Clinical trials: Anastomotic Leakage
Postoperative Complications
Probiotics in the Prevention of Complications After Colorectal Surgery
Based on the need of large-scale, trials to explore the use of probiotics to reduce post-operative complication rate, a randomized controlled trial is designed to investigate the impact of a probiotics treatment protocol on…
- Trial name
- NCT02313519
- Testing
- Probiotics
- Volunteers
- 164 people
- Sponsor
- Evangelos J. Giamarellos-Bourboulis, M.D.
Colorectal Cancer (CRC), Rectal Cancer Surgery
Indocyanine Green Fluorescence Angiography in Laparoscopic Sigmoid and Rectal Cancer Surgery
Anastomotic leakage remains a major complication after colorectal cancer surgery. Indocyanine green fluorescence angiography (ICG-FA) allows real-time intraoperative assessment of bowel perfusion; however, its clinical impact…
- Conditions
- Colorectal Cancer (CRC), Rectal Cancer Surgery, Sigmoid Colon Cancer
- Trial name
- NCT07423130
- Where
- Poland
- Volunteers
- 115 people
- Sponsor
- Jagiellonian University
Adenocarcinoma Colon
Study for the Efficacy and Security Analysis in the Protection of Ileocolic Anastomosis Conducted in Laparoscopic Right Hemicolectomy Because of Colon Cancer, Using a NHS-PEG Coated Collagen Patch.
The aim of this study is to analyse the effectiveness and security in the prevention of anastomotic leakage by protecting the ileocolic anastomosis with a reabsorbable NHS-PEG collagen patch.
- Trial name
- ANASTOPATCH (NCT04109105)
- Testing
- NHS-PEG coated collagen patch
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Anastomotic Complication
The Effect of Inulin Supplementation on Colorectal Surgery Outcomes
Colorectal cancer (CRC) is the third most diagnosed cancer in Canada. The most common surgical procedure in patients with CRC is an intestinal resection followed by a reconnection to rejoin the ends of the remaining bowel.
- Trial name
- INULINE (NCT05860322)
- Testing
- Inulin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Anastomotic Leak Esophagus, Swallowing Disorder
Functional Outcome After Anastomotic Leak After Oesophagectomies
The main surgical treatment for oesophageal cancer is a curative resection, mostly performed according to Ivor Lewis. However, despite careful work and refined surgical techniques, anastomotic leakage (AL) occurs in more than…
- Trial name
- FOAL (NCT05945654)
- Testing
- Anastomotic Leak after Ivor Lewis Oesophagectomy
- Where
- Switzerland
- Sponsor
- Stefan Gutknecht
Anastomotic Leak
Non-invasive Detection of Anastomotic Leakage
Esophagectomy or pancreaticoduodenectomy is the standard surgical approach for patients with malignant tumors of the esophagus or pancreatic head.
- Trial name
- NCT03203434
- Testing
- Urinary volatile organic compound analysis
- Volunteers
- 66 people
- Sponsor
- Amsterdam UMC, location VUmc
Anastomosis, Leaking
Assessing the Validity of Dulk Score in Identifying Anastomotic Leak in Early Postoperative Period
Anastomotic leak is a commonly seen post-operative complication in patients who undergo bowel anastomosis. The outcome of which can range from conservative management to re-exteriorisation of bowel loop.
- Trial name
- DULK (NCT06733571)
- Where
- India
- Volunteers
- 86 people
- Sponsor
- Sawai Mansingh Medical College
Colo-rectal Cancer, Crohn Disease
Anastomotic Leakage and Value Of Indocyanine Green in Decreasing Leakage Rates
Anastomotic leakage (AL) is one of the major complications after gastrointestinal surgery. Compromised tissue perfusion at the anastomosis site increases the risk of AL.
- Conditions
- Colo-rectal Cancer, Crohn Disease, Resectable Colorectal Carcinoma
- Trial name
- AVOID (NCT04712032)
- Testing
- ICG-guided bowel perfusion assessment
- Where
- Netherlands
- Volunteers
- 978 people
- Sponsor
- Leiden University Medical Center
Colorectal Cancer, Colon Cancer
Factors Affecting the Results of Treatment of Patients With Colorectal Cancer
The study attempts to quantify the relative risks for mortality, anastomotic leakage and other early and late postoperative complications, recurrence rate, cancer-specific survival, recurrence-free survival after colorectal…
- Conditions
- Colorectal Cancer, Colon Cancer, Rectal Cancer, Colorectal Adenocarcinoma
- Trial name
- NCT06050447
- Testing
- Right hemicolectomy, Left hemicolectomy, Sigmoid colon resection
- Where
- Russia
- Volunteers
- 1,200 people
- Sponsor
- Immanuel Kant Baltic Federal University
Rectal Carcinoma, Laparoscopy
Laparoscopic Anterior Resection With or Without "Dog Ear" Double-stapled Anastomosis for Rectal Cancer
The study evaluates the feasibility and advantage of modified laparoscopic double-staple anastomosis technique which to eliminate the 'dog ears' in laparoscopic rectal anterior resection.
- Conditions
- Rectal Carcinoma, Laparoscopy, Anastomotic Leak
- Trial name
- NCT02770911
- Testing
- without "Dog Ear" group, with "Dog Ear" group
- Volunteers
- 250 people
- Sponsor
- Fujian Medical University
Anastomotic Leak, Anastomosis; Complications
ESCP Safe Anastomosis proGramme in coLorectal surgEry
EAGLE is an international service improvement study to investigate the value of an educational tool delivered to surgeons and their teams to reduce the risk of anastomotic leak (leak of a join in the bowel) after right…
- Trial name
- EAGLE (NCT04270721)
- Testing
- The EAGLE Safe Anastomosis Quality Improvement Intervention
- Where
- Russia
- Volunteers
- 4,400 people
- Sponsor
- University of Birmingham
Colorectal Cancer
C-Reactive Protein and Sodium in Predicting Anastomotic Leakage
Anastomotic leakage is serious morbidity that can develop in patients operated on for colorectal cancer and can reach potentially life-threatening dimensions.
- Trial name
- NCT04717648
- Testing
- Biochemical test
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Tepecik Training and Research Hospital
Anastomotic Leak
Economic Evaluation of Stream™ Platform
This Economic Evaluation study is a multi-center, two-arm, non-randomized, interventional trial. The purpose of this study is to evaluate the economic and patient outcomes of using the Stream™ Platform for early detection of…
- Trial name
- CostAL (NCT05994625)
- Testing
- Stream™ Platform, Stream™ Platform with Risk Score Omitted
- Where
- 2 sites in Canada
- Volunteers
- 215 people
- Sponsor
- FluidAI Medical
Pancreatic Anastomotic Leak
Comparative Study Between Duct to Mucosa and Invagination Pancreaticojejunostomy After Pancreaticoduodenectomy:
Postoperative pancreatic fistula (POPF) remains a challenge even at specialized centers, and also affect significantly the surgical outcomes .
- Trial name
- PJ (NCT02142517)
- Testing
- Duct to mucosa PJ group, Invagination PJ group
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Mansoura University
Rectal Cancer, Anastomotic Leak
CRP-guided Transanal Drainage Removal After Rectal Surgery
Transanal drainage tube (TDT) has the benefit of reducing intraluminal pressure after rectal surgery and may provide ideal regional environment for anastomotic healing.
- Trial name
- NCT05502354
- Testing
- removal of transanal drainage tube
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Qilu Hospital of Shandong University
Obesity, Obesity, Morbid
Endoscopic Metabolic and Bariatric Therapies
This is a prospective collection of data from adult patients who have had an endoscopic metabolic and bariatric endoscopy procedure (EMBT) for primary or revision surgical procedures for obesity.
- Conditions
- Obesity, Obesity, Morbid, Obesity Associated Disorder, Bariatric Surgery Candidate
- Trial name
- EMBTs (NCT05725967)
- Testing
- Primary Obesity Endoscopic Procedures, Endoscopic Revision of Bariatric Surgical Procedures, Bariatric Surgery Procedures
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Colorectal Cancer, Anastomotic Leakage
Prospective Phase II Study on Continuous Circumferential Reinforcement of Laparoscopic Rectal Anastomosis to Prevent Complications
Anastomotic leakage (AL) is one of the most severe complications following laparoscopic rectal cancer surgery. According to the International Study Group of Rectal Cancer (ISREC), AL is defined as a defect of intestinal wall…
- Conditions
- Colorectal Cancer, Anastomotic Leakage, Operation
- Trial name
- NCT06495853
- Testing
- Continuous Circumferential Reinforcement of the Anastomotic
- Where
- China
- Volunteers
- 208 people
- Sponsor
- ZHI-ZHONG PAN
Mediastinitis, Esophageal Neoplasms
Endoscopic-vacuum Assisted Closure of Intrathoracic Postsurgical Leaks
The purpose of this study is to determine the short and long term outcome of endoscopic vacuum assisted closure of intrathoracic postsurgical leaks.
- Conditions
- Mediastinitis, Esophageal Neoplasms, Anastomotic Leakage
- Trial name
- EVACoIL (NCT00876551)
- Testing
- Endoscopic vacuum assisted closure
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Hannover Medical School
Rectal Cancer
Transanal Reinforcement of Low Rectal Anastomosis in Rectal Cancer Surgery
Anastomotic leak after low rectal cancer surgery occurs between 3 and 24% of the cases and is a severe complication leading to sepsis, permanent colostomy, higher risk of local cancer recurrence and eventually death.
- Trial name
- LessStoReS (NCT02279771)
- Testing
- transanal anastomotic reinforcement, protective ileostomy group, a circular anal dilator (CAD)
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Donato F Altomare
Rectal Cancers
Local Methylene Blue Injection for Prevention of Anastomotic Leakage and Permanent Stoma After Low Anterior Resection for Rectal Cancer
Rectal cancer surgery has become increasingly effective, allowing many patients to avoid permanent colostomy. However, anastomotic leakage remains one of the most serious complications after rectal cancer surgery, especially in…
- Trial name
- PKUCH-R10 (NCT07833319)
- Testing
- methylene blue injection
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Peking University Cancer Hospital & Institute