Clinical trials: Analgesics, Opioid
Pain
Efficacy of Low Analgesic Doses of Ketamine Associated With Opioids in Refractory Cancer Pain Treatment
Long-term opioid therapy is commonly administered for the management of severe cancer pain. Increasing doses of opioids are titrated against effects until analgesia is achieved or intolerable adverse effects occur.
- Trial name
- KEPAL (NCT01326325)
- Testing
- Ketamine, NaCl
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Pain
Patient Activation to Address Chronic Pain and Opioid Management in Primary Care
Will a primary care-based behavioral intervention for patient activation and engagement and self-management, for patients with chronic pain who are taking opioid pain medication, result in better patient outcomes than Usual Care?
- Trial name
- NCT02290223
- Testing
- Behavioral Based Treatment Model
- Where
- 2 sites in United States
- Volunteers
- 376 people
- Sponsor
- Kaiser Permanente
Pain, Postoperative, Anesthesia, Local
Improving Pain Relief Following Laparoscopic Ventral Hernia Repair
Aim The general aim of this study is to improve post-operative pain and reduce morphine consumption following laparoscopic ventral hernia repair (LVHR).
- Conditions
- Pain, Postoperative, Anesthesia, Local, Hernia, Ventral, Laparoscopy
- Trial name
- NCT02785276
- Testing
- AutoFuser Pain Pump, Ropivacaine, Normal Saline (0.9%)
- Where
- New Zealand
- Sponsor
- University of Auckland, New Zealand
Acute Pain
Opioid Analgesics for Acute Fracture Pain in Adults Discharged From the ED
Background: Emergency department (ED) providers are frequently challenged with how best to treat acute pain, specifically when non-opioid analgesics are insufficient or contraindicated.
- Trial name
- NCT03478423
- Testing
- Codeine, Oxycodone, Hydromorphone
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Mount Sinai Hospital, Canada
Analgesics Opioid
A Strategy to Reduce Opioid Drug Prescribing by Clinicians
Under the auspices of the Oral Health Section of the NC Department of Health and Human Services clinician-investigators from the UNC Oral and Maxillofacial Surgery Department are conducting a survey to assess current analgesic…
- Trial name
- NCT03809507
- Testing
- Qualtrics survey questions
- Where
- United States
- Volunteers
- 895 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Opioid Use Disorders, Opioid-related Disorders
Prevalence and Predictors of Prolonged Post-surgical Opioid Use: a Prospective Observational Cohort Study
Post-surgical opioid prescribing intended for the short-term management of acute pain may lead to long-term opioid use, and its associated harms.
- Conditions
- Opioid Use Disorders, Opioid-related Disorders, Surgery, Pain, Postoperative
- Trial name
- NCT02571400
- Testing
- Continued use of opioid analgesics >90 days post-surgery
- Where
- Australia
- Volunteers
- 1,013 people
- Sponsor
- University of Notre Dame Australia
Pain Management, Orthopedic Procedure Pain
The Analgesic Efficacy of Nefopam in Orthopedics Surgery
Pain-free and relief are one of the anesthesiologist's most important concerns during the operation. General aim is always to effectively control pain but while simultaneously reducing opioid requirements to reduce opioid related…
- Trial name
- NCT06680609
- Testing
- Nefopam 20 MG/ML
- Where
- Jordan
- Volunteers
- 49 people
- Sponsor
- King Abdullah University Hospital
Chronic Pain
Safety and Effectiveness of Buprenorphine Transdermal System in Elderly Subjects With Chronic Pain: Pilot Study.
This pilot study was designed to evaluate the effectiveness and tolerability of the buprenorphine transdermal system versus placebo on health outcomes in elderly residents in supervised living environments.
- Trial name
- NCT00313833
- Testing
- Buprenorphine transdermal delivery system
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- Purdue Pharma LP
Acute Pain
Analgesic Efficacy and Safety of ADL5859 in Subjects With Acute Dental Pain After Third Molar Extraction
The objective of this study is to evaluate the analgesic efficacy and safety of ADL5859 compared with placebo and an active control (ibuprofen) in subjects with acute dental pain after third molar extraction.
- Trial name
- NCT00993863
- Testing
- ADL5859 30 mg, ADL5859 100 mg, ADL5859 200 mg
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Pain, Postoperative
Preoperative Ketamine Has no Preemptive Analgesic Effect in Patients Undergoing Colon Surgery.
The analgesic properties of ketamine are associated with its non-competitive antagonism of the N-methyl-D-aspartate receptor; these receptors exhibit an excitatory function on pain transmission and this binding seems to inhibit…
- Trial name
- NCT02241278
- Testing
- Ketamine
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Hospital Arquitecto Marcide
Post-craniotomy Pain Management, Post-craniotomy
Comparison of Pain Using CPOT Score With Ketamine vs. Dexmedetomidine in Post-Craniotomy ICU Patients
Study Overview: This study is designed to compare two different medications used to manage pain after craniotomy surgery in the ICU.
- Conditions
- Post-craniotomy Pain Management, Post-craniotomy, Pain Control in ICU, Ketamine vs Dexmedetomidine for Pain Relief
- Trial name
- CPOT-KD (NCT07254936)
- Testing
- ketamine, Dexmedetomidine
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Universitas Sumatera Utara
Analgesics, Opioid, Anesthesia, Endotracheal
Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery
Opioid-free anesthesia (OFA) is a multimodal technique that eliminates intraoperative opioids by combining dexmedetomidine, ketamine, lidocaine, NSAIDs, and regional analgesia.
- Conditions
- Analgesics, Opioid, Anesthesia, Endotracheal, Anesthesia, General
- Trial name
- NCT06380244
- Testing
- anesthesia without opioids
- Where
- Poland
- Volunteers
- 600 people
- Sponsor
- Jagiellonian University
Postoperative Pain
Safety of Buprenorphine Transdermal System (BTDS) in Subjects With Acute Postoperative Pain After Total Knee Replacement
The objectives in this study are to evaluate: (1) efficacy of buprenorphine transdermal system (BTDS, Butrans™) on postoperative pain following total knee replacement surgery; (2) the impact of BTDS on functional rehabilitative…
- Trial name
- NCT00403234
- Testing
- Buprenorphine transdermal patch
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Purdue Pharma LP
Pain, Postoperative, Opioid Use
Comparison of Postoperative Nociception Between NOL-guided and Standard Intraoperative Analgesia Based on Fentanyl
Pain is defined as an unpleasant sensory and emotional conscious experience, associated with actual or potential tissue damage. Nociception is the sympathetic response to noxious stimuli during unconsciousness.
- Conditions
- Pain, Postoperative, Opioid Use, Nociceptive Pain, Postoperative Pain
- Trial name
- NOLFentanyl (NCT03858621)
- Testing
- fentanyl NOL guided
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Victor Contreras, MSN
Postoperative Pain
Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients
This is a randomized, double-blind, multicenter, fixed dose factorial study of Q8003 12 mg/8 mg and Q8003 6 mg/4 mg versus its individual morphine sulfate and oxycodone hydrochloride components for the management of acute…
- Trial name
- NCT00831051
- Testing
- Q8003, Morphine sulfate, Oxycodone HCl
- Where
- 6 sites in United States
- Volunteers
- 197 people
- Sponsor
- QRxPharma Inc.
Epidermolysis Bullosa
Improve Adherence to Weak or Strong Opioid Analgesics at the Time of Care in Children With Hereditary Epidermolysis Bullosa
Hereditary epidermolysis bullosa (HEB) are rare genodermatoses, clinically characterized by epithelial and subepithelial fragility leading to the formation of blisters and spontaneous erosions on skin at the slightest contact…
- Trial name
- ODEB (NCT04853667)
- Testing
- Interview
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Opioid Consumption, Pain Postoperative
Comparison of Analgesic Efficacy of Quadratus Lumborum Type 3 and Suprainguinal Fascia Iliaca Compartment Block in Total Hip Arthroplasty Surgery
Total Hip Arthroplasty (THA) is a complex surgical procedure frequently performed to treat degenerative conditions in the hip joint. As people's life expectancy increases, the need for hip arthroplasty increases.
- Trial name
- NCT06838156
- Testing
- Bupivacain
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Opioid Overdose
Incidence and Predictors of Opioid Overdose and Death Among Long-Term Users of Opioid Analgesics
Retrospective study to assess incidence and predictors of opioid abuse overdose and death associated with opioid overdose among patients prescribed opioid products in long-term use.
- Trial name
- NCT02662153
- Testing
- Observation only
- Where
- 4 sites in United States
- Volunteers
- 808,455 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Emergency Service, Hospital, Child/Adolescent Problem
A RCT of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture
MSK-I is the most common cause for ED visits for children with pain, with a child's risk of sustaining a fracture ranging from 27-42% by the age of 16 years.
- Conditions
- Emergency Service, Hospital, Child/Adolescent Problem, Acute Pain, Fentanyl
- Trial name
- CAST (NCT02985177)
- Testing
- INF2.0 + IBU, INF1.0 + IBU
- Where
- 3 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Opioid Use
The Effect of Preoperative Maxigesic® on Intraoperative Remifentanil Requirement
Maxigesic is combined intravenous analgesic of ibuprofen and acetaminphen. The purpose of this study is investigate weather preoperative Maxigesic administration can reduce intraoperative remifentanil requirement.
- Trial name
- NCT06015711
- Testing
- Maxigesic administration
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Ajou University School of Medicine