Clinical trials: Analgesic Effect
Pain, Postoperative
Analgesic Effect of Laser Therapy in Children
Pain management after tonsillectomy could be challenging, with different protocols and various outcome depending on individual patient; moreover, odynophagia due to surgery can, in extreme cases, lead to block oral fluid intake…
- Trial name
- NCT04693208
- Testing
- Laser therapy
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- IRCCS Burlo Garofolo
Peripheral Nerve Block, Pain
The Analgesic Effect of Combined Nerve Block and Systemic High Dose Glucocorticoid After Total Knee Arthroplasty.
Purpose: The purpose of this study is to evaluate the postoperative analgesic effect of a combined Saphenous nerve block and Obturator nerve block with local infiltration analgesia in the tissue around the knee after total…
- Trial name
- HOBSALIplus (NCT02374008)
- Testing
- Ropivacaine
- Volunteers
- 74 people
- Sponsor
- Regionshospitalet Silkeborg
Inguinal Hernia, Postoperative Pain
Safety, Tolerability, PK, and Analgesic Effect of INL-001 in Children Following Open Inguinal Hernia Repair
A multicenter, single-dose study in children 12 to <17 years of age, 6 to <12 years of age, and 2 to <6 years of age who are scheduled for elective open inguinal hernia repair.
- Trial name
- NCT03262688
- Testing
- Bupivacaine HCl collagen-matrix implant, Bupivacaine HCl infiltration
- Where
- 11 sites in United States
- Volunteers
- 159 people
- Sponsor
- Innocoll
Neonatal Abstinence Syndrome
Non-Opiate Treatment After Prenatal Opiate Exposure to Prevent Postnatal Injury to the Young Brain
The long term goals of our research are to establish the best pharmacological treatment for NAS and determine how pharmacologic treatment of NAS affects long-term developmental outcomes.
- Trial name
- No-POPPY (NCT03396588)
- Testing
- Clonidine, Morphine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Henrietta Bada
Post-endodontic Pain
Comparison Of The Effect Of Final Rinse Of Tramadol and Dexamethasone on Post-Endodontic Pain in Teeth With SIP
Briefly, 105 teeth with symptomatic irreversible pulpitis will be included in the study and randomly allocated to three groups (A, B and C).
- Trial name
- NCT07036237
- Testing
- Tramadol group, Dexamethasone Group
- Where
- Pakistan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Postoperative Pain
Effect of Intravenous Dexmedetomidine on Analgesic Duration of Infraclavicular Block
The study will evaluate the effect of Dexmedetomidine sedation on the duration of infraclavicular block in patients scheduled for surgery of elbow, forearm and/or hand.
- Trial name
- NCT01981369
- Testing
- Dexmedetomidine, Propofol, Infraclavicular block
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Laparoscopic Gynecological Surgery
Bellomic PCA in Laparoscopic Gynecologic Surgery
In laparoscopic gynecological surgery, when intravenous patient-controlled analgesia (IV-PCA) device is used after surgery, the degree of postoperative side effects and pain control is compared when a combination of fentanyl and…
- Trial name
- NCT05489796
- Testing
- Fentanyl selector, Fentanyl continuous, Ketorolac continuous
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul National University Bundang Hospital
Postoperative Analgesia, S-ketamine
Analgesic Effects of Caudal S-ketamine for Supplementation of Ropivacaine Caudal Analgesia in Children With Hypospadias
Caudal analgesia with ropivacaine is commonly used in sub-umbilical pediatric surgery. However, increasing the dosage of ropivacaine has not been found to prolong the action significantly while complications will be serious.
- Conditions
- Postoperative Analgesia, S-ketamine, Pediatrics, Caudal Block
- Trial name
- NCT05922605
- Testing
- S-ketamine & Ropivacaine, Ropivacaine
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Tao Zhang
Postoperative Pain, Acute
Dexamedatomidine vs. Dexamethasone in Rhomboidal Intercostal Plain Block and Subserratus Block in Breast Surgery
The aim of this study is to evaluate the analgesic efficacy and safety of adding dexmedetomidine and dexamethasone to bupivacaine in rhomboidal intercostal and subserratus (RISS) block for patients undergoing modified radical…
- Trial name
- NCT05385523
- Testing
- Rhomboid Intercostal and Sub-Serratus block technique (RISS), General Anaesthesia, dexamedatomidine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Armed Forces College of Medicine, Cairo, Egypt
Preemptive Analgesia, Sex Difference
Sex Difference in Preemptive Analgesic Effects With Flurbiprofen Axetil on Postoperative Pain and Sleep Quality
In humans and animals, circadian rhythm sleep cycle plays an important role on maintaining and regulating basic physiological homeostasis, such as cognitive function, glucose metabolism, memory consolidation, immune function and…
- Conditions
- Preemptive Analgesia, Sex Difference, Flurbiprofen Axetil, Postoperative Pain
- Trial name
- NCT04627779
- Testing
- preemptive analgesia with flurbiprofen axetil
- Volunteers
- 100 people
- Sponsor
- Beijing Friendship Hospital
Hemorrhoid
Subarachnoid or Infiltration for Hemorrhoidectomy
There will be compared the postoperative analgesic effect of infiltration or spinal block for hemorrhoidectomy
- Trial name
- NCT01927874
- Testing
- Infiltration, Spinal block, Bupivacaine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Pediatrics
Effect of Intraoperative Remifentanil Infusion Rate on Postoperative Tolerance and Analgesic Consumption in Pediatric Laparoscopic Ureteroneocystostomy
Effect of intraoperative remifentanil infusion rate on postoperative tolerance and analgesic consumption in pediatric laparoscopic ureteroneocystostomy.
- Trial name
- NCT01147757
- Testing
- remifentanil
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Labor Pain
Analgesic Effects of Intravenous Paracetamol on Labor Pain
The purpose of this study is to determine whether intravenous paracetamol is effective in treating labor pain.
- Trial name
- NCT01394731
- Testing
- Acetaminophen, Meperidine
- Where
- Saudi Arabia
- Sponsor
- King Abdulaziz University
Hepatectomy
Intravenous Lidocaine for Hepatectomy
Liver resection is increasingly performed for hepatic tumors, mainly primary liver cancers and resectable metastases, but also for some benign lesions.
- Trial name
- ILHEP (NCT07590830)
- Testing
- Standardized General Anesthesia Induction and Maintenance Protocol incorporating Intravenous Lidocaine
- Where
- 9 sites in France
- Volunteers
- 312 people
- Sponsor
- Rennes University Hospital
Sacro Iliac Joint Pain, Low Back Pain
Analgesic Effect of Sacral Submultifidus Block as an Adjunct to Sacroiliac Joint Injection
The aim of this study is to assess whether the addition of sacral submultifidus block to standard image-guided SIJ injection provides superior analgesia and functional improvement compared with SIJ injection alone in patients…
- Conditions
- Sacro Iliac Joint Pain, Low Back Pain, Sacroiliatis
- Trial name
- NCT07814729
- Testing
- SIJ Injection Alone, receive SIJ Injection & Sacral Submultifidus Block
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Fayoum University Hospital
Breast Cancer, Post Operative Pain
Analgesic Effect of Serratus Plane Block With Adjuvant Agents in Breast Cancer Surgery
Pain after breast surgery has been described as moderate to severe in intensity and, if inadequately treated, increases postoperative morbidity, hospital cost, and the incidence of persistent postoperative pain.
- Trial name
- NCT07081581
- Testing
- Bupivacain, Bupivacaine and Magnesium sulfate, Bupivacaine and Dexmedetomidine ile Blokaj
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
S-ketamine, Postoperative Analgesia
Analgesic Effects of Low-dose S-ketamine in Major Spine Fusion Surgery
Despite opioid-based multimodal analgesia, moderate-to-severe pain remains a big problem in patients following multi-segment spinal fusion.
- Conditions
- S-ketamine, Postoperative Analgesia, Spine Fusion
- Trial name
- NCT04964219
- Testing
- S-ketamine
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Peking University First Hospital
Idiopathic Scoliosis, Erector Spinae Plane Block
Erector Spinae Plane Block v.s Patient Controlled Analgesia in Correction Surgery for Idiopathic Scoliosis
Scoliosis correction surgery involves extensive surgical wounds, intense intraoperative stimulation, and severe postoperative pain, often necessitating the use of potent opioids.
- Conditions
- Idiopathic Scoliosis, Erector Spinae Plane Block, Patient Controlled Analgesia
- Trial name
- NCT06728046
- Testing
- ESPB, PCA
- Where
- China
- Volunteers
- 40 people
- Sponsor
- West China Hospital
Osteoarthritis, Knee, Healthy
Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects
This is a study of participants that will receive an intravenous (IV) infusion of oxytocin (naturally occurring hormone that is made in the brain).
- Trial name
- NCT04431206
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Sufentanil, Morphine
Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Surgeries: a Randomized Control Trial
Objective: This study aimed to compare the efficacy and safety of oliceridine versus morphine and sufentanil for postoperative analgesia following elective lumbar spine surgery.
- Conditions
- Sufentanil, Morphine, Validity, Safety
- Trial name
- NCT06990893
- Testing
- Oliceridine, Morphine, Sufentanil
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Anqing Municipal Hospital