Clinical trials: Anal Fissure
Chronic Anal Fissure
Diltiazem Hydrochloride Cream for Anal Fissure
A Phase III, multicentre, randomised, double blind, placebo-controlled study in subjects having anal fissure (AF) with AF-related pain.
- Trial name
- NCT01217515
- Testing
- Diltiazem hydrochloride 4% cream, Diltiazem hydrochloride 2% cream
- Where
- 27 sites in Bulgaria, Germany and 4 more
- Volunteers
- 465 people
- Sponsor
- S.L.A. Pharma AG
Chronic Anal Fissures
Efficacy and Safety Study With Diltiazem Hydrochloride Cream to Treat Anal Fissures
The purpose of this study is to determine if the study drug, VEN307 (diltiazem hydrochloride cream) is safe and to see if it will help with treatment of pain associated with anal fissures.
- Trial name
- NCT01690221
- Testing
- VEN 307
- Where
- 103 sites in United States
- Volunteers
- 434 people
- Sponsor
- Ventrus Biosciences, Inc
Adult Subjects With Anal Fissures.
An Open-Label, Single- and Multi-Dose Pharmacokinetic (PK) Study of Oral Diltiazem and Topical Diltiazem Hydrochloride
The study is a single-center, open-label, safety and pharmacokinetic study in12 adult subjects with Anal Fissures. Subjects will be screened to determine eligibility within 7 days of treatment.
- Trial name
- NCT01816191
- Testing
- Diltiazem Hydrochloride Cream and Oral Diltiazem
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ventrus Biosciences, Inc
Anal Fissures Treatment and Oligoantigenic Diet
Oligo-antigenic Diet in the Treatment of Chronic Anal Fissures.
Patients with chronic constipation due to food hypersensitivity (FH) had an elevated anal sphincter resting pressure. No studies have investigated a possible role of FH in anal fissures (AF).
- Trial name
- NCT01637857
- Testing
- oligoantigenic diet
- Where
- Italy
- Volunteers
- 161 people
- Sponsor
- University of Palermo
Chronic Anal Fissure
Conventional Lateral Internal Sphincterotomy, V-Y Anoplasty and Tailored Lateral Internal Sphincterotomy With V-YF in Treatment of Chronic Anal Fissure(CAF)
The investigators compared conventional lateral internal sphincterotomy (CLIS), V-Y anal flap, and combined tailored lateral internal sphincterotomy with V-Y anal flap (TLIS with V-YF) in a randomized prospective study in…
- Trial name
- CAF (NCT01500889)
- Testing
- Group I: Conventional Lateral internal sphincterotomy:, GroupII: V-Y advancement flap, GroupIII: Tailored LIS with V-Y advancement flap
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Mansoura University
Chronic Anal Fissure
An Open Label Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing in Human Subjects
This is an open label study. The study will consist of 1 treatment group: coated Nifedipine suppository containing 12 mg of Nifedipine, administered BID to subjects with chronic anal fissure.
- Trial name
- NCT00972907
- Testing
- Nifedipine coated suppositories
- Where
- 2 sites in Israel
- Volunteers
- 20 people
- Sponsor
- RDD Pharma Ltd
Chronic Anal Fissure
Perianal Versus Endoanal Application of Glyceryl Trinitrate 0.4% Ointment for Chronic Anal Fissure
Perianal topical nitroglycerin has been widely used as a means for avoiding surgery in patients with anal fissure. However, nitroglycerin has not been universally accepted for this application because of inconsistency of efficacy…
- Trial name
- NCT01132391
- Testing
- Rectogesic® (glyceryl trinitrate 0.4% ointment)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Elche
Puerperal Infection, Fever
Diet and Lifestyle Intervention Study in Postpartum Women in China
Previous studies have shown "Doing the month", a traditional practice for postpartum women in China and other Asian countries, may be associated with higher prevalence of postpartum problems.
- Conditions
- Puerperal Infection, Fever, Constipation, Hemorrhoids
- Trial name
- NCT01039051
- Testing
- Diet and Lifestyle Intervention in Chinese Postpartum Women
- Where
- 3 sites in China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Anal Fissure
The Importance of Lateral Internal Sphincterotomy Incision: Parallel or Vertical
The purpose of this study is to determine effective incision type for the treatment of chronic anal fissures.
- Trial name
- NCT00980369
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- SB Istanbul Education and Research Hospital
Anal Fissure
Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure
The standard treatment of anal fissure in the netherlands (ISDN ointment) is being compared to a relatively new treatment (injection of Botox in the internal anal sphincter).
- Trial name
- NCT00827736
- Testing
- Botox, ISDN ointment
- Where
- Netherlands
- Volunteers
- 73 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Hemorrhoids, Anal Fissures
Trial to Evaluate Effect of Lactulose on Hard Stools in Patients With Hemorrhoids or Anal Fissures
To demonstrate that lactulose acts as a stool softener, relieving the pain at defecation, improving the number of defecations and regulating the colonic transit time in patients suffering of hemorrhoids or anal fissure.
- Trial name
- NCT00160290
- Testing
- Lactulose, Plantago ovata
- Where
- 8 sites in Spain
- Volunteers
- 97 people
- Sponsor
- Solvay Pharmaceuticals
Biological Therapy for Chronic Anal Fissure, Treatment by Biological Factors - Activated Macrophages
Treatment of Anal Fissure by Activated Human Macrophages
Chronic anal fissure is a linear tear in the distal anal canal. Most chronic fissures require intervention to heal. Surgical sphincterotomy is currently performed.
- Conditions
- Biological Therapy for Chronic Anal Fissure, Treatment by Biological Factors - Activated Macrophages, Interventional Study
- Trial name
- NCT00507364
- Testing
- Local injection of activated macrophages to anal fissure
- Where
- Israel
- Sponsor
- Hadassah Medical Organization