Clinical trials: Analgesic Effect
Opioid Analgesic Adverse Reaction
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia
Pain is 'a double-edged sword', disturbing daily life of the sufferers and activating the intrinsic protective mechanisms. Transient receptor potential vanilloid 1 (TRPV1), play such role as 'a double agent', transmitting the…
- Trial name
- NCT04553536
- Testing
- Esketamine, Sulfentanil or/and Remifentanil
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Hospital of Shanxi Medical University
Obesity
Erector Spina Plane Block in Laparoscopic Sleeve Gastrectomy Surgery
The aim of the study is to evaluate the effect of erector spina plane (ESP) block on pulmonary functions and postoperative analgesic consumption in patients undergoing bariatric surgery.
- Trial name
- NCT04039321
- Testing
- ESPB group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Antalya Training and Research Hospital
Leukemia, Leukemia, Myeloid
Natural Killer Cell (CYNK-001) Infusions in Adults with AML
This study will find the maximum tolerated dose or the maximum planned dose of CYNK-001 which contains natural killer (NK) cells derived from human placental CD34+ cells and culture-expanded.
- Conditions
- Leukemia, Leukemia, Myeloid, Leukemia, Myeloid, Acute, Neoplasms by Histologic Type
- Trial name
- CYNK001AML01 (NCT04310592)
- Testing
- CYNK-001
- Where
- 10 sites in United States
- Volunteers
- 27 people
- Sponsor
- Celularity Incorporated
Healthy
Assessment of the Analgesic Effects of PF-05089771 and Pregabalin in Healthy Volunteers Using Evoked Pain Endpoints
This study will examine the activity of PF-05089771 and pregabalin, alone and in combination on a panel of evoked pain tests carried out from 0.5 to 10 hours following oral dosing in healthy male subjects
- Trial name
- NCT02349607
- Testing
- PF-05089771 300mg, PF-05089771 300 mg + pregabalin 300 mg, pregabalin 300 mg
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Pfizer
Craniosynostosis Repair, Untethering of Cord
The Effect of Gender on the Consumption of Pain Medication in Infants Undergoing Craniosynostosis Repair or Untethering of Cord in ITU
Postoperative pain is a major concern in routine management of children admitted to pediatric intensive care treatment. There are significant negative physiological and psychological ramifications of postoperative pain such as…
- Trial name
- NCT01996163
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Coronavirus, Coronavirus Infection
Natural Killer Cell (CYNK-001) Infusions in Adults With COVID-19
This study is a Phase 1 / 2 trial to determine the safety and efficacy of CYNK-001, an immunotherapy containing Natural Killer (NK) cells derived from human placental CD34+ cells and culture-expanded, in patients with moderate…
- Conditions
- Coronavirus, Coronavirus Infection, Severe Acute Respiratory Syndrome Coronavirus 2, Pneumonia
- Trial name
- CYNKCOVID (NCT04365101)
- Testing
- CYNK-001
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- Celularity Incorporated
Pain Postoperative, Caesarean Section; Pain
Supportive Analgesic Effect of Auricular Acupressure (AA) After Cesarean Section (CS)
Introduction: Severe acute pain after cesarean section is an independent risk factor for the development of chronic pain and increases the risk of postpartum depression threefold.
- Trial name
- AA-CS (NCT07322601)
- Testing
- Auricular Acupressure
- Where
- Vietnam
- Volunteers
- 70 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Painless Labor, Epidural Analgesia
The Post Cesarean Section Analgesic Effect of Various Quadratus Lumborum Block Approaches
included patients were divided into 4 groups and each group received a mode of post cesarian section analgesia and pain was assessed by visual analogue scale at rest and movement. 1. st group epidural analgesia 2.
- Conditions
- Painless Labor, Epidural Analgesia, Cesarean Section
- Trial name
- NCT06393192
- Testing
- Epidural analgesia (EA) only group, Quadratus lumborum block (QL2), Quadratus lumborum block 3(QL3)
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Sohag University
Chronic Pain
Observational Study of the Analgesic Effect of Treatment With rTMS in Patients With Chronic Neuropathic Pain
For ten years, rTMS, repetitive transcranial magnetic stimulation of the motor cortex, has found its place in the treatment of drug-resistant neuropathic pain.
- Trial name
- rTMSDOULNEURO (NCT02506699)
- Testing
- analgesic effect of rTMS
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen
Maxillofacial Injuries
Ultrasound Guided Trigeminal Nerve Block in Maxillofacial Surgeries
This study aims to evaluate the perioperative analgesic effect of USG Trigeminal Nerve Block in adult patients undergoing maxillofacial surgery.
- Trial name
- NCT05567497
- Testing
- trigeminal nerve block
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Suez Canal University
Neuropathic Pain, Reflex Sympathetic Dystrophy
Effects of Vaporized Marijuana on Neuropathic Pain
This study theorized that a low dose of vaporized cannabis could alleviate nerve injury pain.
- Conditions
- Neuropathic Pain, Reflex Sympathetic Dystrophy, Peripheral Neuropathy, Post-herpetic Neuralgia
- Trial name
- NCT01037088
- Testing
- Mild dose cannabis, Low dose cannabis, Cannabis
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, Davis
Pain
The Neurobiology of Expectancy and Pain Perception
This study will use using fMRI (functional Magnetic Resonance Imaging) to elucidate how contextual learning/expectation relieves or aggravates pain experience in the same cohort of subjects and the same study session.
- Trial name
- NCT01575106
- Testing
- Heat pain applied using TSA or CHEPS
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Surgery
Analgesic Effect of Ibuprofen, Paracetamol (Acetaminophen), and Paracetamol (Acetaminophen) Plus Codeine on Acute Pain
The purpose of this placebo controlled clinical trial is to evaluate the dose response relationship of ibuprofen in doses from 400 mg to 800 mg and paracetamol (acetaminophen)in doses from 500 mg to 1000 mg compared with…
- Trial name
- NCT00699114
- Testing
- Ibuprofen 400 mg, Ibuprofen 600 mg, Ibuprofen 800 mg
- Where
- Norway
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Mild Cognitive Impairment (MCI), Opioid Use
Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment
Mild cognitive impairment (MCI) affects a substantial proportion of older adults undergoing major surgery and may alter pain processing, pain experience, and opioid use after surgery.
- Conditions
- Mild Cognitive Impairment (MCI), Opioid Use, Cognitive Dysfunction, Postoperative Pain
- Trial name
- NCT07885085
- Where
- United States
- Volunteers
- 552 people
- Sponsor
- Miklos Kertai
Rib Fractures, Pain
Analgesic Effect of Intranasal Calcitonin on Patients With Fractured Ribs
This study, which will be conducted at the emergency room of the Sacré-Cœur hospital, requires the recruitment of 60 subjects and involves some telephone follow-up.
- Trial name
- NCT00444808
- Testing
- Intranasal calcitonin
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Université de Montréal
Arthroscopy, Analgesia
Ultrasound-Guided Extrafascial Versus Intrafascial Interscalene Brachial Plexus Block in Shoulder Arthroscopy
The aim of the study is to compare the diaphragmatic excursion and postoperative analgesia in the extrafascial versus intrafascial Interscalene brachial plexus block in patients undergoing shoulder arthroscopy.
- Conditions
- Arthroscopy, Analgesia, Intrafascial Interscalene Brachial Plexus Block
- Trial name
- NCT05222334
- Testing
- Intrafascial interscalene brachial plexus block, Extrafascial interscalene brachial plexus block group, Bupivacaine
- Volunteers
- 50 people
- Sponsor
- Tanta University
Labor Pain, Pregnancy
Neuraxial Versus Systemic Analgesia for Latent Phase Labor Effect on Rate of Operative Delivery
The purpose of this study in nulliparous women undergoing induction of labor is to determine whether initiation of neuraxial analgesia compared to systemic opioid analgesia early in labor (< 4 cm cervical dilation)affects the…
- Trial name
- NCT00380978
- Testing
- combined spinal epidural analgesia, late analgesia (systemic)
- Where
- United States
- Volunteers
- 1,026 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pain Due to Certain Specified Procedures
Pilot Study of Sucrose to Reduce Pain in Sick Babies
Small amounts of sweet tasting sugar water reduces pain in babies during painful blood tests and injections. The investigators do not know if sugar also reduces pain in babies already receiving a continuous infusion of opioid…
- Trial name
- NCT01438008
- Testing
- 24% sucrose po solution
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Myotoxicity
Effects of Postoperative Analgesic Modalities on Plasma Creatine Phosphokinase(CPK) Levels After Knee Artroplasty
Regional anesthesia and analgesia technics are widely and securely used during orthopedic surgery. Interfascial plane blocks are the latest used ones for analgesia.
- Trial name
- NCT05505890
- Testing
- suprainguinal fascia iliaca block
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Samsun University
Fibromyalgia Syndrome
Evaluation of the Antinociceptive and Analgesic Effects of Milnacipran
Evaluation of the antinociceptive effect of 7 weeks of treatment with milnacipran, compared to placebo, in fibromyalgia out-patients
- Trial name
- NCT00757679
- Testing
- Milnacipran
- Where
- Switzerland
- Volunteers
- 153 people
- Sponsor
- Pierre Fabre Medicament