Clinical trials: Anal Fistulas
Anorectal Abscess, Fistula in Ano
Feasibility Study to Assess the Early Use of Porcine Cross-linked Collagen Paste in Cryptoglandular Anorectal Fistulas
This study is designed to assess the effectiveness of porcine cross-linked collagen paste for the treatment of patients with ano-rectal abscess with underlying cryptoglandular fistula in ano.
- Trial name
- FIX-IT1 (NCT02686580)
- Testing
- Collagen paste
- Volunteers
- 2 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Chronic Anal Fissure, Hemorrhoidal Disease
Female Sexual Function After Surgery for Benign Perianal Diseases
Benign perianal diseases such as chronic anal fissure, hemorrhoidal disease, and cryptoglandular anal fistula may negatively affect female sexual function through pain, bleeding, discharge, discomfort, and impairment in quality…
- Conditions
- Chronic Anal Fissure, Hemorrhoidal Disease, Cryptoglandular Anal Fistula
- Trial name
- PERISEX (NCT07666035)
- Testing
- Surgical Treatment for Benign Perianal Diseases
- Volunteers
- 120 people
- Sponsor
- Gazi University
Fistula in Ano
Efficacy of an Anorectal Fistula Plug With Sealing of the Internal Opening as a Treatment for Perianal Fistula
The investigators aim to assess the efficacy of the Curaseal anal plug in patients with idiopathic uncomplicated fistulous tracts. Healing of the fistula tract will be assessed both clinically and radiologically with MR imaging.
- Trial name
- NCT03381365
- Testing
- CuraSeal Percutaneous Intraluminal Closure System
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- London North West Healthcare NHS Trust
Anal Fistula, Crohn's Disease
Treatment of Crohn's Fistula Using a Porcine Intestine Submucosa Graft
Healing anal fistulas in Crohn's patients with an anal fistula plug.
- Trial name
- SurgiSIS AFP (NCT00610207)
- Testing
- Surgisis Biodesign Anal Fistula Plug (SurgiSIS AFP)
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Cook Group Incorporated
High-type Anal Fistulae
Anal Fistula Plug for High-type Anal Fistulae
The aim of this pilot study is to evaluate the efficacy and safety of anal fistula plug in the management of high-type anal fistulae among Hong Kong Chinese patients.
- Trial name
- NCT00487071
- Testing
- Anal fistula plug
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
Anal Fistula
Ethibond Suture vs Vessel Loop as Draining Seton for Complex Anal Fistulas
Drainage seton is usually placed for long-term control of symptoms, and hence it has to be effective in drainage of infection, durable, and comfortable to the patients.
- Trial name
- NCT05933343
- Testing
- Ethibond suture, Vessel loop
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The Cleveland Clinic
Fistula in Ano, Crohn Disease
Pediatric MSC-AFP Sub-study for Crohn's Fistula
The purpose of this study is to determine the safety of using an autologous mesenchymal stromal cell (MSC) coated fistula plug in people with fistulizing Crohn's disease.
- Trial name
- NCT03449069
- Testing
- MSC-AFP
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Crohn Disease, Anal Fistula
Study on the Treatment of Anal Fistulas Using Alofisel Versus Fat Autologous Stem Cells
One of the newest and most innovative medicinal approaches is cell therapy. Several clinical trials and experimental investigations have looked into the feasibility of treating CD-related fistulas with stem cells.
- Trial name
- CHAZAM (NCT05974280)
- Testing
- Alofisel, Fat stem cell
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Perianal Fistula, Anal Fistula
Laser Ablation Versus Conventional Fistulectomy for Uncomplicated Perianal Fistula
This randomized controlled trial aims to compare conventional open fistulectomy and laser ablation in the treatment of uncomplicated perianal fistula.
- Trial name
- NCT07681531
- Testing
- Laser ablation, Conventional Open Fistulectomy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- PNS Hafeez - Naval Hospital
Crohn's Disease, Anal Fistula
Study to Assess the Safety and Efficacy of Expanded Allogenic Adipose-derived Stem Cells (eASCs) (Cx601), for Treatment of Complex Perianal Fistulas in Perianal Crohn's Disease.
The purpose of this study is to asses the safety and efficacy of adipose-derived adult stem cells from healthy donnors for treatment of complex perianal fistulas in Crohn's disease.
- Trial name
- NCT01372969
- Testing
- Cx601
- Where
- 6 sites in Spain
- Volunteers
- 24 people
- Sponsor
- Tigenix S.A.U.
Anal Fistula
Surgisis Anal Fistula Plug Study: An Experience in Saudi Arabia
The Surgisis Anal Fistula Plug study is a clinical trial conducted in Saudi Arabia to study the safety and effectiveness of the Surgisis AFP Plug in the treatment of chronic anal fistulas.
- Trial name
- SurgiSIS AFP (NCT00703131)
- Testing
- Anal Fistula Plug (SurgiSIS AFP)
- Where
- Saudi Arabia
- Volunteers
- 35 people
- Sponsor
- Cook Group Incorporated
Kegel Exercises
Effect of Anal Lift Exercise on Rehabilitation After Anal Fistula Surgery
This prospective randomized controlled study aims to include patients who have undergone anal fistula surgery, to observe the impact of early postoperative pelvic floor muscle training combined with dietary intervention on…
- Trial name
- NCT07250711
- Testing
- Kegel exercises
- Where
- China
- Volunteers
- 124 people
- Sponsor
- The Affiliated Hospital of Putian University
Anal Fistula
Tissue Therapy of Transsphincteric Anal Fistula
This clinical study aims to evaluate the outcome of the treatment of complex perianal fistulas (PAF) by the combination of minimal surgical debridement with regenerative cellular therapeutics.
- Trial name
- REP-PAF (NCT06303752)
- Testing
- ADRC injection, ADRC001 injection
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- University of Southern Denmark
Hemorrhoids, Anal Fissure
Effects of Sodium Pentaborat Based Gel on Perianal Benign Diseases
New produced and patented sodium pantaborat based gel will be use for treatment of benign perianal diseases (hemooroidal disease, anal fissura anda perianal fistula)
- Conditions
- Hemorrhoids, Anal Fissure, Perianal Fistula
- Trial name
- NCT03780998
- Testing
- Life7
- Volunteers
- 250 people
- Sponsor
- SB Istanbul Education and Research Hospital
Anal Fistula
Effectiveness of Silver Nitrate Solution in the Treatment of Anal Fistula
Effectiveness of silver nitrate solution in treatment of anal fistula is is aimed to be investigated.
- Trial name
- NCT01929525
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Marmara University
Anal Fistulas, Rectal Fistulas
A Prospective European Post-Market Clinical Evaluation of the CuraSeal Percutaneous Intraluminal Closure System for Anorectal Fistulas
The study is designed as a prospective, non-randomized clinical trial comparing safety and effectiveness of the CuraSeal PICS-AF device to historical data from commercially available devices for the treatment of anorectal…
- Trial name
- NCT02456324
- Testing
- PICS-AF Device, Historical Controls Treated with Commercially Available Fistula Plugs
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Curaseal Inc.
Complex Anal Fistula, Cryptoglandular Anal Fistula
Patient-Reported Outcomes Following Loose Seton Material Replacement in Complex Anal Fistula
This prospective, single-center, self-controlled pilot cohort study evaluates whether loose seton biomaterial is associated with patient-reported outcomes in adults with recurrent or persistent complex cryptoglandular anal…
- Trial name
- SETon PROM (NCT07818642)
- Testing
- Loose Seton Biomaterial
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Acibadem Kent Hospital
Quality of Recovery
Comparison of Propofol and Sevoflurane Anesthesia on the Quality of Recovery After Ambulatory Surgery in Obese Patients
This study was designed to compare propofol intravenous anesthesia to sevoflurane inhalation anesthesia on the quality of recovery after surgery for anal fistula in obese patients.
- Trial name
- NCT05529875
- Testing
- Propofol, sevoflurane
- Where
- China
- Sponsor
- Jiangang Song
Anal Fistula
Ligation of Intersphincteric Fistula Tract Versus Rectal Advancement Flap in the Treatment of Complex Anal Fistula
Objective: Rectal advancement flap (RAF) is currently considered the gold standard in the treatment of complex anal fistula (CAF). Clinical trials are a priority given the few consistent results available with level 1 evidence.
- Trial name
- LIFTRAF-RCT (NCT05263661)
- Testing
- LIFT, FLAP
- Volunteers
- 72 people
- Sponsor
- Hospital General Universitario Reina Sofía de Murcia
Fissure;Anal, Fistula;Rectal
Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery
Double-blinded multicenter randomized clinical trial to evaluate the efficacy and safety of CLIFE2 (lidocaine, referred as treatment A) respect CLIFE1 (lidocaine plus diclofenac, referred as treatment B) in benign anorectal…
- Conditions
- Fissure;Anal, Fistula;Rectal, Hemorrhoids
- Trial name
- NCT02961855
- Testing
- anesthesics plus antiinflammatory, CLIFE1, local anesthesics, CLIFE2
- Volunteers
- 120 people
- Sponsor
- Hospital de Viladecans