Clinical trials: Androgen Deprivation Therapy
Prostate Cancer
Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Androgens can cause the growth of prostate cancer cells.
- Trial name
- NCT00567580
- Testing
- PBRT, PLNRT, AA
- Where
- 460 sites in United States, Canada and 2 more
- Volunteers
- 1,792 people
- Sponsor
- Radiation Therapy Oncology Group
Metabolic Syndrome, Hypercholesterolemia
Metformin in Preventing Androgen Deprivation Therapy Induced Insulin Resistance and Metabolic Syndrome
The main purpose of this study is to assess the efficacy of metformin in abrogating androgen deprivation therapy (ADT) induced insulin resistance as measured by homeostasis model assessment (HOMAIR) in men with non-metastatic…
- Trial name
- MVENT (NCT01077479)
- Testing
- Metformin
- Where
- Australia
- Volunteers
- 28 people
- Sponsor
- Western Sydney Local Health District
Prostate Cancer
A Study of Degarelix in Taiwanese Patients With Prostate Cancer
A phase III trial investigating the efficacy and safety of degarelix one-month depot in Taiwanese patients with prostate cancer.
- Trial name
- NCT01220869
- Testing
- Degarelix
- Where
- 10 sites in Taiwan
- Volunteers
- 110 people
- Sponsor
- Ferring Pharmaceuticals
Prostate Cancer
Intermittent Fasting in Prostate Cancer Patients Receiving Androgen Deprivation Therapy
This is a a pilot study to assess the feasibility of intermittent caloric restriction (plus a plant-enriched diet optionally) in prostate cancer patients receiving androgen deprivation therapy.
- Trial name
- NCT06172283
- Testing
- Intermittent Fasting
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo
Prostatic Neoplasms, Exercise Therapy
Supervised Group Based Exercise for Men With Prostate Cancer on Androgen Deprivation Therapy
Exercise intervention for men with prostate cancer on androgen deprivation therapy.
- Conditions
- Prostatic Neoplasms, Exercise Therapy, Androgen Deprivation Therapy
- Trial name
- NCT02631681
- Testing
- Group based exercise
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Herlev Hospital
Prostate Cancer, Metabolic Syndrome
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
The overriding objectives of this study are: 1. Primary outcomes: 1. To confirm that administration of oral acetate increases the proportion of A.
- Conditions
- Prostate Cancer, Metabolic Syndrome, Obesity, Cardiovascular Morbidity
- Trial name
- NCT05802121
- Testing
- Apple Cider Vinegar
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Western University
Prostate Cancer
Radiation Therapy With Androgen Suppression in Treating Patients With Prostate Cancer
RATIONALE: Imaging procedures such as MRI may improve the ability to determine the response of prostate tumors to therapy. PURPOSE: Phase II trial to study MRI results in patients with prostate cancer that has been treated with…
- Trial name
- NCT00002889
- Testing
- flutamide, goserelin, leuprolide acetate
- Where
- 12 sites in United States
- Volunteers
- 180 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Prostate Cancer
Hormone Therapy and Radiation Therapy or Hormone Therapy and Radiation Therapy Followed by Docetaxel and Prednisone in Treating Patients With Localized Prostate Cancer
RATIONALE: Androgens can cause the growth of prostate cancer cells. Hormone therapy using drugs, such as leuprolide, goserelin, flutamide, or bicalutamide, may fight prostate cancer by lowering the amount of androgens the body…
- Trial name
- NCT00288080
- Testing
- Dexamethasone, Prednisone, docetaxel
- Where
- 254 sites in United States, Canada
- Volunteers
- 612 people
- Sponsor
- Radiation Therapy Oncology Group
Prostate Cancer
Study of External Beam Radiation Therapy With and Without Hormonal Therapy to Treat Prostate Cancer
This clinical study was to determine if the use of 6 months of total androgen suppression (hormonal therapy) when added to radiation therapy for localized-high risk prostate cancer would improve overall survival.
- Trial name
- NCT00116220
- Testing
- Flutamide (Eulexin) and Lupron or Zoladex, External Beam Radiotherapy
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Dana-Farber Cancer Institute
Prostate Cancer, Prostate Cancer (Adenocarcinoma)
Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy
The goal of this clinical trial is to learn if fezolinetant can treat hot flashes (vasomotor symptoms) in men with prostate cancer undergoing androgen deprivation therapy.
- Conditions
- Prostate Cancer, Prostate Cancer (Adenocarcinoma), Prostate Cancer Metastatic Disease, Prostate Cancer Recurrent
- Trial name
- Fezo-ADT (NCT06957691)
- Testing
- fezolinetant - reference formulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Shehzad Basaria, M.D.
Prostate Cancer Patients, Androgen Deprivation Therapy
Effects of Combined Training in Prostate Cancer Patients
Prostate cancer is the most prevalent type among men in Brazil, after non-melanoma skin cancer. One of the main treatment approaches is androgen suppression therapy (AST), which, although effective in controlling tumor growth…
- Trial name
- Proactive (NCT07680920)
- Testing
- Combined training
- Volunteers
- 46 people
- Sponsor
- Universidade Federal de Santa Catarina
Prostatic Neoplasm, Osteoporosis
Exercise for Physical Health in Men With Prostate Cancer
The purpose of this study is to conduct a 12-month randomized controlled trial comparing the effects of strength and impact exercise training to flexibility/relaxation training on body composition (bone, muscle and fat mass)…
- Trial name
- NCT00660686
- Testing
- Resistance Exercise, Flexibility Training
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- OHSU Knight Cancer Institute
Prostate Cancer
Mild Cognitive Impairment in Men Following Androgen Deprivation
MCI with ageing is thought in part to be related to reduced serum sex hormones which is well-recognised, especially in females, but poorly understood.
- Trial name
- NCT01691976
- Testing
- Oestrogen Patches, LHRHa
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
Osteoporosis
Changes in Bone Mineral Density and Fracture Risk in Patients Receiving Androgen Deprivation Therapy for Prostate Cancer
The aim of this study is to determine the long term effects of two types of hormonal treatment for advanced prostate cancer (LHRH agonists and the antiandrogen bicalutamide)on the bone mineral density of patients.
- Trial name
- NCT00536653
- Testing
- Bicalutamide and Calcium/ Vitamin D supplementation, LHRH agonists (Goserelin acetate) and Calcium/ Vitamin D supplementation, LHRH agonists (Goserelin acetate)
- Where
- United Kingdom
- Volunteers
- 618 people
- Sponsor
- Wirral University Teaching Hospital NHS Trust
Prostate Adenocarcinoma, Stage I Prostate Cancer
Androgen Deprivation Therapy and Vorinostat Followed by Radical Prostatectomy in Treating Patients With Localized Prostate Cancer
This phase II trial studies how well androgen deprivation therapy and vorinostat followed by radical prostatectomy works in treating patients with prostate cancer that has not spread to other parts of the body.
- Conditions
- Prostate Adenocarcinoma, Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer
- Trial name
- TARGET (NCT00589472)
- Testing
- Bicalutamide, Goserelin Acetate, Laboratory Biomarker Analysis
- Where
- 15 sites in United States
- Volunteers
- 19 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer
Hormone Sensitive Prostate Cancer Patients Switched to Degarelix Therapy After Failing on GnRH Agonists
This Phase IV observational trial is intended to identify patients who are failing GnRH agonist therapy as evidenced by a rising PSA and who have yet to initiate secondary manoeuvres involving antiandrogens.
- Trial name
- DELAY (NCT01366053)
- Where
- 17 sites in Canada
- Volunteers
- 125 people
- Sponsor
- CMX Research
Prostate Cancer
Predicting Cognitive Decline From Androgen Deprivation Therapy
Androgen Deprivation Therapy (ADT) is associated with cognitive impairment and dementia in men with prostate cancer. Pre-clinical data suggest that ADT-induced hypogonadism leads to accumulation of beta-amyloid plaques in the…
- Trial name
- ABC (NCT05820932)
- Testing
- Blood-based assay, Cognitive assessments, Quality of Life Surveys
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Prostate Cancer
Evaluation of dAroLutamide Addition to anDrogen Deprivation Therapy and radIatioN Therapy in Newly Diagnosed Prostate Cancer With Pelvic Lymph Nodes Metastases
Prospective, multicenter, comparative, randomized placebo-controlled Phase III trial - patients with hormone-naïve prostate cancer and pelvic lymph nodes metastases
- Trial name
- ALADDIN (NCT05116475)
- Testing
- Darolutamide 300 mg
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie
Recurrent Prostate Cancer, Stage IV Prostate Cancer
Intensive Diet and Exercise or Standard of Care in Improving Physical Function and Quality of Life in Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy
This randomized pilot clinical trial studies intensive diet and exercise or standard of care in improving physical function and quality of life in patients with prostate cancer undergoing androgen deprivation therapy.
- Trial name
- IDEA-P (NCT02050906)
- Testing
- behavioral dietary intervention, exercise intervention, behavioral activity counseling
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
High-risk Localized Prostate Cancer
A Study to Learn How Well a Combination of Darolutamide and Androgen Deprivation Therapy (ADT) Works as a Treatment Before Surgery for Men Who Have High-risk Localized Prostate Cancer.
Researchers are looking for a better way to treat men who have high-risk localized prostate cancer, which refers to a type of prostate cancer that is still confined to the prostate gland but has certain characteristics that make…
- Trial name
- CHINANEO (NCT07450599)
- Testing
- Darolutamide, ADT
- Where
- 23 sites in China
- Volunteers
- 250 people
- Sponsor
- Bayer