Clinical trials: Anal Fissure Chronic
Chronic Anal Fissure
Surgical Treatment of a Chronic Anal Fissure
This study is aimed at studying the effectiveness and safety of surgical treatment of chronic anal fissure.
- Trial name
- STCAF (NCT05117697)
- Testing
- lateral subcutaneous sphincterotomy
- Where
- 2 sites in Russia
- Volunteers
- 120 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Pain
Comparison of Botulinum Toxin and Sphincterotomy in the Treatment of Chronic Anal Fissure
Intra-sphincteric injection of botulinum toxin seems to be a reliable option causing temporary alleviation of sphincter spasm and allowing the fissure to heal.
- Trial name
- NCT01095900
- Testing
- conservative lateral internal sphincterotomy, Intra-sphincteric Botulinum-toxin injection
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Theodor Bilharz Research Institute
Fissure in Ano
Percutaneous Tibial Nerve Stimulation (PTNS) for the Treatment of Chronic Anal Fissure
Chronic anal fissure rarely heals spontaneously. About 50% heal on administration om topical muscle relaxants (e.g. diltiazem) and/or injection of Botulinum toxin, but for the remainder of patients surgery (with lateral internal…
- Trial name
- NCT04604483
- Testing
- PTNS
- Where
- Sweden
- Volunteers
- 52 people
- Sponsor
- Region Skane
Anal Fissure Chronic, PRP
Short Term Results of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure
Autologous PRP currently has many uses in surgical and medical therapy. Compared with other regenerative therapies, PRP is easy-to-prepare, low-cost, and does not require complex equipment.
- Trial name
- NCT04320498
- Testing
- prp injection, Anrecta, sitz bath
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- KTO Karatay University
Chronic Anal Fissure
High Dose Multiple Site Injection of Botox Versus Lateral Sphincterotomy in Chronic Analfissure
comparison between the effect of lateral sphincterotomy against high dose botox injection in chronic anal fissure the outcome was healing time, recurrence continence relapse pain pruritus
- Trial name
- professor (NCT04166175)
- Testing
- botox injection in intersphincteric space, lateral internal sphincterotomy
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Zagazig University
Fissure in Ano
Complex Treatment of a Chronic Anal Fissure
This study is aimed at studying the efficacy and safety of treating chronic anal fissure with botulinum toxin versus lateral subcutaneous sphincterotomy.
- Trial name
- NCT03855046
- Testing
- IncobotulinumtoxinA 50 U Intramuscular Powder for Solution, Lateral subcutaneous sphincterotomy.
- Where
- 7 sites in Russia
- Volunteers
- 340 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Chronic Anal Fissure
AI-Assisted Written Information in Chronic Anal Fissure
This single-center, prospective, 1:1 randomized, parallel-group controlled superiority trial compares standard verbal counseling with AI-assisted written patient information in adults with primary chronic anal fissure receiving…
- Trial name
- AF-AI (NCT07701811)
- Testing
- AI-assisted written patient information, Standardized verbal counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Sanliurfa Education and Research Hospital
Anal Fissure Chronic
Comparison of Botulinum Toxin Injection and Lateral Internal Sphincterotomy in Chronic Anal Fissure Management
This study aims to compare two commonly used treatments for chronic anal fissure: botulinum toxin injection and lateral internal sphincterotomy.
- Trial name
- BOT-LIS-CAF (NCT07568314)
- Testing
- Botulinum Toxin Type A (BOTOX) Injection, Lateral Internal Sphincterotomy
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Islamabad Medical and Dental College
Chronic Anal Fissure
The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients With Anal Fissure
The objective of the study is to examine the effect of Nifedipine, applied intra-anally through our drug delivery device, on rectal pain severity in anal fissure patients that are being managed with conservative treatment.
- Trial name
- NCT02527109
- Testing
- Nifedipine
- Where
- 24 sites in Bulgaria, Moldova and 2 more
- Volunteers
- 339 people
- Sponsor
- RDD Pharma Ltd
Pain
Glyceryl Trinitrate Ointment vs Posterior Tibial Nerve Stimulation in the Treatment of Anal Fissure
A prospective randomized study was performed. Compliance with the treatment and healing rate of chronic anal fissure in patients receiving glyceryl trinitrate ointment (GTO) and subjects undergoing percutaneous posterior tibial…
- Trial name
- NCT02700438
- Testing
- Glyceryl trinitrate ointment, Urgent PC Neuromodulation System®
- Volunteers
- 80 people
- Sponsor
- Hospital General Universitario Elche
Fissure in Ano, Rectal Diseases
Diltiazem Ointment With Lidocaine vs. Nifedipine Ointment With Lidocaine Ointment for Treatment of Chronic Anal Fissure
Anal fissure is a common anorectal diseases characterized by tear of the anoderm from the dentate line to the anal verge leading to pain and bleeding during and post defecation.
- Conditions
- Fissure in Ano, Rectal Diseases, Rectal Bleed
- Trial name
- NCT04887818
- Testing
- 2% Diltiazem ointment with 1.5% lidocaine, 0.3% Nifedipine ointment with 1.5% lidocaine
- Where
- Canada
- Volunteers
- 430 people
- Sponsor
- University of Calgary
Fissure in Ano
The Use of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure
use of platelet rich plasma had good effect in treating chronic wounds. healing of perianal fissure could be prolonged and associated with pain.
- Trial name
- NCT05837403
- Testing
- Platelet rich plasma injection, Nitroglycerin ointment
- Where
- Iraq
- Volunteers
- 460 people
- Sponsor
- Al-Kindy College of Medicine
Fissure in Ano
Comparison of Injections of Botulinum Toxin and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure
Patients will be randomized to receive treatment with either a total of 20 U of botulinum toxin(diluted in saline to a concentration of 50 U per milliliter.
- Trial name
- NCT05590520
- Testing
- Botulinum injection, GTN OINTMENT
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Pak Emirates Military Hospital