunk position sense and muscle activation, balance and quality of life in individuals with transtibial amputation.
- Conditions
- Amputation, Muscle Activation, Balance, Quality of Life
- Trial name
- NCT06046300
- Testing
- Investigation of the relationship between trunk position sense and muscle activation, balance and quality of life in individuals with transtibial amputation.
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Amputation
Dual-tasking for Individuals With Lower Limb Amputation: Exploring the Relationship to Falls and Instrumental Activities of Daily Living
Veterans with dysvascular lower limb amputation (LLA) have a high fall risk, which persists despite completion of conventional rehabilitation.
- Trial name
- DIAL (NCT05119192)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Abdominal Aortic Aneurysm, Carotid Atherosclerosis
Preconditioning Shields Against Vascular Events in Surgery
Major vascular surgery involves operations to repair swollen blood vessels, clear debris from blocked arteries or bypass blocked blood vessels.
- Conditions
- Abdominal Aortic Aneurysm, Carotid Atherosclerosis, Critical Lower Limb Ischaemia
- Trial name
- SAVES (NCT01691911)
- Testing
- Remote preconditioning
- Where
- Ireland
- Volunteers
- 200 people
- Sponsor
- Mid Western Regional Hospital, Ireland
Amputation; Traumatic, Limb, Postural; Defect
Comparison of Transtibial and Transfemoral Amputees' Posture Parameters
With the onset of prosthesis use following lower extremity amputations, body shows biomechanical changes according to the amputation level and consequently develops adaptation mechanisms both on the healthy and ampute side.
- Trial name
- NCT04456244
- Testing
- Evaluation of the static posture
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Lower Limb Amputation
Evaluation of Limb Health Associated With a Prosthetic Vacuum Socket System
The purpose of the study is to evaluate residual limb circulation and skin health associated with the use of a prosthetic vacuum socket. A conventional non-vacuum prosthetic socket will be compared to a vacuum prosthetic socket.
- Trial name
- NCT01839123
- Testing
- Prosthetic Suction or Pin Socket, Prosthetic LimbLogic Vacuum Socket
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ohio Willow Wood
Amputation, Diabetes Complications
Study to Determine if Different Prosthetic Sockets Effect How Much Oxygen is in the Tissue of Lower Limb Amputees While They Are Walking
Amputee gait produces periodic occlusion of residual limb blood vessels. During the stance phase of gait, body weight cause the prosthesis to compresses the soft tissue of the residual limb and occlude blood flow.
- Conditions
- Amputation, Diabetes Complications, Leg Injuries, Traumatic Amputation
- Trial name
- NCT00985842
- Testing
- Pe-Lite and sleeve suspension socket, Total Surface bearing a socket with a sleeve suspension but without suction, Total surface bearing suction socket with a pin lock suspension
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- VA Office of Research and Development
Lower Limb Amputation Below Knee (Injury)
Restoration of Normative Postural Control
The objective of this proposal is to investigate the effects of training to use direct electromyographic (dEMG) control of a powered prosthetic ankle on transtibial amputees'. The aimed questions to answer: 1.
- Trial name
- NCT06452186
- Testing
- direct EMG controlled prosthetic ankle, PT guided prosthetic training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- North Carolina State University
Peripheral Arterial Disease, Peripheral Vascular Disease
The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD
Lower limb amputation is common in the United States, with approximately 150,000 amputations annually. Most individuals walking with a prosthesis demonstrate asymmetrical loading-i.e., they favor the amputated side by placing…
- Conditions
- Peripheral Arterial Disease, Peripheral Vascular Disease, Amputation, Lower Limb Amputation Knee
- Trial name
- NCT04937179
- Testing
- Ischemic Conditioning High - Active Comparator
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Illinois Chicago
Low Back Pain
The Impact of Unilateral Lower Limb Amputation on Spinal Loads
The prevalence of low back pain among persons with unilateral lower limb amputation is significantly higher than the rate experienced by the general public.
- Trial name
- NCT02897973
- Testing
- Activity of daily living
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Diabetic Foot Ulcer
Prevention of Amputation in Diabetic Foot Ulcers Using Amniotic Tissue
The purpose of this study is to see whether the use of AMNIOEXCEL® improves healing and reduces the need to cut off all or part of a leg (amputation) in high-risk patients who have diabetes and foot sores (also sometimes called…
- Trial name
- NCT02632929
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boise VA Medical Center
Diabetes, Foot Ulcer
Preventing Amputations by Tailored Risk-based Intervention to Optimize Therapy
The PATRIOT study will evaluate a risk-based personalized behavioral intervention to improve foot self-care, self-monitoring, and modifiable risks for amputation such as blood glucose, blood pressure and cholesterol in order to…
- Trial name
- PATRIOT (NCT02356757)
- Testing
- Personalized Behavioral Intervention, Current Best Practice
- Where
- United States
- Volunteers
- 406 people
- Sponsor
- VA Office of Research and Development
Diet, Food, and Nutrition, Nutrition Disorders
Nutrition in People With a Lower Limb Amputation
The goal of this prospective longitudinal observational cohort study is to determine the nutritional intake, nutritional status, and physical activity level in people who have undergone a major dysvascular lower limb amputation…
- Conditions
- Diet, Food, and Nutrition, Nutrition Disorders, Amputation
- Trial name
- NCT05747066
- Testing
- No intervention
- Where
- 6 sites in Netherlands
- Volunteers
- 81 people
- Sponsor
- University Medical Center Groningen
Amputation; Lower Extremity, Pain, Persistent Postsurgical
Altius Peripheral Nerve Stimulation in Amputees After TMR/RPNI
This is a single-center, prospective, within-subject study. This study seeks to enroll a total of 32 prospective subjects who will undergo surgical implantation of the FDA-approved Altius® system.
- Trial name
- NCT07571239
- Testing
- Surgical Implantation
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- NYU Langone Health