Clinical trials: Anaesthesia and Analgesia
Analgesia, Epidural, Pain, Postoperative
Programmed Intermittent Bolus Versus Continuous Infusion for Epidural Analgesia in Abdominal Surgery
Epidural analgesia is an efficient way to relieve pain after major abdominal surgery. Two different protocols are used to provide analgesia: continuous epidural infusion (CEI) and programmed intermittent boluses (PIEB).
- Trial name
- NCT04254523
- Testing
- Programmed intermittent epidural bolus (PIEB) of bupicavaine, Continuous epidural infusion (CEI) of bupivacaine, Continuous epidural infusion (CEI) of morphine
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- CHU de Quebec-Universite Laval
Butorphanol
Study on Gynecological Laparoscopy Under Total Intravenous Anesthesia
To investigate the effect of preemptive analgesia with tartaric acid butorphanol on postoperative pain in gynecological laparoscopy under total intravenous anesthesia with remifentanil.This randomised, double-blind…
- Trial name
- NCT06524596
- Testing
- tartaric acid butorphanol, normal saline, propofol and remifentanil
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Wuhan Children's Hospital
Nociceptive Pain, Anesthesia
Effect of Dexmedetomidine on Nol-Index Guided Remifentanil Analgesia
Background: Analgesia remains to this day a challenge for anesthesiologists. Dexmedetomidine, a potent central alpha-2 agonist, has been shown to have analgesic and opioid sparing effects.
- Conditions
- Nociceptive Pain, Anesthesia, Opioid Use, Perioperative/Postoperative Complications
- Trial name
- NCT03912740
- Testing
- Dexmedetomidine, sodium chloride, Remifentanil
- Where
- Belgium
- Volunteers
- 58 people
- Sponsor
- Erasme University Hospital
Preemptive, Postoperative Timing
Preemptive and Postoperative Timing of Real-Time Sonar Guided Caudal Anesthesia for Pediatric Infra-Umbilical Procedures Analgesia
This study compared preemptive and postoperative real-time ultrasound-guided caudal block with respect to analgesic efficacy, opioid consumption, and hemodynamic stability in children undergoing infra-umbilical procedures.
- Conditions
- Preemptive, Postoperative Timing, Real-Time, Sonar
- Trial name
- NCT07853339
- Testing
- Caudal block immediately following induction of general anesthesia, Caudal block at the end of surgery
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Postoperative Pain
USG-Guided Infiltration Popliteal Artery Capsule Knee Block Versus Adductor Canal Block Application as Postoperative Analgesia
The purpose was to evaluate the effect of USG-guided adductor canal block and infiltration popliteal artery capsule knee block combination on postoperative analgesia before total knee arthroplasty.
- Trial name
- NCT05956275
- Testing
- Tramadol, Morfin
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Siirt Training and Research Hospital
Healthy
Dexamethasone Intravenous Versus Intrathecal in Spinal Anesthesia
The purpose of this study is to compare the the effect of intravenous and the intrathecal dexamethasone when added to spinal anesthesia in cesarean section.
- Trial name
- NCT05470530
- Testing
- Dexamethasone
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain, Postoperative
Glossopharyngeal Nerve Block in Pediatric Adenotonsillectomy Operations
Tonsilloadenoidectomy operations in pediatric patients cause local pain. Especially, in order to reduce the need for narcotic painkillers, to ensure patient compliance and well-being, and to provide better quality pain management…
- Trial name
- NCT07873307
- Testing
- Bupivacaine hydrogen chloride (HCl) %0.125 in 0,2 milliliter/kilogram (ml/kg)+ 0,2 milliliter/kilogram (ml/kg) injection, Bupivacaine hydrogen chloride (HCl) %0.25 in 0,2 milliliter/kilogram (ml/kg)+ 0,2 milliliter/kilogram (ml/kg) injection
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul University
Coronary Artery Disease
Epidural Anesthesia and Postoperative Analgesia With Ropivacaine and Fentanyl
The aim of the present study was to assess the efficacy of thoracic epidural anesthesia followed by postoperative epidural infusion and patient-controlled epidural analgesia with ropivacaine/fentanyl in off-pump coronary artery…
- Trial name
- NCT01384175
- Testing
- intravenous analgesia, epidural infusion, patient-controlled epidural analgesia
- Where
- Russia
- Volunteers
- 93 people
- Sponsor
- Northern State Medical University
Breech Presentation
Impact of Analgesia on Success of External Version: Comparison of Spinal Anesthesia Versus Sedation
At the time of birth, nearly 5% of children are in breech presentation. This type of presentation requires a medical environment and leads to more frequent use of Caesarean sections.
- Trial name
- RaVem (NCT02801201)
- Testing
- Midazolam, Bupivacaine
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hepatectomy
Intravenous Lidocaine for Hepatectomy
Liver resection is increasingly performed for hepatic tumors, mainly primary liver cancers and resectable metastases, but also for some benign lesions.
- Trial name
- ILHEP (NCT07590830)
- Testing
- Standardized General Anesthesia Induction and Maintenance Protocol incorporating Intravenous Lidocaine
- Where
- 9 sites in France
- Volunteers
- 312 people
- Sponsor
- Rennes University Hospital
Pain Management
Methadone Versus Standard of Care for Pain Control in Minimally Invasive Lung Resection Surgery
This study is being done to find out if methadone is more effective in controlling pain in patients presenting for minimally invasive lung resection surgery compared to the standard of care.
- Trial name
- NCT07914751
- Testing
- Methadone, Standard of Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Wake Forest University Health Sciences
Pain, Postoperative, Delirium
Study to Determine if Pre- and Post- Operative TAP Catheters With Ropivacaine Versus Placebo Affects Anesthetic, Narcotic Dosing, and Pain Scores
A randomized controlled trial to determine if pre- and post- operative regional pain control (transversus abdominis plane block) with ropivacaine versus placebo leads to lower anesthetic and narcotic dosing, and alters pain…
- Conditions
- Pain, Postoperative, Delirium, Anesthesia, Local
- Trial name
- TAP RCT (NCT03149783)
- Testing
- Ropivacaine HCL, sodium chloride
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Anesthesia, Analgesia
The Efficacy and Safety of S-ketamine in Elective Cesarean Section
During the past years, a large number of clinical trials have investigated the use of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist racemic ketamine as an adjunct to local anaesthetics, opioids, or other…
- Conditions
- Anesthesia, Analgesia, Depression, Cesarean Section
- Trial name
- ES-CS (NCT04657107)
- Testing
- S-ketamine, normal saline
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Arthroplasty, Replacement, Hip
Total Hip Arthroplasty Outcomes With Regional and Multimodal Analgesia
The goal of this retrospective chart review is to evaluate if the implementation of lumbar plexus block placement for postoperative pain and administration of multimodal oral analgesia have improved conditions in the…
- Conditions
- Arthroplasty, Replacement, Hip, Arthritis
- Trial name
- THA (NCT02186795)
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Medical University of South Carolina
Shoulder Pain
Determining the Minimal Effective Volume (MEAV95) for Interscalene Brachial Plexus Block for Surgical Anesthesia
Interscalene block (ISB) consistently demonstrates superior pain relief after shoulder surgery. However, patients can experience complications such as blurred vision, hoarseness and shortness of breath with the standard volumes…
- Trial name
- MEAV 95 (NCT01703130)
- Testing
- Dose of of ropivacaine 0.75% used in block procedure
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Perioperative Care, Pediatric Anesthesia
Giving Children a Voice in Paediatric Anaesthesia
This project will identify the research priorities for paediatric anaesthesia and perioperative medicine in participating countries and highlight areas where further research and information can be provided to optimise the…
- Conditions
- Perioperative Care, Pediatric Anesthesia, Pain Management, Anxiety
- Trial name
- TR-VP26 (NCT07524049)
- Where
- 7 sites in Switzerland
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Dental Anxiety, Pain Management
Impact of Local Anesthesia Techniques on Children's Dental Treatment Experience
compare the effectiveness of several local anesthetic delivery systems in managing pain, anxiety, behavior, and vital signs among pediatric dental patients.
- Conditions
- Dental Anxiety, Pain Management, Pediatric Dentistry
- Trial name
- NCT07106138
- Testing
- Conventional syringe injection, Star Pen, Comfort-In
- Where
- Syria
- Volunteers
- 112 people
- Sponsor
- Latakia University
Anesthesia, Spinal Puncture
Intravenous Fentanyl or Local Anesthetic Infiltration for Pain Reducing During Spinal Needle Insertion
Background and Objectives: Spinal puncture is painful procedure which may cause patient refusal of spinal anesthesia in future surgery.
- Trial name
- NCT01157247
- Testing
- Comparison of intravenous fentanyl and local anesthetic infiltration in pain reducing during spinal needle puncture
- Where
- Croatia
- Volunteers
- 88 people
- Sponsor
- Croatian Society of Regional Anesthesia and Analgesia
Postoperative Pain
An International Trial to Evaluate the Efficacy and Safety of SABER®-Bupivacaine for Postoperative Pain Control in Patients Undergoing Hysterectomy
The objective is to identify the optimal dose of SABER-Bupivacaine for postoperative pain control in patients undergoing hysterectomy on the basis of pharmacokinetics, efficacy and safety evaluations.
- Trial name
- NCT00993226
- Testing
- SABER-Bupivacaine Treatment 1a, Bupivacaine HCl Treatment 1c, SABER-Bupivacaine Treatment 2a
- Where
- 14 sites in France, Germany and 4 more
- Volunteers
- 115 people
- Sponsor
- Durect
Hip Fractures, Pain, Postoperative
Effects of Pericapsular Nerve Group Block Applied in Patients Undergoing Hip Fracture Surgery.
In this study, it was aimed to compare the multimodal analgesia application or the pericapsular nerve group (PENG) block methods in patients undergoing hip surgery.
- Trial name
- NCT06183541
- Testing
- Pericapsular Nerve Group (PENG) Block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Umraniye Education and Research Hospital
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