Clinical trials: Anastomosis, Leaking
Morbid Obesity, Anastomotic Leak
Stratafix vs. Vicryl OAGB / MGB Suture Study
To compare shorttime (6 months) results of two competitive suture materials with regard to time demanded to perform the concerned surgical step and secondary to study anastomotic site safety and complications like leakage and…
- Conditions
- Morbid Obesity, Anastomotic Leak, Anastomotic Stenosis, Hemorrhage Postoperative
- Trial name
- NCT04613635
- Testing
- Stratafix, Vicryl
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- St. Franziskus Hospital
Colorectal Cancer (CRC), Surgery, Colorectal
Study of Colorectal Anastomosis Failures With First Sigmoid or Left Colonic Artery Preservation With D3 Lymphadenectomy
This study is a randomized, controlled trial comparing the short- and long-term outcomes of left colonic artery or first sigmoid artery preservation for rectal surgery.
- Conditions
- Colorectal Cancer (CRC), Surgery, Colorectal, Oncology
- Trial name
- COLAP-D3 (NCT06938490)
- Testing
- Anterior rectal resection with D3-lymphatic dissection
- Where
- Russia
- Volunteers
- 778 people
- Sponsor
- the BELOOSTROV Clinic of High Technologies
Rectal Cancer
Transanual Tube Placement in Low Anterior Resection (LAR) for Rectal Cancer
The purpose of this study is to evaluate the effectiveness of transanual tube placement in low anterior resection (LAR) for rectal cancer in preventing anastomotic leakage.
- Trial name
- NCT02905968
- Testing
- transanual tube placement
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Fudan University
Cancer of Rectum
Peritoneal Microdialysis in Patients Undergoing Low Anterior Resection (LAR) for Recto-sigmoid Cancer
Anastomotic leakage is a serious complication after LAR with high morbidity and mortality rates. Early diagnosis and treatment is mandatory.
- Trial name
- NCT00271986
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Anastomotic Leak, Surgical Site Infection
Bowel Prep vs Non-Bowel Prep for Laparoscopic Colorectal Surgery
Research Question: Are anastomotic leak and surgical site infection rates equivalent in patients having laparoscopic bowel resections without bowel preparation vs those having bowel preparation? Bowel preparation is a distressing…
- Trial name
- NCT00643084
- Testing
- low residue diet/no standard bowel preparation, standard bowel preparation
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Hamilton Health Sciences Corporation
Colorectal Cancer, Leakage Testing
Efficacy and Safety of Colorectal Anastomotic Leak Testing
To evaluate the effectiveness of the gastroscopy, air, and methylene blue (GAM) leak testing in reducing the incidence of postoperative anastomotic complications, especially anastomotic leakage, in patients with colorectal…
- Conditions
- Colorectal Cancer, Leakage Testing, Colorectal Surgery, Complications
- Trial name
- NCT06865638
- Testing
- Intraoperative leak testing
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Nanchong Central Hospital
Colorectal Cancer
Indicators of Anastomotic Leak After Colorectal Surgery
We reviewed the patient underwent colorectal surgery with anastomosis and identified patients with anastomotic leak. Then we started to figure out what blood investigation could be related to anastomotic leak.
- Trial name
- NCT06156358
- Testing
- No intervention
- Volunteers
- 441 people
- Sponsor
- King Abdulaziz University
Rectal Cancer, Surgery Indication
Low Powered Colorectal Anastomosis After Rectal Excision (OASIS)
The objectiive of this prospective, international cohort is to compare two anastomotic techniques (DS vs TTSS) by collecting data during the surgery, and postoperatively (morbidity and functional outcomes).
- Trial name
- OASIS (NCT07146334)
- Where
- 15 sites in Belgium, Canada and 4 more
- Volunteers
- 400 people
- Sponsor
- Bordeaux Colorectal Institute
Esophageal Neoplasm, Anastomotic Leak
Prediction of Anastomotic Complications and Recurrent Laryngeal Nerve Injury Based on Postoperative Early Endoscopic Evaluation
Analyze the correlation between the conformity of the anatomy (based on endoscopic examination) and postoperative anastomotic fistula and anastomotic stenosis; establish an anastomotic classification; and construct a predictive…
- Conditions
- Esophageal Neoplasm, Anastomotic Leak, Recurrent Laryngeal Nerve Injuries, Anastomotic Stenosis
- Trial name
- NCT06348381
- Testing
- No intervention
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Chest Hospital
Anastomosis, Leaking, Anastomotic Stenosis
Outcomes Of Single-Layer Extramucosal Colostomy Closure With Full-Thickness (All-Layers) Colostomy Closure
to compare the clinical outcomes of single-layer extramucosal colostomy closure with full-thickness (all-layers) colostomy closure in paediatric patients.
- Trial name
- NCT07411885
- Testing
- extramucasal colostomy closure, full thickness closure
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Children Hospital and Institute of Child Health, Lahore
Colorectal Cancer
Does Administration of Antibiotics in Patients Undergoing Surgery for Colorectal Cancer Result in Less Complications and Better Prognosis?
The primary objectives of this randomized clinical trial are to evaluate if perioperative SDD can reduce clinical anastomotic leakage rate and its septic consequences as well as other infectious complications.
- Trial name
- SELECT (NCT01740947)
- Testing
- Selective decontamination of the digestive tract (SDD) (colistin sulfate, tobramycin, amphotericin B)
- Where
- 5 sites in Netherlands
- Volunteers
- 485 people
- Sponsor
- H. Jaap Bonjer, PhD
Esophagojejunal Anastomotic Leak
Impact of Endo-vac Therapy for Esophago-jejunal Anastomotic Leak
The goal of this observational study is to assess the impact of endoscopic vacuum therapy in patients who underwent total gastrectomy due to gastric cancer and developed esophago-jejunal anastomotic leakage.
- Trial name
- ENDO-VAL (NCT07295236)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Clinical Oncology
Perforation of the Oesophagus, Perforation of the Colon
VAC-Stent Registry
This registry is intended to collect data on quality assurance and use of the VAC-Stent® and thus verify the suitability of the VAC-Stent® for sealing leakages in the oesophagus or colon.
- Trial name
- NCT04884334
- Testing
- VAC-Stent®
- Where
- 14 sites in Germany
- Volunteers
- 110 people
- Sponsor
- Markus M. Heiss
Anastomotic Complication, Anastomotic Leak Small Intestine
Open Abdomen and Delayed Anastomosis After Anastomotic Dehiscences to Avoid Stomas
Phase III clinical trial to evaluate the efficacy of the open abdomen as bridging therapy to perform transit reconstruction in patients with anastomotic dehiscence.
- Conditions
- Anastomotic Complication, Anastomotic Leak Small Intestine, Anastomotic Leak Large Intestine
- Trial name
- STOP-STOMA (NCT05233995)
- Testing
- Damage Control Surgery
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Anastomotic Leak, Microbial Colonization
SURGIcal COmplication and MIcrobiome ChangeS in Colorectal Surgery
The microbiome, the collection of microorganisms that live in our gut, plays an important role in maintaining our health, proper nutrient absorption, nutrient turnover and immunity.
- Trial name
- Surgi-Comics (NCT05779254)
- Testing
- Neomycin Sulfate
- Where
- 3 sites in Hungary
- Volunteers
- 100 people
- Sponsor
- Uzsoki Hospital
Rectal Cancer
Transanal Versus Laparoscopic Total Mesorectal Excision for Rectal Cancer.
This study is designed as a prospective, multi-center, randomized, open-labelled, parallel group, non-inferiority trial. The aim of this study is to evaluate the TaTME technique compared with conventional laparoscopic rectal…
- Trial name
- taTME (NCT03413904)
- Testing
- transanal TME, laparoscopic TME
- Where
- Italy
- Volunteers
- 184 people
- Sponsor
- IRCCS San Raffaele
Gastrointestinal Anastomotic Complication
a Study to Investigate the Efficacy, and Safety of the Colovac Colorectal Anastomosis Protection Device.
The purpose of this study is to evaluate theColovac device, a single use, temporary intraluminal bypass device,intended to reduce contact of fecal content with an anastomotic site, following colorectal surgery (open or…
- Trial name
- SAFE-1 (NCT03352570)
- Testing
- COLOVAC
- Where
- 3 sites in Belgium, France
- Volunteers
- 15 people
- Sponsor
- Safeheal
Anastomotic Leak
Neutrophil-to-lymphocyte Ratio vs C-reactive Protein as Early Predictors of Anastomotic Leakage After Colorectal Surgery
Introduction: Colorectal surgery (CRS) is associated with high morbidity rates, being anastomotic leakage (AL) one of the most serious complications with an incidence as high as 15%, accounting for up to a third of mortality in…
- Trial name
- NCT04673110
- Testing
- Neutrophil to Lymphocyte Ratio and C-reactive protein
- Volunteers
- 116 people
- Sponsor
- Clinica Universitaria Reina Fabiola, Universidad Catolica de Cordoba
Esophageal Carcinoma, Esophageal Adenocarcinoma
Postoperative Hypoxemia Increases the Risk of Anastomotic Leak After Radical Esophagectomy
This study aims to determine whether postoperative hypoxia (arterial partial pressure of oxygen (PaO₂)<80 mmHg) is an independent risk factor for anastomotic leakage after esophagectomy.
- Conditions
- Esophageal Carcinoma, Esophageal Adenocarcinoma, Esophagectomy, PaO2
- Trial name
- NCT07309991
- Where
- 6 sites in China
- Volunteers
- 2,500 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer
C-Reactive Protein and Sodium in Predicting Anastomotic Leakage
Anastomotic leakage is serious morbidity that can develop in patients operated on for colorectal cancer and can reach potentially life-threatening dimensions.
- Trial name
- NCT04717648
- Testing
- Biochemical test
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Tepecik Training and Research Hospital