Clinical trials: Anastomotic Leakage
Rectum Cancer, Faecal Incontinence
Exploring the Effect of Colonic J-pouch in Anorectal Preservation Surgery for Ultra-low Rectal Cancer.
The occurrence of colorectal cancer has increased from the third most common cancer in 2018 to the second most common cancer in 2023.
- Conditions
- Rectum Cancer, Faecal Incontinence, Faecal Incontinence with Faecal Urgency, Low Anterior Resection Syndrome
- Trial name
- NCT06601985
- Testing
- J-pouch anastomosis, direct anastomosis
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Shanghai 10th People's Hospital
Esophageal Cancer, Esophagus Cancer
Endoluminal Vacuum Therapy to Prevent Anastomotic Leakage After Esophagectomy Due to Esophageal Cancer
A prospective, multi-centre, exploratory and observational one-arm study to evaluate preventive Endoluminal Vacuum Therapy(pEVT) to prevent anastomotic leakage after esophagectomy due to esophageal cancer.
- Conditions
- Esophageal Cancer, Esophagus Cancer, Anastomotic Leak
- Trial name
- ESPY (NCT06097078)
- Testing
- Eso-SPONGE®
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Aesculap AG
Colorectal Cancer
Indicators of Anastomotic Leak After Colorectal Surgery
We reviewed the patient underwent colorectal surgery with anastomosis and identified patients with anastomotic leak. Then we started to figure out what blood investigation could be related to anastomotic leak.
- Trial name
- NCT06156358
- Testing
- No intervention
- Volunteers
- 441 people
- Sponsor
- King Abdulaziz University
Perforation Esophagus, Esophageal Cancer
Feasibility and Efficacy of a Combination of a SEMS and Vacuum Wound Treatment (VACStent)
Open, prospective, one-arm feasibility and efficacy study of a European conformity (CE) certified Combination product of two CE certified medical devices in the intended indication.
- Conditions
- Perforation Esophagus, Esophageal Cancer, Esophageal Achalasia, Esophageal Diseases
- Trial name
- VACStent (NCT03962179)
- Testing
- VACStent
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital of Cologne
Liver Transplantation, Liver Transplant; Complications
EBD RCT Trial in Living Donor Liver Transplantation
This study was designed to demonstrate incidence of biliary complication rates after living donor liver transplantation according to the implantation of external biliary drainage throug duct-to-duct anastomosis site.
- Conditions
- Liver Transplantation, Liver Transplant; Complications, Bile Stricture, Bile Leakage From Biliary Anastomosis
- Trial name
- NCT04622540
- Testing
- External biliary drainage
- Where
- South Korea
- Volunteers
- 124 people
- Sponsor
- Seoul National University Hospital
Gastric Cancer, Anastomotic Leak
Human Albumin and Anastomotic Leakage After Gastric Cancer Surgery
We investigate whether the intravenously administered human albumin is beneficial to prevent anastomotic leakage after gastric cancer surgery.
- Trial name
- NCT04490668
- Testing
- Human albumin
- Volunteers
- 1,049 people
- Sponsor
- Ruijin Hospital
Colorectal Cancer Postoperative Complications
Circular Staplers and Anastomotic Leak After Colorectal Surgery
The goal of this observational study is to evaluate whether different circular stapling devices influence the success of the surgical connection between the bowel ends after colorectal cancer surgery in patients undergoing…
- Trial name
- PROTECT (NCT07643857)
- Testing
- Two-row circular stapler, Three-row circular stapler, Powered circular stapler
- Volunteers
- 597 people
- Sponsor
- Azienda Ospedaliera Bolognini di Seriate Bergamo
Anastomotic Leak, Anastomotic Leak Large Intestine
A1Check: the External Validation of a Machine Learning Model Predicting Colorectal Anastomotic Leakage
Anastomotic leakage is a severe complication that can arise following a colorectal resection. It impairs both the short- and long-term outcomes, and negatively influences cancer recurrence rates.
- Conditions
- Anastomotic Leak, Anastomotic Leak Large Intestine, Anastomotic Complication, Anastomotic Leak Rectum
- Trial name
- A1Check (NCT05810207)
- Testing
- Colorectal resection
- Where
- 8 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Freek Daams
Colorectal Cancer, Anastomotic Leak
Indocyanine Green Fluorescent Imaging in Robotic Assisted Rectosigmoidal Resection; a Multicenter Assessment of Interobserver Variation and Comparison With Computer-based Pixel Analysis
A serious complication to colorectal surgery is anastomotic leakage (AL). AL increases post-operative mortality, decreases long-term survival, reduces the functional result and reduces qual-ity of life.
- Trial name
- NCT04766060
- Testing
- Fluorescent Imaging
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Odense University Hospital
Anastomotic Leak, Rectal Cancer
Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of Microbes in Anastomotic Healing
Rationale: The surgical complication of intestinal anastomotic leak remains a clear and present danger to patients despite advances in surgical technique and ever more powerful antibiotics.
- Trial name
- SES-DTA (NCT02682485)
- Testing
- Cipro, metronidazole, neomycin combo, Serial Endoscopic Surveillance, Saline
- Sponsor
- University of Chicago
Anastomotic Leak, Sigmoid Diseases
Lateral Invagination of the Colorectal Anastomosis by Double Stapling
Anastomotic dehiscence is the most feared complication in colorectal surgery, occurring in 6.3% -13.7% in patients with pelvic anastomoses [1-4].
- Trial name
- NCT04553250
- Testing
- Doubled-stapled colorectal anastomosis
- Volunteers
- 786 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Anastomotic Leak
Neutrophil-to-lymphocyte Ratio vs C-reactive Protein as Early Predictors of Anastomotic Leakage After Colorectal Surgery
Introduction: Colorectal surgery (CRS) is associated with high morbidity rates, being anastomotic leakage (AL) one of the most serious complications with an incidence as high as 15%, accounting for up to a third of mortality in…
- Trial name
- NCT04673110
- Testing
- Neutrophil to Lymphocyte Ratio and C-reactive protein
- Volunteers
- 116 people
- Sponsor
- Clinica Universitaria Reina Fabiola, Universidad Catolica de Cordoba
Anastomotic Leaks
Surgical Intuition in Anastomotic Leakage After Colorectal Surgery
The SURGUT study aims to assess how well a computer model predicts bowel leaks after surgery. It will also examine whether adding surgeons' intuition improves these predictions.
- Trial name
- SURGUT (NCT07888478)
- Where
- 2 sites in Switzerland
- Volunteers
- 4,300 people
- Sponsor
- University Hospital, Basel, Switzerland
Anastomotic Leak
Anastomotic Leakage in Right Colectomy
Data of patients undergoing elective right colectomy for benign and malignant disease using an open or laparoscopic approach are to be collected in seven colorectal units among Austria for the period between January 2010 and…
- Trial name
- NCT06553261
- Testing
- suturing of leak, lavage, drainage, Formation of a new anasthomosis, Fecal diversion
- Where
- Austria
- Volunteers
- 3,446 people
- Sponsor
- Barmherzige Brüder Vienna
Anastomotic Leak Rectum, Rectal Cancer
Healing of Rectal Anastomosis Sealed With a Concentrate Derived From the Patient's Blood, After Rectal Cancer Surgery
Rectal cancer is one of the most frequent cancer diseases, with more than 1500 new cases per year in Denmark. Fortunately, if the tumor is discovered early, surgeons can remove the part of the intestine that is afflicted, and…
- Conditions
- Anastomotic Leak Rectum, Rectal Cancer, Anastomotic Leakage
- Trial name
- OBANORES (NCT05293054)
- Testing
- Application of autologous fibrin matrix (Obsidian)
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Surgical Anastomosis
ICG Anastomotic Control in Digestive System Surgery
This was a parallel single-center retrospective cohort study conducted at Linglong Yingcheng Hospital, Shandong, China. The purpose of this study was to investigate the effect of indocyanine green (ICG) on patients undergoing…
- Trial name
- NCT06270745
- Testing
- indocyanine green
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shandong Linglong Yingcheng Hospital
Anastomosis; Complications, Anastomosis, Surgical
Role of Indexed Oxygen Delivery in Anastomotic Insufficiencies in Elective Laparoscopic Colorectal Resections for Cancer
Colorectal cancer is a very commonly diagnosed malignancy worldwide, and surgical resection remains the mainstay of treatment. Outcomes depend on preoperative staging, surgical quality, complication rates, and multidisciplinary…
- Conditions
- Anastomosis; Complications, Anastomosis, Surgical, Anastomosis, Leaking, Anastomotic Leaks
- Trial name
- NCT07099820
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Saint Camillus International University of Health Sciences
Fracture of Hip, Ileus
Peripheral Perfusion Index in Acute Surgical Patients
Introduction Perioperative haemodynamic instability is associated with postoperative morbidity and mortality. Macrocirculatory parameters, such as the conventionally obtained mean arterial blood pressure and cardiac output, may…
- Conditions
- Fracture of Hip, Ileus, Perforated Viscus, Anastomotic Leak
- Trial name
- NCT03757442
- Where
- Denmark
- Volunteers
- 1,338 people
- Sponsor
- Hvidovre University Hospital
Esophageal Cancer, Esophageal Neoplasms
TreatmENT of AnastomotiC Leakage After Esophagectomy
Rationale: Anastomotic leakage (0% - 30%) is a severe complication after esophagectomy with mortality rates approximately ranging from 2% - 12%. In addition, it is associated with a prolonged ICU treatment and hospital stay.
- Trial name
- TENTACLE (NCT03829098)
- Testing
- Intervantions for anastomotic leakage after esophagectomy
- Where
- Netherlands
- Volunteers
- 1,509 people
- Sponsor
- Radboud University Medical Center
Postoperative Peritonitis, Anastomotic Leakage
Delayed Small-Bowel Anastomosis in Patients With Postoperative Peritonitis
Surgical management results for 114 patients with postoperative peritonitis due to small-bowel perforations, necrosis, and anastomotic leakage were comparatively analyzed.
- Conditions
- Postoperative Peritonitis, Anastomotic Leakage, Intestinal Perforation Small
- Trial name
- Peritonitis (NCT03690687)
- Testing
- Primary anastomosis, Delayed anastomosis, Enterostomy
- Volunteers
- 114 people
- Sponsor
- Andrey Nikolayevich Zharikov