Clinical trials: Analgesic Effect
Nephrectomy
Analgesic Effect of Ketamine Vs Ketamine Magnesium Infusion and Their Effect on Postoperative Morphine Consumption
Ketamine and magnesium-ketamine are two analgesics that are being studied for use as adjuvants. They were shown to have anaesthetic and analgesic properties, and as a consequence of this finding, it has been postulated that they…
- Trial name
- NCT05596669
- Testing
- Ketamine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Egymedicalpedia
Breast Cancer, Mastectomy
Effect of Patient-Anesthesiologist Gender Concordance and Analgesia Method on Postoperative Pain in Mastectomy Patients
This prospective observational study aims to evaluate the effect of anesthesiologist gender and patient-anesthesiologist gender concordance, as well as the analgesia method, on postoperative pain levels and analgesic requirements…
- Conditions
- Breast Cancer, Mastectomy, Postoperative Pain, Analgesic Use
- Trial name
- NCT07035275
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Pain, Hyperalgesia
Analgesic Effect of Oxytocin Receptor Modulation
Carbetocin is a synthetic analogue of the hormone Oxytocin and is routinely used in obstetric anesthesiology to control uterine bleeding after cesarean section.
- Conditions
- Pain, Hyperalgesia, Central Sensitization
- Trial name
- NCT01918475
- Testing
- Carbetocin
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Colorectal Cancer
Analgesia of Erector Spinae Plane Block Versus Quadratus Lumborum Block
Colorectal cancer is the third most common cancer worldwide. These patients usually undergo open surgical resection of cancer under general anaesthesia.
- Trial name
- NCT03803267
- Testing
- Erector spinae plane block, Quadratus lumborum block, Propofol
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Mansoura University
Renal Colic
Morphine Versus Ketorolac in Renal Colic
The study is prospective, double blinded, randomised controlled and has the purpose to compare the analgesic effects of ketorolac or morphine intravenous in renal colic.
- Trial name
- NCT02782273
- Testing
- Ketorolac, Morphine
- Volunteers
- 100 people
- Sponsor
- Loredana Ghinea
Laparoscopic Cholecystectomy, Postoperative Analgesia
Analgesic Effect of TAP Block After Laparoscopic Cholecystectomy
TAP block is a locoregional analgesic technique that consists of infiltrating a local anesthetic solution between the muscle layers of the abdominal wall. This block produces prolonged parietal analgesia.
- Trial name
- NCT03391531
- Testing
- Bilateral subcostal TAP block
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University of Liege
Chronic Pain
Real-World Registry Study on Clinical Analgesic Effect of Acetylaconitine Tablets
1. To observe the clinical analgesic effect, safety and adverse reactions of acetylaconitine. 2. To study and analyze the main influencing factors of the acetylaconitine tablets.
- Trial name
- NCT05687929
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Ke Ma
Postherpetic Neuralgia
Safety and Efficacy Study of KAI-1678 to Treat Pain in Subjects With Postherpetic Neuralgia
The purpose of this study is to determine whether KAI-1678 is effective in the treatment of postherpetic neuralgia pain
- Trial name
- NCT01106716
- Testing
- KAI-1678, Lidocaine
- Where
- Australia
- Volunteers
- 23 people
- Sponsor
- KAI Pharmaceuticals
Acute Pain
Effect of Early Pain Management at Triage on Opioid Consumption
introduction: Pain remains one of the most common reasons of emergency department admission. Opioids are overprescribed in emergency departments to treat severe pain.
- Trial name
- NCT03243006
- Testing
- Paracetamol, Tramadol/Paracetamol combination
- Volunteers
- 1,500 people
- Sponsor
- University of Monastir
Mild to Heavy Alcohol Consumption
Cognitive, Behavioral and Aging Effects of Pain Medication in Alcohol Users
The purpose of this study is to examine the relationship between heavy alcohol use, pain, and response to pain medication in older adults.
- Trial name
- CAAP (NCT02945293)
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Washington
Impacted Wisdom Teeth
Efficacy Study of IV Ibuprofen vs IV Acetaminophen Post Surgical Extraction
This study will compare how effective a single dose of an intravenous (IV) ibuprofen is when compared to single dose of IV acetaminophen in reducing pain.
- Trial name
- Caldolor (NCT02133326)
- Testing
- Caldolor, Ofirmev
- Where
- 2 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Tufts University School of Dental Medicine
Bariatric Surgery Analgesia
The Effect of Preoperative Gabapentin on Postoperative Pain Control and Analgesic Requirements Following Bariatric Surgery
The importance of bariatric anesthesia and analgesia research cannot be ignored as it can inform and improve the perioperative protocols for other patients with morbid obesity irrespective of the surgical procedures they are…
- Trial name
- NCT07169006
- Testing
- Group 1, Group 2
- Volunteers
- 102 people
- Sponsor
- Ain Shams University
Post Operative Pain
Comparison of Postoperative Analgesic Effect of Intrathecal Clonidine and Fentanyl Added to Bupivacaine in Patients Undergoing Cesarean Section
Objective :To compare the analgesic effect of intrathecal clonidine and fentanyl as an additive to bupivacaine in patients undergoing cesarean section .
- Trial name
- NCT01425658
- Testing
- distilled water, Clonidine, Fentanyl
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Qazvin University Of Medical Sciences
Supratentorial Brain Tumor
Comparison of the Analgesic Effects of Scalp Nerve Block and Intravenous Ibuprofen Applications Under the Guidance of Nociception Level Index (NoL) in Patients Undergoing Elective Supratentorial Craniotomy
Introduction: Scalp incision is a powerful nociceptive stimulus that can exacerbate rapid changes in hemodynamic and sympathetic activity.
- Trial name
- NCT05763836
- Testing
- Ibuprofen 800 Mg in 8 mL INTRAVENOUS INJECTION [Caldolor], Scalp nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ankara University
Dental Pain
Maxi-Analgesic Phase 2 Study to Compare the Analgesic Effects in Different Dosing Groups to Treat Teeth Extraction Pain
The aim of the study is to examine the dose response relationship in the treatment of dental pain (teeth extraction) for the different potential doses of the investigational drug, i.e.
- Trial name
- NCT01104844
- Testing
- Full Dose Strength, Quarter dose strength, Half dose strength
- Where
- United States
- Sponsor
- AFT Pharmaceuticals, Ltd.
Sleep
Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine
The objectives of the study are to evaluate the analgesic and hypnotic efficacy of naproxen sodium and diphenhydramine combination when compared to naproxen sodium, diphenhydramine, and an ibuprofen and diphenhydramine combination
- Trial name
- NCT01118273
- Testing
- Naproxen Sodium 440 mg (BAYH6689) / DPH 50mg, Naproxen Sodium 440 mg (BAYH6689), Naproxen Sodium 220 mg (BAYH6689) / DPH 50mg
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Bayer
Pain
Analgesic Effect of Oral 25% Glucose Versus Oral 24% Sucrose for Pain Relief During Heel Lance in Preterm Neonates
RESEARCH HYPOTHESIS-In preterm neonates during heel lance oral 25% glucose is more efficacious in reducing pain as compared to oral 24% sucrose when assessed by PIPP(Premature infant pain profile)
- Trial name
- NCT01931020
- Testing
- Sucrose, Glucose
- Where
- India
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Lady Hardinge Medical College
Nociceptive Pain
The Effect of Ongoing Beta-blockers Administration on Analgesic Requirements in the Immediate Perioperative Period.
This study is designed to discover if chronic use of Beta adrenergic receptor blockers affects pain sensation during and after an elective procedure of hip or knee replacement.
- Trial name
- NCT03498898
- Testing
- Chronic use of Beta adrenergic receptor blocker
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Cadiac Surgery, Median Sternotomy
Analgesic Effect of Bilateral Erector Spinae Plane Block With Ropivacaine After Sternotomy for Cardiac Surgery
The sternotomy site is the most painful area after cardiac surgery. Erector spinae plane block is effective in thoracic and abdominal surgery, but literature is lacking in cardiac surgery.
- Conditions
- Cadiac Surgery, Median Sternotomy, Regional Anesthesia, Postoperative Pain
- Trial name
- ESB-Sterno (NCT05160298)
- Testing
- Ropivacaine 0,2% Injectable Solution, Control group
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Clermont-Ferrand
Back Pain
The Effect of Chiropractic Care on Opioid Use for Chronic Spinal Pain: A Feasibility Study
The investigators will conduct a pilot cluster randomized controlled trial (RCT) of chiropractic care added to usual medical care, versus usual medical care alone, for adult patients prescribed opioid therapy for chronic…
- Trial name
- ACCESS-DC (NCT06160947)
- Testing
- Usual Medical Care, Usual Medical Care + Chiropractic Care
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University