Clinical trials: Analgesia, Postoperative
Surgery, Pain
Clinical Validation of Medasense Pain Response Index (PRI)
In our previous study, NCT01631695, we proposed and clinically evaluated the Medasense pain response index, PRI, in anesthetized patients undergoing surgery. Note: the name PRI has been changed to NoL (Nociception Level) Index.
- Trial name
- NCT01762332
- Testing
- Base level of remifentanil effect side concentration: 2ng/ml, Base level of remifentanil effect side concentration: 4ng/ml, chronic beta-blocker treatment
- Where
- Israel
- Volunteers
- 82 people
- Sponsor
- Medasense Biometrics Ltd
Opioid Pain Medication
Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
This study is a prospective randomized trial examining the effect of topically combined antifibrinolytics (Tranexamic acid) with local anesthetics in all electively created surgical wound beds in hand surgery to provide long term…
- Trial name
- NCT04814433
- Testing
- Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Post-Operative Analgesia, Opioid Use, Unspecified
Comparing Post-Operative Analgesic Effects of PCAM With Dexmedetomidine 1 mcg/ml vs PCAM With Dexmedetomidine 2 mcg/ml
PCA morphine have been a common method in providing excellent analgesia for post-operative period. However, the usage of morphine is not without any side effects such as nausea, vomiting, respiratory depression, and over…
- Conditions
- Post-Operative Analgesia, Opioid Use, Unspecified, Laparotomy Surgery
- Trial name
- NCT05288738
- Testing
- Dexmedetomidine 1 mcg/ml, Dexmedetomidine 2 mcg/ml
- Where
- Malaysia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Pain Management of Inguinal Herniorrhaphy
Ultrasound-Guided Transversalis Fascia Plane Block Versus Transmuscular Quadratus Lumborum Block for Post-operative Analgesia in Inguinal Hernia Repair
Regional blocks as a part of multimodal analgesia can improve pain control in the postoperative period. The transversalis fascia plane (TFP) block can block the proximal portions of the T12 and L1 nerves, while the main advantage…
- Trial name
- NCT04026243
- Testing
- QL block, TF block
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post Operative Pain, Opioid Use
Serratus vs ESP Block for Postoperative Pain in Unilateral Breast Surgery
This prospective, randomized, assessor-blinded trial compares serratus posterior superior intercostal plane block (SPSIPB) and erector spinae plane block (ESPB) for postoperative analgesia in unilateral breast surgery.
- Trial name
- NCT07541040
- Testing
- Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Engin Çetin
Postoperative Acute Pain, Chronic Pain
Comparison of Postoperative Analgesic Efficacy of Interscalene and Suprascapular Blocks Used in Arthroscopic Shoulder Surgery
The Importance of Postoperative Analgesia in Shoulder Surgery Shoulder surgery is an orthopedic procedure that can be performed either through open surgery or arthroscopically.
- Trial name
- NCT07483814
- Testing
- rescue analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Anesthesia, Postoperative Pain
The Effect of Ultrasound-guided Erector Spinae Block and Intraoperative Intercostal Nerve Block on Postoperative Analgesia in Thoracic Surgery
This study aims to compare the effect of ultrasound-guided erector spinae plane block and interthoracic intercostal nerve block in thoracic surgery.
- Conditions
- Anesthesia, Postoperative Pain, Ultrasound Therapy; Complications
- Trial name
- NCT04581616
- Testing
- Intrathoracic Intercostal Nerve Block, Erector Spinae Plane Block
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pain, Postoperative
Erector Spinae Plane Block for Post-thoracotomy Pain
Post-thoracotomy pain is one of the most severe forms of post-operative pain. Among the most common techniques for the management of post-thoracotomy pain, there are the intercostal nerve block, and a recently described block…
- Trial name
- NCT04013815
- Testing
- erector spinae plane block with ropivacaine, Intercostal nerve block with ropivacaine
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Pain, Postoperative
Perioperative Electroacupuncture on Postoperative Analgesia in Prostatectomy
The aim of the present study is the comparison of the efficacy of the perioperative application of a multimodal analgesia model to the patients, combing common used analgesics via intravenous (IV) route, such as tramadol and…
- Trial name
- NCT01526525
- Testing
- Tramadol, Ketamine, Morphine
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- G.Gennimatas General Hospital
Knee Arthropathy
The Efficacy Of Ultrasound-Guided Adductor Canal Block for Arthroscopic Knee Surgery
The ultrasound-guided selective blockade of the saphenous nerve in the adductor canal provides effective analgesia and reduces postoperative pain in patients undergoing arthroscopic medial meniscectomy.
- Trial name
- NCT04010916
- Testing
- Group Preoperatively Adductor Canal Block, Group Preoperatively Tourniquet Adductor Canal Block, Group Postoperatively Adductor Canal Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Medipol University
Gastric Cancer (GC), Stomach Neoplasms
TEAS for Gastrectomy Recovery
The goal of this clinical trial is to learn if transcutaneous electrical acupoint stimulation (TEAS) works to help people recover faster after laparoscopic surgery for stomach cancer.
- Trial name
- TEAS (NCT07898293)
- Testing
- Transcutaneous Electrical Acupoint Stimulation
- Where
- 8 sites in China
- Volunteers
- 104 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Postoperative Protein Catabolism
Effect of Intravenous Nutrition and Epidural Analgesia on Protein Loss After Surgery
Loss of muscle mass and body protein are the main causes of fatigue after bowel surgery, which may result in a longer hospital stay and a higher rate of complications.
- Trial name
- NCT00614133
- Testing
- Intravenous nutrition with glucose and amino acids, Intravenous nutrition with glucose and amino acids.
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Collapse of Thoracic Vertebra, Collapse of Lumbar Vertebrae
Study of Dexmedetomidine in Spine Surgery
The investigators will conduct a prospective randomized double blind study comparing methadone plus methadone and intraoperative dexmedetomidine in multi-level spine surgery in two randomized groups.
- Trial name
- NCT01850017
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Anterior Cruciate Ligament Injury
Preemptive Analgesia in Cruciate Reconstruction
The aims of this study was to compare analgesic efficacy of preoperative administration of etoricoxib versus celecoxib for post-operative pain relief after arthroscopic anterior cruciate ligament reconstruction.
- Trial name
- NCT01017380
- Testing
- Celecoxib, etoricoxib
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Prince of Songkla University
Skin Graft Complications, Pain Management
The Rule of Bupivacaine Hydrochloride in Skin Graft Donor Site
Split Thickness Skin Graft is frequently utilized for reconstructing skin loss of various causes. Unfortunately, the donor site of the STSG has an unavoidable, annoying post-operative pain
- Trial name
- NCT06766474
- Testing
- Bupivacain
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Immediate Severe Postoperative Pain, Perioperative Hemodynamic
GOAL-Directed ANalgesia (GOALDAN)
The primary purpose of GOALDAN study is to demonstrate the superiority of a targeted perioperative analgesic strategy by the ANI over the usual practice on the incidence of immediate postoperative pain.
- Trial name
- GOALDAN (NCT03618082)
- Testing
- Anesthesic agent guided by ANI (Interventional Group), Administration of the lowest effective concentration of desflurane (Interventional Group)
- Where
- France
- Volunteers
- 380 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hip Fracture, Postoperative Pain
Fascia Iliaca vs Femoral Nerve Block in Hip Fracture Patients
Hip fractures are common orthopedic injuries, especially in older adults, and surgical repair such as hip arthroplasty is often required.
- Conditions
- Hip Fracture, Postoperative Pain, Peripheral Nerve Block, Femoral Nerve
- Trial name
- CPTH (NCT07597317)
- Testing
- Fascia Iliaca Compartment Block (FICB)
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Central Park Teaching Hospital, Lahore
Bowel Diseases, Inflammatory, Bowel Surgery
Use of Dexmedetomidine to Improve Pain Control and Recovery After Laparocopic-Assisted Bowel Surgery in Adults
This study is testing whether continuing a medication called dexmedetomidine after surgery can improve quality of recovery for adults undergoing laparoscopic-assisted bowel surgery.
- Conditions
- Bowel Diseases, Inflammatory, Bowel Surgery, Laparoscopic Abdominal Surgeries
- Trial name
- PODEX (NCT07434310)
- Testing
- Dexmedetomidine infusion
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Dr. Naveed Siddiqui
Pain, Postoperative
The Effect of Femoral Nerve Block on Opioid Requirements After Surgery for a Femur Fracture in Children
This study evaluates the effect of a femoral nerve block on opioid requirements following femoral fracture fixation with flexible nails in the paediatric population. This is a double blind, prospective randomized clinical trial.
- Trial name
- NCT00175591
- Testing
- Administration of a femoral nerve block (bupivacaine HCL)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of British Columbia
Postoperative Pain
Non-invasive Assessment of Immediate Postoperative Analgesia Using Analgesia/Nociception Index (ANI)
The aim of this study is to evaluate the clinical performance on Analgesia/Nociception Index (ANI) in the assessment of immediate postoperative analgesia in PACU in adult patients undergoing general anesthesia.
- Trial name
- NCT01633320
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hôpital Edouard Herriot
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