Clinical trials: Analgesic
PENG Block, Hip Arthroplasty, Total
PENG vs PHPB for Hip Arthroplasty Analgesia
Total hip arthroplasty (THA) is a commonly performed surgical procedure, and its incidence continues to rise with the aging population. Effective postoperative analgesia facilitates early mobilization and accelerates recovery.
- Conditions
- PENG Block, Hip Arthroplasty, Total, QoR-15, Numeric Rating Scale
- Trial name
- NCT07263932
- Testing
- PENG Block and Posterior Hip Pericapsular Block, PENG Block
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people
- Sponsor
- Ankara City Hospital Bilkent
Dental Pain
Maxi-Analgesic Phase 2 Study to Compare the Analgesic Effects in Different Dosing Groups to Treat Teeth Extraction Pain
The aim of the study is to examine the dose response relationship in the treatment of dental pain (teeth extraction) for the different potential doses of the investigational drug, i.e.
- Trial name
- NCT01104844
- Testing
- Full Dose Strength, Quarter dose strength, Half dose strength
- Where
- United States
- Sponsor
- AFT Pharmaceuticals, Ltd.
Pain, Postoperative
A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks (QLB)vs Intrathecal Morphine(ITM) for Post Cesarean Section Pain
the purpose of this study is to compare opioid consumption in morphine equivalents between the groups that received postoperative analgesia with intrathecal morphine versus US guided QL blocks versus US guided QL catheters
- Trial name
- NCT04368364
- Testing
- Intrathecal morphine sulfate (ITM), Bupivacaine hydrochloride, ropivacaine hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Pain, Postoperative
Surgical Approach Affect on Post-operative Analgesic Requirement Following Laparoscopic Nephrectomy
Background: We performed this prospective clinical study to compare the post-operative recovery profile of our patients after transperitoneal and retroperitoneal laparoscopic nephrectomy techniques.
- Trial name
- NCT02622893
- Testing
- Transperitoneal laparoscopic nephrectomy, Retroperitoneal laparoscopic nephrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Post Operative Pain
Parent Nurse Controlled Analgesic in Pediatric Patients With Developmental Delay
The purpose of this study is to compare, the safety, efficacy and level of parent and nurse satisfaction with three methods of opioid administration post-operatively in children (4-18 years of age) with developmental delay.
- Trial name
- PNCA (NCT00743730)
- Testing
- Pain and standard side effect management for PNCA with basal method., Pain and standard side effect management with PNCA without basal, Pain and standard side effect management with IV on an as needed basis method.
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Medical College of Wisconsin
Pain
Study to Determine Efficacy and Safety of Inhaled AeroLEF in the Treatment of Acute Post-op Pain in Adult Patients Undergoing Elective Orthopedic Surgery
The purpose of this study is to determine the effect of pain relief with AeroLEF in adult patients, following orthopedic surgery.
- Trial name
- NCT00286065
- Testing
- AeroLEF
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- YM BioSciences
Knee Osteoarthritis (OA), Postoperative Pain
Effect of Adding a Biceps Femoris Short Head Block to Adductor Canal Block for Analgesia After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is frequently associated with moderate to severe postoperative pain, which may delay mobilization, increase opioid consumption, and impair functional recovery.
- Trial name
- BiFeS-TKA (NCT07803887)
- Testing
- Ultrasound-Guided Adductor Canal Block, Ultrasound-Guided Biceps Femoris Short Head Block
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Antalya Training and Research Hospital
Chronic Pain, Addiction Opiate
Cross-cultural Validation of a Screening Scale for the Misuse of Opioid Analgesics in Primary Care
Objective: Analgesic Opioids misuse among patients with chronic pain ranges from 0% to 50%. The general practitioner is the first prescriber of opioid analgesics Our objective was to validate in primary care the POMI…
- Trial name
- VAMOS (NCT05431985)
- Where
- 5 sites in France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Clermont-Ferrand
Standard Opioid Analgesic Treatment of Cancer-related Chronic Pain.
Efficacy and Safety of FITpatch Compared to Standard Opioid Treatment in Cancer Pain (FT-015-IN)
Primary objectives: To determine non-inferiority of FITpatch with regard to efficacy compared to standard opioid treatment To assess the safety of FITpatch compared to standard opioid treatment Secondary objectives: To assess the…
- Trial name
- NCT00279344
- Testing
- Fentanyl (Matrifen)
- Volunteers
- 220 people
- Sponsor
- Nycomed
Arthroscopy, Analgesia
Ultrasound-Guided Extrafascial Versus Intrafascial Interscalene Brachial Plexus Block in Shoulder Arthroscopy
The aim of the study is to compare the diaphragmatic excursion and postoperative analgesia in the extrafascial versus intrafascial Interscalene brachial plexus block in patients undergoing shoulder arthroscopy.
- Conditions
- Arthroscopy, Analgesia, Intrafascial Interscalene Brachial Plexus Block
- Trial name
- NCT05222334
- Testing
- Intrafascial interscalene brachial plexus block, Extrafascial interscalene brachial plexus block group, Bupivacaine
- Volunteers
- 50 people
- Sponsor
- Tanta University
HIV Infections
Toxicity Substudy of Evaluation of Subcutaneous Proleukin in a Randomised International Trial (ESPRIT): TOXIL-2 Substudy
This substudy is an open-label, randomised study comparing the uptake of recombinant interleukin-2 (rIL-2) in HIV-1 infected individuals receiving different combinations of antiemetics and analgesic agents during rIL-2 dosing in…
- Trial name
- NCT00147355
- Testing
- ondansetron, ibuprofen, paracetamol, metoclopramide, ibuprofen, paracetamol, Metoclopramide, codeine phosphate, ibuprofen, paracetamol
- Where
- 16 sites in Argentina, Australia and 1 more
- Volunteers
- 28 people
- Sponsor
- Kirby Institute
Pediatric Dentistry
The Efficacy of Analgesic Buffering With Sodium Bicarbonate for the Pediatric Dental Patient
As a dentist, administering anesthetic to patients, especially children, proves to be one of the most difficult parts of a procedure. Pain is one of the most common symptom in dentistry, and a serious concern for the dentist.
- Trial name
- NCT01883232
- Testing
- Onset Mixing Pen by Onpharma, 2% lidocaine with 1:100,000 epinephrine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Amputation
Combined Local Anesthetic Blockade and Neuromodulation vs Local Anesthetic Blockade Only for Analgesia After Below-knee Amputation: RCT
This multi-site clinical trial aims to assess the efficacy and safety of combining peripheral nerve stimulation with local anesthetic nerve blockade compared to the standard of care, i.e., local anesthetic blockade only using…
- Trial name
- NCT06964347
- Testing
- Ropivacaine 0.2% + nerve stimulator set, Ropivacaine 0.2%
- Where
- 4 sites in United States, Canada
- Volunteers
- 62 people
- Sponsor
- Stanford University
Back Pain
The Effect of Chiropractic Care on Opioid Use for Chronic Spinal Pain: A Feasibility Study
The investigators will conduct a pilot cluster randomized controlled trial (RCT) of chiropractic care added to usual medical care, versus usual medical care alone, for adult patients prescribed opioid therapy for chronic…
- Trial name
- ACCESS-DC (NCT06160947)
- Testing
- Usual Medical Care, Usual Medical Care + Chiropractic Care
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
Palatal Donor Site Wound Healing, Platelet Rich Fibrin
Characterizing the Effects of Platelet-Rich Fibrin (PRF) as a Palatal Wound Dressing on Quality of Life and Sleep Following Mucogingival Surgery. Study Was Conducted at the Air Force Post Graduate Dental School. All HIPPA Consents and Research Informed Consents Are Located at JBSA-Lackland.
The goal of this clinical trial (2-arm) is to determine if the application of platelet rich fibrin (PRF) to palatal donor sites influence patients quality of life, sleep efficiency, and healing following mucogingival surgery.
- Conditions
- Palatal Donor Site Wound Healing, Platelet Rich Fibrin, Sleep Quality, Pain
- Trial name
- NCT07637838
- Testing
- Platelet rich fibrin, Control Group: collagen matrices or oxidized cellulose membrane
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- 59th Medical Wing
Pain
Analgesic Effect of Ropivacaine Plus Fentanyl vs Ropivacaine for Continuous 3-in-1 FNB After Total Knee Arthroplasty
The postoperative analgesic effect of the continuous 3-in-1 femoral nerve block (FNB) with ropivacaine/fentanyl or with ropivacaine were compared in total knee arthroplasty.
- Trial name
- NCT02501863
- Testing
- Femoral nerve block with ropivacaine+fentanyl, Femoral nerve block with ropivacaine
- Volunteers
- 40 people
- Sponsor
- National Medical Center, Seoul
Bariatric Surgery Candidate, Obesity, Morbid
Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery
The aim of this study is to evaluate and to compare the effectiveness of iv ibuprofen and iv paracetamol during bariatric surgery.
- Trial name
- NCT02778958
- Testing
- paracetamol, ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Inonu University
Low Back Pain
Imaging Study of Chronic Low Back Pain in Patients Taking Pain Medication
Duloxetine has recently been shown to be effective in reducing the pain in chronic pain patients. Duloxetine is known to exert a central mechanism, however the precise human brain structures responsible for mediating its…
- Trial name
- NCT00388414
- Testing
- duloxetine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Stanford University
Analgesics, Opioid, Anesthesia, Spinal
Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery
Pain management after total hip replacement is one of the most important aspects of postoperative care for patients and clinicians alike.
- Conditions
- Analgesics, Opioid, Anesthesia, Spinal, Total Hip Replacement, Adverse Anesthesia Outcome
- Trial name
- NCT06878014
- Testing
- Spinal Anesthesia (bupivacaine), Postoperative pain management with acetaminophen, PCA IV Oxycodone
- Where
- 3 sites in Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Silesia
Analgesic Effect
Comparison of Caudal Blockade and Dorsal Penile Nerve Block With and Without the Intravenous Administration of Dexamethasone for Analgesia After Paediatric Male Circumcision
Male infant circumcision is a frequently performed, but painful procedure. A variety of methods, both systemic and locoregional, have been developed to overcome postoperative pain after circumcision.
- Trial name
- NCT05598255
- Testing
- Dexamethasone, Caudale Blockade with levobupivacaine, Dorsal penile nerve block with levobupivacaine
- Where
- Belgium
- Volunteers
- 54 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
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