Clinical trials: Analgesic Effect
Opioid Dependence, Pain
Study of the Treatment of Experimental Pain in Opioid Dependent Persons on Methadone or Buprenorphine Maintenance
Pain is very common in persons with a history of addiction, but few studies have examined the best treatment of pain in this population.
- Conditions
- Opioid Dependence, Pain, Addiction
- Trial name
- NCT01642030
- Testing
- Hydromorphone, Buprenorphine
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Johns Hopkins University
Transcranial Direct Current Stimulation (tDCS)
Evaluation of the Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) for Sedated Patients in Intensive Care Unit.
Pain management for sedated ICU patients is complex, partly because of the difficulty of assessing pain in non-communicative patients, and partly because of the side effects associated with excessive use of morphine.
- Trial name
- REASTIM (NCT06179199)
- Testing
- SOOMA™ tDCS™
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Treatment Resistant Depression, Major Depressive Disorder
Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression
The purpose of this study is to assess the effects of simultaneous administration of oral aspirin and oral ketamine as a therapeutic for those with Treatment Resistant Depression.
- Conditions
- Treatment Resistant Depression, Major Depressive Disorder, Analgesia, Ketamine
- Trial name
- NCT05615948
- Testing
- VTS-K
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Theresa Jacob, PhD, MPH
Breast Cancer, Aromatase Inhibitors
Assessment of Cryotherapy's Analgesic Impact in Anti-aromatase-induced Arthralgia
The first aim of this comparative, randomized, prospective, multicenter study is to evaluate the analgesic effect at 6 weeks of whole-body cryotherapy, compared to placebo cryotherapy, in patients suffering from arthralgia under…
- Trial name
- CRYOMATASE (NCT05315011)
- Testing
- Whole-body cryotherapy
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Postoperative Pain
Tramadol Infiltration for Tonsillectomy
The purpose of this study is to evaluate the analgesic effect and IL-6 after tramadol infiltration or intravenous for tonsillectomy.
- Trial name
- NCT01636700
- Testing
- Tramadol 2mg/kg, Saline solution
- Where
- Brazil
- Sponsor
- Federal University of São Paulo
Ankyloglossia
Analgesic Effect of Inhaled Lavender Essential Oil for Clipping of Tongue-ties
Clipping of the tongue-tie is a common procedure that neonatologists perform in our neonatal unit to help establish breastfeeding.
- Trial name
- LEO-SME1 (NCT04877392)
- Testing
- Lavender essential oil
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Parc de Salut Mar
Leukemia, Leukemia, Myeloid
Natural Killer Cell (CYNK-001) Infusions in Adults with AML
This study will find the maximum tolerated dose or the maximum planned dose of CYNK-001 which contains natural killer (NK) cells derived from human placental CD34+ cells and culture-expanded.
- Conditions
- Leukemia, Leukemia, Myeloid, Leukemia, Myeloid, Acute, Neoplasms by Histologic Type
- Trial name
- CYNK001AML01 (NCT04310592)
- Testing
- CYNK-001
- Where
- 10 sites in United States
- Volunteers
- 27 people
- Sponsor
- Celularity Incorporated
Post Operative Pain, Acute
Comparison Between the Analgesic Effect of Fascia Transversalis Block vs Caudal Block
Despite the growing interest in interfascial blocks and their successful use in pediatric surgeries, no previous randomized clinical trials have directly compared the analgesic efficacy, opioid-sparing effect, and safety profile…
- Trial name
- NCT07235475
- Testing
- Caudal Block Anesthesia, Fascia Transversalis Block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Analgesia; Postoperative
Effect of Single Dose Intravenous Magnesium Sulfate on Postoperative Analgesic Consumption in Patients Undergoing Laparoscopic Cholecystectomy
This study describes a randomized controlled trial designed to evaluate the impact of a single intravenous dose of magnesium sulfate on postoperative analgesic consumption in patients undergoing laparoscopic cholecystectomy.
- Trial name
- NCT07328893
- Testing
- Magnesium Sulfate 30 mg/kg intravenous diluted in 100 ml Normal Saline.
- Where
- 2 sites in India
- Volunteers
- 106 people
- Sponsor
- Tata Main Hospital
Opioid Analgesic Treatment Response, Chronic Pain
Predictive Markers of the Effects of Opioid Therapy
The overall goal of the ABILITY study is to help improve pain diagnostics and treatment by developing an implementable clinical computerised decision support system based on individual patient characteristics.
- Trial name
- ABILITY (NCT02308306)
- Where
- 5 sites in Belgium, Denmark and 1 more
- Volunteers
- 62 people
- Sponsor
- University of Aarhus
Opioid Use, Postoperative Pain
Analgesic Effects of Intrathecal Morphine and Bilateral Erector Spina Plane Block in Elective Cesarean Section
Cesarean section cause severe pain due to surgical incision, abdominal wall retraction and visceral organ movements. Cesarean section can be performed with general anesthesia, spinal anesthesia, epidural anesthesia and combined…
- Trial name
- NCT05698927
- Testing
- Erector Spinae Plane Block (bilaterally, via 20ml % 0.25 bupivacain) and Intrathecal Morphine (100 mcg)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Marmara University
Pain, Postoperative, Analgesic Requirement
Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy
Laparoscopic Cholecystectomy is the treatment of choice for patients with symptomatic gall stones. For pain relief following laparoscopic cholecystectomy both intraperitoneal and intravenous administration of lignocaine has been…
- Conditions
- Pain, Postoperative, Analgesic Requirement, Stress Response, Return of Bowel Activity
- Trial name
- NCT01717222
- Testing
- Intraperitoneal Lignocaine, Intravenous Lignocaine
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
Post Operative Pain, Acute
Subcostal Transversus Abdominis Block Versus Erector Spinae Block in Open Cholecystectomy
Open cholecystectomy is a surgical procedure involving the removal of the gallbladder through a traditional, open abdominal incision the surgeon makes an incision in the upper abdomen, exposes the gallbladder, and carefully…
- Trial name
- NCT06410911
- Testing
- Subcostal Transversus Abdominis Plane block in patients undergoing open cholecystectomy surgery., Erector Spinae Block in patients undergoing open cholecystectomy, Sbcostal transversus Abdominis block and erector spinae block for both groups
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Post Endodontic Pain, Mechanical Detection Threshold
The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy.
A clinical trial comparing preemptive multimodal analgesics with placebo in the management of immediate and chronic post-endodontic pain.
- Conditions
- Post Endodontic Pain, Mechanical Detection Threshold, Mechanical Pain Threshold, Mechanical Pain Sensitivity
- Trial name
- NCT07400471
- Testing
- Pregabalin- Acetaminophen, Duloxetine- Acetaminophen
- Where
- Bangladesh
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Chattogram International Dental College
Varicocelectomy
Sedative and Analgesic Effects of Dexmedetomidine Versus Ketamine in Patients Undergoing Varicocelectomy Under Spinal Anaesthesia: A Prospective Randomized Comparative Trial
The demand for safe and effective sedation during spinal anesthesia has increased in recent years, particularly in ambulatory and minor surgical procedures.
- Trial name
- NCT07214701
- Testing
- Ketamine (0.5 mg/kg), Dexmedetomidine
- Volunteers
- 58 people
- Sponsor
- Assiut University
Pain, Postoperative, Preemptive Peripheral Nerve Block
Preemptive Analgesic Effects of Popliteal Sciatic Nerve Block in Patients With Bilateral Hallux Valgus Surgery
The purpose of this study was to investigate the preemptive effect of ultrasound guided popliteal scistic nerve block on postoperative acute pain in patients with bilateral hallux valgus.
- Conditions
- Pain, Postoperative, Preemptive Peripheral Nerve Block, Acute Pain
- Trial name
- NCT03414593
- Testing
- Ultrasound guided popliteal sciatic nerve block with 0.2% ropivcaine
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Chronic Pain, rTMS
Mechanism of Analgesic Effect on Prolonged Continuous Theta Burst Stimulation
It has been shown that prolonged continuous theta burst stimulation (pcTBS) , a relatively new repetitive transcranial magnetic simulation (rTMS) protocol, of the primary motor cortex (M1) or dorsolateral prefrontal cortex…
- Trial name
- NCT05360030
- Testing
- Naloxone, Saline, Ketamine Hydrochloride
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Low Back Pain
A Study of Tanezumab in Adults With Chronic Low Back Pain
The purpose of this study is to evaluate the efficacy and safety of multiple doses of tanezumab administered every 8 weeks in treating chronic low back pain.
- Trial name
- NCT00876187
- Testing
- Tanezumab 20 mg IV, Tanezumab 10 mg IV, Tanezumab 5 mg IV
- Where
- 135 sites in United States
- Volunteers
- 1,359 people
- Sponsor
- Pfizer
Depression, Major Depressive Disorder
Nitrous Oxide for the Treatment of Major Depressive Disorder
The investigators are conducting a randomized controlled trial to evaluate the antidepressant effects of nitrous oxide in people with Major Depressive Disorder (MDD).
- Trial name
- NCT03869736
- Testing
- Nitrous Oxide
- Where
- 2 sites in United States, Australia
- Volunteers
- 81 people
- Sponsor
- Bayside Health
Hip Pain Chronic
Comparison of the Analgesic Efficacy and Duration of Analgesic Effect of Pericapsular Nerve Group Block Block Application With PENG Block and Pulse Radiofrequency Ablation in Chronic Hip Pain
Comparison of the analgesic efficacy and duration of analgesic effect of PENG block application with PENG block and pulse radiofrequency ablation in chronic hip pain.
- Trial name
- NCT06728488
- Testing
- PENG Block, PENG block and pulse radiofrequency ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kocaeli University