Clinical trials: Anal Fissure
Anal Fissure
Efficacy Study of Dysport® in the Treatment of Anal Fissure.
To evaluate the effect on healing rates of two different prognostic factors in patients treated with Dysport® for anal fissure: duration of fissure and dose of study drug
- Trial name
- NCT00210444
- Testing
- Botulinum toxin type A
- Where
- 7 sites in Czechia, Poland and 2 more
- Volunteers
- 168 people
- Sponsor
- Ipsen
Chronic Anal Fissure
Treatment Of Chronic Anal Fissure
The purpose of this study is to investigate the effect of Levorag Emulgel compared with diltiazem gel on the healing of chronic anal fissures.
- Trial name
- TOCA (NCT02158013)
- Testing
- Levorag Emulgel, Diltiazem
- Where
- 2 sites in Denmark
- Volunteers
- 55 people
- Sponsor
- Bispebjerg Hospital
Chronic Anal Fissure
High Dose Multiple Site Injection of Botox Versus Lateral Sphincterotomy in Chronic Analfissure
comparison between the effect of lateral sphincterotomy against high dose botox injection in chronic anal fissure the outcome was healing time, recurrence continence relapse pain pruritus
- Trial name
- professor (NCT04166175)
- Testing
- botox injection in intersphincteric space, lateral internal sphincterotomy
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Zagazig University
Anal Fissure
Topical Minoxidil Versus Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure
This randomized trial aims to compare two topical treatments in the treatment of chronic anal fissure: minoxidil gel and glycreyl trintrate cream.
- Trial name
- NCT03528772
- Testing
- Minoxidil, Glyceryl trinitrate
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Mansoura University
Chronic Anal Fissure
Outcomes of the Use of CO2 (Carbon Dioxide) Laser in the Treatment of Chronic Anal Fissure
Outcomes of using CO2 (Carbon Dioxide) laser in the management of chronic anal fissure as an alternative to conventional methods
- Trial name
- NCT03872765
- Testing
- Laser surgery
- Volunteers
- 236 people
- Sponsor
- University of Nineveh
Hemorrhoids, Anal Fissure
Effects of Sodium Pentaborat Based Gel on Perianal Benign Diseases
New produced and patented sodium pantaborat based gel will be use for treatment of benign perianal diseases (hemooroidal disease, anal fissura anda perianal fistula)
- Conditions
- Hemorrhoids, Anal Fissure, Perianal Fistula
- Trial name
- NCT03780998
- Testing
- Life7
- Volunteers
- 250 people
- Sponsor
- SB Istanbul Education and Research Hospital
Chronic Anal Fissure
The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients With Anal Fissure
The objective of the study is to examine the effect of Nifedipine, applied intra-anally through our drug delivery device, on rectal pain severity in anal fissure patients that are being managed with conservative treatment.
- Trial name
- NCT02527109
- Testing
- Nifedipine
- Where
- 24 sites in Bulgaria, Moldova and 2 more
- Volunteers
- 339 people
- Sponsor
- RDD Pharma Ltd
Chronic Anal Fissure
Percutaneous Tibial Nerve Stimulation - an Alternative Treatment Option for Chronic Therapy Resistant Anal Fissure
At a tertiary referral centre, 10 patients (4 male and 6 female; mean age 49.8 years) were given neuromodulation via the posterior tibial nerve to the sacral nerve for 30 min on 10 consecutive days.
- Trial name
- NCT03554421
- Testing
- Percutaneous tibial nerve stimulation
- Volunteers
- 10 people
- Sponsor
- Region Skane
Acute Anal Fissure
Pain and Bleeding in Subjects With Acute Anal Fissure: Comparative Evaluation of Three Treatments
Starting from the observation that acute anal fissure (AAF) in 6-8 weeks can heal spontaneously and that some of the commonly used commercial products in clinical practice would seem to be useful, the rationale of the comparative…
- Trial name
- PBSAAF (NCT03355846)
- Testing
- Centella, Proctocella, Flavonil® cps
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- University of Roma La Sapienza
Anal Fissure, Anal Fistula
Ultrasound Guided Caudal Block for Benign Anal Surgery
Interventional study that evaluate analgesia and side effects of Ultrasound guided Caudal block preoperatively in benign canal anal surgery
- Conditions
- Anal Fissure, Anal Fistula, Hemorrhoids, Pain, Postoperative
- Trial name
- NCT03345511
- Testing
- Ultrasound Guided Caudal Block
- Where
- Colombia
- Volunteers
- 23 people
- Sponsor
- Universidad de Antioquia
Anal Fissure
Posterolateral Versus Lateral Internal Anal Sphincterotomy for Chronic Anal Fissure
The present study aimed to compare the standard lateral internal sphincterotomy at 3 o'clock with posterolateral internal sphincterotomy at 5 o'clock in regards healing time, postoperative recurrence and complications…
- Trial name
- NCT03426449
- Testing
- posterolateral sphincterotomy, lateral sphincterotomy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Hemorrhoids, Fissure in Ano
Pre-Emptive Analgesia in Ano-Rectal Surgery
The perianal region is the region around the anus. Administering a pain medication before a surgery starts is called preemptive analgesia.
- Conditions
- Hemorrhoids, Fissure in Ano, Rectal Fistula, Anal Condyloma
- Trial name
- PEAARS (NCT02402543)
- Testing
- Gabapentin, Ketamine, Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Vermont
Anal Fissure
PK, PD and Safety Comparative Trial of Isosorbide Mononitrate Gel in Healthy Participants and With Anal Fissure
This is a Phase I trial to evaluate Pharmacokinetics, Pharmacodynamics and Safety of Isosorbide Mononitrate gel for usage in participants with anal fissure and healthy volunteers.
- Trial name
- NCT02667535
- Testing
- Isosorbide Mononitrate
- Volunteers
- healthy volunteers welcome
- Sponsor
- Biolab Sanus Farmaceutica
Fissure;Anal, Fistula;Rectal
Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery
Double-blinded multicenter randomized clinical trial to evaluate the efficacy and safety of CLIFE2 (lidocaine, referred as treatment A) respect CLIFE1 (lidocaine plus diclofenac, referred as treatment B) in benign anorectal…
- Conditions
- Fissure;Anal, Fistula;Rectal, Hemorrhoids
- Trial name
- NCT02961855
- Testing
- anesthesics plus antiinflammatory, CLIFE1, local anesthesics, CLIFE2
- Volunteers
- 120 people
- Sponsor
- Hospital de Viladecans
Anal Fissure
A Novel Method for Chronic Anal Fissure Treatment
Investigators performed a prospective pilot study to test the feasibility and safety of autologous adipose derived regenerative cell (ADRC) transplantation in treatment of anal fissures.
- Trial name
- NCT02628522
- Testing
- ADRCs therapy, Celution, Tulip cannulas
- Volunteers
- 6 people
- Sponsor
- Clinical Centre of Serbia
Anal Fissure
An Open Label Multi-Dose Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing
This is an open label study. The study will consist of 2 treatment group: coated Nifedipine suppository containing 12 mg of Nifedipine applied twice daily (group 1) and coated Nifedipine suppository containing 12 mg of Nifedipine…
- Trial name
- NCT02023047
- Testing
- Nifedipine 12 mg coated suppositories
- Where
- 4 sites in Israel
- Volunteers
- 33 people
- Sponsor
- RDD Pharma Ltd
Fistula-in-ano, Rectal Polyp
Trial on Use of Coloshield in Transanal and Anal Surgery
In various transanal and anal procedures it is desirable to clean the operating field from stool contamination. Thus mechanical bowel preparation is not well tolerated by patients. Enema does not provide sufficient effect.
- Conditions
- Fistula-in-ano, Rectal Polyp, Rectal Adenoma, Hemorrhoids
- Trial name
- NCT02579330
- Testing
- Coloshield, Control
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- Daniel Steinemann, MD
Anal Fissure
Pharmacokinetic,Safety and Exploratory Efficacy of RECTIV® in Adolescents With Chronic Anal Fissure
RECTIV® is an ointment containing 0.4% nitroglycerin (NTG) for the treatment of moderate to severe pain associated with chronic anal fissure approved in June 2011 by the US Food and Drug Administration (FDA) for adults.
- Trial name
- NCT01920074
- Testing
- Nitroglycerin Ointment 0.4%
- Where
- 6 sites in United States
- Sponsor
- Forest Laboratories
Chronic Anal Fissure
Transcutaneous Posterior Tibial Nerve Stimulation for Treatment of Chronic Anal Fissure
Lateral internal sphinterotomy (LIS) is the gold standard against which all treatments are compared with a healing rate over 92%. However, the most serious complication of this procedure is anal incontinence.
- Trial name
- NCT02395809
- Testing
- lateral internal sphincterotomy, TENS
- Volunteers
- 94 people
- Sponsor
- Mansoura University
Focus: Anal Incontinence After Lateral Sphincterotomy for Chronic Anal Fissure
Ultrasound Guided Lateral Sphincterotomy: Long Term Results
Ultrasound guided placement of the knife intersphincteric increases accuracy and safety during sphincterotomy. Secondly 3-D ultrasound visualizes that the internal anal sphincter is divided.
- Trial name
- NCT02020915
- Testing
- lateral sphincterotomy, ultrasound guided lateral sphincterotomy
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Hvidovre University Hospital