Clinical trials: Analgesic Medication
Acute Pain
Study to Evaluate Analgesic Effect of Intravenous Administration of Kappa Agonist CR845 After Hysterectomy Surgery
The purpose of this study is to determine the effectiveness and safety of single intravenous doses of the kappa opioid agonist CR845 in relieving pain in patients following laparoscopic-assisted hysterectomy surgery.
- Trial name
- NCT00877799
- Testing
- CR845
- Where
- 12 sites in United States
- Volunteers
- 114 people
- Sponsor
- Cara Therapeutics, Inc.
Osteoarthritis, Knee
A Controlled Study of an Herbal Topical Patch in Treating Osteoarthritis (OA) of the Knee
An evaluation of the safety and efficacy of an herbal patch in treating osteoarthritis pain of the right or left knee.
- Trial name
- NCT01183624
- Testing
- Herbal Patch
- Where
- 12 sites in China
- Volunteers
- 626 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Cancer, Pain
An Efficacy and Safety Study of Hydromorphone Hydrochloride (HCl) Oral Osmotic System (OROS) in the Reduction of Breakthrough Pain Medication Frequency in Participants With Cancer
The purpose of this study is to evaluate the clinical efficacy of hydromorphone hydrochloride (HCl) Oral Osmotic System (OROS) by assessing the extent of reduction of medication frequency for the management of breakthrough pain…
- Trial name
- NCT01006356
- Testing
- Hydromorphone HCl OROS
- Volunteers
- 141 people
- Sponsor
- Janssen Korea, Ltd., Korea
Narcotic Use, Postoperative Pain
A Prospective Assessment of Opioid Utilization Post-operatively in Sports Orthopaedic Surgeries
There was a study titled "A prospective evaluation of opioid utilization after upper extremity surgical procedures: Identifying consumption patterns and determining prescribing guidelines" by Dr.
- Conditions
- Narcotic Use, Postoperative Pain, Narcotic Abuse, Opioid Use
- Trial name
- Opioids (NCT03422211)
- Testing
- Questionnaire
- Where
- 3 sites in United States
- Volunteers
- 223 people
- Sponsor
- St. Louis University
Post-traumatic Pain
Effect of Telemedecine on Post -Trauma Pain Medication Adherence .
The impact of telemonitoring on patients' adherence to post trauma pain treatment , their satisfaction and pain relief after discharge from the ED.
- Trial name
- NCT05149417
- Testing
- SMS reminding, telemonitoring
- Where
- 2 sites in Tunisia
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Analgesic Drugs, Analgesic, Nonopioid
Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia
Currently the prevalent approach to perioperative management of patients is ERAS (Enhanced Recovery After Surgery) concept. This approach includes numerous aspects, among which the perioperative use of multimodal analgesia takes…
- Conditions
- Analgesic Drugs, Analgesic, Nonopioid, Analgesic Efficacy, Analgetic Consumption
- Trial name
- NCT07070050
- Testing
- Ibuprofen continuous infusion, Ibuprofen bolus injection
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology
Chronic Pain
Validating and Evaluating the Pain Medicine Digital Workflow Algorithm (PGS 1.0)
This is a prospective, non-randomized, double blind, single center, single arm, validation study, to evaluate the performance of PGS 1.0 algorithm in analyzing pain specific symptoms and medical history data of pain patients…
- Trial name
- NCT07195162
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- PG Medical Systems Ltd.
Hip Joint Disorders
Role of Patient-controlled Epidural Analgesia After Total Hip Replacement
Total hip replacement (THR) is frequently followed by high pain experience. Epidural analgesia is a mainstay in postoperative treatment in patients after THR.
- Trial name
- NCT03599024
- Testing
- PCEA, Non-PCEA, Total hip replacement
- Where
- Czechia
- Volunteers
- 111 people
- Sponsor
- University Hospital Ostrava
Anesthetics, Local Anesthetics
Lidocaine Versus ESP - After Bariatric Surgery
The Erector Spinal Block (ESP) is based on the deposition of the local anesthetic in the inter-fascial space between the dorsal extensor muscle and the intercostal muscles at the height of the transverse processes.
- Trial name
- NCT05700214
- Testing
- Ropivacaine injection, Lidocaine IV
- Where
- Poland
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Medication Adherence
Study to Test the Efficacy of Online Education to Increase Safe Use of Opioid Medication.
The purpose of this project is to test whether an online pain medication intervention is a feasible and effective way to increase opioid pain medication safety.
- Trial name
- NCT01770314
- Testing
- Experimental
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Inflexxion, Inc.
Pain, Postoperative, Analgesics, Opioid
Evaluation of Abdominal Wall Block With Liposomal Bupivacaine for Post-Operative Analgesia in Donor Nephrectomy
A blinded randomized control trial in living kidney donors. The study group will receive a liposomal bupivacaine Trans Quadratus Lumborum (TQL) block after the induction of general anesthesia.
- Conditions
- Pain, Postoperative, Analgesics, Opioid, Analgesics, Non-Narcotic, Physiological Effects of Drugs
- Trial name
- NCT03294109
- Testing
- Abdominal wall block with liposomal bupivicaine
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Neuropathic Chronic Pain
Analgesic Stimulation Non-invasive of the Motor Cortex
Prevalence of neuropathic pain raise to 6.9 % in the general population and can reach more than 58 % for patients that carry a lesion of the spinal cord.
- Trial name
- DOLORIS (NCT02854332)
- Testing
- tDCS session, rTMS session
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Surgery, Analgesics, Opioids
Methods for Effective Disposal of Surplus Analgesics to Facilitate Elimination
The primary objective is to evaluate the difference in outcomes for mail-in vs. in-home disposal methods for leftover prescription opioids after discharge from surgery.
- Trial name
- MEDSAFE (NCT05991687)
- Testing
- In-home drug disposal pouch, Mail-in prepaid envelope
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Michigan
Self-Administered Versus Nurse Administered Pain Medication.
Patient Controlled Oral Analgesia for Postoperative Pain Management After Total Knee Replacement
Patient Centered Care (PCC) is "an approach that consciously adopts the patient's perspective...about what matters" (Gerteis, Edgeman, Levitan, Walker, Stokes, Cleary, Delbanco, 1993).
- Trial name
- NCT00221936
- Testing
- Self-administration or nurse administered medication
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Pharmacokinetics, Extracorporeal Membrane Oxygenation
Population PK of Antibiotics, Sedative and Analgesics, and Antiplatelet Drugs During ECMO
The purpose of this study is to optimize the dosage regimen of drugs in patients during during Extracorporeal Membrane Oxygenation (ECMO) by population pharmacokinetic modeling.
- Trial name
- NCT05406492
- Testing
- Residual blood
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Gachon University Gil Medical Center
Osteoarthritis
A Study of Etoricoxib in Participants With Osteoarthritis Not Responding to Analgesic Drugs (MK-0663-142)
This two-part study will evaluate the effectiveness of etoricoxib in controlling pain in participants with osteoarthritis who are experiencing inadequate response to their current treatments.
- Trial name
- RESPOND-EUROPE (NCT01429168)
- Testing
- Etoricoxib
- Sponsor
- Organon and Co
Acute Pain, Opioid Analgesic Adverse Reaction
the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery
The goal of this clinical trial is to learn if Oliceridine fumarate injection works to treat acute pain after abdominal surgery. It will also learn about the safety of Oliceridine fumarate injection.
- Trial name
- NCT06530563
- Testing
- Oliceridine Injection [Olinvyk], Sufentanil Citrate
- Where
- China
- Volunteers
- 606 people
- Sponsor
- Xiangya Hospital of Central South University
Inguinal Hernia Unilateral, Pain Management
Comparing Opioids Vs NSAIDs for Postoperative Pain Management in Unilateral Primary Open Inguinal Hernia Repair
To control post-operative pain, multiple drugs are available, and in the western countries opioids are preferred. However, they have their own side effects, and so to reduce their dependence, multiple adjuncts are used.
- Trial name
- NCT06608056
- Testing
- Pain management after surgery
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Pakistan Air Force (PAF) Hospital Islamabad
Lumbosacral Radicular Pain, Sciatic Radiculopathy
Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy
The purpose of this study is to evaluate the safety and tolerability of C-1101 administered as a single dose, transforaminal epidural injection compared to sterile saline
- Conditions
- Lumbosacral Radicular Pain, Sciatic Radiculopathy, Sciatic Leg Pain, Sciatica
- Trial name
- NCT07264270
- Testing
- C-1101
- Where
- 6 sites in United States, Australia
- Volunteers
- 24 people
- Sponsor
- Consano Bio
Prescription Drug Abuse
Using m-Health Tools to Reduce the Misuse of Opioid Pain Relievers
The aim of this study is to pilot test a web-based, patient-centered educational program that encourages the patient to have an informed discussion about pain medication options with their emergency department (ED) provider.
- Trial name
- NCT03012087
- Testing
- MyHealthyChoices, Health Risk Assessment
- Where
- 2 sites in United States
- Volunteers
- 123 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health