Clinical trials: Analgesic
Analgesia
Comparison of Analgesic Effect and Prognosis of Butorphanol and Fentanyl in Patients With Mechanical Ventilation
ICU patients often in a strong stress environment. Various invasive procedures such as wound dressing change, sputum suction,Pull out the thoracic duct etc.
- Trial name
- NCT04315935
- Testing
- Butorphanol and Propofol, Fentanyl and Propofol
- Where
- China
- Volunteers
- 355 people
- Sponsor
- Jiangsu Hengrui Pharmaceutical Co., Ltd.
Elderly, Older Adults
The PAINFREE Initiative, a Stepped Wedge Cluster Randomized Trial
The PAINFREE (Improving PAIN control following FRactures; towards an Elder-friendly Emergency department) Initiative is a patient-centered multifaceted intervention which aims to improve pain management in patients 75 years and…
- Conditions
- Elderly, Older Adults, Bone Fracture, Emergency Department
- Trial name
- PAINFREE (NCT03082417)
- Testing
- Implementation
- Where
- Canada
- Volunteers
- 1,375 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pain Management, Shared Decision Making
ACE Pilot 3: Decision Aid 2 Options vs 3 Options
This research protocol is exploring a behavioral intervention: shared decision making with the use of a decision aid to select a post-operative analgesic.
- Trial name
- NCT07011472
- Testing
- Decision-Aid with 2-options, Decision aid with 3 options
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rutgers, The State University of New Jersey
Renal Colic
Analgesic Effect of Erector Spinae Plane Block for Renal Colic Pain
Plane blocks have become very popular in recent years with the introduction of ultrasonography into the regional anesthesia and algology practice.
- Trial name
- NCT04209439
- Testing
- 30 ml %0.25 bupivacaine, Dexketoprofen-trometamol
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ataturk University
Oocyte Retrieval for IVF, Pain
Analgesic Effect of TENS-WAA Combined With Tramadol Hydrochloride During Oocyte Retrieval Surgery
This study is a single-centre randomised controlled trial. It aimed to evaluate the efficacy and safety of transcutaneous electrical nerve stimulation based on wrist-ankle acupuncture theory(TENS-WAA) combined with tramadol…
- Trial name
- NCT07212127
- Testing
- Transcutaneous Electrical Nerve Stimulation based on Wrist-Ankle Acupuncture theory（TENS-WAA)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical University
Healthy Participants
A Trial Investigating the Pain-relieving Properties of Lu AG06474 in Healthy Adult Participants
The main goal of this trial is to learn about the effect of Lu AG06474 on a battery of Evoked Pain Tests when a single dose is given to healthy adult participants.
- Trial name
- NCT06077786
- Testing
- Lu AG06474, Ibuprofen, Pregabalin
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Nociceptive Pain, Anesthesia
NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus Sevoflurane
The purpose of this prospective randomized controlled study is to compare the analgesic properties of propofol and sevoflurane using variation of the NOL index and standard monitoring (Heart Rate and Mean Arterial Blood Pressure)…
- Trial name
- PROSEVNOL (NCT04567160)
- Testing
- Propofol, Sevoflurane
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Opioid-use Disorder, Opioid Use
The Analgesic Efficacy of Continuous Sub-fascial Bupivacaine Infusion and Lidocaine Patches in Post-cesarean Patients With Opiate Use Disorder: A Comparative Efficacy Analysis
Pregnant women with a history of opioid use disorder, chronic opioid use or those who are on medication assisted treatment will be randomly assigned to receive either a sub-fascial continuous infusion of bupivacaine or…
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Dependence, Opioid Abuse
- Trial name
- NCT04033562
- Testing
- Lidocaine patch, Ambu ACTion pump, 0.125% bupivacaine at 8cc/hr
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- WellSpan Health
Chronic Headache
Feasibility Study of Normobaric Oxygen Delivered by a High Flow Concentrator in the Treatment of Chronic Headache
Chronic headache is most often associated with drug abuse and medication overuse headache (MOH) is the main complication of migraine disease results in chronic daily headache.
- Trial name
- O214 (NCT02302027)
- Testing
- platinium IRC9LXO2AWQ
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Association pour la Recherche au Centre d'Urgence des Céphalées
Serratus Plane Block
Analgesic Efficacy of Serratus Anterior Plane Block in The Rib Fractures Pain
Serratus Anterior Plane Block (SAPB) is a facial plane block that was first described by Blanco in 2013 and that blocks the lateral cutaneous branches of the T2-T9 intercostal nerves, the intercostobrachial nerve, n.
- Trial name
- NCT04293354
- Testing
- Serratus Plane Block, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Laparoscopic Cholecystectomy
Dexamethasone-Enhanced TAP Block in Lapchole
The transversus abdominis plane (TAP) block is widely used as part of analgesia for abdominal surgeries such as laparoscopic cholecystectomy. While bupivacaine is commonly used for TAP blocks with reported success.
- Trial name
- NCT07182110
- Testing
- Dexamethasone enhanced TAP Block, Marcaine- 0.25%
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makassed General Hospital
External Oblique Intercostal Plane Block, Laparoscopic Cholecystectomy
Bilateral External Oblique Intercostal Plane Block in Laparoscopic Cholecystectomy
Pain after laparoscopic cholecystectomy (LC) is a common complaint that prolongs hospital stay and thus increases morbidity. There are three primary sources of pain after LC, incision site, local and systemic effects of…
- Trial name
- NCT06541613
- Testing
- local anesthetic injection (bupivacaine), normal saline injection
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Theodor Bilharz Research Institute
Pain
A Study to Assess How the Body Processes a Strong Painkiller When it is Given Alongside a Drug That Counteracts the Side Effects of Strong Painkillers in a Fasted and Fed State.
To assess whether an opioid antagonist has any impact on the release of a strong painkiller in the blood when it is given to healthy volunteers when they have eaten and also when they have fasted.
- Trial name
- NCT02133820
- Testing
- 4 mg 12 hourly capsule - strong pain killer fasted, 4 mg 12 hourly capsule - strong pain killer fed, 12 hourly capsule strong painkiller with antagonist fasted)
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mundipharma Research Limited
Distal Radius Fracture
"Supracondylar Radial Nerve Block Guided by Ultrasound Versus Hematoma Block for Analgesic Management in Closed Reduction of Distal Radius Fractures"
Non-surgical treatment with closed reduction and immobilization using a splint or cast is the preferred approach for stable distal radius fractures, particularly in elderly patients.
- Trial name
- NCT06857110
- Testing
- ultrasound-guided supracondylar block of the radial nerve, hematoma block, 5 mg of intramuscular diclofenac
- Where
- Colombia
- Volunteers
- 50 people
- Sponsor
- Hospital Universitario San Ignacio
Fractures, Closed, Pain, Postoperative
Pain and Narcotic Usage After Orthopaedic Surgery
This study aims to 1) observe the course of pain, 2) utilization of opioid pain medication, and 3) possible effect of a behavioral intervention delivered via an automated mobile phone messaging robot in patients undergoing…
- Conditions
- Fractures, Closed, Pain, Postoperative, Pain Catastrophizing, Pain, Acute
- Trial name
- NCT03991546
- Testing
- Acceptance and Commitment Therapy Delivered via an Automated Mobile Messaging Robot
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Christopher Anthony
Pain, Postoperative
Perioperative Pain Management for Lumbar Spine Surgery
Perioperative pain management is crucial for patients undergoing elective lumbar spine surgery. Moderate to severe postoperative pain can significantly impact recovery, worsen patient outcomes, and potentially lead to chronic…
- Trial name
- NCT06662318
- Testing
- Fentanyl Citrate, Dexmedetomidine, Lidocaine Hydrochloride
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Benha University
Pain, Postoperative Arthroscopy
Effect of Rofecoxib and a Narcotic Analgesic to Treat Pain Following Arthroscopic Surgery (0966-179)(COMPLETED)
Study the effect of rofecoxib 50 mg compared to both placebo, and hydrocodone 7.5 mg with acetaminophen 750 mg, to treat moderate to severe pain following arthroscopic knee surgery.
- Trial name
- NCT00390260
- Testing
- MK0966 / Duration of Treatment: 1 Days, Comparator: acetaminophen (+) hydrocodone bitartrate / Duration of Treatment: 1 Days
- Volunteers
- 420 people
- Sponsor
- Merck Sharp & Dohme LLC
Analgesia
The Central Analgesic Effects of Paracetamol on Serotonergic Pathways
1. Introduction Paracetamol, an analgesic prescribed daily, has been in use for more than 50 years. Surprisingly, its mode of action is still unclear.
- Trial name
- NCT00970450
- Testing
- Paracetamol, Tropisetron
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pain, Postoperative, Nerve Block
The Comparison of the Analgesic Efficacy and Hemodynamic Effects of Paravertebral Block Compared With Paravertebral and Intercostal Nerve Block for Thoracotomy in Adults.
Thoracotomy is a surgical procedure associated with severe post operative pain during the first day of surgery and is responsible for prolonged hospital stay, patient dissatisfaction and delayed return to normal activities along…
- Conditions
- Pain, Postoperative, Nerve Block, Thoracotomy
- Trial name
- NCT04715880
- Testing
- Paravertebral block/Intercostal Block (PVB/ICB) group, Paravertebral Block (PVB) group
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aga Khan University Hospital, Pakistan
Cholecystitis, Appendicitis
Ultrasound Guided Rectus Sheath Block and Transversus Abdominis Plane Block
The current study aimed to assess the efficacy of Dexmedetomidine (DEX) and Dexamethasone as an adjuvant to ultrasound guided TAP and RS block to prolongation of postoperative analgesia and better pain control in children…
- Trial name
- NCT04838379
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
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