Clinical trials: Analgesic Effect
Arthritis, Osteoarthritis
A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, in Patients With Rheumatoid Arthritis or Osteoarthritis
The purpose of this study is to assess the degree of pain control achieved by treatment with fentanyl, administered via adhesive patches applied to the skin ('transdermal system") in patients with rheumatoid arthritis or…
- Conditions
- Arthritis, Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT00524160
- Testing
- Fentanyl transdermal patch
- Volunteers
- 264 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Renal Colic
Comparing the Analgesic Effect of Intravenous Acetaminophen and Morphine on Patients With Renal Colic Pain Reffering to the Emergency Department: A Randomized Controlled Trial
Kidney stone is one of the most common diseases in every human society and also Iran. What is normally used to treat renal colic pain is Intravenous Opioid with a variety of side effects including hypotension, respiratory…
- Trial name
- NCT01906762
- Testing
- Acetaminophen, Morphine
- Volunteers
- 124 people
- Sponsor
- Seyed Mehdi Pourafzali
Arthroscopy
Effect of Celecoxib Versus Placebo Before and After Knee Surgery on the Overall Use of Analgesics After Surgery
To compare the total analgesic use at 24 hours after arthroscopic knee surgery in patients treated with celecoxib versus placebo.
- Trial name
- NCT00633386
- Testing
- Celecoxib
- Where
- 9 sites in United States
- Volunteers
- 200 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Postoperative Pain, Chronic Pain Post-Proceduraal
QLB and Radical Cystectomy, Postoperative Pain
There are ca 1000 new cases of bladder cancer in Finland/year. The curative therapy for high risk bladder cancer is radical cystectomy. The golden standard is still an open surgery despite development of laparoscopic techniques.
- Conditions
- Postoperative Pain, Chronic Pain Post-Proceduraal, Nausea and Vomiting, Postoperative
- Trial name
- BladderQLB (NCT03328988)
- Testing
- QLB
- Where
- Finland
- Volunteers
- 41 people
- Sponsor
- Tampere University Hospital
Neuropathic Pain, Reflex Sympathetic Dystrophy
Effects of Vaporized Marijuana on Neuropathic Pain
This study theorized that a low dose of vaporized cannabis could alleviate nerve injury pain.
- Conditions
- Neuropathic Pain, Reflex Sympathetic Dystrophy, Peripheral Neuropathy, Post-herpetic Neuralgia
- Trial name
- NCT01037088
- Testing
- Mild dose cannabis, Low dose cannabis, Cannabis
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, Davis
Post Operative Nausea and Vomiting
the Effect of Three Different Analgesic Techniques on the Incidence of Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) is a distressing adverse effect that may result in postoperative complications including bleeding, wound dehiscence, aspiration pneumonitis, as well as fluid and electrolyte imbalances…
- Trial name
- NCT03313479
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Osteoarthritis, Arthritis
A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, Compared With Placebo in Patients With Osteoarthritis
The purpose of the study is to determine if fentanyl, delivered through the skin via an adhesive patch, has a superior pain-relieving effect compared with placebo in patients with osteoarthritis pain that is inadequately…
- Trial name
- NCT00236366
- Testing
- fentanyl
- Volunteers
- 418 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Musculoskeletal Pain
Analgesic Effect of a Biophotonic Foot Massage Cream
This study aims to evaluate the effectiveness of a biophotonic cosmetic massage cream in reducing musculoskeletal foot pain in adults.
- Trial name
- No acronym (NCT07501273)
- Testing
- Biophotonic cosmetic massage cream
- Volunteers
- 170 people
- Sponsor
- University of Seville
Pain, Ketamine Adverse Reaction
Cardiovascular Safety After Continuous Ketamine Infusion
Observational study that evaluate the cardiovascular and neuropsychiatric side effects of ketamine analgesic infusions for acute pain
- Conditions
- Pain, Ketamine Adverse Reaction, Postoperative Pain
- Trial name
- NCT03979105
- Testing
- Ketamine
- Where
- 2 sites in Colombia
- Volunteers
- 300 people
- Sponsor
- Universidad de Antioquia
Osteoarthritis
Maxi-Analgesic Osteoarthritis (OA) Study
The purpose of this study is to determine whether the analgesic effects of Maxigesic USA are greater than acetaminophen, ibuprofen or placebo in patients who have painful osteoarthritis of the hip or knee.
- Trial name
- NCT01420666
- Testing
- Acetaminophen, Maxigesic 325, Ibuprofen
- Sponsor
- AFT Pharmaceuticals, Ltd.
Postoperative Pain, Acute
Effect of Sufentanil on the Postoperative Pain
This study is a randomized, controlled trial. A total of 48 patients will be randomized to receive sufentanil or remifentanil during robot-assisted nephrectomy surgery.
- Trial name
- NCT06260046
- Testing
- Sufentanil, Remifentanil
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Seoul National University Hospital
Leg Ulcer
Topical Sevoflurane for Treatment of Chronic Leg Ulcers
Patients with painful non-healing leg ulcer will be enrolled in the clinical single-blinded randomized study. The active treatment group will have sevoflurane applied at approximately 1 ml/cm2 at the start of wound treatment, the…
- Trial name
- NCT05303805
- Testing
- Sevoflurane, Cyteal
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Labor Pain, Analgesia
Comparison of Epidural, Combined and Dural Puncture Labor Epidural on Pain, and Course of Vaginal Delivery
The three standard techniques used for labor analgesia, thus epidural, combined spinal-epidural and dural puncture epidural will be compared regarding their impact on pain intensity, analgesic and local anesthetic consumption and…
- Trial name
- NCT04290702
- Testing
- regional analgesia for labor
- Where
- 2 sites in Greece
- Volunteers
- 90 people
- Sponsor
- University of Athens
Pain and Anxiety in Patients Undergoing Surgery for Lumbar Laminectomy.
Perioperative Melatonin in Lumbar Laminectomy
Patients undergoing lumbar laminectomy surgery will receive either 5 or 10 mg melatonin or placebo once the evening before surgery and again 90 minutes before surgery.
- Trial name
- NCT01126294
- Testing
- 5 mg melatonin, 10 mg melatonin
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- University Health Network, Toronto
Brain Tumor Adult, Cerebrovascular Disease
The Analgesic Effect of Scalp Nerve Block Using Bupivacaine Liposomes for Postoperative Pain Relief After Craniotomy
After undergoing craniotomy, 60% to 84% of neurosurgery patients experience moderate to severe acute pain, primarily in the first 48 hours. This pain is mostly superficial, affecting the muscles and soft tissues around the skull.
- Trial name
- NCT07049094
- Testing
- scalp nerve block with 0.25% hydrochloride bupivacaine and 0.67% bupivacaine liposome solution, scalp nerve block with 0.50% hydrochloride bupivacaine
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Zhejiang University
Pupil, Analgesics
Validation of Pupillary Response to Nociceptive Stimulation in Cardiac Surgery During Extracorporeal Circulation Period
The relationship between the target effect site concentration of remifentanil and the pupil diameter and reactivity in response to a standard noxious stimulus in cardiac surgery during extra corporeal circulation will be…
- Conditions
- Pupil, Analgesics, Opioid Use, Dose-Response Relationship, Drug
- Trial name
- DOLOCEC (NCT03568396)
- Testing
- Pupillometer
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Pain Management, Burn Injury
Perioperative Lidocaine Infusions for the Management of Pain From Burn Injury
The purpose of this study is to find out if IV lidocaine infusion decreases the need of opioids, improves pain management, and reduces the risks of developing complications from prolonged opioid use in burn injury participants…
- Conditions
- Pain Management, Burn Injury, Lidocaine
- Trial name
- NCT06828601
- Testing
- IV Lidocaine, IV Saline
- Volunteers
- 20 people
- Sponsor
- University of Washington
Pain, Acute, Postoperative Pain
Quadratus Lumborum Block vs Erector Spinal Block for Post Abdomen Surgery Analgesia
Prior to surgery, patients will be stratified into groups according to the type of surgical procedure. The anticipated groups are as follows: Patients with colorectal cancer Patients with prostate cancer Patients with renal…
- Conditions
- Pain, Acute, Postoperative Pain, Anesthetics, Local
- Trial name
- NCT05446727
- Testing
- Ropivacaine injection
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
Postoperative Pain, Chronic Pain
The Effect of Intraoperative Ketamine on Opioid Consumption and Pain After Spine Surgery in Opioid-dependent Patients
Patients with a daily use of opioids may develop higher postoperative pain levels, often need high doses of morphine and therefore their pain may be difficult to treat.
- Conditions
- Postoperative Pain, Chronic Pain, Analgesics
- Trial name
- NCT02085577
- Testing
- (S)-(+)-Ketamine Hydrochloride Solution 25 mg/ml, Isotonic sodium chloride 0.9 percent, Paracetamol 1 g
- Where
- Denmark
- Volunteers
- 147 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Pain
The Effect of Adding Nalbuphine to Intrathecal Morphine on Analgesic Efficacy and Side Effects After Cesarean Section
The primary endpoint of this study is to investigate the effect of adding nalbuphine to intrathecal morphine on quality of postoperative analgesia and Morphine related side effects post- cesarean delivery.
- Trial name
- NCT02716129
- Testing
- Morphine, Morphine plus Nalbuphine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Abdelrady S Ibrahim, MD