Clinical trials: Analgesics, Opioid
Cancer of Endometrium, Cancer of Cervix
Efficacy of PENS of the Auricle as an Opioid Sparing Postoperative Analgesic Technique in Cancer Endometrium and Cancer Cervix Patients
Pain relief following laparotomy surgery requires a variety of techniques including invasive ones like epidural or nerve blocks along with different classes of drugs, out of which opioids are most predominant.
- Trial name
- NCT05742711
- Testing
- Primary Relief
- Where
- India
- Volunteers
- 48 people
- Sponsor
- DyAnsys, Inc.
Anesthesia, Postoperative Pain
Lateral QL Block vs Intrathecal Morphine for Cesarean Section
Effective postoperative analgesia after cesarean delivery is essential for maternal recovery, early mobilization, breastfeeding, and maternal-infant bonding.
- Conditions
- Anesthesia, Postoperative Pain, Regional Anesthesia
- Trial name
- NCT07712783
- Testing
- Lateral Quadratus Lumborum Block, ıv morphine PCA, Intrathecal morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Ondokuz Mayıs University
Healthy Volunteers
Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers
Background: Opioid drugs are often prescribed for acute and chronic pain. But these drugs are addictive, and they lead to more than 14,000 overdose deaths in the United States each year.
- Trial name
- NCT07504601
- Testing
- (2R,6R)-Hydroxynorketamine
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Pain, Hypogonadism
Analgesic Efficacy of Testosterone Replacement in Hypogonadal Opioid-treated Chronic Pain Patients: A Pilot Study.
The purpose of this pilot study is to test the effects of testosterone replacement on pain, fatigue, mood, cognition and libido in hypogonadal men on long-term opioid therapy for chronic pain.
- Trial name
- NCT00398034
- Testing
- Testosterone Gel
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Opioid Consumption, Visual Analog Score
Perioperative Effects of Lateral Quadratus Lumborum Block in Percutaneous Transhepatic Cholangiography
The frequency of non-operating room anesthesia (ADA) applications is increasing and has gained an important place in anesthesia practice.
- Conditions
- Opioid Consumption, Visual Analog Score, Demographic Data, Rescue Analgesic Status and Time
- Trial name
- NCT06618781
- Testing
- Sedation, Sedation + Quadratus Lumborum Block
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ankara Etlik City Hospital
Comparison of US Bilateral Erector Spinae Plane Block, US Bilateral Quadratus Lumborum Block and Lumbar Epidural
Comparison of US Bilateral Erector Spinae Plane Block, US Bilateral Quadratus Lumborum Block and Lumbar Epidural for Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy
The investigators hypothesize that US Bilateral Erector Spinae Plane Block, US Bilateral Quadratus Lumborum Block and Lumbar Epidural for Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy resulting in…
- Trial name
- NCT06397300
- Testing
- bilateral Ultrasound guided erector spinae plane (ESP) block, quadratus lumborum block, lumbar epidural
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute, Egypt
Opioid Consumption, Pain Postoperative
Comparison of Analgesic Efficacy of Quadratus Lumborum Type 3 and Suprainguinal Fascia Iliaca Compartment Block in Total Hip Arthroplasty Surgery
Total Hip Arthroplasty (THA) is a complex surgical procedure frequently performed to treat degenerative conditions in the hip joint. As people's life expectancy increases, the need for hip arthroplasty increases.
- Trial name
- NCT06838156
- Testing
- Bupivacain
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Analgesia, Cesarean Section Complications
Trans Abdominis Plane (TAP) Block in Patients With Cesarean Section
Objective: To compare Trans Abdominis Plane block in providing post cesarean analgesia with control group, in terms of mean postoperative use of Opioids. Study design: Randomized controlled trial.
- Trial name
- TAP (NCT04809532)
- Testing
- Transverse abdominis plane (TAP) block, Bupivacain, Tramadol
- Where
- 2 sites in Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Armed Forces Hospital, Pakistan
Analgesic Drug Dependence, Sensory Deficit
Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering
Few studies have used quantitative sensory tests to study the effect of chronic opioid treatment on sensation. The investigators will test chronic pain patients who are on different MEDDs, normal volunteers, and patients…
- Trial name
- NCT03375216
- Testing
- sensory testing (Heat, cold, and pressure), Promis Survey
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
CBD, Chronic Pain
Cannabidiol, Morphine, Pain
The purpose of the proposed study is to investigate the interaction of cannabidiol (CBD) and morphine effects on pain sensitivity.
- Trial name
- CMP (NCT04030442)
- Testing
- Immediate-release Oral Morphine Sulfate Tablets, Thermal and Pressure Nociceptive Sensitivity
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Chronic Pain
Veterans' Pain Care Organizational Improvement Comparative Effectiveness Study
Background and significance: Treatment with opioid pain medications (like hydrocodone and morphine) is common for severe pain, but studies show these medications may not always help and can cause serious problems.
- Trial name
- VOICE (NCT03026790)
- Testing
- Medication management, Non-pharmacological pain management, Buprenorphine-Naloxone
- Where
- United States
- Volunteers
- 820 people
- Sponsor
- University of Minnesota
Knee Injuries, Knee Injuries and Disorders
Opioid Reduction Program for Total Knee Replacement Patients
In the context of prescribed opioids, research suggests that increased exposure is associated with long-term opioid use. Orthopedic surgeries are associated with the prescribing of more opioid narcotics than any other surgical…
- Conditions
- Knee Injuries, Knee Injuries and Disorders, Opioid Use
- Trial name
- TKR ORP (NCT05414942)
- Testing
- Opioid Reduction Program
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Tennessee
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International