Clinical trials: Analgesia, Postoperative
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Femoral Triangle Block vs Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty
The goal of this clinical trial is to compare the effects of femoral triangle block (FTB) and adductor canal block (ACB) on early quadriceps function after total knee arthroplasty (TKA).
- Conditions
- Total Knee Arthroplasty, Total Knee Arthroplasty Recovery, Total Knee Arthroplasty Postoperative Pain
- Trial name
- NCT07524387
- Testing
- Femoral Triangle Block (FTB) Group, Adductor Canal Block (ACB) Group
- Where
- Japan
- Volunteers
- 136 people
- Sponsor
- Social Medical Corporation Daiyukai
Postoperative Nausea and Vomiting
Anti Emetic Efficacy of Combination of Ramosetron and Premixture of Naloxone With Patient-controlled Analgesia
Postoperative nausea and vomiting (PONV) is one of the most undesirable complications after general anesthesia, and may lead to increased hospital stay and health care costs.
- Trial name
- NCT02416115
- Testing
- Ramosetron, Naloxone, saline
- Volunteers
- 90 people
- Sponsor
- Kyungpook National University Hospital
Analgesia, Pain, Postoperative
Comparison Between Perineural and Systemic Effect of Dexamethasone as an Adjuvant for Prolongation of Four Nerve Blocks With Bupivacaine in Total Knee Arthroplasty
The addition of dexamethasone (DxaM) to local anesthetic may significantly prolong the duration of a block in total knee arthroplasty. The aim of this study is to determine whether this is a systemic or local effect.
- Trial name
- NCT02253784
- Testing
- Dexamethasone, Bupivacaine
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Hillel Yaffe Medical Center
Pediatric Patients, Orthopedic Surgery
Nociception Level Index as a Verbal Tool of Pain in Children
60 children under 6 years old, scheduled for orthopedic surgery for limb fracture or neuromuscular and bone deformities will be randomized by closed envelope method into two groups (n=30) either receiving standard pain management…
- Conditions
- Pediatric Patients, Orthopedic Surgery, Extremity Fractures Lower, Extremity Fractures Upper
- Trial name
- NCT05716243
- Testing
- The nociception level index monitorization, The nociception level index measurement;postoperative
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Haseki Training and Research Hospital
Postoperative Pain, Hysterectomy
Ibuprofen Versus Ketorolac for Perioperative Pain Control After Open Hysterectomy
The aim of this study is to compare the analgesic effect of intravenous ibuprofen to ketorolac for pain control after open hysterectomy
- Trial name
- NCT05610384
- Testing
- Ketorolac Injectable Solution, Ibuprofen 800 mg
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Obstetric Pain, Obstetric Anesthesia Problems
TAP Block vs LAWI for Analgesia Post-cesarean Section
Adequate pain control after cesarean delivery is a significant concern both for parturients and obstetric anesthesiologists. Transversus Abdominis Plane (TAP) block and local Wound infiltration with anesthetics are alternatives…
- Trial name
- NCT05447455
- Testing
- Transversus Abdominis Plane Block, Local anesthetic wound infiltration
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Acute Pain, Lidocaine
Pharmacokinetic Profile of Lidocaine Given as a Weight-based Infusion for Postoperative Surgical Pain Control
Study Summary Title Pharmacokinetic profile of lidocaine given as a weight-based infusion for postoperative surgical pain control Short Title Pharmacokinetic profile of lidocaine given as a weight-based infusion for postoperative…
- Conditions
- Acute Pain, Lidocaine, Administration and Dosage
- Trial name
- NCT05402293
- Testing
- Blood samples to measure lidocaine levels
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University of Alberta
Elective Major Abdominal Surgery
Postoperative Analgesia of Quadratus Lumborum Block Versus Epidural Block After Major Abdominal Surgeries
Acute postoperative pain is an important issue after major abdominal surgeries for which different analgesic modalities have been tried.
- Trial name
- NCT04541732
- Testing
- Thoracic epidural block, Ultrasound-guided bilateral quadratus lumborum block, Induction of general anaesthesia with propofol
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Postoperative Pain, Fibroid Uterus
QL Block in Laparoscopic Myomectomy
This study aims to determine the efficacy of a quadratus lumborum (QL) block in decreasing postoperative pain in patients undergoing myomectomy for uterine fibroids.
- Trial name
- NCT05979493
- Testing
- Bupivacain, Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Joseph Findley MD
Postoperative Pain
Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Abdominal Surgery
This clinical trial is a multiple-center, randomized, double-blind, placebo- and active-controlled parallel-group Phase II/III clinical trial, to evaluate the efficacy and safety of HL-1186 Tablets for Postoperative Analgesia in…
- Trial name
- NCT07709598
- Testing
- HL-1186, Oxycodone-Acetaminophen
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Huilun Pharmaceutical Co., Ltd.
Pain, Postoperative
Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management: A Pilot Study
Overall Aim: To evaluate the feasibility and potential benefits of investigating bilateral continuous erector spinae blocks (BESB) for postoperative pain management in a small cohort of children undergoing surgical sternotomy…
- Trial name
- NCT03936387
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Spine Surgery, Postoperative Pain Management
Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes
The goal of this clinical trial is to learn if using calcium sulfate beads that contain vancomycin (an antibiotic) and pain-relieving medicines during spine surgery can improve recovery compared to standard care with intravenous…
- Trial name
- NCT07201987
- Testing
- Vancomycin (local, via calcium sulfate beads), Morphine (local, via calcium sulfate beads), Bupivacaine (local, via calcium sulfate beads)
- Volunteers
- 100 people
- Sponsor
- Ganesh M. Shankar
Post Operative Analgesia
Tibial Nerve Versus Sciatic Nerve Block
The purpose of this study is to analyse the ability to selectively block the posterior tibial nerve sparing the function of the common peritoneal nerve.
- Trial name
- NCT01415193
- Testing
- Selective Tibial Nerve block, Sciatic Nerve Block
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Trinity Health Of New England
Colon Cancer, Rectal Cancer
The Effect of Dexmedetomidine on Postoperative Analgesia
The purpose of this study is to determine whether additional Dexmedetomidine to patient controlled analgesia can reduce fentanyl consumption.
- Trial name
- NCT01373021
- Testing
- Fentanyl, Dexmedetomidine
- Where
- South Korea
- Volunteers
- 95 people
- Sponsor
- Seoul National University Hospital
Postoperative Pain
Spinal Hydromorphone Versus Morphine for Post-Cesarean Delivery Analgesia
Morphine is usually used for pain relief after cesarean delivery. However, sometimes it is not available, the patient might be allergic to morphine or intolerant to its side effects.
- Trial name
- NCT03592992
- Testing
- Spinal Hydromorphone, Spinal Morphine
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Postoperative Pain, Postoperative Pain Management
Evaluating the Efficacy and Utility of the Automated Pupillometer in Pain Assessment and Opioid Administration Guidance During the Perioperative Period: A Randomized Controlled Trial
Effective intraoperative and postoperative pain management is critical for patient comfort and recovery, yet traditional methods for assessing pain under general anaesthesia are limited by their subjective nature and reliance on…
- Trial name
- NCT07614607
- Testing
- Opioid Analgesic, automated pupillometry
- Where
- Malaysia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Postoperative Pain, Postoperative Nausea and Vomiting (PONV)
Transauricular Vagus Nerve Stimulation Frequencies for Postoperative Pain
The goal of this clinical trial is to learn whether different frequencies of transauricular vagus nerve stimulation (tVNS) can reduce postoperative pain and opioid consumption in adults undergoing abdominal or urologic surgery.
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting (PONV), Opioid Consumption, Postoperative
- Trial name
- TVNS-PAIN (NCT07633444)
- Testing
- Transauricular Vagus Nerve Stimulation (tVNS)
- Where
- Brazil
- Volunteers
- 174 people
- Sponsor
- Federal University of Bahia
Pain, Postoperative
TAP Block With Two Different Doses of Levobupivacaine
The aim of the current study is to investigate the effects of two different doses of levobupivacaine in TAP (transversus abdominus plane) block for postoperative management.
- Trial name
- NCT02567487
- Testing
- Levobupivacaine
- Volunteers
- 50 people
- Sponsor
- Ankara University
Post Operative Pain, Chronic
Pericapsular Nerve Group Block Versus Lumber Erector Spinae Plane Block for Pain Management After Total Hip Arthroplasty
Pain is a major problem that has to be dealt with in case of hip fracture, as it presents an obstacle for examination, positioning for receiving neuroaxial anesthesia and postoperative mobility and physiotherapy.
- Trial name
- NCT05050487
- Testing
- PENG block, lumbar erector spinae plane block
- Volunteers
- 60 people
- Sponsor
- Assiut University
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