Clinical trials: Anal Fissure
Fissure;Anal, Fistula;Rectal
Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery
Double-blinded multicenter randomized clinical trial to evaluate the efficacy and safety of CLIFE2 (lidocaine, referred as treatment A) respect CLIFE1 (lidocaine plus diclofenac, referred as treatment B) in benign anorectal…
- Conditions
- Fissure;Anal, Fistula;Rectal, Hemorrhoids
- Trial name
- NCT02961855
- Testing
- anesthesics plus antiinflammatory, CLIFE1, local anesthesics, CLIFE2
- Volunteers
- 120 people
- Sponsor
- Hospital de Viladecans
Chronic Anal Fissure
Effect of Shock Waves Therapy on Chronic Anal Fissure
the study conducted to assess if there is an effect of Extracorporeal Shock Wave Treatment on anal fissure
- Trial name
- NCT04793347
- Testing
- shock master (shock waves device)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- amr bayoumi salama
Fissure in Ano
The Role of Fitostimoline Proctogel in Symptoms Relief and Healing in Patients Affected by Anal Fissure
Evaluate the effectiveness of fitostimoline proctogel in the anal fissure healing and in the need for invasive interventions (primary endpoints) and in the healing of the fissure (secondary endpoint) using Fitostimoline in…
- Trial name
- NCT04714684
- Testing
- Fitostimoline proctogel, Fitostimoline proctogel + muscle relaxant
- Volunteers
- 100 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Pain
Comparison of Botulinum Toxin and Sphincterotomy in the Treatment of Chronic Anal Fissure
Intra-sphincteric injection of botulinum toxin seems to be a reliable option causing temporary alleviation of sphincter spasm and allowing the fissure to heal.
- Trial name
- NCT01095900
- Testing
- conservative lateral internal sphincterotomy, Intra-sphincteric Botulinum-toxin injection
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Theodor Bilharz Research Institute
Chronic Anal Fissure
Perianal Versus Endoanal Application of Glyceryl Trinitrate 0.4% Ointment for Chronic Anal Fissure
Perianal topical nitroglycerin has been widely used as a means for avoiding surgery in patients with anal fissure. However, nitroglycerin has not been universally accepted for this application because of inconsistency of efficacy…
- Trial name
- NCT01132391
- Testing
- Rectogesic® (glyceryl trinitrate 0.4% ointment)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Elche
Chronic Anal Fissure
Topical Nitroglycerin Versus Lateral Internal Sphincterotomy for Chronic Anal Fissure
Chronic anal fissure is a tear in the lining of the anal canal that can cause pain during and after defecation. This randomized controlled trial will compare topical 0.2% nitroglycerin ointment with lateral internal…
- Trial name
- NCT07884916
- Testing
- Topical 0.2% Glyceryl Trinitrate (Nitroglycerin) Ointment, Lateral Internal Sphincterotomy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Perianal Crohn Disease, Perianal Fistula
The Impact of Perianal Disease on Patient's Sex Life
Perianal diseases, such as perianal abcesses, anal fistulae and perianal Crohn's disease, are often associated with significant physical symptoms, including pain and chronic drainage.
- Conditions
- Perianal Crohn Disease, Perianal Fistula, Fistula in Ano, Perianal Abscess
- Trial name
- SEXTON (NCT07519850)
- Testing
- Patient Reported Outcome Assessment (Questionnaires)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- AHEPA University Hospital
Anal Fissure Chronic
Short-Term Outcome of Medical Vs. Surgical Management Of Chronic Anal Fissure
Several topical agents have been proposed for Chronic anal fissure (CAF) treatment with the common goal of increasing anodermal blood flow to promote healing but approaching the use of medical treatment in CAFs is not…
- Trial name
- NCT06617026
- Testing
- Sucralfate, Azadirachtin, fissurectomy and lateral sphincterectomy
- Where
- Egypt
- Volunteers
- 99 people
- Sponsor
- Suez Canal University
Chronic Anal Fissure
Transcutaneous Posterior Tibial Nerve Stimulation for Treatment of Chronic Anal Fissure
Lateral internal sphinterotomy (LIS) is the gold standard against which all treatments are compared with a healing rate over 92%. However, the most serious complication of this procedure is anal incontinence.
- Trial name
- NCT02395809
- Testing
- lateral internal sphincterotomy, TENS
- Volunteers
- 94 people
- Sponsor
- Mansoura University
Anal Fissure Chronic
Pulsed Electromagnetic Field on Chronic Anal Fissure Healing
The purpose of this study is to find the effect of Pulsed Electromagnetic Field on chronic Anal fissure healing. Included both male and female aged 30-60 suffering from Anal fissure symptoms.
- Trial name
- PEMF (NCT07729709)
- Testing
- PEMS, Lidocaine and general advice, Lidocaine cream and general advice
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Galala University
Anal Fissure
The Importance of Lateral Internal Sphincterotomy Incision: Parallel or Vertical
The purpose of this study is to determine effective incision type for the treatment of chronic anal fissures.
- Trial name
- NCT00980369
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- SB Istanbul Education and Research Hospital
Perianal Fistula, Fissure in Ano
Perianal Nerval Block in Proctological Interventions
The aim of this study is to evaluate whether a local perianal block performed during a proctological intervention can reduce the postoperative pain.
- Conditions
- Perianal Fistula, Fissure in Ano, Hemorrhoids
- Trial name
- NCT03405922
- Testing
- 40 mL Ropivacain 0.5%
- Where
- Switzerland
- Volunteers
- 166 people
- Sponsor
- University Hospital, Basel, Switzerland
Anal Fissure
Efficacy Study of Dysport® in the Treatment of Anal Fissure.
To evaluate the effect on healing rates of two different prognostic factors in patients treated with Dysport® for anal fissure: duration of fissure and dose of study drug
- Trial name
- NCT00210444
- Testing
- Botulinum toxin type A
- Where
- 7 sites in Czechia, Poland and 2 more
- Volunteers
- 168 people
- Sponsor
- Ipsen
Inflammatory Bowel Diseases, Anal Fissure
Laser Versus Surgery in Anal Diseases in Inflammatory Bowel Patients
This is a randomized comparative clinical trial carried out to compare between laser ablation and surgery in treating anal diseases in inflammatory bowel diseases patients and find out if one is superior to the other.
- Conditions
- Inflammatory Bowel Diseases, Anal Fissure, Hemorrhoids
- Trial name
- NCT06216223
- Testing
- treatment of anal diseases in inflammatory bowel patients, Laser, traditional surgery
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Zagazig University
Chronic Anal Fissure
Postero-lateral Internal Sphincterotomy vs Botulinum Toxin Injection in the Treatment of Chronic Anal Fissure
We hypothesized that optimization of the dose of the Botulinum toxin injection (BT) and standardization of the technique of lateral internal sphincterotomy to posterolateral internal sphincterotomy (PIAS) could, in turn, report a…
- Trial name
- NCT03920449
- Testing
- Botulinum Toxins, Posterolateral internal sphincterotomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Acute Anal Fissure
Effectiveness of Anal Enlargement by Dilators as a Therapeutic Physical Tool in Acute Anal Fissure
The treatment of anal fissure is mainly surgical. There are complications to this treatment, including damage to the inner anal sphincter and the appearance of fecal incontinence.
- Trial name
- NCT04828889
- Testing
- Anal dilators, lateral internal sphincterotomy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Chronic Anal Fissure
Conventional Lateral Internal Sphincterotomy, V-Y Anoplasty and Tailored Lateral Internal Sphincterotomy With V-YF in Treatment of Chronic Anal Fissure(CAF)
The investigators compared conventional lateral internal sphincterotomy (CLIS), V-Y anal flap, and combined tailored lateral internal sphincterotomy with V-Y anal flap (TLIS with V-YF) in a randomized prospective study in…
- Trial name
- CAF (NCT01500889)
- Testing
- Group I: Conventional Lateral internal sphincterotomy:, GroupII: V-Y advancement flap, GroupIII: Tailored LIS with V-Y advancement flap
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Mansoura University
Anal Fissure Chronic
Comparative Outcomes of Inj Botox Alone vs Inj Botox Combined With Fissurectomy and Anoplasty in the Management of Chronic Anal Fissure
Chronic anal fissure is a common benign anorectal condition characterized by severe pain during defecation, rectal bleeding, and reduced quality of life.
- Trial name
- NCT07665528
- Testing
- Botulinum Toxin Type A (BOTOX) Injection, Botulinum Toxin Type A (BOTOX) Injection, Fissurectomy and Anoplasty
- Where
- Pakistan
- Volunteers
- 108 people
- Sponsor
- Islamabad Medical and Dental College
Fissure in Ano, Diarrhea
The Efficacy of Asacol (Mesalazine) Suppository on the Treatment of Diarrhea-Induced Acute Fissure
Anal fissure define as a superficial tearing in mucosa on the anoderm surface distal to dentate line . The most important factor is hard stool passing with trauma to anal mucosa.
- Trial name
- NCT05091775
- Testing
- Asacol is used to treat and prevent mild to moderate acute fissure disease
- Where
- Iran
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Perianal Fistula, Perianal Crohn Disease
Regenerative Therapy With Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cells and Platelet-rich Plasma to Treat Complex Perianal Diseases
Consecutive patients with complex anal fistula were prospectively followed for 12 months. Routine MRI was performed before and at 4 and 12 months after surgery. Continence was assessed likewise using a validated questionnaire.
- Conditions
- Perianal Fistula, Perianal Crohn Disease, Anal Fissure, Rectovaginal Fistula
- Trial name
- NCT05709717
- Testing
- Regenerative therapy with SVF-PRP to supplement perianal surgery
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Kantonsspital Winterthur KSW