Clinical trials: Analgesic Effect
Children, Inguinal Hernia
Tamadol Wound Infiltration in Children Under Inguinal Hernioplasty
Tramadol is a centrally acting analgesic, is primarily Indicated for the treatment of acute pain, moderate to severe. The hernioplasty in children is an outpatient procedure, and the possibility of postoperative analgesia with…
- Trial name
- NCT01943760
- Testing
- tramadol, 0.9% saline
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Arthroscopic Shoulder Surgery
Comparison of the Analgesic Effects of Catheter-Based Versus Single-Shot Serratus Posterior Superior Intercostal Plane Block in Arthroscopic Shoulder Surgery
Patients undergoing arthroscopic shoulder surgery often experience moderate to severe postoperative pain. Various medical treatments are employed to provide analgesia for these patients.
- Trial name
- NCT06826846
- Testing
- Serratus posterior superior intercostal plane block (single-shot), Serratus posterior superior intercostal plane block (catheter-based intermittent bolus)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Goztepe Prof Dr Suleyman Yalcın City Hospital
Pacemaker Implantation, Pain
Effect of Local Anesthetic EMLA (Lidocaine 2.5% and Prilocaine 2.5%) Cream and Reduction in Dose, Pain and Intravenous Analgesic During Permanent Pacemaker Implantation
The investigators believe that the local anesthetic EMLA (Lidocaine 2.5% and Prilocaine 2.5%) cream will lessen pain and reduce the need for anesthesia and analgesia, when implanting a permanent pacemaker.
- Trial name
- NCT02016976
- Testing
- EMLA Analgesic Cream, Dormicum 2.5 mg and Pethidine 25 mg
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hillel Yaffe Medical Center
Migraine, Analgesic Affect
Comparision of the Analgesic Effects of Intravenous Ibuprofen and Tenoxicam in Acute Migraine Attack
The aim of this clinical trial is to compare the efficacy of two different non-steroidal anti-inflammatory analgesic drugs in the palliation of headache in acute migraine attack. The main questions it aims to answer are: 1.
- Conditions
- Migraine, Analgesic Affect, Emergency Medicine
- Trial name
- NCT06786650
- Testing
- Tenoxicam Injectable Product, ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Postoperative Pain, Nerve Block
Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery
The TTP block is a novel regional anesthetic technique that shows promise in providing analgesia for anterior chest wall incisions and median sternotomy.
- Conditions
- Postoperative Pain, Nerve Block, Cardiac Surgery
- Trial name
- NCT03128346
- Testing
- Transthoracic Transversus Plane Block, Hydromorphone Hydrochloride, Aspirin
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Western University, Canada
Post Operative Pain
The Efficacy of PSB and Recto-intercostal Block Combination on Postoperative Pain in Patients Undergoing Cardiac Surgery Via Sternotomy: Case Series
The aim of this study was to investigate the effectiveness of the combination of Superficial Parasternal Block and Recto-Intercostal Fascial Plane Block in patient groups undergoing cardiac surgery via sternotomy by evaluating…
- Trial name
- NCT06553560
- Testing
- Parasternal Block and Recto-İntercostal Fascial Plane Block
- Volunteers
- 10 people
- Sponsor
- Cumhuriyet University
Arthroscopy
Effect of Celecoxib Versus Placebo Before and After Knee Surgery on the Overall Use of Analgesics After Surgery
To compare the total analgesic use at 24 hours after arthroscopic knee surgery in patients treated with celecoxib versus placebo.
- Trial name
- NCT00633386
- Testing
- Celecoxib
- Where
- 9 sites in United States
- Volunteers
- 200 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Total Knee Arthroplasty
The Analgesic Effect of Nitroglycerin Patch for Postoperative Pain After Total Knee Replacement
Patients who undergo general anestheesia for total knee arthroplasty pften have sever postoperative pain which hinders their rehabilitation.
- Trial name
- NCT00375362
- Testing
- Nitroderm patch
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Hip Pain Chronic
Comparison of the Analgesic Efficacy and Duration of Analgesic Effect of Pericapsular Nerve Group Block Block Application With PENG Block and Pulse Radiofrequency Ablation in Chronic Hip Pain
Comparison of the analgesic efficacy and duration of analgesic effect of PENG block application with PENG block and pulse radiofrequency ablation in chronic hip pain.
- Trial name
- NCT06728488
- Testing
- PENG Block, PENG block and pulse radiofrequency ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Pain
The Impact of Local Analgesia for Postoperative Analgesia in Posterior Thoracolumbar Operation
Posterior thoracolumbar operation always chooses general anesthesia. Due to surgical trauma and rich periosteum and joint capsule innervation, patients after general anesthesia immediately feel acute pain.The use of appropriate…
- Trial name
- NCT01872494
- Testing
- local, intravenous, 0.33% ropivacaine 250ml
- Where
- China
- Volunteers
- 71 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Colo-rectal Cancer
Does Omission of NSAIDs After Colorectal Cancer Operation Affect the Consumption of Opioids?
Patients undergoing an operation for colorectal cancer are normally treated with non-steroid-anti-inflammatory-drugs (NSAIDs) e.g. ibuprofen as pain medication after the operation.
- Trial name
- NCT04448652
- Testing
- NSAID
- Where
- Denmark
- Volunteers
- 502 people
- Sponsor
- Zealand University Hospital
Opioid Use, Post Operative Pain
Comparing Intrathecal Morphine With Erector Spina Plane Block in Open Gastrectomy Surgery
Open gastrectomy causes severe postoperative pain due to wide surgical incisions, retraction of the abdominal wall and direct manipulation of the visceral organs.
- Conditions
- Opioid Use, Post Operative Pain, Pain Assessment Scales
- Trial name
- NCT05706285
- Testing
- Regional Block Comparison
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Marmara University
Pain, Procedural, Pain, Acute
Effect of Reflexology on Pain Management in Newborns
Introduction: Approximately 10-14 painful procedures per day are performed in preterm and term infants during the hospital stay in the first week.
- Conditions
- Pain, Procedural, Pain, Acute, Analgesia
- Trial name
- NCT05235893
- Testing
- Reflexology, Sucrose %24, Kangaroo care
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Marmara University
Dexmedetomidine, External Oblique Intercostal Plane Block
Different Doses of Dexmedetomidine in External Oblique Intercostal Plane Block in Splenectomy
The aim of this study is to compare the analgesic effects of different doses of dexmedetomidine as an adjuvant in external oblique intercostal plane block (EOIPB) in splenectomy.
- Conditions
- Dexmedetomidine, External Oblique Intercostal Plane Block, Splenectomy
- Trial name
- NCT06363578
- Testing
- Dexmedetomidine 0.5 μg/kg, Dexmedetomidine 1 μg/kg
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Healhty
Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants
This study investigates whether MDMA may have a pain-reducing effect. The effect of MDMA is compared with a placebo (a substance with no active effect).
- Trial name
- MDPS (NCT07494214)
- Testing
- MDMA 25 mg, MDMA 75 mg, MDMA 125 mg
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Pain
The Effect Of Ultrasound-guided Modified Pectoral Nerves Block Versus Ketamine Plus Magnesium Infusion On Analgesic Profile In Breast Cancer Surgeries
Background: Postoperative pain is one of the greatest patient concerns following surgery. However, general anesthesia cannot provide adequate postoperative pain control and the routine use of parenteral opioids aggravates…
- Trial name
- NCT04095455
- Testing
- pectoral nerves block group, Ketamine plus magnesium group, Control group
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute, Egypt
Postoperative Pain
Erector Spinae Plane Block and Oblique Subcostal Transverse Abdominis Plane Block in Laparoscopic Cholecystectomy
Erector Spinae Plane Block is a newly defined regional anesthesia technique. Its use for many indications has been identified by case reports in the literature.
- Trial name
- NCT03508531
- Testing
- ESP Block, OSTAP block, Standard Pain Followup and Monitorization
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Maltepe University
Varicocelectomy
Sedative and Analgesic Effects of Dexmedetomidine Versus Ketamine in Patients Undergoing Varicocelectomy Under Spinal Anaesthesia: A Prospective Randomized Comparative Trial
The demand for safe and effective sedation during spinal anesthesia has increased in recent years, particularly in ambulatory and minor surgical procedures.
- Trial name
- NCT07214701
- Testing
- Ketamine (0.5 mg/kg), Dexmedetomidine
- Volunteers
- 58 people
- Sponsor
- Assiut University
Pharmacoresistant Neuropathic Pain
Analgesic Effect of Non Invasive Stimulation : Comparison of rTMS and tDCS Efficacy
The aim of this study is to compare analgesic efficacy of two non invasive techniques based on motor cortex stimulation in neuropathic pain patients.
- Trial name
- NI-MCS (NCT01800136)
- Testing
- Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Pain
Comparison Between the Analgesic Effectiveness of Virtual Reality and Topical Anesthesia: A Clinical Study
A split-mouth, controlled trial aimed to clinically compare and evaluate the effectiveness of virtual reality versus topical anesthesia gel prior to administration of dental anesthesia injection in reducing the perceived pain and…
- Trial name
- NCT04919421
- Testing
- Dental injection and topical gel application, Dental injection and virtual reality device
- Where
- Saudi Arabia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University