Clinical trials: Analgesic Effect
Postoperative Pain
The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery
The effects of none-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase inhibitors (Coxibs) on the formation of bone and fracture healing have been a matter of debate since long.
- Trial name
- NCT00733421
- Testing
- etoricoxib, tramadol
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Hysterectomy
Comparative Study Between the Analgesic Effect of Dexmedetomidine and Magnesium Sulfate as Adjuvant to Bupivacaine Using Ultrasound-Guided Transversus Abdominis Plane Block in Abdominal Hysterectomy : A Randomized Double-blinded Study
Over 80% of patients who undergo surgery suffer from acute postoperative pain, with 75% of them rating the pain severity as moderate, severe, or extreme.
- Trial name
- NCT06720337
- Testing
- bupivacaine 0.5%, Dexmedetomidine, MgSO4
- Volunteers
- 64 people
- Sponsor
- Assiut University
Postoperative Pain, Analgesics, Opioid
The Effects of TFPB on Opioid Consumption in Patients Undergoing HLDN
This study aims to evaluate whether a regional anesthesia technique called the transversalis fascia plane block (TFPB) can improve pain control after hand-assisted laparoscopic donor nephrectomy (HALDN), a minimally invasive…
- Conditions
- Postoperative Pain, Analgesics, Opioid, Pain Management, Anesthesia Regional
- Trial name
- NCT07396753
- Testing
- Ultrasound-guided transversalis fascia plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Koç University
Low Back Pain
Fatty Infiltration in Paraspinal Muscles and Lumbar Erector Spina Plane Block
This study aimed to investigate the relationship between fatty infiltration in the lumbar paraspinal (multifidus and erector spinae) muscles, clinical characteristics, and treatment response after lumbar erector spinae plane…
- Trial name
- NCT06208865
- Testing
- lumbar erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 147 people
- Sponsor
- Diskapi Teaching and Research Hospital
Low Back Pain
Analgesic Effect of a Prototype Device of Virtual Reality in a Population of Patients With Chronic Low Back Pain
Chronic low back pain and sciatica in adults represent a major medical and economic problem. During the chronic back pain (persisting continuously over 3 months), therapeutic responses to conventional pharmacologic type are often…
- Trial name
- REVLOC (NCT01407653)
- Testing
- Virtual reality, Usual care
- Where
- France
- Volunteers
- 122 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Neuropathic Pain
aiTBS and rTMS in Neuropathic Pain and Prediction of Response
This study evaluates the analgesic benefit of two non-invasive brain stimulation techniques: high frequency repetitive transcranial magnetic stimulation (rTMS) and accelerated intermittent theta burst stimulation (aiTBS) …
- Trial name
- TRIPP (NCT07650526)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospital Ambroise Paré Paris
Pregnancy, Ceasarian Section, Anaesthesia
Transversus Abdominis Plane Block Versus Spinal Morphine After Caesarean Section : A Comparison Study
Many counties in sub-Saharan Africa have very limited post-operative nursing capacity, and relatively little data have been published about post-operative maternal pain control in these settings.
- Trial name
- NCT03263689
- Testing
- Intrathecal morphine
- Volunteers
- 130 people
- Sponsor
- Mbarara University of Science and Technology
Central Neuropathic Pain in Multiple Sclerosis
Efficacy and Safety of the Pain Relieving Effect of Dronabinol in Central Neuropathic Pain Related to Multiple Sclerosis
The purpose of this study is to determine whether Dronabinol is effective and safe in relieving central neuropathic pain in multiple sclerosis patients.
- Trial name
- NCT00959218
- Testing
- Dronabinol
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- Bionorica Research GmbH
Pain
Randomized, Double-Blind Cross-Over Trial Of Buprenorphine and Low-Dose Naloxone Versus Buprenorphine
This study compares two medications for analgesic potency and side effects in a sample of individuals with moderate pain. After screening, eligible participants will be randomly assigned to begin blinded treatment with one of two…
- Trial name
- NCT00679458
- Testing
- buprenorphine and low-dose naloxone, buprenorphine alone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, Los Angeles
Analgesic Effects, Systemic Stress Response
Bilateral Ultrasound Guided Pectoralis Nerve Block Induces Hemodynamic Stability With Reducing Systemic Stress Response for Off-pump Coronary Artery Bypass Graft
Opioids used in attenuation of the neuroendocrine stress response in patients undergoing off-pump coronary artery bypass graft (OPCAB) it produces predictable satisfactory analgesia and sedation but with side effects such as…
- Conditions
- Analgesic Effects, Systemic Stress Response, Hemodynamic Stability
- Trial name
- NCT03734848
- Testing
- Bilateral Ultrasound Guided Pectoralis Nerve Block.
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Vitrectomy
Analgesic Effect and Safety of Oliceridine and Oxycodone in Vitrectomy
Traditional opioid analgesia is a method to treat moderate to severe pain. However, the use of opioids is not without risks. When treating acute pain, patients may have hypotension, respiratory depression, hypoxia, nausea and…
- Trial name
- NCT07097038
- Testing
- Oliceridine, Oxycodone
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Intrathecal Dexmedetomidine, Bupivacaine
Intrathecal Dexmedetomidine With Bupivacaine, in Patients Undergoing Knee Orthopedic Surgery
This study aims to compare the duration of analgesia (as the primary outcome) and adverse effects (as the secondary outcome) after intrathecal administration of dexmedetomidine with hyperbaric bupivacaine to patients undergoing…
- Conditions
- Intrathecal Dexmedetomidine, Bupivacaine, Knee Orthopedic Surgery
- Trial name
- NCT07522736
- Testing
- Dexmedetomidine 4 μg, Dexmedetomidine 8 μg, Dexmedetomidine 12 μg
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Transcranial Direct Current Stimulation (tDCS)
Evaluation of the Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) for Sedated Patients in Intensive Care Unit.
Pain management for sedated ICU patients is complex, partly because of the difficulty of assessing pain in non-communicative patients, and partly because of the side effects associated with excessive use of morphine.
- Trial name
- REASTIM (NCT06179199)
- Testing
- SOOMA™ tDCS™
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Forearm Surgery, US-Guided Supraclavicular Block
Analgesic Effect of Supraclavicular Block and Interscalene Analgesia Versus an Intercostobrachial Nerve Block Versus PCA in Forearm Surgery
The etiology of tourniquet pain is complex, and the study team hypothesizes that blocking with Interscalene brachial plexus block (ISBPB) is more efficient in decreasing the incidence of tourniquet pain in comparison with other…
- Conditions
- Forearm Surgery, US-Guided Supraclavicular Block, Interscalene Analgesia, Tourniquet Pain
- Trial name
- NCT05602636
- Testing
- bupivacaine, midazolam
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Pain Assessment, Quality of Life (QOL)
Supplemental Postoperative Bupivacaine Following Non-Surgical Endodontic Treatment
The study will investigate the impact of an additional injection of long-acting anesthetic on pain level, quality of life, and use of pain medication after a nonsurgical endodontic treatment.
- Conditions
- Pain Assessment, Quality of Life (QOL), Analgesic Use
- Trial name
- NCT06655454
- Testing
- Supplemental Postoperative Bupivacaine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York University
Multiple Myeloma
Study of Vorinostat (MK-0683) or Placebo, in Combination With Bortezomib in Participants With Multiple Myeloma (MK-0683-088 AMN)
Study of the efficacy and safety of bortezomib administered in combination with vorinostat in patients with relapsed or refractory multiple myeloma.
- Trial name
- NCT00773747
- Testing
- Vorinostat, bortezomib
- Volunteers
- 637 people
- Sponsor
- Merck Sharp & Dohme LLC
Osteo Arthritis Knee
The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty
It is well recognized that a multimodal analgesia program targeting multiple pain pathways, is more effective for controlling pain during the hospital stay and in the acute postoperative period than monotherapy-based regimens…
- Trial name
- NCT04003350
- Testing
- Oxycodone, Tramadol, Tylenol
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Rothman Institute Orthopaedics
Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Ketamine Infusions for PTSD and Treatment-Resistant Depression
The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning.
- Trial name
- NCT02577250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Severe Depression, Moderate Depression
Nebulized Ketamine for the Treatment of Major Depressive Disorder
This is a double-blind active placebo controlled clinical trial for individuals with moderate to severe depression. The purpose of this study is to assess if nebulized ketamine can reduce depressive symptoms.
- Conditions
- Severe Depression, Moderate Depression, Ketamine, Midazolam
- Trial name
- NCT06752759
- Testing
- nebulized ketamine, nebulized midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Theresa Jacob, PhD, MPH
Lower Abdominal Oncologic Surgery
Epidural Steroids With Intrathecal Nalbuphine for Lower Abdominal Oncologic Surgery
Intraoperative pain, nausea, vomiting, hypotension, bradycardia are known side effects during lower abdominal surgery under spinal anesthesia, Time to 2 segment regression of sensory block and duration of effective analgesia…
- Trial name
- NCT03276325
- Testing
- Dexamethasone-nalbuphine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University