Clinical trials: Analgesic
Neuropathic Traumatic Pain, Pain NRS ≥ 4
Assessment of the Effectiveness of Ethosuximide in the Treatment of Peripheral Neuropathic Pain.
Currently, it is established that the voltage-gated calcium channels modulate pain perception due to an influence on the neuronal transmission and excitability.
- Conditions
- Neuropathic Traumatic Pain, Pain NRS ≥ 4, Peripheral Neuropathic Pain, Neuropathic Pain Diagnostic Questionnaire (DN4) ≥ 4
- Trial name
- EDONOT (NCT02100046)
- Testing
- Zarontin® (ethosuximide) and Stodal®
- Where
- France
- Volunteers
- 114 people
- Sponsor
- University Hospital, Clermont-Ferrand
Meniscopathy Surgery, Peripheral Nerve Block
Comparison of Analgesic Effects of ACB Versus ACB Combined With BiFeS Block in Meniscopathy Surgery
Meniscopathy surgeries are commonly associated with moderate postoperative pain, particularly during early mobilization and rehabilitation.
- Conditions
- Meniscopathy Surgery, Peripheral Nerve Block, Pain Management
- Trial name
- NCT07603323
- Testing
- Adductor Canal Block Group, Adductor Canal Block + BiFeS (Biceps Femoris Short Head) Block Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Ankara Etlik City Hospital
Onset and Duration of Sensory and Motor Block of Femoral Nerve,, Visual Analogue Pain Scores,
Perineural Dexmedetomidine and Femoral Nerve Block
The duration of sensory block after single dose of long acting local anesthetics is not sufficient to avoid the postoperative use of opioids.
- Conditions
- Onset and Duration of Sensory and Motor Block of Femoral Nerve,, Visual Analogue Pain Scores,, Time to First Request of Rescue Analgesics,, Total Morphine Consumption in 24 Hours
- Trial name
- NCT01964040
- Testing
- peri-neural dexmedetomidine as adjuvant to bupivacaine in femoral nerve block
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Chronic Low Back Pain, Back Pain
Predicting Analgesic Response to Acupuncture: A Practical Approach
In this placebo controlled, patient and assessor blinded clinical trial, the investigators will administer electroacupuncture vs sham electroacupuncture to patients suffering from chronic low back pain, and monitor their symptoms…
- Trial name
- NCT02890810
- Testing
- Real Acupuncture with Electrical Stimulation, Simulated Acupuncture with Electrical Stimulation
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Stanford University
Renal Transplantation, Nerve Block
Comparison Between Ultrasound Guided Quadratus Lumborum Block and Erector Spinae Plane Block as an Analgesic Modality in Renal Transplant Donors
Open surgery remains one of the approaches used for those patients requiring partial or radical nephrectomy and is associated with a high incidence of intense immediate postoperative pain (Gupta et al., 2013; Bravi et al., 2019).
- Trial name
- NCT07749040
- Testing
- Renal transplantation
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain
Analgesic Effect of Levobupivacaine in Breast Augmentation
The purpose of this study is to determine whether levobupivacaine is effective in the acute postoperative pain treatment in periprosthetic breast augmentation
- Trial name
- NCT02465008
- Testing
- Levobupivacaine
- Volunteers
- 66 people
- Sponsor
- General University Hospital of Valencia
Outpatient Use of Analgesics in Children and Adolescents
Outpatient Use of Analgesics in Children and Adolescents in France
outpatient use of analgesics in children and adolescents in France from 2012 to 2015
- Trial name
- NCT03371043
- Testing
- users of analgesic medications
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Surgery, Postoperative Pain
Erector Spinae Plane (ESP) Block With 20 ml Versus 30 ml in Cardiac Surgery
Even though erector spinae plane (ESP) block is shown to be efficient in cardiac surgery, it is still controversial how much volume is necessary for efficient analgesic effect for sternotomy and drain tube pain relief.
- Trial name
- NCT04928521
- Testing
- bilateral erector spinae plane block with 30 mL 0.25 % bupivacaine, bilateral erector spinae plane block with 20 mL 0.25 % bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ankara City Hospital Bilkent
Pain, Breast Feeding
Non-pharmacological Analgesic Effects on Term Newborns
The purpose of this study is to compare the analgesic effects of four non-pharmacological interventions: skin-to-skin contact, breastfeeding, oral sucrose and nonnutritive sucking in newborns receiving a heel lance procedure.
- Trial name
- NCT03421158
- Testing
- breastfeeding, oral sucrose, Skin-to-Skin contact
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Stanford University
Opioid Dependency
A Six-Month Randomized Controlled Trial (RCT) of Probuphine Safety and Efficacy in Opioid Addiction
Probuphine (buprenorphine implant) is an implant placed just below the skin containing buprenorphine (BPN). BPN is an approved treatment for opioid dependence. This study will confirm the efficacy of Probuphine vs.
- Trial name
- NCT01114308
- Testing
- Probuphine (buprenorphine implant), Buprenorphine
- Where
- 20 sites in United States
- Volunteers
- 287 people
- Sponsor
- Titan Pharmaceuticals
Pain, Postoperative
Effective Postoperative Pain Relief After Laparoscopic Cholecystectomy With TENS
The study evaluates the effect of TENS (transcutaneous electrical nerve stimulation) treatment for first line of treatment compared with conventional treatment with opioids on pain relief and time spent time in the…
- Trial name
- NCT04114149
- Testing
- TENS (transcutaneous electrical nerve stimulation), iv opioid
- Where
- Sweden
- Volunteers
- 166 people
- Sponsor
- Göteborg University
Thoracic Surgery, Analgesics, Opioid
Opioid Free Anesthesia in Thoracic Surgery
Proper assessment of pain and adequate analgesia in thoracic surgery is a challenging issue for medical practitioners. Basic aspects of thoracic anaesthesia are general anesthesia, intubation with double lumen tube and separation…
- Conditions
- Thoracic Surgery, Analgesics, Opioid, Anesthesia, Conduction
- Trial name
- NCT04355468
- Testing
- Opioid Anesthesia, Opioid Free Anaesthesia
- Where
- Poland
- Volunteers
- 66 people
- Sponsor
- Medical University of Silesia
Postoperative Pain, Regional Anaesthsia
Parasternal and Adductor Canal Blocks in CABG
This randomized controlled trial evaluates the effectiveness of different postoperative analgesic strategies in patients undergoing coronary artery bypass graft (CABG) surgery.
- Conditions
- Postoperative Pain, Regional Anaesthsia, Pain Management
- Trial name
- NCT07599748
- Testing
- parasternal block, Parasternal block + Adductor canal block, conventional analgesic regimen
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Zonguldak Bulent Ecevit University
Anesthesia, Local
Comparing Analgesic Effects of Three Ultrasound Guided Regional Anesthetic Techniques in Pediatrics
This study evaluates analgesic effects of ultrasound-guided (USG) regional anesthetic techniques; caudal block , transversus abdominis plane (TAP) block and quadratus lumborum block (QLB) by comparing postoperative pain scores […
- Trial name
- NCT03780790
- Testing
- Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Istanbul University
Anesthesia, Local
Analgesic Efficacy of Lidocaine Plus Bupivacaine Versus Bupivacaine Alone Caudally
Optimal analgesia following ambulatory surgery is an important matter for patient satisfaction and it reduces unnecessary hospital admissions.
- Trial name
- NCT03911648
- Testing
- 0.5 ml.kg-1 bupivacaine 0.25%, 0.5 ml.kg-1 bupivacaine 0.25% with the addition of 3 mg/kg lidocaine 1%
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Ayancık State Hospital
Abdominal Pain
Lateral Quadratus Lumborum Block Versus Transversus Abdominis Plane Block in Laparoscopic Surgery
The transversus abdominis plane (TAP) block is an already established technique and is considered now as an efficient part of the multimodal pain management approach for abdominal surgical procedures.
- Trial name
- NCT04553991
- Testing
- Ultrasound guided QL block, Ultrasound guided TAP block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Fayoum University Hospital
Laparoscopic Cholecystectomy, Pain
A Randomized, Double-Blind Study of the Efficacy and Safety of Valdecoxib Compared to Placebo for Treatment of Post- Cholecystectomy Surgery Pain
To evaluate the analgesic efficacy, general safety, and effects on health outcome measures and opioid-related symptoms of 2 valdecoxib dosing regimens compared with placebo in patients with moderate or severe pain following…
- Trial name
- NCT00661635
- Testing
- valdecoxib
- Where
- 65 sites in United States
- Volunteers
- 490 people
- Sponsor
- Pfizer
Cervical Spine Surgery
Analgesic Efficacy of the Novel Intra- Semispinal Fascial Plane Block in Posterior Cervical Spine Surgery
Posterior cervical spine surgery often requires a large posterior midline incision, resulting in poorly controlled postoperative pain, which arises from iatrogenic mechanical damage, intraoperative retraction, and resection to…
- Trial name
- NCT04974658
- Testing
- Inter-semispinal plane block
- Where
- 2 sites in Egypt
- Volunteers
- 52 people
- Sponsor
- Zagazig University
Multimodal Analgesia, Nonsteroidal Anti-inflammatory Drugs
NSAID vs. Narcotics
This will be a single-center, prospective observational study. The study will compare post-operative pain scores and narcotic consumption between two groups of patients - one cohort will receive ibuprofen (Motrin) and Percocet…
- Trial name
- NCT02915055
- Testing
- Ibuprofen 600 mg, standard oxycodone/acetaminophen
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Adverse Effects in the Therapeutic Use of Analgesic, Antipyretic and Anti-Inflammatory Drug, Unspecified
A Prospective Study on the Comparison of Postoperative Pain According to the Use of Cocktail Therapy in Laminoplasty
This study is the first prospective randomized controlled trial to analyze the effects and safety of multimodal cocktail injections after cervical laminoplasty
- Trial name
- NCT06113497
- Testing
- Cocktail injection
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.