Clinical trials: Analgesic
First Trimester Abortion, Surgical Abortion
The Effect of Music Therapy Under Ultrasound Guided Manual Vacuum Aspiration
Manual vacuum aspiration (MVA) is one of the surgical treatment options for managing early pregnancy loss. When compared to traditional surgical method; MVA is safer, more cost-effective, due to its shorter hospitalisation period…
- Conditions
- First Trimester Abortion, Surgical Abortion, Music Intervention, Local Anesthesia
- Trial name
- NCT04708808
- Testing
- music therapy
- Where
- Hong Kong
- Volunteers
- 176 people
- Sponsor
- Chinese University of Hong Kong
Acute Pain
A Phase 2 Study to Evaluate Analgesic Effect of IV CR845 For Pain Following Bunionectomy Surgery
This is a single-center, randomized, double blind, placebo controlled, parallel group proof of concept study to evaluate the analgesic efficacy as well as the safety, tolerability and pharmacokinetic profile of CR845 in patients…
- Trial name
- NCT01789476
- Testing
- CR845
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Cara Therapeutics, Inc.
Chronic Pain
Analgesic Efficacy of Sacral Neuromodulation for Pelvic Cancer Pain: A Preliminary Report
in this trial, we will test the analgesic efficacy of sacral neuromodulation for patients with pelvic cancer, complaining of chronic pelvic pain in comparison to medical treatment.
- Trial name
- NCT04549818
- Testing
- sacral neuromodulation
- Volunteers
- 44 people
- Sponsor
- Assiut University
Fentanyl
Impact of CYP3A4*1G Polymorphism on Non-analgesic Effects of Fentanyl in Chinese Han Patients
Purpose: This study aimed to investigate the impact of CYP3A4*1G genetic polymorphism on non-analgesic effects of fentanyl in Chinese Han patients.
- Trial name
- NCT03869346
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Hip Fracture
Femoral Nerve Block With Bupivacaine and Adjuvant Dexamethasone in Patients With Hip Fracture
Prolongation of the analgesic effect of a femoral nerve block from the present 15 hours to 24 hours in patients with hip fracture would have a major impact in order to provide better preoperative analgesia for this group.
- Trial name
- NCT02248870
- Testing
- Dexamethasone, Saline
- Where
- Denmark
- Volunteers
- 7 people
- Sponsor
- University of Aarhus
Pain
The Impact of Local Analgesia for Postoperative Analgesia in Posterior Thoracolumbar Operation
Posterior thoracolumbar operation always chooses general anesthesia. Due to surgical trauma and rich periosteum and joint capsule innervation, patients after general anesthesia immediately feel acute pain.The use of appropriate…
- Trial name
- NCT01872494
- Testing
- local, intravenous, 0.33% ropivacaine 250ml
- Where
- China
- Volunteers
- 71 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Osteoarthritis, Arthritis
A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, Compared With Placebo in Patients With Osteoarthritis
The purpose of the study is to determine if fentanyl, delivered through the skin via an adhesive patch, has a superior pain-relieving effect compared with placebo in patients with osteoarthritis pain that is inadequately…
- Trial name
- NCT00236366
- Testing
- fentanyl
- Volunteers
- 418 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Post Operative Nausea and Vomiting
the Effect of Three Different Analgesic Techniques on the Incidence of Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) is a distressing adverse effect that may result in postoperative complications including bleeding, wound dehiscence, aspiration pneumonitis, as well as fluid and electrolyte imbalances…
- Trial name
- NCT03313479
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Extracorporeal Membrane Oxygenation, Pharmacokinetics
Pharmacokinetics in Extracorporeal Membrane Oxygenation
The main purpose of the present study is to investigate the risk factors that affect drug pharmacokinetic (PK) during extracorporeal membrane oxygenation (ECMO).
- Trial name
- NCT03766282
- Testing
- ECMO
- Where
- China
- Volunteers
- 50 people
- Sponsor
- China-Japan Friendship Hospital
Postoperative Pain, Acute
Effect of Sufentanil on the Postoperative Pain
This study is a randomized, controlled trial. A total of 48 patients will be randomized to receive sufentanil or remifentanil during robot-assisted nephrectomy surgery.
- Trial name
- NCT06260046
- Testing
- Sufentanil, Remifentanil
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Seoul National University Hospital
Nerve Block
Opioid-Free Pain Management After NUSS Surgery in Adolescents
The investigators applied ultrasound-guided bilateral transverse thoracic fascia block combined with intercostal nerve block-a previously unreported analgesic approach for post-thoracic surgery-to NUSS patients.
- Trial name
- NCT07288424
- Testing
- Nerve block
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Qin Zhang
Analgesics, Opioid, Anesthesia; Adverse Effect
Comparison of Total Intravenous Anesthesia and Inhalational Anesthesia in Opioid-Free Anesthesia for Bariatric Surgery: A Randomized Controlled Trial
Total intravenous general anesthesia and combined general anesthesia are recognized methods used during anesthesia. They allow you to effectively control pain and reduce the number of complications associated with taking large…
- Trial name
- NCT06390046
- Testing
- TIVA versus Inhalation
- Where
- Poland
- Volunteers
- 280 people
- Sponsor
- Jagiellonian University
Dexamethasone, Dexmedetomidine
Intravenous Dexamethasone and Dexmedetomidine on the Analgesic Efficacy of Erector Spinae Plane Block
Patients having lumbar spinal fusion often complain about severe postoperative pain and postoperative rehabilitation process can be affected negatively.
- Conditions
- Dexamethasone, Dexmedetomidine, Nerve Block
- Trial name
- NCT04767256
- Testing
- Dexamethasone and dexmedetomidine, Dexmedetomidine, Ultrasound-guided lumbar erector spinae plane block
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology
Ankle Sprains, Telerehabilitation
Telehealth Delivered Physical Rehabilitation for an Ankle Sprain
A vast majority (75-85%) of ankle sprain patients treated in emergency departments (ED) receive pain medication and are not referred for physical rehabilitation.
- Conditions
- Ankle Sprains, Telerehabilitation, Analgesic, Opioid, Analgesics, Non-narcotic
- Trial name
- NCT04520854
- Testing
- Telehealth Protocol, Usual Care
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Kyle Kosik
Painful Diabetic Neuropathy (PDN)
Training "Pain Connoisseurs" for Efficient Analgesic Proof-of-Concept Studies
The purpose of this study is to assess the ability of Evoked Pain Training (EPT) and Drug/ Placebo Administration (DPA) training to increase subjects' ability to discriminate between active and placebo treatments in a…
- Trial name
- NCT02842554
- Testing
- EPT, C
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Analgesic Solutions
Pain, Acute, Pain, Postoperative
Intraoperative Methadone in Children Undergoing Surgery
A prospective double-blind, randomized controlled trial investigating the effect of a single-dose of intraoperative methadone on postoperative pain and opioid consumption in 96 children undergoing open urological surgery.
- Conditions
- Pain, Acute, Pain, Postoperative, Children, Only
- Trial name
- METACEBO (NCT04680286)
- Testing
- Methadone Hydrochloride
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Brain Tumor Adult, Cerebrovascular Disease
The Analgesic Effect of Scalp Nerve Block Using Bupivacaine Liposomes for Postoperative Pain Relief After Craniotomy
After undergoing craniotomy, 60% to 84% of neurosurgery patients experience moderate to severe acute pain, primarily in the first 48 hours. This pain is mostly superficial, affecting the muscles and soft tissues around the skull.
- Trial name
- NCT07049094
- Testing
- scalp nerve block with 0.25% hydrochloride bupivacaine and 0.67% bupivacaine liposome solution, scalp nerve block with 0.50% hydrochloride bupivacaine
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Zhejiang University
Pain, Postoperative
Retrospective Evaluation of Erector Spinae Plane Blocks
Retrospective Evaluation of Erector Spinae Plane Blocks
- Trial name
- NCT03739086
- Testing
- erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 182 people
- Sponsor
- Maltepe University
Pain Management
Ketorolac at Lower Doses for Analgesic Pain Control in ICU: A Pilot Feasibility Study
Opiates are commonly used to control pain in critically ill patients in the ICU. However, increased rates of opiate use in hospital may lead to increased prescription-based opiate dependence after leaving the ICU.
- Trial name
- KETOROLAC-ICU (NCT06819956)
- Testing
- Ketorolac
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Opioid Dependency
Study of Probuphine in Patients With Opioid Dependence
Buprenorphine (BPN) is an approved treatment for opioid dependence; however, in taking oral tablets, patients experience withdrawal and cravings when the variable BPN levels in the blood are low.
- Trial name
- PRO-809 (NCT00772785)
- Testing
- Probuphine (buprenorphine implant)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Titan Pharmaceuticals
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