Clinical trials: Analgesic Effect
Parkinson Disease
Effects of PR Oxycodone and of Levodopa, vs Placebo, on Central Neuropathic Pain in Parkinson's Disease
This study will be conducted in three parallel groups receiving oxycodone, levodopa or placebo, administered as an add-on therapy, in addition to the usual antiparkinsonian treatment.
- Trial name
- OXYDOPA (NCT02601586)
- Testing
- PR Oxycodone, Levodopa
- Where
- 18 sites in France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Toulouse
Nephrectomy
Analgesic Effect of Ketamine Vs Ketamine Magnesium Infusion and Their Effect on Postoperative Morphine Consumption
Ketamine and magnesium-ketamine are two analgesics that are being studied for use as adjuvants. They were shown to have anaesthetic and analgesic properties, and as a consequence of this finding, it has been postulated that they…
- Trial name
- NCT05596669
- Testing
- Ketamine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Egymedicalpedia
Surgical Procedure, Unspecified
TFPB vs QLB III in Infra-umbilical Pediatric Surgeries
Regional anesthetic techniques; they reduce postoperative morbidity, provide early mobilization and provide great advantages by significantly reducing the need for narcotic analgesics.
- Trial name
- NCT05671484
- Testing
- Transversalis Fascial Plane Block, Quadratus Lumborum Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Namik Kemal University
Acetaminophen
Acetaminophen Given Per Os and Intravenous in Sinus Surgery
The primary objective of this study is to investigate the Visual Analog Score (VAS) for pain within the post-operative setting and determine if there is a statistically significant difference between the VAS for PO or IV…
- Trial name
- NCT03295214
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Pain
Pre-operative Ketorolac Administration Has no Pre-emptive Analgesic Effect Following Total Abdominal Hysterectomy
Background: Experimental models using short duration noxious stimuli have led to the concept of pre-emptive analgesia. Ketorolac, a non-steroidal anti-inflammatory drug (NSAID), has been shown to have a post-operative narcotic…
- Trial name
- NCT02642718
- Testing
- Ketorolac Tromethamine
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 48 people
- Sponsor
- Hospital Arquitecto Marcide
Pain
Analgesic Effect of Breast Feeding vs Sucrose in Neonatal Screening
The purpose of this study is to compare the antinociceptive effect of 1 ml of 30% sucrose solution vs breastfeeding on neonatal screening heel lance
- Trial name
- NCT00482560
- Testing
- Sucrose solution 30%1 ml, Breastfeeding
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Turin, Italy
Pain
Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1386
The primary aim of this study is to investigate if AZD1386 can relieve the pain induced by the surgical removal of one lower wisdom-tooth.
- Trial name
- NCT00672646
- Testing
- AZD1386, Naproxen
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Postoperative Analgesia, Lower Abdominal Cancer
Ketamine Versus Dexmedetomidine With Local Anesthetic in TAP Block
Comparing the analgesic effects of ketamine and dexmedetomidine when added to local anesthetic in TAP block for postoperative analgesia after lower abdominal cancer surgery.
- Trial name
- NCT03060070
- Testing
- Ketamine, dexmedetomidine, control group
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Analgesic Adverse Reaction, Nociceptive Pain
The Correlation Between Sevoflurane and qNOX
This study purpose to observation the sevoflurane analgesia effect, and using nociception real-time monitoring NOX to test the correlation between the sevoflurane and NOX index.
- Conditions
- Analgesic Adverse Reaction, Nociceptive Pain, Inhalation; Vapor
- Trial name
- NCT03665792
- Testing
- nociception index qNOX
- Where
- China
- Volunteers
- 58 people
- Sponsor
- China International Neuroscience Institution
Cesarean Section, Analgesia
IV and Intrathecal Ketamine in Cesarean Section
In the current study, the investigators will compare the effects of low-dose intravenous (i.v.) ketamine versus intrathecal Ketamine added to spinal anesthesia on the time to first request for analgesia and maternal pain scores…
- Trial name
- NCT05679375
- Testing
- Intrathecal ketamine, Intravenous ketamine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Analgesia
Ketamine and Magnesium in Erector Spinae Plane Block
In this study, it will aimed to evaluate the effect of magnesium sulfate and ketamine HCl added to local anesthetic on postoperative pain management in the ultrasound-guided erector spina plane (ESP) block in patients will…
- Trial name
- NCT05855798
- Testing
- Bupivacain, Magnesium sulfate, Ketamine Hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Cadiac Surgery, Median Sternotomy
Analgesic Effect of Bilateral Erector Spinae Plane Block With Ropivacaine After Sternotomy for Cardiac Surgery
The sternotomy site is the most painful area after cardiac surgery. Erector spinae plane block is effective in thoracic and abdominal surgery, but literature is lacking in cardiac surgery.
- Conditions
- Cadiac Surgery, Median Sternotomy, Regional Anesthesia, Postoperative Pain
- Trial name
- ESB-Sterno (NCT05160298)
- Testing
- Ropivacaine 0,2% Injectable Solution, Control group
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Clermont-Ferrand
Postoperative Pain After Video Assisted Thoracic Surgery
Analgesic Effect of Intravenous Patient-Controlled Analgesia (IV PCA) Versus Paravertebral Block After Video Assisted Thoracic Surgery (VATS)
The purpose of this study is to compare the analgesic effect of paravertebral block with that of intravenous patient-controlled analgesia after video assisted thoracic surgery.
- Trial name
- NCT01538914
- Testing
- paravertebral block, PCA
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Seoul National University Hospital
Mild to Heavy Alcohol Consumption
Cognitive, Behavioral and Aging Effects of Pain Medication in Alcohol Users
The purpose of this study is to examine the relationship between heavy alcohol use, pain, and response to pain medication in older adults.
- Trial name
- CAAP (NCT02945293)
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Washington
Postoperative Pain, Postoperative Sedation
Analgesic Effect of Gabapentin in Total Knee Arthroplasty (TKA)
Pain is a major problem after TKA. Gabapentin may reduce acute postoperative pain. The investigators therefore investigate the effect of Gabapentin as a perioperative analgesic.
- Trial name
- NCT01507363
- Testing
- Gabapentin
- Where
- 3 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Hvidovre University Hospital
Anesthesia
Bispectral Index (BIS) Monitoring in Abdominal Surgery
Bispectral Index Monitoring (BIS) has been proven to be effective in preventing awareness. Optimizing anesthesia level using BIS monitoring, neither to light nor to deep will probably help to shorten recovery time and reduce drug…
- Trial name
- NCT01470898
- Testing
- bispectral index monitoring
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- University Hospital Dubrava
Erector Spinae Plane Block
Patients' Positions on Analgesic Efficacy of ESPB
The goal of this clinical trial is to learn if patients remaining different positions for 30min after receiving ultrasound-guided erector spinae plane block influenced the postoperative analgesia.
- Trial name
- NCT06441071
- Testing
- position
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Postoperative Pain
Effect of TAP Block on Time Required for First Analgesic Dose After Cesarean Cection Under Spinal Anesthesia
While opioids are the mainstay for post-operative analgesia after caesarean section, they are associated with various side effects.
- Trial name
- NCT04623632
- Testing
- Transversus abdominus plane block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams Maternity Hospital
Cesarean Section, Dexamethasone
Intravenous Dexamethasone Effectiveness in Post Caesarean Section Analgesia
The management of postpartum pain is essential to ensure early rehabilitation for parturients. Intravenous dexamethasone has a potent analgesic action when used in the context of general anesthesia.
- Conditions
- Cesarean Section, Dexamethasone, Postoperative Pain, Spinal Anesthesia
- Trial name
- NCT05535036
- Testing
- Dexamethasone 4mg
- Where
- Tunisia
- Volunteers
- 84 people
- Sponsor
- Mongi Slim Hospital
Post Operative Pain
Comparison of M-TAPA and TAP Blocks on Postoperative Analgesia in Laparoscopic Inguinal Hernia Surgeries
The goal of this study is to compare the analgesic efficacy of M-TAPA block and TAP block in patients undergoing laparoscopic inguinal hernia surgeries.
- Trial name
- NCT06483607
- Testing
- M-TAPA block with bupivacaine 25%, TAP block with bupivacaine 25%
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Cumhuriyet University