Clinical trials: Analgesic
Osteoarthritis of the Hands
The Analgesic Activity of a Topical Formulation in Patients With Osteoarthritis of the Hands
Osteoarthritis (OA) affects over 30 million people in the United States and represents our nation's leading cause of disability.
- Trial name
- NCT02485145
- Testing
- A/B, B/A
- Volunteers
- 40 people
- Sponsor
- Transdermal Therapeutics, Inc.
Pain, Low Back Pain
Longterm Safety Study of BEMA Buprenorphine in Subjects With Chronic Low Back Pain
This is an open label study of up to approximately 52 weeks duration to assess the safety and effectiveness of BEMA Buprenorphine in the management of moderate to severe chronic low back pain.
- Trial name
- NCT01431742
- Testing
- BEMA Buprenorphine
- Where
- United States
- Sponsor
- BioDelivery Sciences International
Neuralgia, Postherpetic
RN624 For Pain Of Post-Herpetic Neuralgia
This study will test the efficacy and safety of two doses levels of RN624 versus placebo for the relief of pain caused by post-herpetic neuralgia (PHN).
- Trial name
- NCT00568321
- Testing
- RN624
- Where
- 31 sites in United States
- Volunteers
- 99 people
- Sponsor
- Pfizer
Cancers, Pain, Lower Back Pain
Open-Label Extension to Evaluate the Long-Term Safety, Tolerability and Analgesic Efficacy
The purpose of this study is to evaluate the long-term safety and tolerability of oxymorphone ER as an analgesic in cancer and lower back pain subjects having chronic moderate to severe pain.
- Trial name
- NCT00904280
- Testing
- Oxymorphone ER
- Where
- United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Bone Neoplasms
Bonefos and the Consumption of Analgesics
The effect of Bonefos on consumption of analgesics (drugs used for pain treatment) in patients with proven bone metastases.
- Trial name
- BICAM (NCT00909142)
- Testing
- Bonefos (Clodronate, BAY94-8393)
- Where
- Czechia
- Volunteers
- 149 people
- Sponsor
- Bayer
Osteoarthritis, Knee
A Controlled Study of an Herbal Topical Patch in Treating Osteoarthritis (OA) of the Knee
An evaluation of the safety and efficacy of an herbal patch in treating osteoarthritis pain of the right or left knee.
- Trial name
- NCT01183624
- Testing
- Herbal Patch
- Where
- 12 sites in China
- Volunteers
- 626 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Pain, Diabetic Neuropathy
Study to Evaluate the Analgesic Efficacy of 28 Days' Oral Administration of AZD2066 Compared With Placebo in Patients With Painful Diabetic Neuropathy
The purpose of this study is to investigate if AZD2066 can relieve the pain arising from painful diabetic neuropathy compared to placebo.
- Trial name
- NCT00857623
- Testing
- AZD2066
- Where
- 19 sites in United States
- Volunteers
- 127 people
- Sponsor
- AstraZeneca
Fibromyalgia
A Study to Assess the Analgesic Efficacy and Safety of ASP0819 in Patients With Fibromyalgia
This study assessed analgesic efficacy of ASP0819 relative to placebo as well as the safety and tolerability. This study assessed treatment differences in physical function as well as the improvements in overall subject status…
- Trial name
- NCT03056690
- Testing
- ASP0819
- Where
- 24 sites in United States
- Volunteers
- 186 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Moderate to Severe Pain Due to Diabetic Polyneuropathy
A Study to Demonstrate the Analgesic Efficacy of Oxycodone/Naloxone Prolonged Release Tablets in Addition to Pregabalin Compared to Pregabalin Alone in Opioid-naïve Subjects Treated With Pregabalin Suffering From Moderate to Severe Pain Due to Diabetic Polyneuropathy
To show superior analgesic efficacy of OXN PR in addition to a patient's current dose of pregabalin compared to pregabalin alone.
- Trial name
- NCT00944697
- Testing
- Oxycodone Naloxone
- Where
- Germany
- Volunteers
- 98 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Pain
Metamizol for the Treatment of Neoplastic Chronic Pain
Study to evaluate the efficacy of metamizole in reducing morphine requirements in patients with moderate to severe chronic cancer pain in comparison to administration of placebo or diclofenac.
- Trial name
- NCT02181920
- Testing
- Metamizole, Diclofenac
- Volunteers
- 6 people
- Sponsor
- Boehringer Ingelheim
Sleep
Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine
The objectives of the study are to evaluate the analgesic and hypnotic efficacy of naproxen sodium and diphenhydramine combination when compared to naproxen sodium, diphenhydramine, and an ibuprofen and diphenhydramine combination
- Trial name
- NCT01118273
- Testing
- Naproxen Sodium 440 mg (BAYH6689) / DPH 50mg, Naproxen Sodium 440 mg (BAYH6689), Naproxen Sodium 220 mg (BAYH6689) / DPH 50mg
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Bayer
Chronic Low Back Pain
Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)
The primary purpose of the study was to test the efficacy of 2 tablets (twice daily) of ABT-712, compared to placebo, administered over a 4-week period in participants with moderate to severe mechanical chronic low back pain…
- Trial name
- NCT00761150
- Testing
- ABT-712
- Where
- 32 sites in United States
- Volunteers
- 308 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Acute Pain
Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction
This study aims to evaluate the analgesic efficacy of single and multiple doses of a new fixed dose combination of nefopam hydrochloride 30 mg and paracetamol 500mg taken orally in comparison to each single component.
- Trial name
- NCT04622735
- Testing
- nefopam hydrochloride 30mg / paracetamol 500mg X2, Paracetamol 500 Mg Oral Tablet X2, Nefopam HCl 30 MG Oral Tablet X2
- Where
- 19 sites in Belgium, France and 3 more
- Volunteers
- 321 people
- Sponsor
- Unither Pharmaceuticals, France
Pain
A Study to Assess How the Body Processes a Strong Painkiller When it is Given Alongside a Drug That Counteracts the Side Effects of Strong Painkillers in a Fasted and Fed State.
To assess whether an opioid antagonist has any impact on the release of a strong painkiller in the blood when it is given to healthy volunteers when they have eaten and also when they have fasted.
- Trial name
- NCT02133820
- Testing
- 4 mg 12 hourly capsule - strong pain killer fasted, 4 mg 12 hourly capsule - strong pain killer fed, 12 hourly capsule strong painkiller with antagonist fasted)
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mundipharma Research Limited
Acute Pain
Efficacy of XP20B Following Bunionectomy Surgery
The purpose of this study is to determine if XP20B is an effective treatment for the relief of pain following bunionectomy surgery.
- Trial name
- NCT00655291
- Testing
- XP20B
- Where
- 6 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Xanodyne Pharmaceuticals
Pain, Analgesics
Mentholated Cream Containing Oxygenated Glycerol Triesters on Acute Pain of the Muscles and Joints
A single center trial to evaluate the efficacy, tolerance, and acceptability of Oxygenated Glycerol Triesters (OGT) mentholated cream on acute musculoskeletal pain in normal healthy adult volunteers suffering from a recent…
- Trial name
- NCT01387750
- Testing
- Mentholated Cream, Mentholated Cream with OGT
- Volunteers
- 71 people
- Sponsor
- NEMA Research, Inc.
Acute Low Back Pain
A Pharmacodynamic/Pharmacokinetic Study to Determine the Onset of Analgesic Effect and Plasma Levels of Tramadol in Patients With Acute Low Back Pain Receiving a Single 200 mg Dose of Tramadol Contramid® Once-a-Day
The primary objective of this study is to determine the time of onset of analgesic effect of Tramadol Contramid® Once-A-Day (OAD) in acute low back pain.
- Trial name
- NCT00952068
- Testing
- Tramadol Contramid® OAD 200mg
- Volunteers
- 47 people
- Sponsor
- Labopharm Inc.
Low Back Pain
Study Evaluating Dexketoprofen Trometamol/Tramadol Hydrochloride Analgesic Efficacy in Acute Low Back Pain
A randomized, double-blind, study to evaluate the analgesic efficacy and safety of Dexketoprofen trometamol and Tramadol hydrochloride combination versus placebo on moderate to severe acute pain in patients with acute low back…
- Trial name
- Dante (NCT05170841)
- Testing
- Dexketoprofen Trometamol 25 mg/Tramadol Hydrochloride 75 mg, Tramadol Hydrochloride 100 mg
- Where
- Italy
- Volunteers
- 538 people
- Sponsor
- Menarini International Operations Luxembourg SA
Opioid Related Disorders, Opiate Addiction
Monitoring Patterns of Prescribing to Identify Changes in Access to ER/LA Opioid Analgesics
Changes in prescribing will be compared in prescribers from specialties whose prescribing is hypothesized to be relatively unaffected by the REMS (such as oncologists and hospice providers) versus those for whom the REMS could…
- Conditions
- Opioid Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02920775
- Testing
- Non-interventional study - retrospective database review
- Volunteers
- 360,000 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Pain
Efficacy And Safety Of Parecoxib 40mg vs. Ketoprofen 100mg In The Management Of Acute Renal Colic
This is a multicenter, randomized, double blind, double dummy, comparative, active-controlled trial designed to assess the analgesic activity and safety of intravenous doses of parecoxib 40 mg relative to intravenous doses of…
- Trial name
- NAP (NCT00553605)
- Testing
- Ketoprofen 100mg, Parecoxib 40mg
- Where
- 17 sites in Brazil, Chile and 4 more
- Volunteers
- 340 people
- Sponsor
- Pfizer