Clinical trials: Analgesic
Behavioral Symptoms, Suicide
Natural History of Depression, Bipolar Disorder and Suicide Risk
Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different treatments.
- Conditions
- Behavioral Symptoms, Suicide, Self-Injurious Behavior, Sensory System Agents
- Trial name
- NCT06462196
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Mental Health (NIMH)
Osteoarthritis of the Knee
Proof-of Concept Study of Topical 3%-Diclofenac-Nano-Emulsion Cream for Knee OA Pain
This study valuates the safety and efficacy of treatment with 3% Diclofenac Nano-Emulsion Cream versus Placebo in subjects with osteoarthritis of the knee.
- Trial name
- NCT00484120
- Testing
- 3%-Diclofenac-Nano-Emulsion Cream
- Where
- 4 sites in Israel
- Volunteers
- 123 people
- Sponsor
- Pharmos
Postherpetic Neuralgia, Pain
Study of a Bupivacaine Patch (Eladur™) to Treat Post- Herpetic Neuralgia
Neuropathic pain is caused by a virus commonly associated with chicken pox. This virus may become dormant in the nervous system and later reactivate causing herpes zoster, also known as "shingles".
- Trial name
- NCT00478179
- Testing
- Transdermal/Patch (Bupivacaine TTS [Eladur™])
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Durect
Anxiety, Postoperative Pain
Evaluation of the Postoperative Agitation Prevention and Analgesic Efficacy of Perioperative Dexmedetomidine Infusion in a Pediatric Patient Group to Undergo Tonsillectomy and Adenoidectomy
Dexmedetomidine is a drug known for its pain-relieving and restlessness-reducing effects. The purpose of this run is to use the association between this use during surgery and the attrition of post-operative pain and discomfort.
- Conditions
- Anxiety, Postoperative Pain, Bleeding
- Trial name
- NCT05986942
- Testing
- Fentanyl, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Burak Omur
Delirium, Cognitive Dysfunction
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients
Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated.
- Conditions
- Delirium, Cognitive Dysfunction, Cognition Disorder, Neurocognitive Disorders
- Trial name
- CODEX (NCT04289142)
- Testing
- Dexmedetomidine Hydrochloride Group
- Where
- 8 sites in Canada
- Volunteers
- 2,400 people
- Sponsor
- Sunnybrook Health Sciences Centre
Post-Operative Pain
Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Laparoscopic Colorectomy
The purpose of this phase 2 study is to evaluate the efficacy and safety of an analgesic drug candidate, VVZ-149 Injections. The study is designed as randomized, double-blind, parallel, placebo-controlled study.
- Trial name
- NCT02992041
- Testing
- VVZ-149 Injections
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Vivozon, Inc.
Drug Use Disorders
Treatment Outcomes Among Patients With Prescription Narcotic Drug Use Disorder
This study follows up patients who receive standard treatment for prescription narcotic drug use disorder, including opioids, benzodiazepines, and benzodiazepine-like drugs (z-drugs), at a specialized addiction service.
- Trial name
- TAPE (NCT03713983)
- Testing
- Observational study
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Johan Franck
Impacted Third Molar Tooth, Pain, Acute
Variability in Analgesic Response to Ibuprofen
Nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, are recommended as first-line treatment for post-surgical dental pain.
- Trial name
- NCT06539741
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sinusitis, Opioid Use
Pain Control Following Sinus Surgery
Given the ongoing national opioid epidemic, an increased interest has developed in optimizing opioid prescribing practices of physicians, including otolaryngologists.
- Conditions
- Sinusitis, Opioid Use, Opioid Abuse, Narcotic Use
- Trial name
- NCT03783702
- Testing
- OxyCODONE 5 Mg (milligram) Oral Tablet, Ibuprofen 600 Mg (milligram) Oral Tablet, Acetaminophen 650 MG (milligram) Oral Tablet
- Where
- 6 sites in United States, Canada
- Volunteers
- 118 people
- Sponsor
- Stanford University
Surgery, Arthroscopic, Analgesia
Preoperative Fluoroscopy Guided Hip Articular Branch Blocks and Analgesic Outcomes Following Hip Arthroscopy
Arthroscopic hip surgeries are increasingly being performed as both diagnostic and therapeutic interventions. These procedures are considerably painful, thus requiring the proper pain management techniques in order to provide…
- Conditions
- Surgery, Arthroscopic, Analgesia, Pain, Acute
- Trial name
- NCT04538105
- Testing
- Control, Articular Branch Block (ABB)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Bladder Tumors, Spinal Anesthesia
Magnesium vs. Dexmedetomidine in TURBT Under Spinal Anesthesia
This randomized controlled trial evaluated the effects of intraoperative intravenous magnesium sulfate versus dexmedetomidine on postoperative pain, analgesic consumption, hemodynamic stability, and respiratory function in…
- Conditions
- Bladder Tumors, Spinal Anesthesia, Postoperative Pain, Magnesium Sulfate
- Trial name
- TURBT (NCT07445451)
- Testing
- magnesium sulfate, Dexmedetomidine, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Pain
Analgesic Effect of Pregabalin in Patients Undergoing Total Abdominal Hysterectomy
Pregabalin will decrease the total amount of opioid required in patients undergoing total abdominal hysterectomy. In addition, pregabalin will decrease the incidence of opioid-related side effects in patients undergoing total…
- Trial name
- NCT01466101
- Testing
- Pregabalin administration
- Sponsor
- Northwestern University
Low Back Pain, Brace
Lumbar Brace Deployment in the Emergency Department for Benign Low Back Pain
Low back pain accounts for billions of dollars in health care expenditures. Most cases of back pain do not have a clear cause. Thus, low back pain management methods usually rely on targeting people' pain and discomfort.
- Conditions
- Low Back Pain, Brace, Emergencies, Pain
- Trial name
- NCT03829631
- Testing
- Horizon 627 Lumbar Brace, Aspen Medical Company, Oak Canyon, Irvine, CA 92618
- Where
- Australia
- Volunteers
- 152 people
- Sponsor
- University of Alberta
Neuropathic Pain
Analgesic Effects of rTMS in Peripheral Neuropathic Pain
This study aims to evaluate the long term efficacy over 25 weeks of repeated sessions of magnetic transcranial stimulation of the motor cortex or prefrontal cortex on average pain intensity, quality of life, sleep, neuropathic…
- Trial name
- TRANSNEP (NCT02010281)
- Testing
- rTMS of prefrontal or motor cortex
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Pain
Quadratus Lumborum Block in Pediatric Patients
Quadratus lumborum block (QLB) is a newly-defined trunk block performed with local anesthetic injection by imaging the abdominal muscles with ultrasonography (US) guidance; thus, analgesia is expected to be ensured from the T7-L1…
- Trial name
- NCT03693222
- Testing
- Tramadol Hydrochloride, Morphine Sulfate
- Volunteers
- 40 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Breast Cancer, Surgery
Analgesic Effect of Resistance Training for Breast Cancer Survivors
Persistent pain after treatment for breast cancer is a major clinical problem, affecting 25-60 % of the patients and is a source of considerable physical disability and psychological distress.
- Conditions
- Breast Cancer, Surgery, Chemotherapy Effect, Radiotherapy Side Effect
- Trial name
- (ANTRAC) (NCT04509284)
- Testing
- Training, Control
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aalborg University
Pain, Post Operative, Pain, Acute
Opioid-free Anesthesia in Thyroidectomies
The aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective thyroidectomies.
- Conditions
- Pain, Post Operative, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT05243940
- Testing
- dexmedetomidine-ketamine-lidocaine (DKL), remifentanil infusion
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Arthroscopic Meniscus Surgery
Naproxen Codeine in Arthroscopic Surgery
In this study, the aim is to compare the efficacy of single dose naproxen sodium and combination of naproxen sodium-codeine phosphate on post-operative pain in adult patients undergoing arthroscopic menisectomy.Pre-emptive oral…
- Trial name
- NCT01952652
- Testing
- Group N:Naproxen sodium, Group NC :naproxen sodium codeine phosphate
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Baskent University
Postoperative Pain, Analgesic Consumption
Analgesic Consumption in the Early Postoperative Period: A Prospective Observational PACU Study
Postoperative pain remains a significant clinical challenge that directly affects patient recovery, functional outcomes, and overall quality of care.
- Conditions
- Postoperative Pain, Analgesic Consumption, Pain Management
- Trial name
- NCT07547618
- Testing
- Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 254 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Lumbar Fixation Surgery
Evaluation Of Three Different Anagesic Techniques In Patients Undergoing Lumbar Fixation Surgery
Lumbar spinal stenosis is a degenerative condition characterized by the narrowing of the space surrounding the neurovascular structures of the lumbar vertebrae, resulting from age-related changes in the intervertebral discs…
- Trial name
- NCT06801574
- Testing
- Erector Spinae Plane Block, infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ataturk University
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