Clinical trials: Anastomosis, Leaking
Gynecologic Cancers, Ovarian Cancer
Near-Infrared Fluorescence Imaging With Indocyanine Green to Evaluate Bowel Anastomoses in Gynecologic Oncology Surgery
The goal of this study is to evaluate if indocyanine green (ICG) fluorescence imaging helps reduce complications in bowel surgery performed during gynecologic cancer operations.
- Conditions
- Gynecologic Cancers, Ovarian Cancer, Endometrial Cancers, Cervical Cancers
- Trial name
- INOCA (NCT06871787)
- Testing
- Indocyanine Green, Near-Infrared Fluorescence Imaging System
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Mesenteric Vascular Disease, Colorectal Surgery
Anastomotic Leakage Prevention by Endovascular Stenting of the Superior Mesenteric Artery
Rationale: Anastomotic leakage (AL) is a severe complication of colon surgery, with an incidence of 2.7-11.9%. It is associated with long-term increased mortality, reduced quality of life, and high healthcare costs due to…
- Conditions
- Mesenteric Vascular Disease, Colorectal Surgery, Preventive Intervention
- Trial name
- ALPrES²MA (NCT07486570)
- Testing
- Percutaneous transluminal angiopasty and endovascular stenting of the superior mesenteric artery, Colon surgery, Mono antiplatelet therapy with Ascal 80mg daily
- Where
- 18 sites in Netherlands
- Volunteers
- 360 people
- Sponsor
- Medisch Spectrum Twente
Esophageal Cancer
Tissue Oxygenation Are Associated With Anastomotic Leak Rates After an Ivor Lewis Esophagectomy
The purpose of this study is to test whether after an Ivor Lewis esophagectomy (the removal of a portion of the stomach and esophagus with re-attachment) there is an association between the intraoperative level of oxygen at the…
- Trial name
- NCT01551433
- Testing
- wireless pulse oximeter (Wipox)
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Anastomotic Leaks
Study of Eso-SPONGE for Treating Leaks After Upper Gastrointestinal Surgery
To evaluate the safety and effectiveness of sponge-based Endoscopic Vacuum Therapy (EVT) using Eso-SPONGE for the treatment of anastomotic leaks in the upper gastrointestinal tract in a prospective multi-center study.
- Trial name
- DRAIN Upper (NCT07711093)
- Testing
- sponge-based Endoscopic Vacuum Therapy (EVT) using Eso-SPONGE
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Boston Scientific Corporation
Colo-rectal Cancer, Anastomosis, Leaking
The Factors Influencing the Success of Redo Surgery and Anal Function for Anastomosis Failure or Local Tumor Recurrence
To analyze the influencing factors of the success of redo surgery due to anastomotic fistula or anastomotic recurrence after rectal cancer surgery and to evaluate the anal function of patients
- Trial name
- NCT07440888
- Testing
- redo surgery
- Volunteers
- 143 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Pancreatic Fistula, Pancreas Neoplasm
Biodegradable Pancreatic Stents for the Prevention of Postoperative Pancreatic Fistula After Cephalic Pancreaticoduodenectomy
Background: postoperative pancreatic fistula (POPF) remains the most important morbidity after pancreaticoduodenectomy (PD). There is no consensual technique for pancreatic reconstruction and many surgeons use a transanastomotic…
- Conditions
- Pancreatic Fistula, Pancreas Neoplasm, Stent Disintegration, Pancreatic Cancer
- Trial name
- NCT04783831
- Testing
- Biodegradable stent
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Colorectal Disease Requiring Elective Laparoscopic Resection, Colorectal Anastomotic Leak
ICG Fluorescence Angiography to Reduce Anastomotic Leak After Laparoscopic Colorectal Resection
This prospective randomized controlled trial evaluates whether intraoperative indocyanine green (ICG) fluorescence angiography reduces clinically significant anastomotic leakage after elective laparoscopic colorectal resection…
- Trial name
- NCT07826156
- Testing
- Visual assessment, ICG visuals assessment
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Rectal Neoplasms
Defunctioning Cannula Ileostomy After Lower Anterior Resection of Rectal Cancer
Most surgeons suggest the use of fecal diverting to address the high morbidity and mortality associated with anastomotic leakage (AL) in patients with high risk factors on AL who are undergoing anterior resections.
- Trial name
- NCT01980238
- Testing
- cannula ileostomy, loop ileostomy, LAR
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Colorectal Cancer
Indicators of Anastomotic Leak After Colorectal Surgery
We reviewed the patient underwent colorectal surgery with anastomosis and identified patients with anastomotic leak. Then we started to figure out what blood investigation could be related to anastomotic leak.
- Trial name
- NCT06156358
- Testing
- No intervention
- Volunteers
- 441 people
- Sponsor
- King Abdulaziz University
Rectum Cancer, Stoma Colostomy
Effects of Modified Precision Functional Sphincter-Preserving Surgery (PPS) on Ultralow Rectal Cancer
RATIONALE: Colorectal cancer is one of the most common cancers. However, approaches to minimize surgical trauma, preserve anal function, avoid abdominal stoma, and improve quality of life for patients with ultralow rectal cancers…
- Conditions
- Rectum Cancer, Stoma Colostomy, Faecal Incontinence, Leakage, Anastomotic
- Trial name
- NCT05245565
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai 10th People's Hospital
Microdialysis, Ischemia
Local Metabolism of the Gastric Tube Reconstruction After Esophagectomy
Postoperative surveillance of local metabolism of the surgical reconstruction after esophagectomy by means of Microdialysis. Dialysate is collected continuously for seven postoperative Days.
- Conditions
- Microdialysis, Ischemia, Anastomotic Leakage
- Trial name
- NCT04319835
- Testing
- OnZurf Probe
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Anastomotic Leakage
Drainage Fluid Biomarkers and Anastomotic Leakage in Colorectal Surgery. A Monocentric Prospective Observational Study
Anastomotic leakage (AL) is one of the most feared intra-abdominal septic complications (IASC) after colorectal surgery. It is defined as the leak of intestinal content due to an anastomotic dehiscence.
- Trial name
- ALbiomarkers (NCT04846283)
- Testing
- Elective or emergency colorectal surgery for cancer, diverticular disease, inflammatory bowel-disease or reversal of Hartmann's procedure
- Where
- Italy
- Volunteers
- 207 people
- Sponsor
- University of Palermo
Rectal Cancer
Anastomotic Leakage After Anterior Resection of Rectal Cancer
Anastomotic leakage (AL) is one of the most-feared postoperative complications after anterior resection of rectal cancer. This complication compromises both short term and long term outcome of patients.
- Trial name
- NCT03281070
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Friendship Hospital
Anastomosis, Leaking
Study With Dehisgel Used in Adult Patients Undergoing Colorectal Anastomosis
A two-phase, multicenter, open-label, "first-in-human" prospective study evaluating the product's safety and efficacy in a pivotal phase.
- Trial name
- NCT07490080
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Contipro Pharma a.s.
Colorectal Cancer, Anastomotic Leakage
Prospective Phase II Study on Continuous Circumferential Reinforcement of Laparoscopic Rectal Anastomosis to Prevent Complications
Anastomotic leakage (AL) is one of the most severe complications following laparoscopic rectal cancer surgery. According to the International Study Group of Rectal Cancer (ISREC), AL is defined as a defect of intestinal wall…
- Conditions
- Colorectal Cancer, Anastomotic Leakage, Operation
- Trial name
- NCT06495853
- Testing
- Continuous Circumferential Reinforcement of the Anastomotic
- Where
- China
- Volunteers
- 208 people
- Sponsor
- ZHI-ZHONG PAN
Esophageal Cancer
Preoperative Arterial Embolization Before Oncologic Esophagectomy as a Technique for Ischemic Gastric Conditioning
This retrospective monocentric comparative study aims to assess the efficacy of preoperative ischemic conditioning, in preventing anastomotic leakage in esophageal cancer surgery.
- Trial name
- NCT06312839
- Testing
- Collecting data from the medical record
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Anastomotic Leak
Prevention of Anastomotic Leak in Gastrointestinal (GI) Anastomosis With the Application of Tisseal in the Anastomotic Line
The anastomotic leak is one of the most feared complications in abdominal surgery. Certain control methods have been described but the incidence of that complication remains high and is the first cause of mortality in operations…
- Trial name
- NCT01306851
- Testing
- Fibrin glue
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Colorectal Cancer, Postoperative Complications
The Impact of Transanal Decompression Tube Placement After Colorectal Anastomosis: A Randomized Trial
There is currently no standardization in the use of the transanal decompressive tube during the postoperative after a colorectal surgery. The available evidence is based on studies with methodological differences.
- Conditions
- Colorectal Cancer, Postoperative Complications, Anastomotic Leak, Anastomotic Complication
- Trial name
- SONDES (NCT04890015)
- Testing
- Intraoperative transanal decompression tube placement
- Where
- Spain
- Volunteers
- 202 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Gastric Cancer
Validation of a Model for Predicting Anastomotic Leakage
This study will validate a machine learning model for predicting anastomotic leakage of esophagogastrostomy and esophagojejunostomy.
- Trial name
- NCT05646290
- Where
- China
- Volunteers
- 512 people
- Sponsor
- Jichao Qin
Esophageal Anastomotic Leak
Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage (PLACE030)
The primary objective is to evaluate the efficacy and assess the role of Porcine Fibrin Sealant (Bioseal®) in preventing cervical anastomotic leakage after esophagectomy in the patients with resectable thoracic esophageal cancer…
- Trial name
- NCT03847857
- Testing
- Porcine Fibrin Sealant (PFS), McKeown esophagectomy
- Where
- 6 sites in China
- Volunteers
- 360 people
- Sponsor
- Sun Yat-sen University