Clinical trials: Analgesic Effect
Osteoarthritis, Arthritis
A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, Compared With Placebo in Patients With Osteoarthritis
The purpose of the study is to determine if fentanyl, delivered through the skin via an adhesive patch, has a superior pain-relieving effect compared with placebo in patients with osteoarthritis pain that is inadequately…
- Trial name
- NCT00236366
- Testing
- fentanyl
- Volunteers
- 418 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Neck Pain
Effects of Radio-frequency in Patients With Myofascial Chronic Neck Pain
The aim of this study was to evaluate the potential clinical benefits of Monopolar Capacitive Resistive Radio-frequency (448 kHz) (MCRR)F for the treatment of myofascial chronic neck pain.
- Trial name
- NCT02353195
- Testing
- Radiofrequency
- Volunteers
- 50 people
- Sponsor
- Universidad Rey Juan Carlos
Pain Management, Burn Injury
Perioperative Lidocaine Infusions for the Management of Pain From Burn Injury
The purpose of this study is to find out if IV lidocaine infusion decreases the need of opioids, improves pain management, and reduces the risks of developing complications from prolonged opioid use in burn injury participants…
- Conditions
- Pain Management, Burn Injury, Lidocaine
- Trial name
- NCT06828601
- Testing
- IV Lidocaine, IV Saline
- Volunteers
- 20 people
- Sponsor
- University of Washington
Postoperative Analgesia
Post-operative Analgesic Effects of Dexamethasone Added to Bupivacaine in Transversusabdominis Plane (TAP) Block
To compare the postoperative analgesic effect of two doses of dexamethasone added to bupivacaine in ultrasound-guided TAP block for inguinal hernia repair.
- Trial name
- NCT03863977
- Testing
- Dexamethasone, Bupivacaine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Pain
The Impact of Local Analgesia for Postoperative Analgesia in Posterior Thoracolumbar Operation
Posterior thoracolumbar operation always chooses general anesthesia. Due to surgical trauma and rich periosteum and joint capsule innervation, patients after general anesthesia immediately feel acute pain.The use of appropriate…
- Trial name
- NCT01872494
- Testing
- local, intravenous, 0.33% ropivacaine 250ml
- Where
- China
- Volunteers
- 71 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Acute Pain
Assessment of PF614 Effects on Experimental Pain in the Cold Pressure Test (PF614-201)
The primary objective of the study is to evaluate the onset of analgesia following administration of a single oral dose of PF614 (50 mg or 100 mg) or placebo in healthy male subjects in an experimental pain model (cold pressor…
- Trial name
- CPT (NCT06629402)
- Testing
- PF614
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ensysce Biosciences
Post Endodontic Pain, Mechanical Detection Threshold
The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy.
A clinical trial comparing preemptive multimodal analgesics with placebo in the management of immediate and chronic post-endodontic pain.
- Conditions
- Post Endodontic Pain, Mechanical Detection Threshold, Mechanical Pain Threshold, Mechanical Pain Sensitivity
- Trial name
- NCT07400471
- Testing
- Pregabalin- Acetaminophen, Duloxetine- Acetaminophen
- Where
- Bangladesh
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Chattogram International Dental College
Aortic Coarctation
Comparison Between Serratus Anterior Plane Block and Erector Spinae Plane Block in Coarctectomy
Pain is considered to be subjective, however, in children, it is believed to be felt rather than expressed because they often depend on the caregiver for their safety and well-being.
- Trial name
- NCT06567275
- Testing
- Erector Spinae Plane Block, Serratus Anterior Plane Block
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Interscalene Block, Superficial Cervical Block
Interscalene Block Versus Pericapsular Nerve Block and Superficial Cervical Plexus Block for Arthroscopic Shoulder Surgery
Interscalene brachial plexus block (ISB) is considered the standard nerve block for shoulder surgery . It provides superior analgesia and reduced opioid-related adverse effects .
- Trial name
- NCT05768009
- Testing
- Interscalene brachial plexus block (ISB)
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tanta University
Acetaminophen
Acetaminophen Given Per Os and Intravenous in Sinus Surgery
The primary objective of this study is to investigate the Visual Analog Score (VAS) for pain within the post-operative setting and determine if there is a statistically significant difference between the VAS for PO or IV…
- Trial name
- NCT03295214
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Thoracic Sympathectomy
Analgesic Effect of Erector Spinae Versus Serratus Anterior Plane Block for Thoracoscopic Sympathectomy
Thoracic incisions are painful and associated with chronic post-surgical pain and inadequate analgesia is associated with poorer postoperative outcomes.
- Trial name
- NCT04486014
- Testing
- Erector spinae plane block, Serratus anterior plane block
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Mansoura University
Pain, Postoperative, Pain, Acute
Opioid Sparing Anesthesia in Lumbar Spine Surgery
The aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus remifentanil analgesia in lumbar…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Nociceptive
- Trial name
- NCT05594407
- Testing
- dexmedetomidine-ketamine-lidocaine, Remifentanil
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aretaieion University Hospital
Pain
Analgesic and Antihyperalgesic Effects of Morphine and Buprenorphine
Tissue injury is associated with pain from the injured site (primary hyperalgesia) and pain from non-injured tissue in the vicinity of the trauma (secondary hyperalgesia).
- Trial name
- PASORII (NCT01296334)
- Testing
- morphine LO, Morphine Hi, Buprenorphine LO
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- mads u werner
Pain
Evaluation of a TNF-Alpha Modulator for Clinical and Molecular Indicators of Analgesic Effect
This study will evaluate the role of thalidomide, a tumor necrosis factor (TNF)-alpha modulator, on severe inflammation and relief of pain following extraction of wisdom teeth.
- Trial name
- NCT00121563
- Testing
- Thalidomide, Ibuprofen or Diazepam
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Nursing Research (NINR)
Postoperative Pain
Bilateral Cervical Plexus Block for Postoperative Pain After Thyroidectomy
Patients undergoing thyroidectomy frequently experience moderate postoperative pain that may require opioid analgesics. Opioid use is associated with adverse effects such as nausea, vomiting, respiratory depression, and delayed…
- Trial name
- NCT07496970
- Testing
- Ultrasound-Guided Bilateral Superficial Cervical Plexus Block, Standard general anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- University of Gaziantep
Symptomatic Irreversible Pulpitis
Pretreatment Aceclofenac Effect on Pain and Analgesic Intake After Endodontic Treatment
The aim of this prospective, randomized, double-blind, clinical trial is to evaluate the effect of a preoperative, single, oral dose of aceclofenac (100 mg) on postendodontic pain at 6, 24 and 48 hours, postoperative pain at…
- Trial name
- NCT03335007
- Testing
- Aceclofenac
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Abdominal Cancer
Cardio-pulmonary and Analgesic Effects of Pre-peritoneal VS Epidural Infusion of L-bupivacaine on Abd. Cancer Patients
60 Patients will be randomly assigned using computer generated randomization program (http://www.randomizer.org) into two groups, First group (Control group ,Group of continous epidural infusion [CEI]), where patients will…
- Trial name
- NCT04152564
- Testing
- levo-bupivacaine infusion via Thoracic epidural catheter, levo-bupivacaine infusion via preperitoneal catheter
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- South Egypt Cancer Institute
Transversalis Fascia Plane Block
Adding Calcitonin to Bupivacaine in Transversalis Fascia Plane Block for Cesarean Section
Evaluate calcitonin as an adjuvant to bupivacaine in ultrasound guided tansversalis fascia plane block
- Trial name
- NCT07033104
- Testing
- us guided Transversalis fascia plane block
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Low Back Pain, Opiate Addiction
Study of Opioid Use After Lumbar and Cervical Spine Surgery
The purpose of this project is to assess the impact of an educational video on the use of prescription opioid medication during a 6-month period following spine surgery.
- Conditions
- Low Back Pain, Opiate Addiction, Neck Pain
- Trial name
- SOULCS (NCT02674711)
- Testing
- Educational Video
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brooke Army Medical Center
Postoperative Pain
Effect of TAP Block on Time Required for First Analgesic Dose After Cesarean Cection Under Spinal Anesthesia
While opioids are the mainstay for post-operative analgesia after caesarean section, they are associated with various side effects.
- Trial name
- NCT04623632
- Testing
- Transversus abdominus plane block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams Maternity Hospital