Clinical trials: Analgesia Duration
Cognitive Pain Control
Real-Time fMRI Feedback Effects on Pain Perception
The purpose of this study is to determine whether real-time functional magnetic resonance imaging may be a viable treatment for chronic pain in the future.
- Trial name
- NCT01588197
- Testing
- Attention/Distraction Strategy, Stimulus Quality/Severity Strategy, Control Strategy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Osteoarthritis, Hip
Systemic Steroids for Peripheral Nerve Blocks
This study will investigate the ability of systemic dexamethasone to prolong the sensory block duration for lumbar plexus nerve blockade.
- Trial name
- NCT02464176
- Testing
- Dexamethasone, Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pain, Postoperative
An Efficacy and Safety Study to Compare Fentanyl Ionsys and Routine Care With Intravenous (IV) Morphine Patient-controlled Analgesia (PCA) in Participants Who Have Undergone Elective Major Abdominal or Orthopedic Surgery
The purpose of this study is to evaluate the mobilization characteristics, clinical use, safety and Ease of Care (EOC) of a fentanyl Iontophoretic Transdermal Patient Controlled Analgesia (PCA) system (Ionsys) and morphine…
- Trial name
- NCT00766506
- Testing
- Fentanyl IONSYS, Morphine IV PCA
- Where
- 7 sites in United Kingdom
- Volunteers
- 108 people
- Sponsor
- Janssen-Cilag Ltd.
Analgesia Duration
Dexamethasone and Lower Extremity Block Duration
Dexamethasone has shown to prolong upper extremity blocks. No one ha studied its effect on lower extremity blocks. The study would evaluate that point.
- Trial name
- NCT01756586
- Testing
- Dexamethasone, Bupivacaine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Chicago
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International
Labor Pain
Programmed Intermittent Epidural Bolus Time Interval and Injection Volume
Studies suggest that administration of maintenance epidural solutions as programmed or automated intermittent boluses, rather than continuous infusions, result in lower bupivacaine consumption, decreased need for manual boluses…
- Trial name
- NCT00417027
- Testing
- Programmed Intermittent Epidural Bolus (PIEB)
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Northwestern University
The Duration of Motor Block May Vary Between 12-36 Hrs
The Use of Bupivacaine and Ropivacaine for Sciatic Nerve Block
The duration of motor block for infragluteal parabiceps sciatic nerve block following total knee replacement may vary between 12-36 hrs depending on the amount of local anesthetic given.
- Trial name
- NCT01272921
- Testing
- Bupivacaine, Ropivacaine
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Northwestern University
Cervical Pain, Pelvic Pain
Tenaculum Pain Control Study
The purpose of this clinical trial is to evaluate the effect of an intracervical lidocaine injection versus topical lidocaine gel on the pain experienced by patients undergoing tenaculum application to the cervix during office…
- Trial name
- NCT01421641
- Testing
- Intracervical Lidocaine Injection, Topical Lidocaine Gel
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Prostate CA
Evaluation of Addition of Dexamethasone to Transversus Abdominis Plane (TAP) Peripheral Nerve Block
Transversus abdominis plane (TAP) blocks are increasingly being performed after abdominal surgery to provide post operative analgesia.
- Trial name
- NCT01303003
- Testing
- Dexamethasone, TAP block
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Total Knee Arthroplasty, Osteoarthritis
Single Shot vs 24hr vs 48hr Continuous Adductor Canal Block After TKA
The purpose of this study is to compare a single shot block, 24 hours, and 48 hour continuous catheter nerve block done via the adductor canal method in adult patients who have under gone total knee arthroplasty.
- Conditions
- Total Knee Arthroplasty, Osteoarthritis, Post Operative Pain Control
- Trial name
- NCT02730728
- Testing
- 20ml bolus of 0.5% ropivicaine, 0.2% Ropivicaine at 8 milliliter/hour, 5ml bolus of 0.5% ropivicaine
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- University of Pennsylvania
Rib Fractures
Continuous Intercostal Nerve Blockade for Traumatic Rib Fractures
Rib fractures are common injuries in accident patients and can be associated with significant pain during recovery. If poorly controlled, pain from splinting due to rib fractures can result in difficulty in breathing leading to…
- Trial name
- NCT02604589
- Testing
- hydromorphone hydrochloride, Infusion catheter placement, bupivicaine 0.25%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Anthony Iacco
Labor Pain, Post-cesarean Delivery
Mu-Opioid Receptor Genetic Polymorphism and Intrathecal Analgesia
Pharmacogenetics has allowed clinicians to identify associations between an individual's genetic profile and his/her response to drugs.
- Trial name
- NCT00418015
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Patients Undergoing Ankle Surgery
Duration of Analgesia After Popliteal Fossa Nerve Blockade: Effects of Dexamethasone and Buprenorphine
Patients scheduled to go home after ankle surgery at HSS typically receive a sciatic nerve block in the popliteal fossa and oral analgesic tablets (such as Percocet).
- Trial name
- NCT01277159
- Testing
- A. Control Nerve Block. IV Dexamethasone (4 mg)., B. Nerve Block with Dexamethasone (4 mg). IV saline., C. Control Nerve Block. IV Dexamethasone (4 mg). IV Buprenorphine (0.3 mg)
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Hospital for Special Surgery, New York
Anesthesia, Local
Analgesia Duration of Dexamethasone, Buprenorphine, or Clonidine With Ropivacaine for Interscalene Nerve Block
This is a prospective randomized controlled triple-masked study looking at the duration of nerve block analgesia when using the listed adjuvants (dexamethasone, buprenorphine and clonidine) plus ropivacaine versus plain…
- Trial name
- NCT03117140
- Testing
- Ropivacaine 0.75%, Ropivacaine 0.75% + 300 mcg Buprenorphine, Ropivacaine 0.75% + 75 mcg clonidine
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Melinda Seering
Chronic Pain, Depression, Anxiety
Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell Via Mobile Applications
The investigators are conducting a comparative effectiveness trial among adult patients with sickle cell disease (SCD) who report chronic pain (N = 350), randomized to receive either mobile phone-delivered computerized cognitive…
- Conditions
- Chronic Pain, Depression, Anxiety, Opioid Use
- Trial name
- CaRISMA (NCT04419168)
- Testing
- cCBT, m-Education
- Where
- 7 sites in United States
- Volunteers
- 359 people
- Sponsor
- University of Pittsburgh
Duration of Pain Relief
Dexamethasone and Block Duration in Upper Extremity
Effect of dexamethasone on prolonging upper extremity block is well known. But it not known if the effect comes from its local effect on the nerves or from its general analgesic effect.
- Trial name
- NCT01756573
- Testing
- Dexamthsone, Bupivacaine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Chicago
Virtual Reality, Anesthesia
HoloLens: an Objective Alternative to the Operator's Memory
Neuraxial anesthesia has traditionally been a 'blind' technique relying on users' feel and skill, both are subjective, lack complete accuracy and influenced by patient's physique variations that are quite challenging, and lead to…
- Conditions
- Virtual Reality, Anesthesia, Epidural
- Trial name
- Hololens (NCT04028284)
- Testing
- HoloLens-guided epidural, US-guided epidural
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Foot and Ankle Procedures
Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
The purpose of this research study to evaluate the effects of dexamethasone as an addition to peripheral nerve block (Put the nerve to sleep with Bupivacaine a numbing medication) on length of pain relief (analgesia)…
- Trial name
- NCT01975285
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Tympanomastoid Surgery, Cochlear Implant
Great Auricular Nerve Block for Children Undergoing Tympanomastoid Surgery
The investigators goal is to determine the efficacy and duration of analgesia with the addition of Clonidine, an alpha-2 agonist, to local anesthetic blockade using bupivacaine, of the great auricular nerve in children undergoing…
- Conditions
- Tympanomastoid Surgery, Cochlear Implant, Mastoidectomy, Cholesteatoma
- Trial name
- NCT01638052
- Testing
- 0.25% Bupivacaine + Clonidine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Labor Pain
Combined Spinal/Epidural (CSE) Saline Duration/Spread
An attempt is being made to see if by injecting a set volume of sterile saline into the epidural space during the treatment of labor pain with a combined spinal/epidural (CSE) increases the amount of pain relief obtained and…
- Trial name
- NCT01062893
- Testing
- Sterile normal saline 0 mls, 15 mls sterile normal saline
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Wake Forest University Health Sciences