Clinical trials: Analgesic
Minimal Invasive Heart Surgery, Rhomboid Intercostal Nerve Block
Analgesic Efficacy of Rhomboid Intercostal Nerve Block for Minimal Invasive Heart Surgery
The goal of this clinical trial is to test the analgesic efficacy of rhomboid intercostal nerve block (RINB) in patients undergoing minimal invasive heart surgery (MIHS).
- Trial name
- NCT05861804
- Testing
- Rhomboid Intercostal Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Koç University
Pain
Pregabalin and Remifentanil - Analgesia and Ventilation
In this experimental study on healthy volunteers we explored the effect of pregabalin alone and in combination with remifentanil on acute experimental pain and ventilatory function.
- Trial name
- NCT01419405
- Testing
- Pregabalin, Remifentanil, sugar pill, saline infusion
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Kidney Stone, Surgery
Regional Erector Spinae Analgesic Block vs Standard of Care Undergoing Percutaneous Nephrolithotomy
The purpose of this study is to determine if adding a spinal block (medicine that will numb parts of the body to block pain) along with standard pain control at the incision site will decrease the need for narcotics for pain…
- Trial name
- NCT04663269
- Testing
- 4mg PF Dexamethasone, Control Test
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Indiana University
Hypogonadism, Opioid-Related Disorders
Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration
The purpose of this randomized controlled clinical trial is to evaluate the effects of clomiphene citrate compared to placebo (substance without active medication) in men who are taking pain medication (opioids) for chronic pain…
- Conditions
- Hypogonadism, Opioid-Related Disorders, Male Infertility
- Trial name
- NCT01880086
- Testing
- Clomiphene citrate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Weill Medical College of Cornell University
Postoperative Complications
Does Local Morphine Add to Local Anesthetics in Serratus Anterior Plane Block Has a System Analgesic Effect?
the investigators aim is to investigate and explore the effect 10 mg morphine added to local anesthetics in serratus anterior plane block for post mastectomy pain management after modified radical mastectomy in patients with…
- Trial name
- NCT02962024
- Testing
- Morphine Sulfate, Bupivacaine Hydrochloride
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Fatma Adel El sherif,MD
Post Operative Pain
Caudal Block vs Retrolaminar Block on Analgesic Consumption in Undescended Testis Surgeries
This study compares the postoperative analgesic effectiveness of Caudal Block (CB) and Retrolaminar Block (RLB) in pediatric patients undergoing undescended testis surgeries.
- Trial name
- NCT06725862
- Testing
- Retrolaminar Block (RLB), Caudal Block (CB)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Bladder Tumors, Spinal Anesthesia
Magnesium vs. Dexmedetomidine in TURBT Under Spinal Anesthesia
This randomized controlled trial evaluated the effects of intraoperative intravenous magnesium sulfate versus dexmedetomidine on postoperative pain, analgesic consumption, hemodynamic stability, and respiratory function in…
- Conditions
- Bladder Tumors, Spinal Anesthesia, Postoperative Pain, Magnesium Sulfate
- Trial name
- TURBT (NCT07445451)
- Testing
- magnesium sulfate, Dexmedetomidine, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Pain
Intracervical Lidocaine Gel for IUD Insertional Pain
The intrauterine device (IUD) is a form of birth control that is extremely effective and safe, even in women who have not yet had children.
- Trial name
- NCT01214161
- Testing
- 2% lidocaine gel
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Columbia University
Osteoarthritis of the Knee, Chronic Lower Back Pain
A Study to Assess the Analgesic Efficacy of ASP7962 in Patients With Pain Due to Osteoarthritis of the Knee
The purpose of the study is to evaluate the analgesic efficacy of ASP7962 relative to placebo. This study will also evaluate the efficacy of ASP7962 relative to placebo on pain on walking, function and stiffness; the time course…
- Trial name
- OAK (NCT02611466)
- Testing
- ASP7962, Naproxen
- Where
- 34 sites in Belgium, Czechia and 4 more
- Volunteers
- 215 people
- Sponsor
- Astellas Pharma Europe B.V.
Cardiopathy, Coronary Artery Disease
Efficacy and Safety of Dexmedetomidine in the Analgesic Prophylaxis , in Patients Undergoing Cardiovascular Surgery
Acute pain is one of the complications after cardiothoracic surgeries . It can delay patients´recovery and may increase patients´morbity and mortality.
- Conditions
- Cardiopathy, Coronary Artery Disease, Valve Heart Disease, Pain
- Trial name
- NCT05079672
- Testing
- Dexmedetomidine, 0,9% Saline
- Where
- 2 sites in Brazil
- Volunteers
- 102 people
- Sponsor
- University of Sao Paulo
INFERTILITY
Analgesic Efficacy of Dexamethasone in Different Routes of Administration in Transverse Abdominis Plane Block
Transverse abdominis plane (TAP) block is a regional anaesthesia technique that provides analgesia to the parietal peritoneum as well as skin and muscles of the anterior abdominal wall.
- Trial name
- AEDDATB (NCT02838719)
- Testing
- Perineural Dexamethasone acetate, Intravenous dexamethasone acetate
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pain, Ketamine Adverse Reaction
Cardiovascular Safety After Continuous Ketamine Infusion
Observational study that evaluate the cardiovascular and neuropsychiatric side effects of ketamine analgesic infusions for acute pain
- Conditions
- Pain, Ketamine Adverse Reaction, Postoperative Pain
- Trial name
- NCT03979105
- Testing
- Ketamine
- Where
- 2 sites in Colombia
- Volunteers
- 300 people
- Sponsor
- Universidad de Antioquia
Pain, Postoperative
Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination
The purpose of this study is to determine whether the combination of paracetamol (acetaminophen) and other NSAIDs with or without weak opioids can give synergistic analgesic effect.
- Trial name
- NCT00921700
- Testing
- Ibuprofen + Paracetamol, Ibuprofen + Paracetamol + Codeine, Paracetamol + Codeine
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Ullevaal University Hospital
Back Pain
Celebrex vs Tramadol in the Treatment of Chronic Lower Back Pain.
This study investigates if Celebrex is as effective as tramadol hydrochloride (Ultram) for patients with chronic low back pain, when administered over a 6-week period.
- Trial name
- NCT00290901
- Testing
- Tramadol Hydrochloride 50mg, Celebrex 200mg
- Where
- 54 sites in United States, Puerto Rico
- Volunteers
- 754 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Serratus Anterior Plane Block
Comparison of the Analgesic Efficacy of Ultrasound-guided Retrolaminar Block Versus Serratus Anterior Plane Block in Patients Undergoing Radical Mastectomy
All patients will be taught how to interpret the visual analogue scale (VAS) of 0 to 10 with 0 experiencing no pain and 10 being the worst pain imaginable.
- Trial name
- NCT07649837
- Testing
- Serratus Anterior Plane Block (SAPB) group, Retrolaminar block group
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Surgery, Pain, Postoperative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll.
- Trial name
- CARES (NCT05722002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 8 sites in United States, Canada
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Sepsis
Effect of Remazolam Besylate Combined With Remifentanil Analgesic Sedation on the Prognosis of Patients With Sepsis
In this study, midazolam was used as a control to investigate the effect of remazolam besylate combined with remifentanil on analgesia and sedation in patients with mechanical ventilation of sepsis on the prognosis of patients…
- Trial name
- NCT06731088
- Testing
- Midazolam, Remazolam besylate
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Post-extraction Pain (PEP), Post-extraction Lip or Cheek Biting Injury (PEBI)
Evaluation of Post-operative Discomforts in Children After Extraction of Temporary Teeth
This prospective observational study aim to evaluate discomforts after extraction of temporary tooth under local anesthesia. The first objective is to describe the prevalence of the post-extraction pain (PEP), post-extraction…
- Conditions
- Post-extraction Pain (PEP), Post-extraction Lip or Cheek Biting Injury (PEBI), Post-extraction Bleeding (PEB), Tooth Removal
- Trial name
- DEXTRAFANT (NCT03878173)
- Testing
- No intervention
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Nantes University Hospital
Pain
Safety, Tolerability, Analgesic Effect, and Feasibility of Intranasal CT001 in Pediatric Patients
The proposed study aims to investigate the safety, tolerability, analgesic efficacy, and feasibility of intranasal sufentanil/ketamine (CT001) in pediatric participants attending an acute care (i.e. emergency) setting.
- Trial name
- NCT06364072
- Testing
- CT001
- Where
- 7 sites in Spain, United Kingdom
- Volunteers
- 155 people
- Sponsor
- Cessatech A/S
Pain, Postoperative, Anxiety
Effect of VR on Anxiety and Pain in Gynecological Surgery
Rationale: Lack of postoperative acute pain management is associated with increased morbidity, longer recovery time, more opioid use and subsequently increased health care costs.
- Conditions
- Pain, Postoperative, Anxiety, Pain Catastrophizing, State Anxiety
- Trial name
- VRAP-G (NCT04687501)
- Testing
- Virtual Reality
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Zuyderland Medisch Centrum
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