Clinical trials: Anaphylaxis
Food Allergy, Anaphylaxis Food
Inhibition of Anaphylaxis by Ibrutinib
This is a phase II open label study on the use of Ibrutinib on the inhibition of food-induced anaphylaxis in adults with food allergy.
- Trial name
- NCT03149315
- Testing
- Ibrutinib
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Perioperative Complication, Hypersensitivity
Defining ENDOtypes in Perioperative Hypersensitivity by Extensive Cellular and Molecular PHENotyping (ENDOPHEN)
Perioperative Acute Hypersensitivity (PAH) is a systemic reaction that occurs rapidly following injection of a drug during anesthesia.The HSA-PA reaction must occur within a maximum of one hour after the induction of anesthesia…
- Trial name
- ENDOPHEN (NCT04006106)
- Where
- 7 sites in France
- Volunteers
- 103 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypersensitivity, Immediate, Peri-operative Injury
Repertoire and Properties of Anti-drug Antibodies Involved in Immediate Hypersensitivity in the Operating Room
Acute per-anesthetic hypersensitivity reaction (HSA-PA) is a rapidly occurring systemic reaction following injection of a drug during anesthesia (mortality between 3 and 9%).
- Conditions
- Hypersensitivity, Immediate, Peri-operative Injury, Antibiotic Allergy, Antibody Hypersensitivity
- Trial name
- MEDIREP (NCT05420935)
- Testing
- IgG group, IgE group, IgG group + IgE group
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anaphylaxis
Acquisition and Long-term Observation of Patients With Severe Allergic Reactions
The Anaphylaxis Registry aims to assess data in a standardized form about symptoms, triggers, cofactors and therapy management from patients who experienced an anaphylactic reaction.
- Trial name
- NCT05210543
- Testing
- not applicable, observational study
- Where
- Germany
- Volunteers
- 20,000 people
- Sponsor
- Charite University, Berlin, Germany
Anaphylactic Reaction
Study of Inhaled DMC-IH1 and Intramuscular (EpiPen®) Epinephrine in Healthy Male and Female Participants.
This is a phase 1, randomised, double blind placebo controlled 2-part study to assess the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of inhaled DMC-IH1 (epinephrine) and relative bioavailability and carryover effects…
- Trial name
- NCT06013150
- Testing
- Epinephrine
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- De Motu Cordis
Anaphylaxis
Use of Dexamethasone in Prevention of the Second Phase or a Biphasic Reaction of Anaphylaxis
Anaphylaxis is an acute serious allergic reaction, with multi-organ system manifestations caused by the release of chemical mediators and it is potentially fatal .
- Trial name
- NCT03523221
- Testing
- Dexamethasone Oral
- Where
- Qatar
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Poisoning
Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects
Paracetamol overdose is the leading cause of acute liver failure in the Western World. N-acetylcysteine (NAC) has been the antidote of choice for over 30 years but its use is associated with adverse effects in 40% of cases.
- Trial name
- NCT01209455
- Testing
- Chlorphenamine and Ranitidine, Paracetamol
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Penicillin Allergy
Oral Penicillin Challenge and Allergy De-labeling in Children
The primary purpose of this study is to investigate the portion of penicillin allergy labels that are not true allergies using oral amoxicillin challenges among pediatric patients.
- Trial name
- NCT05563610
- Testing
- Amoxicillin 500mg
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Phoenix Children's Hospital
Acute Disease, Sepsis
Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Research in acute care faces many challenges, including enrollment challenges, legal limitations in data sharing, limited funding, and lack of singular ownership of the domain of acute care.
- Conditions
- Acute Disease, Sepsis, Pneumonia, Frailty
- Trial name
- Acutelines (NCT04615065)
- Where
- Netherlands
- Volunteers
- 35,000 people
- Sponsor
- University Medical Center Groningen
Anaphylactic Reaction
Design, Implementation and Evaluation of the Guided Observer Role in Clinical Simulation
The aim of this study is to assess the effectiveness of the guided observed role in a simulation learning programme for nursing students in acquiring the competence (knowledge, skills and attitudes) to care for patients affected…
- Trial name
- NCT06405399
- Testing
- Educational intervention. observation guide
- Where
- Spain
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Food; Allergy, Anaphylactic Shock, Asthma in Children
Omalizumab in Severe Asthmatics With Food Allergy
A prospective assessment of the impact of Omalizumab in terms of efficacy, safety, and quality of life (FA-QoL) in patients with moderate/severe asthma and history of anaphylaxis to peanut, tree nuts, fish, egg, milk, and/or…
- Trial name
- OSAFA (NCT06316414)
- Testing
- Omalizumab
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Peanut Allergic Subjects
Peanut Oral Immunotherapy in Children With Peanut Allergy (Peanut Flour)
Many children who are allergic to peanuts do not outgrow their allergy and have very severe allergic reactions called anaphylaxis.
- Trial name
- PeanutFlour (NCT02203799)
- Testing
- Peanut Oral Immunotherapy (POIT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Baylor College of Medicine
Anaphylaxis
Bioavailability of Nasal Epinephrine
A Study to Compare the Bioavailability of Epinephrine following a Single Nasal Dose of FMXIN002 Microspheres Powder with Epinephrine 0.3 mg Intramuscular Injection in Adult Subjects with Seasonal Allergic Rhinitis with and…
- Trial name
- NCT04696822
- Testing
- Epinephrine Nasal Product, 1.6 mg, Epinephrine nasal product, 1.6 mg + allergen, Epinephrine Injection 0.3 mg
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nasus Pharma
Perioperative/Postoperative Complications, Drug-Induced Anaphylaxis
Perioperative Anaphylaxis in Patients Attending University Hospitals (Egypt - UK).
Perioperative anaphylaxis is associated with significant morbidity and mortality. Most textbooks describe it as a rare event of the order of 1 in 10 to 1 in 20,000 general anaesthetic cases.
- Trial name
- NCT03393091
- Where
- 2 sites in Egypt, United Kingdom
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Assiut University
Food Allergy
Protection From Food Induced Anaphylaxis by Reducing the Serum Level of Specific IgE (Protana).
Anaphylaxis elicited by accidental intake of the offending food constitutes a major health risk to the food allergic patient. Current advice for the food allergic patient is to avoid the offending food allergen and to carry an…
- Trial name
- NCT03964051
- Testing
- Omalizumab Injection
- Where
- Denmark
- Volunteers
- 7 people
- Sponsor
- Carsten Bindslev-Jensen
Food Allergy, Food Allergy Peanut
Preventing Anaphylaxis With Acalabrutinib
Food allergy is a potentially life-threatening condition, and its prevalence continues to increase despite public health efforts. There are currently no known therapies that can reliably prevent food-induced anaphylaxis.
- Trial name
- NCT05038904
- Testing
- Acalabrutinib
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Anaphylactic Reaction
Study of Inhaled Epinephrine and Intramuscular Epinephrine Administered to Healthy Adults
This is a study to determine the relative bioavailability of inhaled epinephrine compared with 0.3mg epinephrine administered IM in healthy male and female participants.
- Trial name
- NCT05152901
- Testing
- EpiPen ®., Epinephrine (0.3mg) inhaled, Epinephrine (1.3mg)
- Where
- Australia
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- De Motu Cordis
Hypersensitivity, Drug
GERAP's Epidemiological Survey on Perioperative Hypersensitivity Reactions
Perioperative hypersensitivity reactions are still associated with significant morbidity and mortality despite early recognition and use of epinephrine.
- Trial name
- SERAP (NCT04654923)
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Strasbourg, France
Anaphylaxis
Evaluation of Medical Care and Patient's Knowledge About the Behavior to Take on Secondary Prevention of Anaphylaxis
Anaphylaxis is a hypersensitivity reaction systemic, generalized, severe, life-threatening that may result from exposure to a triggering factor. The prevalence of anaphylaxis is 0.05 to 2% in the general population.
- Trial name
- NCT03953482
- Where
- 2 sites in France
- Volunteers
- 66 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Anaphylaxis, Biphasic Anaphylactic Reaction
SHARED Study (Saguenay Hospitals Anaphylaxis Rule for Early Discharge)
Anaphylaxis is a potentially fatal condition with a prevalence between 0.05 and 2% in the general population. This is therefore a frequent reason for emergency visits.
- Conditions
- Anaphylaxis, Biphasic Anaphylactic Reaction, Rebound Anaphylactic Reaction
- Trial name
- SHARED (NCT04755881)
- Testing
- Occurence of biphasic reaction following anaphylaxis
- Where
- Canada
- Volunteers
- 191 people
- Sponsor
- Université de Sherbrooke