Clinical trials: Analgesic Effect
Osteoarthritis
A Study to Evaluate the Effect of Analgesics on a Walking Model of Knee Pain (0000-105)(COMPLETED)
This study will evaluate a walking model of osteoarthritis for use in testing of new therapeutic agents. The primary hypothesis is that participants treated with Naproxen or Ultracet will have lower Pain Intensity (PI) than those…
- Trial name
- NCT00772967
- Testing
- Naproxen, Ultracet
- Volunteers
- 22 people
- Sponsor
- Merck Sharp & Dohme LLC
We Are Studying the Effects of Caudal Dexamethasone in Neonates Undergoing Inguinal Hernia Repair
Caudal Dexamethasone - Bupivacaine in Neonates
Randomied controlled study Evaluate the effects of caudal Dexamethasone in neonates
- Trial name
- NCT07609836
- Testing
- We add Dexamethasone to Bupivacaine as adjuvant to Bupivacaine in neonsates undergoing inguinal hernia repair in Dexamethasone - Bupivacaine group
- Volunteers
- 150 people
- Sponsor
- Ain Shams University
Umbilical Hernia
Analgesic Efficacy After Umbilical Hernia Repair in Children
Umbilical hernia repair is a common painful outpatient procedure performed in children. Often analgesia for this procedure is provided by using local infiltration of the surgical site by the surgeons and perioperative opioids and…
- Trial name
- NCT00578136
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Children's Hospital of Philadelphia
Laparocele
Post-Operative Analgesic Effect of Tramadol and Nalbuphine in Smoker and Non-Smoker Patients in LC
This study aims to compare pain severity and analgesic requirements between smokers and nonsmokers following laparoscopic cholecystectomy, evaluating the efficacy of two analgesics, tramadol and nalbuphine.
- Trial name
- NCT07049380
- Testing
- Comparative cross sectional
- Where
- Pakistan
- Volunteers
- 132 people
- Sponsor
- Superior University
Postoperative Pain
Bilateral Cervical Plexus Block for Postoperative Pain After Thyroidectomy
Patients undergoing thyroidectomy frequently experience moderate postoperative pain that may require opioid analgesics. Opioid use is associated with adverse effects such as nausea, vomiting, respiratory depression, and delayed…
- Trial name
- NCT07496970
- Testing
- Ultrasound-Guided Bilateral Superficial Cervical Plexus Block, Standard general anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- University of Gaziantep
Transcutaneous Electrical Nerve Stimulation, Procedural Pain
Effect of TENS Application After Thoracic Surgery
After thoracic surgery, a chest tube is inserted to evacuate the air and fluid formed in the pleural space and to provide hemodynamic stability.
- Trial name
- NCT05927168
- Testing
- TENS
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cukurova University
Pain, Postoperative
Ultrasound Guided Posterior Versus Lateral Transversus Abdominis Plan Block for Prolonged Postoperative Analgesic Effect in Children
Ultrasound Guided Posterior Versus Lateral Transversus Abdominis Plan Block for Prolonged Postoperative Analgesic Effect in Children
- Trial name
- NCT04049838
- Testing
- postoperative analgesia for lower abdominal surgery in children
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Kasr El Aini Hospital
Upper Abdominal Malignancies, Upper Gastrointestinal Cancer
Comparison of CT-Guided Celiac Plexus Neurolysis and Pharmacotherapy
After enrolment, patients were randomly assigned to two groups by means of a lottery procedure, whereby each patient blindly chose one of two labelled slips, resulting in group assignment to receive.
- Trial name
- NCT07761650
- Testing
- CT-guided celiac plexus neurolysis, Standard pharmacotherapy
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Mayo Hospital Lahore
Oocyte Retrieval, Pain
Oocyte Retrieval and Virtual Reality (REVPO)
The aim of the study is to ass wether or not the use of virtual reality during oocyte retrieval provides a better pain relief for patients, compared to a standard analgesic procedure.
- Conditions
- Oocyte Retrieval, Pain, Fertilization in Vitro
- Trial name
- REVPO (NCT04935658)
- Testing
- Hypnotic relaxation induced by virtual reality (device), local anesthesia
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Knee Arthroplasty, Total, Postoperative Pain
Effect of Magnesium Sulphate on Analgesia Following Knee Arthroplasty
This study is designed to investigate the effect of magnesium sulfate added to levobupivacaine in continuous femoral nerve block following total knee arthroplasty.
- Trial name
- NCT03695640
- Testing
- Magnesium Sulfate, continuous femoral nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ufuk University
Subcostal TAP Block for Multiport Laparoscopic Cholecystectomy
Analgesic Effect of Subcostal TAP Block
The purpose of this study was to compare the analgesic efficacy of the ultrasound guided bilateral subcostal tap block with ultrasound guided bilateral posterior tap block for postoperative analgesia after laparoscopic…
- Trial name
- UGS-TAP (NCT02708017)
- Testing
- Ultrasound guided bilateral subcostal TAP block, Ultrasound guided bilateral posterior TAP block
- Volunteers
- 70 people
- Sponsor
- Aga Khan University
Postoperative Pain
Caudal Block v/s Local Wound Infiltration for Pain Control in Pediatric Patients After Operation for Inguinal Hernia
This randomized controlled trial aims to compare the analgesic efficacy of local wound infiltration with Ropivacaine versus Caudal Block with Ropivacaine in pediatric patients undergoing surgery for inguinal hernia
- Trial name
- NCT07747038
- Testing
- Caudal Block with Ropivacaine Intervention, Local Wound Infiltration with Ropivacaine Intervention, Intravenous Paracetamol Suspension Intervention
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Fatima Memorial Hospital
Cholecystectomy, Postoperative Pain
Analgesic Effect of Quadratus Lumborum Block Application After Laparoscopic Cholecystectomy Surgery
Laparoscopy is frequently used today for intraabdominal operations. Laparoscopic procedure has become the treatment of choice for many patients with symptomatic cholelithiasis.
- Conditions
- Cholecystectomy, Postoperative Pain, Nerve Block
- Trial name
- NCT03308955
- Testing
- Tramadol, Ultrasound guided Quadratus Lumborum block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Acute Pain, Wound Care
RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn Pain
The Ketamine for Acute Pain in Burns study is a randomized, double-blind, parallel group trial (RCT) with active control (usual care) contrasting the efficacy and safety of "Ketamine Plus Opiate-based usual care" (O+K) with the…
- Conditions
- Acute Pain, Wound Care, Posttraumatic Stress Disorder
- Trial name
- NCT03305055
- Testing
- ketamine, Fentanyl
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Johns Hopkins University
Quadratus Lumborum Nerve Block, Erector Spinae Block
Comparison of ESP and QL Blocks for Postoperative Pain in Pediatric Appendectomy (ESP-QLB)
This prospective randomized controlled clinical trial aims to compare the analgesic effectiveness of the Erector Spinae Plane (ESP) block and the Quadratus Lumborum (QL) block in pediatric patients undergoing appendectomy.
- Trial name
- ESP-QLB (NCT07301528)
- Testing
- Quadratus Lumborum Block (QLB), Erector Spinae Plane Block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Zeycan Kahya
Healthy
Individual Differences in Placebo Analgesic Effects
This study examines the effects of placebo suggestions tailored to match or mismatch individual participants' motivational styles-an issue of person-situation 'fit' with important effects in public health settings, but which has…
- Trial name
- NCT04669093
- Testing
- Control cream
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Sedative Adverse Reaction, Analgesic Adverse Reaction
The Use of Midazolam and Remifentanil During Dialysis Access Procedures
BACKGROUND: Sedation and analgesia are related to unexpected adverse events in chronic renal failure patients undergoing arteriovenous fistula placement procedures under monitored anesthesia care (MAC).
- Conditions
- Sedative Adverse Reaction, Analgesic Adverse Reaction, Midazolam Adverse Reaction, Adverse Reaction to Drug
- Trial name
- NCT04226443
- Testing
- Midazolam intravenous injection, Remifentanil intravenous bolus dose
- Volunteers
- 99 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Cryptorchidism
Comparison of Dexamethasone Added to Ropivacaine and Ropivacaine Alone in Caudal Analgesia in Children Undergoing Orchiopexy
Single shot caudal epidural block is one of the most widespread technique for pediatric pain management after infraumbilical surgical procedures.
- Trial name
- NCT01604915
- Testing
- Caudal block
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
Mucositis, Head and Neck Cancer
Analgesic Effects of Topical Ketamine Mouthwash in Patients Receiving Chemoradiation or Radiotherapy for Head & Neck Cancer
The primary objective is to determine the reduction in pain score by ketamine mouthwash compared to placebo in head and neck cancer patients with refractory mucositis.
- Trial name
- NCT01653327
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Osteoarthritis, Knee Arthritis Osteoarthritis
The Effect of Two Different Analgesic Methods on QoR-40 Score in Primary Unilateral Knee Arthroplasties
Total knee arthroplasty (TKA) is a very common operation that increases in frequency with advancing age. Similar to other surgical procedures, strategies are being developed to minimize morbidity and mortality while allowing for…
- Conditions
- Osteoarthritis, Knee Arthritis Osteoarthritis, Knee Arthroplasty, Total
- Trial name
- NCT07236073
- Testing
- PRİMER TEK TARAFLI DİZ ARTOPLASTİSİNDE İKİ FARKLI ANALJEZİK YÖNTEMİ, knee replacement
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University