Clinical trials: Anakinra
Amyotrophic Lateral Sclerosis (ALS)
Safety and Tolerability of Anakinra in Combination With Riluzol in Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is an adult neurodegenerative disease that is caused by a selective degeneration of the motor nerve cells in the cortex and myelon.
- Trial name
- NCT01277315
- Testing
- Anakinra
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
B Cell ALL, B-Cell Lymphoma
A Study of Anakinra to Prevent or Treat Severe Side Effects for Patients Receiving CAR-T Cell Therapy
This study is being done to see if the investigational drug, anakinra, prevent or reverse the severe side effects caused by CAR-T cell therapy.
- Conditions
- B Cell ALL, B-Cell Lymphoma, B-cell Non Hodgkin Lymphoma
- Trial name
- NCT04148430
- Testing
- Anakinra
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hidradenitis Suppurativa
Anakinra as a Treatment for Hydradenitis Suppurativa
This is an open-label, proof-of-concept research study to assess the effectiveness of anakinra in the treatment of patients with hidradenitis suppurativa (HS).
- Trial name
- NCT01516749
- Testing
- anakinra
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Francisco
Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma
Anakinra in Preventing Severe Chimeric Antigen Receptor T-Cell Related Encephalopathy Syndrome in Patients With Recurrent or Refractory Large B-cell Lymphoma
This phase II trial studies how well anakinra works in preventing severe chimeric antigen receptor T-cell-related encephalopathy syndrome after chimeric antigen receptor T-cell therapy in patients with large B-cell lymphoma that…
- Conditions
- Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma, Progressive Disease, Recurrent Diffuse Large B-Cell Lymphoma
- Trial name
- NCT04205838
- Testing
- Anakinra, Axicabtagene Ciloleucel, Cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Jonsson Comprehensive Cancer Center
COVID-19 Severe Respiratory Failure
Combination of Inhaled DNase, Baricitinib and Tocilizumab in Severe COVID-19
In patients with COVID-19, severe hypoxemic respiratory failure (SRF) leading to invasive mechanical ventilation (IMV), raises the mortality rate substantially.
- Trial name
- NCT05279391
- Testing
- Dexamethasone, Low molecular weight heparin, Anakinra 100Mg/0.67Ml Inj Syringe
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Democritus University of Thrace
Osteoarthritis
Treatment for Patients With Osteoarthritis (OA) of the Knee
The purpose of this study is to evaluate the clinical response in subjects with symptomatic OA of the knee following a single 50 mg anakinra, 150 mg anakinra or placebo intra-articular (IA) injection.
- Trial name
- NCT00110916
- Testing
- Intra-articular metHuIL-1ra (anakinra)
- Volunteers
- 165 people
- Sponsor
- Amgen
Kawasaki Disease
A Trial Comparing the Efficacy and Safety of Anakinra Versus Intravenous Immunoglobulin (IVIG) Retreatment, in Patients With Kawasaki Disease Who Failed to Respond to Initial Standard IVIG Treatment
Kawasaki disease (KD) is the most frequent vasculitis in younger children <5years, and the first cause of acquired ischemic myocardiopathy in childhood.
- Trial name
- ANACOMP (NCT04656184)
- Testing
- ANAKINRA, Intravenous immunoglobulin
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Glucose Intolerance, Impaired Insulin Secretion
The Effect of Anakinra on Insulin Secretion
Rationale: Once diabetes develops, β-cell function progressively deteriorates and therapeutic approaches that prevent of delay loss of β-cell function are needed in the treatment of type 2 diabetes mellitus.
- Conditions
- Glucose Intolerance, Impaired Insulin Secretion, Diabetes Mellitus Type 2
- Trial name
- NCT01285232
- Testing
- Anakinra
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Familial Mediterranean Fever
Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever
FMF is the most common periodic fever with a worldwide patient population estimated as 150,000, mainly located in the Eastern Mediterranean basin.
- Trial name
- FMF (NCT01705756)
- Testing
- Kineret
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Sheba Medical Center
Still's Disease, Juvenile Onset, Still's Disease, Adult-Onset
A Study of Anakinra in Japanese Patients With Still's Disease (SJIA and AOSD)
A study to demonstrate efficacy and safety of anakinra in pediatric and adult Japanese patients with Still's disease (Systemic juvenile idiopathic arthritis [SJIA] and Adult-onset Still's disease [AOSD]).
- Trial name
- NCT05814159
- Testing
- Anakinra
- Where
- 8 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Swedish Orphan Biovitrum
Idiopathic Recurrent Pericarditis
AnakInRa for Treatment of Recurrent Idiopathic Pericarditis (AIRTRIP)
Recent findings suggest that recurrent pericarditis (RP) may be a previously unrecognized autoinflammatory disease. The pivotal pathogenic role of interleukin (IL)-1 in RP has been shown by the achievement of complete responses…
- Trial name
- AIR TRIP (NCT02219828)
- Testing
- Anakinra
- Where
- 3 sites in Italy
- Volunteers
- 21 people
- Sponsor
- Massimo Imazio
Acute Respiratory Distress Syndrome
Efficacy and Safety of Anakinra in Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition characterized by acute respiratory failure with hypoxemia, noncardiogenic or non-fluid overload pulmonary edema, bilateral diffuse opacities on chest…
- Trial name
- ESKA (NCT05914454)
- Testing
- Anakinra 100Mg/0.67Ml Inj Syringe
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Autoimmune Connective Tissue Disorder, Immune System Diseases
Anakinra for Behcet s Disease
Background: Behcet's disease (BD) is an autoimmune disease where the immune system attacks the body. People with BD may develop oral or genital ulcers, skin problems, and eye disease.
- Trial name
- NCT01441076
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Acute Pericarditis
Treatment of Acute Pericarditis With Anakinra
The goal of this study is to determine the safety and efficacy of anakinra for the treatment of acute pericarditis when initiated within 6 hours of diagnosis and continued for 3 or 7 days. 1.
- Trial name
- NCT03224585
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Virginia Commonwealth University
Sneddon-Wilkinson, Acrodermatitis Continua of Hallopeau
Anakinra for Inflammatory Pustular Skin Diseases
Background: Inflammatory pustular skin diseases are a type of autoinflammatory disease in which the immune system attacks the bodys tissues.
- Conditions
- Sneddon-Wilkinson, Acrodermatitis Continua of Hallopeau, Pustular Psoriasis, Palmoplantar Pustulosis
- Trial name
- NCT01794117
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
COVID-19, Virus Diseases
Personalised Immunotherapy for SARS-CoV-2 (COVID-19) Associated With Organ Dysfunction
Our aim is to conduct one trial of personalized immunotherapy in patients with SARS-CoV-2 (COVID-19) associated with organ dysfunction and with laboratory findings of macrophage activation syndrome or immune dysregulation.
- Conditions
- COVID-19, Virus Diseases, Macrophage Activation Syndrome, Corona Virus Infection
- Trial name
- ESCAPE (NCT04339712)
- Testing
- Anakinra, Tocilizumab
- Where
- 17 sites in Greece
- Volunteers
- 102 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Pulmonary Arterial Hypertension
Pilot Study of the Safety and Efficacy of Anakinra in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) can result in right ventricular failure and death. Anakinra has been used in patients with left sided heart failure, and the present study looks to determine if anakinra is safe and effective…
- Trial name
- NCT03057028
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Virginia Commonwealth University
Subarachnoid Hemorrhage
SC IL-1Ra in SAH - Phase III Trial (SCIL)
This phase III trial will establish whether IL-1Ra, with sub-cutaneous (SC) administration twice daily for up to 21 days post aneurysmal subarachnoid haemorrhage (aSAH), improves clinical outcome as measured by ordinal shift in…
- Trial name
- SCIL (NCT03249207)
- Testing
- IL-1Ra
- Where
- 17 sites in United Kingdom
- Volunteers
- 612 people
- Sponsor
- University of Manchester
Adult-Onset Still's Disease
Treatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized Study
An open, randomized, parallel-group, comparative, multicentre study. Patients on corticosteroids (plus conventional therapy) will be randomized to receive anakinra (Kineret®), or one of the following: methotrexate, azathioprine…
- Trial name
- NordicAOSD05 (NCT01033656)
- Testing
- anakinra, comparators
- Where
- Sweden
- Volunteers
- 23 people
- Sponsor
- University of Helsinki
Hidradenitis Suppurativa
Anakinra in Hidradenitis Suppurativa
Aim of this double-blind, randomized, controlled clinical trial is to compare the safety and the efficacy of anakinra over placebo for the management of patients with hidradenitis suppurativa (HS) of Hurley II and Hurley III…
- Trial name
- NCT01558375
- Testing
- Water for injection, Anakinra
- Where
- 2 sites in Greece
- Volunteers
- 20 people
- Sponsor
- University of Athens