Clinical trials: Analgesic
Schwannomatosis, Pain
Phase 2 Study of Tanezumab in Subjects With Moderate to Severe Pain Due to Schwannomatosis
The primary objective of this study is to determine whether the administration of tanezumab, an anti-nerve growth factor (NGF) antibody, improves pain relief in schwannomatosis patients receiving background non-NSAID therapy.
- Trial name
- NCT04163419
- Testing
- Tanezumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
Postoperative Pain, Ultrasound Guided Nerve Block
Analgesic Efficacy of Trans-muscular Quadratus Lumborum Block After Unilateral Inguinal Hernia Repair
A significant component of pain experienced after abdominal surgery is related to incision of the abdominal wall and adequate analgesia can be a challenge.
- Trial name
- NCT03526731
- Testing
- ultrasound guided quadratus lumborum block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Pain, Postoperative, Anterior Cruciate Ligament Injuries
IPACK on Early Pain Scores After ACL Reconstruction
The goal of this clinical trial is to learn whether using an anesthetic technique called IPACK block will control pain after ACL reconstruction surgery.
- Conditions
- Pain, Postoperative, Anterior Cruciate Ligament Injuries, Analgesics, Opioid
- Trial name
- NCT05985629
- Testing
- IPACK
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Loyola University
SNIIRAM Database
Suicidal Risk Factors Associated With Opioid Analgesics Use
There is an increase in prescriptions for analgesics opioids and overdose mortality in France. In the United States, the consumption of opioid analgesics is associated with excess mortality, especially suicide.
- Trial name
- SANTE (NCT04211077)
- Testing
- Date collection
- Where
- France
- Volunteers
- 273,221 people
- Sponsor
- University Hospital, Montpellier
Diabetes Mellitus, Diabetic Neuropathy
Anodyne Therapy in Diabetic Sensory Neuropathy
The purpose of this research study is to determine if the use of a series of the Anodyne Therapy System in-home treatments over a 90-day period will improve peripheral sensation and quality of life in persons with diabetes…
- Trial name
- NCT00120341
- Testing
- Anodyne Therapy System
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Scott and White Hospital & Clinic
Pain
Comparison Between Two Analgesic Methods for Pain Relief Following Surgical Abortion
To compare between the efficacy of Paracetamol IV vs. Lornoxicam IV in pain relief following surgical abortion. The medication will be given at the time of the procedure. Following the abortion, pain level will be evaluated.
- Trial name
- NCT02025166
- Testing
- Paracetamol, lornoxicam
- Where
- Israel
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Varicocelectomy
Sedative and Analgesic Effects of Dexmedetomidine Versus Ketamine in Patients Undergoing Varicocelectomy Under Spinal Anaesthesia: A Prospective Randomized Comparative Trial
The demand for safe and effective sedation during spinal anesthesia has increased in recent years, particularly in ambulatory and minor surgical procedures.
- Trial name
- NCT07214701
- Testing
- Ketamine (0.5 mg/kg), Dexmedetomidine
- Volunteers
- 58 people
- Sponsor
- Assiut University
Bone Metastasis, Cancer Pain
Phase 3 Study on the Efficacy and Safety of Tanezumab in Patients With Cancer Pain Due to Bone Metastasis Who Are Taking Background Opioid Therapy
The purpose of this study is to determine whether tanezumab is effective in the treatment of cancer pain due to bone metastasis in patients already taking background opioid therapy.
- Trial name
- NCT02609828
- Testing
- Tanezumab
- Where
- 89 sites in Argentina, Australia and 14 more
- Volunteers
- 156 people
- Sponsor
- Pfizer
Pain, Postoperative, Acute Pain
EFFECT - EFFectiveness of ESPB (Erector Spinae Plane Block) in Laparoscopic Cοlectomies Trial
The aim of the trial is to study the efficacy of continuous bilateral Erector Spinae Plane Block (ESPB) in managing perioperative pain in patients who undergo elective laparoscopic colectomy.
- Conditions
- Pain, Postoperative, Acute Pain, Postoperative Complications, Pain
- Trial name
- EFFECT (NCT04879004)
- Testing
- Ropivacaine injection
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Democritus University of Thrace
Pain
Ultrasonography-guided and Surgical Rectus Sheath Block in Single-port Access Laparoscopy
Rectus sheath block is effective in reducing pain in the peri-umbilical region, and the use of ultrasonography is recommended to perform the block at the precise location.
- Trial name
- NCT02431065
- Testing
- Rectus sheath block, Ropivacaine, Normal saline
- Volunteers
- 30 people
- Sponsor
- Chungnam National University Hospital
Postoperative Pain
The Analgesic Effect of QLB II After Robotic Prostatectomy. (QLB II: Quadratus Lomborum Block II Type)
The analgesic effects of Quadratus Lomborum Block II type after robotic-assisted laparoscopic radical prostatectomy, will be assessed.
- Trial name
- QLBII (NCT03941899)
- Testing
- Levobupivacaine in QLB II
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Herpes Zoster, Pain
The Analgesic Efficacy and Safety of Desvenlafaxine in Patients With Herpes Zoster
Herpes zoster (HZ) is characterized by a painful dermatomal rash and significantly affects quality of life, with acute pain increasing the risk of postherpetic neuralgia.
- Trial name
- NCT07361809
- Testing
- Desvenlafaxine combined conventional therapy, Conventional therapy
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Beijing Tiantan Hospital
Ankyloglossia
Analgesic Effect of Inhaled Lavender Essential Oil for Clipping of Tongue-ties
Clipping of the tongue-tie is a common procedure that neonatologists perform in our neonatal unit to help establish breastfeeding.
- Trial name
- LEO-SME1 (NCT04877392)
- Testing
- Lavender essential oil
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Parc de Salut Mar
Intrathecal Dexmedetomidine, Bupivacaine
Intrathecal Dexmedetomidine With Bupivacaine, in Patients Undergoing Knee Orthopedic Surgery
This study aims to compare the duration of analgesia (as the primary outcome) and adverse effects (as the secondary outcome) after intrathecal administration of dexmedetomidine with hyperbaric bupivacaine to patients undergoing…
- Conditions
- Intrathecal Dexmedetomidine, Bupivacaine, Knee Orthopedic Surgery
- Trial name
- NCT07522736
- Testing
- Dexmedetomidine 4 μg, Dexmedetomidine 8 μg, Dexmedetomidine 12 μg
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Hip Arthroplasty, Anesthesia, Regional
FAB Block vs. Placebo for Hip Arthroplasty Patients
Hip arthroplasty surgery can be associated with significant pain. A regional anesthesia technique, the femoral articular branch block (FAB), has recently been proposed to collectively block terminal femoral and accessory…
- Conditions
- Hip Arthroplasty, Anesthesia, Regional, Femoral Articular Branch Block
- Trial name
- NCT04301687
- Testing
- Femoral Articular Branch Block
- Volunteers
- 95 people
- Sponsor
- Women's College Hospital
Low Back Pain
Fatty Infiltration in Paraspinal Muscles and Lumbar Erector Spina Plane Block
This study aimed to investigate the relationship between fatty infiltration in the lumbar paraspinal (multifidus and erector spinae) muscles, clinical characteristics, and treatment response after lumbar erector spinae plane…
- Trial name
- NCT06208865
- Testing
- lumbar erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 147 people
- Sponsor
- Diskapi Teaching and Research Hospital
Pain, Chronic Widespread Pain
Enhancing Analgesia in Chronic Pain Through Exercise
Background: Current pain management strategies for pediatric patients are not integrating the analgesic potential of movement-based therapies.
- Conditions
- Pain, Chronic Widespread Pain, Fibromyalgia
- Trial name
- NCT04862871
- Testing
- Physical Activity - Pediatric Pain Rehabilitation Center
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Inguinal Hernia Unilateral
Comparison of Quadro-Iliac Plane Block and Transversalis Fascia Plane Block for Open Inguinal Hernia Repair
This prospective observational cohort study aims to compare the postoperative analgesic effectiveness of the quadro-iliac plane block (QIPB) and transversalis fascia plane block (TFPB) in patients undergoing elective unilateral…
- Trial name
- NCT07864064
- Testing
- Quadro iliac Plane Block, Transversalis Fascia Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Vezirköprü State Hospital
Postoperative Pain
An Efficacy and Safety Study to Compare Morphine 6-glucuronide (M6G) and Morphine in Patients Suffering With Post-Operative Pain for at Least 24 Hours
To compare the incidence and severity of nausea in the study treatment groups, during the 18-hour period starting 6 hours after titration to pain relief; following confirmation of the assumption of non-inferiority between the two…
- Trial name
- NCT01082471
- Testing
- Morphine 6-glucuronide, Morphine
- Where
- 7 sites in Czechia, France and 4 more
- Volunteers
- 517 people
- Sponsor
- Paion UK Ltd.
Elective Cesarean Section, Pain Management
Efficacy and Safety of EXPAREL Versus Standard of Care (SoC) in Subjects Undergoing Elective Cesarean Section
The purpose of this study is to compare total opioid consumption by subjects in different treatment groups. Another purpose of this study is to assess how well EXPAREL works, collect any safety data and assess your satisfaction…
- Trial name
- CHOICE (NCT03853694)
- Testing
- 50 mcg Duramorph+ EXPAREL + multi-modal pain regimen, 150 mcg Duramorph + multi-modal pain regimen, Exparel TAP + multi-modal pain regimen
- Where
- 18 sites in United States
- Volunteers
- 167 people
- Sponsor
- Pacira Pharmaceuticals, Inc
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